Clinical trials: Anti-Bacterial Agents
Urinary Tract Infection
Febrile Urinary Tract Infection Randomized Short Treatment Trial
The purpose of this study is to determine whether a 7-day duration of antibiotic treatment of febrile urinary tract infection (FUTI) is non inferior to 14-day standard duration of treatment in unselected population presenting at…
- Trial name
- FUTIRST (NCT00809913)
- Testing
- short treatment (ciprofloxacin)
- Where
- 6 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Leiden University Medical Center
Surgical Wound Infection
The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal
The goal of this clinical trial is to learn if reducing bacterial load on the skin and nostrils with topical antibacterial soap and ointment, respectively, reduces rate of infection in surgical sites on lower leg wounds left open…
- Trial name
- NCT07142408
- Testing
- Chlorhexidine gluconate (4%), Mupirocin 2% Ointment
- Where
- United States
- Volunteers
- 848 people
- Sponsor
- The Cooper Health System
Cardiac Surgery
Pharmacokinetics of Cefuroxime in Cardiac Surgery With Cardiopulmonary Bypass
Infection, especially mediastinitis, is major complication in cardiac surgery. Considering that cardiopulmonary bypass (CPB) can alter kinetics of drugs, including antibiotics, the aim of this study was to evaluate the influence…
- Trial name
- NCT01228825
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- University of Sao Paulo
Healthy Volunteer
Evaluation of Bacteria in the Mouth and Throat of Healthy Adults Before and After the Administration of Either Levofloxacin or Azithromycin, Both Antibiotic Medications
Evaluation of bacteria in the mouth and throat before study drug ( Levofloxacin, floroquinolone antibiotic and Azithromycin, a macrolide antibiotic) is started and then periodically for 6 weeks after the last dose of study drug…
- Trial name
- NCT00821782
- Testing
- Levofloxacin; Azithromycin
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Impacted Third Molar Tooth, Surgical Wound Healing
Antibacterial Effect and Soft Tissue Healing of Chlorhexidine-Coated Polyglactin 910 Sutures After Impacted Lower Third Molar Surgery
This study evaluates whether coating Polyglactin 910 sutures with chlorhexidine diacetate (CHX-DA) improves outcomes after the surgical removal of impacted mandibular (lower) third molars (wisdom teeth).
- Trial name
- NCT07794280
- Testing
- Chlorhexidine Diacetate-Coated Polyglactin 910 Suture, Uncoated Polyglactin 910 Suture
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Lymphomas, Tumors
Pilot Study Combining Temozolomide, Oncovin, Camptosar and Oral Antibiotic in Children and Adolescents With Recurrent Malignancy
Determine toxicity and maximum tolerated dose of escalating daily protracted irinotecan, with weekly vincristine, temozolomide and vantin; to evaluate the feasibility of repetitive cycles of this chemotherapy and to estimate the…
- Trial name
- NCT00222443
- Testing
- Irinotecan
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Pneumonia, Radiographic Lung Infiltrates
Use Of Procalcitonin Level For Guidance of The Treatment of Suspected Community Acquired Pneumonia
The purpose of the study is to learn if a blood test is helpful to the doctors in deciding whether you need antibiotic therapy for possible pneumonia.
- Trial name
- NCT00914550
- Testing
- Procalcitonin level, caregiver informed
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Winthrop University Hospital
Septic Shock, Compliance
Effects of Nursing Staff on Empiric Antibiotic in Septic Shock
A retrospective, observational study was performed about the patients with septic shock who admitted into intensive care unit (ICU) from January 1, 2015 to February 29, 2016.
- Conditions
- Septic Shock, Compliance, Antibiotic, Nursing Caries
- Trial name
- NCT03085459
- Testing
- work Time
- Volunteers
- 214 people
- Sponsor
- Chun Pan
Endodontic Treatment, Irreversible Pulpitis
A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment
The effect of Antibacterial Nanoparticles, Incorporated in root canal sealer material and in provisional restoration is going to be examined.
- Conditions
- Endodontic Treatment, Irreversible Pulpitis, Health Pulp, Infected Pulp
- Trial name
- IABN (NCT01167985)
- Testing
- IABN
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Antibiotics
Antibiotic Usage and Resistance; Knowledge and Practices Before and After Educational Sessions
The inappropriate use of antibiotics by patients not only increases the growth of resistant bacterial strains but also, may lead to adverse side effects that range from gastrointestinal disturbances to fatal anaphylactic shock.
- Trial name
- NCT04493008
- Testing
- Experimental: Educational session
- Where
- Egypt
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Misr International University
Cystic Fibrosis
Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis Patients With P. Aeruginosa
The purpose of this study was to evaluate the safety and efficacy of aztreonam for inhalation solution (AZLI) in patients with cystic fibrosis (CF) and lung infection due to Pseudomonas aeruginosa (PA).
- Trial name
- AIR-CF2 (NCT00104520)
- Testing
- AZLI 75 mg two times a day (BID)/three times a day (TID)
- Where
- 56 sites in United States
- Volunteers
- 211 people
- Sponsor
- Gilead Sciences
Postpartum Sepsis, Postpartum Endometritis
Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries
This study, performed over a course of 3 years in 5 collaborating hospitals in Cameroon, Africa, will randomize 750 women in labor with prolonged rupture of membranes ≥ 8 hours or prolonged labor ≥ 18 hours to identical oral…
- Conditions
- Postpartum Sepsis, Postpartum Endometritis, Postpartum Fever
- Trial name
- NCT03248297
- Testing
- Azithromycin, Azithromycin and amoxicillin
- Where
- Cameroon
- Volunteers
- 756 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Neonatal Infections Colonize With Group B Streptococci
Interest of the Detection of Hyper-virulent Clone ST17 of Group B Strep (GBS) for the Prevention of Neonatal GBS Meningitis
The main objective of this study : Demonstrate that GBS (group B streptococci) "ST-17" colonize and persist to 60 days twice in the digestive tract of newborns that strains of GBS non-ST-17.
- Trial name
- Col-Strepto B (NCT01719510)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 949 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19, Coronavirus Infection
Utility of Empiric Antibiotics for Non-intubated Novel Coronavirus Diseases 2019 Patients
This retrospective analysis of inpatient data obtained from administrative and electronic medical records will investigate the role of empiric antibiotics on admission on the mortality for non-intubated patients presenting with…
- Conditions
- Covid19, Coronavirus Infection, Pneumonia
- Trial name
- NCT04674410
- Testing
- Antibiotic
- Where
- United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Dental Caries
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct Treatment of Deep Carious Lesions in Children
This project aims to evaluate the effect of antimicrobial photodynamic therapy (aPDT) in deep carious lesions. This study was approved by the Research Ethics Committee and was conducted on 53 patients between 3 and 12 years.
- Trial name
- NCT02908789
- Testing
- Antimicrobial photodynamic therapy (aPDT), Without Antimicrobial phothodynamic therapy
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Gram Negative Bacteremia
Duration of Antibiotics for the Treatment of Gram-negative Bacilli Bacteremia
The investigators plan an open label randomized controlled trial to compare short-course antibiotic therapy (<=7 days) versus longer treatment (>7 days).
- Trial name
- NCT01737320
- Testing
- short-course antibiotic treatment, accepted prolonged antibiotic treatment
- Where
- 3 sites in Israel, Italy
- Volunteers
- 604 people
- Sponsor
- Rabin Medical Center
Bronchiectasis, Cystic Fibrosis
A Study of the Clinical Benefit of Tobramycin Inhalation Solution
This project will use literature analysis, expert research, real-world data mining and other methods to investigate the current status of the application of antimicrobial aerosolized inhalation in healthcare institutions, combine…
- Conditions
- Bronchiectasis, Cystic Fibrosis, Lung Infection
- Trial name
- NCT06106789
- Testing
- Tobramycin inhalation solution
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Qianfoshan Hospital
Pancreatitis, Acute Necrotizing
A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died
This is a research study in patients having a condition known as necrotizing pancreatitis. This is inflammation of the pancreas (an intestinal organ which assists with digestion) that has resulted in the damage and death of some…
- Trial name
- NCT00061438
- Testing
- meropenem
- Where
- 11 sites in United States, Canada
- Volunteers
- 240 people
- Sponsor
- Pfizer
Glucose Fluctuations in Sepsis
Usage of Glucose Fluctuations as a Prognostic Marker in Septic Shock Patients
To determine whether glucose fluctuations prior to antibiotic administration are associated with sepsis severity and poor clinical outcomes.
- Trial name
- NCT07234526
- Volunteers
- 105 people
- Sponsor
- Assiut University
Acute Rhinosinusitis, Sore Throat
The Development and Testing of a Scaling Strategy for a Community-Based Primary Care Antimicrobial Stewardship Program
Antibiotic resistant infections are expected to cause 10 million deaths worldwide by 2050, and exceed cancer deaths. Reducing antibiotic use can reduce resistance levels.
- Conditions
- Acute Rhinosinusitis, Sore Throat, Acute Cystitis, Acute Bronchitis
- Trial name
- PC-ASP 2 (NCT03517215)
- Testing
- Enhanced CB-ASP, Standard CB-ASP
- Where
- 3 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.