Clinical trials: Anti-Bacterial Agents
Extracorporeal Membrane Oxygenation, Pharmacokinetics
Pharmacokinetics in Extracorporeal Membrane Oxygenation
The main purpose of the present study is to investigate the risk factors that affect drug pharmacokinetic (PK) during extracorporeal membrane oxygenation (ECMO).
- Trial name
- NCT03766282
- Testing
- ECMO
- Where
- China
- Volunteers
- 50 people
- Sponsor
- China-Japan Friendship Hospital
Tooth Diseases, Tooth Wear
Effects of Antibiotic Prophylaxis on the Healing Parameters Following Surgical Crown Lengthening
The goal of this clinical trial is to test the effects of prophylactic antibiotics in healthy individuals who are in need of surgical crown lengthening.
- Trial name
- SCLABP (NCT05925179)
- Testing
- Surgical crown lengthening, Augmentin
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Biruni University
Diaper Dermatitis
Sunflower and Olive Oils for Preventing Diaper Dermatitis in Hospitalized Infants
This quasi-experimental study aimed to evaluate the effects of sunflower oil and olive oil on the development of diaper dermatitis in hospitalized infants receiving antibiotic therapy.
- Trial name
- DD-OIL (NCT07517003)
- Testing
- Sunflower Oil, Olive Oil, Routine Care
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Dicle University
Pneumonia, Pneumococcal, Community-acquired Pneumonia
Quantitative Polymerase Chain Reaction for Improved Detection of Pneumococci in CAP "CAPTAIN"
The purpose of this study is to evaluate the added diagnostic value of a quantitative polymerase chain reaction targeting the lytA gene in detecting pneumococci in patients with community-acquired pneumonia.
- Trial name
- CAPTAIN (NCT03315403)
- Testing
- LytA targeted quantitative polymerase chain reaction (qPCR)
- Where
- 2 sites in Netherlands
- Volunteers
- 922 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Foot Ulcer, Diabetic
The Sorbact® Antimicrobial Dressing in the Holistic Wound Management Of Diabetic Foot ulCers (Phase III Study)
The aim of this study is to demonstrate, during a 12-week follow-up, a greater efficacy of using Sorbact® dressing technology in addition to best local cares compared to best local cares alone in the management of diabetic foot…
- Trial name
- ADHOC (NCT02334241)
- Testing
- Sorbact®, Best local cares
- Where
- 15 sites in Czechia, France and 1 more
- Volunteers
- 200 people
- Sponsor
- INRESA Pharma
Infection
Antibiotic Prophylaxis in Total Knee Prosthesis
Knee prosthesis infection is a severe complication. The use of a tourniquet during surgery impairs the efficacy of the antibiotic prophylaxis.
- Trial name
- NCT00497341
- Testing
- cefuroxime
- Where
- Spain
- Volunteers
- 1,332 people
- Sponsor
- Hospital Clinic of Barcelona
Sepsis
The Clinical and Pharmacoeconomic Impact of Rapid Diagnostic Test (Multiplex PCR FilmArray) on Antimicrobial Decision Making Compared to Conventional Decision Making Among Critically Ill Patients
We will show in this study the impact of use the rapid diagnostic method (multiplex PCR filmArray) on clinical and pharmacoeconomic aspects among Critically Ill Patients.
- Trial name
- NCT05759494
- Testing
- rapid diagnostic test (multiplex PCR filmArray)
- Volunteers
- 100 people
- Sponsor
- Cairo University
Respiratory Distress Syndrome, Adult, Multi-antibiotic Resistance
Multi-drug Resistant Gram-negative Bacteria and Veno-venous Extracorporeal Membrane Oxygenation (ECMO)
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-support technique used in patients with most severe acute respiratory distress syndrome (ARDS).
- Trial name
- MDR-ECMO (NCT06199141)
- Where
- Italy
- Volunteers
- 279 people
- Sponsor
- University of Padova
Antibacterial Agents, Postoperative Dental Pain
Effect of Calcium Silicate-Based Root Canal Medicament After Retreatment
Calcium hydroxide is generally preferred in endodontics as an intracanal medicament due to its antimicrobial and biological effects. However, the antimicrobial effect of calcium hydroxide is limited.
- Conditions
- Antibacterial Agents, Postoperative Dental Pain, Antifungal Agents
- Trial name
- NCT06779370
- Testing
- Calcium Silicate, Calcium hydroxide
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Antibiotic Toxicity
A Pharmacokinetic Study of Polymyxin B in Healthy Subjects and Subjects With Renal Insufficiency
This is an open-label, single-center, single-dose, parallel-group study to evaluate the PK and safety profiles of polymyxin B administered by IV infusion in healthy subjects and subjects with renal insufficiency.
- Trial name
- NCT05359627
- Testing
- Polymyxin B
- Where
- Taiwan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- TTY Biopharm
Respiratory Tract Infection Bacterial, Respiratory Tract Infection Viral
CRP and Patient Information Leaflets to Optimise Antibiotic Treatments for Adults With Respiratory Tract Infections in Primary Care in Kyrgyzstan
This study aims to determine how CRP levels and Patient Information Leaflets (PILs) affect antibiotic prescribing in adults with acute respiratory symptoms in Kyrgyz primary care.
- Conditions
- Respiratory Tract Infection Bacterial, Respiratory Tract Infection Viral, AMR, CRP
- Trial name
- 2CARE INSTALL (NCT07261969)
- Testing
- The C-reactive protein point-of-care test (CRP-POCT), Patient information leaflets
- Where
- 2 sites in Kyrgyzstan
- Volunteers
- 1,050 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Post Procedural Infection, Pacemaker Electrode Infection
Post-procedure Antibiotic Prophylaxis for Cardiac Electrical Device Implantation: ABxFREE Study
This study is a multi-center open-label randomized study, and we sought to investigate the redundancy of post-procedural prophylactic antibiotics in cardiac implantable electronic device implantation.
- Conditions
- Post Procedural Infection, Pacemaker Electrode Infection, Antibiotics, Implantable Defibrillator User
- Trial name
- ABxFREE (NCT04146883)
- Testing
- Antibiotics
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- National Cheng-Kung University Hospital
Pouchitis, Hyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis
The aim of current study is to evaluate the effect of hyperbaric oxygen therapy for the treatment of chronic antibiotic-refractory pouchitis.
- Trial name
- HBOT-pouch (NCT03526796)
- Testing
- Hyperbaric oxygen therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jinling Hospital, China
Peri-implantitis, Periodontal Diseases
Systemic Amoxicillin Plus Metronidazole in Peri-implantitis Treatment
The primary objective of this controlled clinical trial is to evaluate the clinical effect of systemic amoxicillin plus metronidazole therapy in conjunction with initial non-surgical treatment of peri-implantitis.
- Trial name
- NCT04149327
- Testing
- amoxicillin 500 mg + metronidazole 500 mg, non-surgical periodontal and peri-implant treatment
- Volunteers
- 62 people
- Sponsor
- University Medical Center Groningen
Preterm Premature Rupture of Membranes (PPROM), Prophylaxis
Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes
To investigate the effects of different antibiotic regimens used in preterm premature rupture of membranes (PPROM) on maternal and fetal outcomes after 34 weeks of gestation.
- Conditions
- Preterm Premature Rupture of Membranes (PPROM), Prophylaxis, Perinatal Outcomes
- Trial name
- NCT07148622
- Testing
- Antibiotic regimen 1: sulbactam + ampicillin + azithromycin, Antibiotic regimen 2: ceftriaxone + clarithromycin + amoxicillin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yuzuncu Yil University
Early Ventilator Associated Pneumonia
Duration of Antibiotic Treatment for Early VAP (DATE) Trial
Hypothesis: 4 days of antibiotic therapy, as compared to 8 days, is equally effective and results in decreased antibiotic exposure among surgical ICU patients with early VAP.
- Trial name
- DATE (NCT01994980)
- Testing
- Default 4 days antibiotic therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Denver Health and Hospital Authority
Osteomyelitis Acute, Septic Arthritis
Initial Oral Antibiotics for Bone and Joint Infections in Children
Initial oral antibiotic treatment for children and adolescents with uncomplicated bone and joint infections (BJI) has been found non-inferior to initial IV antibiotics in one randomized controlled trial (RCT).
- Conditions
- Osteomyelitis Acute, Septic Arthritis, Bone Infection, Joint Infection
- Trial name
- NCT06827496
- Testing
- Oral antibiotic treatment
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Antibiotics Associated Colitis, Pulmonary Infection
Effect of Probiotic Lactobacilli (Lacidofil Cap®) for the Prevention of Antibiotic-Associated Diarrhea
Antibiotic-Associated Diarrhea (AAD) is a common complication of antibiotic use. The frequency of AAD can be high (26 - 60%) or moderate (13-29%) during hospital outbreaks and is relatively infrequent in outpatients.
- Trial name
- NCT01058356
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Pharmbio Korea Co., Ltd.
Neurosurgery
Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection
Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).
- Trial name
- NCT00925093
- Testing
- Vancomycin, Teicoplanin, Linezolid
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Surgical Wound Infection, Thyroid Nodule
Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy
Transoral endoscopic thyroid surgery is a emerging surgical technique for thyroid surgery. This study to investigate the need for postoperative antibiotics in transoral endoscopic thyroid surgery.
- Trial name
- POTO (NCT03295955)
- Testing
- Amoxicillin Clavulanate
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
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