Clinical trials: Anti-Bacterial Agents
Urinary Tract Infection, Cellulitis
Clinical Efficacy of Stopping Oral Antibiotics When Symptoms Stop, Compared to 'Finishing the Course'
The aim of the StopStop@HITH study is to see if stopping antibiotics when symptoms stop is as good as finishing the course of antibiotics.
- Conditions
- Urinary Tract Infection, Cellulitis, Respiratory Tract Infections, Lymphadenitis
- Trial name
- StopStop@HITH (NCT07532941)
- Testing
- Antibiotics for duration of symptoms, Antibiotics for duration of prescribed course
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Murdoch Childrens Research Institute
Urinary Tract Infections, Recurrent UTI
Probiotics and Multi-Drug Resistant Urinary Tract Infection
This pilot study is a single-site randomized, double blinded placebo-controlled in females with recurrent multi-drug resistant (MDR) urinary tract infections(UTI).
- Conditions
- Urinary Tract Infections, Recurrent UTI, Antibiotic Resistant Infection
- Trial name
- NCT03644966
- Testing
- Bifidobacterium infantis, Antibiotics
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Urinary Tract Infections
A Study in Pediatric Participants Aged ≥2 to <12 Years With a Suspected or Confirmed Bacterial Infection or Receiving Prophylaxis Antibiotics
The study will be conducted to evaluate how a single oral dose of Gepotidacin is processed in the body over time along with safety monitoring in hospitalized pediatric participants who are receiving a standard of care treatment…
- Trial name
- NCT07371429
- Testing
- Gepotidacin, SOC
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- GlaxoSmithKline
Antibiotic Sore Tongue
Antibiotic Observatory for Respiratory Diseases, Apart From Tuberculosis and Reportable Diseases
the study aimed to determine the distribution of respiratory infections in Tunisian population and evaluate the frequency of antibiotics prescribed according to current international recommendations.
- Trial name
- AORD (NCT04482231)
- Where
- Tunisia
- Volunteers
- 9,944 people
- Sponsor
- University of Monastir
Benign Prostatic Hyperplasia, Urinary Tract Infections
Role of Prophylactic Postoperative Antibiotics in HoLEP
The purpose of this study is to investigate whether prescribing a 3-day course of antibiotics after Holmium laser enucleation of the prostate (HoLEP) reduces the risk of urinary tract infection.
- Trial name
- NCT05274672
- Testing
- Nitrofurantoin, Cephalexin, Sulfamethoxazole Trimethoprim Combination
- Where
- 2 sites in United States
- Sponsor
- Baylor Research Institute
Opioid Use Disorder
Determining the Feasibility of Outpatient Parenteral Antibiotic Therapy for Persons Who Inject Opioids
Patients with a history of injection drug use are historically excluded from home outpatient parenteral antibiotic therapy programs.
- Trial name
- NCT05300581
- Testing
- OPAT for PWID
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Antibiotic-associated Diarrhea
Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
The focus of the study is to better understand the mechanisms causing antibiotic-associated diarrhea (AAD) and how probiotics may prevent some of the iatrogenic effects of antibiotic medications.
- Trial name
- YOBIOTIC (NCT03755765)
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Sexually Transmitted Diseases
A Trial to Compare Antibacterial vs. Placebo Mouthwash to Reduce the Incidence of Sexually Transmitted Infections (STIs) in Men Who Have Sex With Men (MSM) Taking HIV Pre-Exposure Prophylaxis (PrEP)
The study involves a randomized placebo controlled trial that aims to assess if a mouthwash (Listerine cool mint, LCM) is able to reduce the cumulative incidence of gonorrhoea (Ng), chlamydia (Ct) and syphilis in men who have sex…
- Trial name
- PReGo (NCT03881007)
- Testing
- Mouthwash with LCM
- Where
- Belgium
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
COVID-19, SARS-CoV2 Infection
Topical Antibacterial Agents for Prevention of COVID-19
The primary objective of this study is to determine whether intranasal application of aminoglycoside (Neosporin) increases local nasal innate immune responses compared to placebo control in healthy participants.
- Trial name
- NCT05449392
- Testing
- Neosporin, Vaseline
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Yale University
Bladder (Urothelial, Transitional Cell) Cancer
Clinical Trial on the Protective Role of Vitamin B3 in Enhancing Immunotherapy for Bladder Cancer Patients
When bladder cancer patients are treated to mobilize their own immune system to fight the tumor, drugs that kill the bacteria can impair the effectiveness of the treatment.
- Trial name
- NCT07119996
- Testing
- Tislelizumab, Cisplatin, Gemcitabine and Vitamin B3
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Clostridium Difficile Infection
Safety and Clinical Effectiveness of Oral Probiotic MIYA-BM to Prevent Recurrent Clostridium Difficile Infections
Patients with confirmed C. difficile infection (CDI) who meet eligibility requirements will be invited to participate. All study patients must receive treatment for CDI with metronidazole or vancomycin.
- Trial name
- NCT01077245
- Testing
- MIYA-BM Fine Granules (CBM588)
- Sponsor
- Osel, Inc.
Simvastatin Pharmacokinetics and Gut Microbiome
Evaluate the Effects of the Environmental Change in Intestine by Antibiotics on the Pharmacokinetic Characteristics of Simvastatin in Healthy Male Volunteers
This phase 1 clinical trial is to evaluate the effects of the environmental change in intestine by antibiotics on the pharmacokinetic characteristics of simvastatin in healthy male volunteers.
- Trial name
- NCT03403972
- Testing
- Vancomycin 250Mg Capsule
- Where
- South Korea
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Infection
A Post-Intervention Surveillance Study Regarding the Acquisition Rate of ESBL-KP, Ecoli
To determine the acquisition rate of ESBL producing E. coli or K. pneumoniae, post- intervention in the selected medical centres
- Trial name
- NCT00724919
- Where
- 2 sites in Taiwan
- Volunteers
- 256 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Ventilator-Associated Pneumonia
Impact of the Duration of Antibiotics on Clinical Events in Patients With Pseudomonas Aeruginosa Ventilator-associated Pneumonia (iDIAPASON)
Ventilator-associated pneumonia (VAP) accounts for 25% of infections in intensive care units (Réseau RAISIN 2012). A short duration (8 days; SD) vs.
- Trial name
- iDIAPASON (NCT02634411)
- Testing
- 8 days of effective antibiotic treatment, 15 days of effective antibiotic treatment
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sinusitis
Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis
The purpose of this study is to evaluate the effectiveness of maxillary sinus saline irrigation in conjunction with systemic antibiotic therapy versus systemic antibiotic therapy alone in the management of chronic rhinosinusitis…
- Trial name
- NCT00335309
- Testing
- Maxillary Sinus Irrigation, IV Amoxicillin and Clavulanate acid
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Ohad Ronen
Bone Infection, Bone Graft Infection
Antimicrobial Synthetic Bone Grafts
This project aims to produce synthetic bone tissue graft that supports bone regeneration and combats infection simultaneously, according to industry standards and regulations.
- Trial name
- NCT03945864
- Testing
- antimicrobial synthetic bone graft, parentaral antimicrobials and pure bone grafts
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Eskisehir Osmangazi University
Pneumonia
Hospitalised Pneumonia With Extended Treatment (HOPE) Study
An intervention study to determine if a longer duration of antibiotics (compared to shorter duration) improves the short and long term clinical outcomes of children hospitalised for pneumonia
- Trial name
- HOPE (NCT02783859)
- Testing
- Amoxicillin-clavulanic Acid
- Where
- 5 sites in Australia, Malaysia and 1 more
- Volunteers
- 314 people
- Sponsor
- Menzies School of Health Research
Cariostatic Agents, Mouthwashes
Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High Risk
Dental caries is a localized, post eruptive pathological process involving softening of the hard tooth tissue and proceeding to the formation of cavity.
- Trial name
- AEXPC (NCT04399161)
- Testing
- Chlorhexidine mouthwash, Xylitol, Probiotic
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Dr. Krupa NC
High Caries Risk Patients, Antimicrobial Effect
Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients
This trial is to test the antibacterial effect of Guava leaves extract mouth wash compared to Chlorhexidine mouth wash in high caries risk patients. Also salivary pH and patient satisfaction to taste will also be tested.
- Conditions
- High Caries Risk Patients, Antimicrobial Effect, Salivary pH, Patient Satisfaction to Taste
- Trial name
- NCT03773094
- Testing
- Guava leaves extract, Chlorhexidine
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Cairo University
Propionibacterium Infection
Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery
INESS Antibiotic Prophylaxis in Orthopedic Guide recommends the use of Cefazolin at induction for all orthopaedic procedure with implantation of internal fixation device. With the increasing rate of identified P.
- Trial name
- PAPA (NCT02996656)
- Testing
- Cefazolin, Ceftriaxone
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- Université de Montréal
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