Clinical trials: Anti-Bacterial Agents
Bladder Cancer
Multicentral Preventive Antibiotics With Cystectomy Within Enhanced Recovery After Surgery
The current usage of antibiotic prophylaxis (AP) in radical cystectomy (RC) is aimed to reducing the incidence of surgical site infections and incidence of unnecessary prescribing of antibiotics.
- Trial name
- MACS (NCT05392634)
- Testing
- Meropenem 1000 mg, Amoxicillin+clavulanic acid 1200 mg or Cefuroksim 1500mg
- Where
- Russia
- Volunteers
- 98 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Congenital Cytomegaloviral (CMV) Disease
CMV CTLs in Neonates With CMV Infection
Patients with moderate or severe CMV disease less than 21 days old who have a maternal donor who has a CMV response to the peptivators will be screened. All patients will receive treatment with valganciclovir or ganciclovir.
- Trial name
- NCT05564598
- Testing
- CMV Cytotoxic T-Lymphocytes, Anti-viral Therapy
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- New York Medical College
Diabetic Foot Ulcers
MSI-78 Topical Cream vs. Oral Ofloxacin in the Treatment of Infected Diabetic Ulcers
224 adults with diabetic foot ulcers will be randomized to either magainin peptide (MSI-78) or ofloxacin (FLOXIN, Ortho-McNeil Pharmaceutical Corporation) an oral fluoroquinolone antibiotic.
- Trial name
- NCT00563433
- Testing
- ofloxacin, MSI-78
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- Abeona Therapeutics, Inc
Prescribing, Off-Label
CMO Letter to Reduce Unnecessary Antibiotic Prescribing and Broad Spectrum Prescribing Winter 2018-9
This trial aims to reduce unnecessary prescription of antibiotics and broad spectrum antibiotics by general practitioners (GPs) in England.
- Trial name
- CMO2018-9 (NCT03862794)
- Testing
- new social norm feedback letter with bar chart, standard social norm feedback letter
- Where
- United Kingdom
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Public Health England
Recurrent Urinary Tract Infections, Chronic Urinary-catheter-carrier
Comparison of Three Different Antibiotic Treatments Against Recurrent Urinary Tract Infections in Catheterized Patients
Recurrent urinary tract infections (UTI) in the patients chronically catheterized are serious challenges clinically. The pathogens are often multidrug-resistant bacteria and such UTIs are actually biofilm infections.
- Conditions
- Recurrent Urinary Tract Infections, Chronic Urinary-catheter-carrier, Biofilm Infection, Antibiotic Treatment
- Trial name
- NCT05402319
- Testing
- Antibiotic combination therapy
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Healthy
Effect of Sustained-Release Cetylpyridinium Chloride Varnish on Streptococcus Mutans and Lactobacillus in Orthodontic Patients
The purpose of the study is to was to evaluate the anti bacterial efficacy of sustain-release Cetylpyridinium chloride varnish on orthodontic patients.
- Trial name
- NCT00416286
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Non-Healing Ulcer of Skin, Autofluorescence Imaging
Retrospective Database Review at LTC and SNFs
The goal of this observational study is to compare the differences in wound outcomes when the MolecuLight imaging procedure is used in combination with standard of care wound assessment in long term care and skilled nursing…
- Trial name
- NCT06068972
- Testing
- MolecuLight
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- Wound Care Plus, LLC
Appendicitis
Restricted or Liberal Antibiotics After Appendectomy - Denver Health
The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.
- Trial name
- CASARELAX (NCT05002829)
- Testing
- Restricted Duration of SOC Antibiotic Use, Liberal Duration of SOC Antibiotic Use
- Where
- United States
- Volunteers
- 657 people
- Sponsor
- Denver Health and Hospital Authority
Increased Drug Resistance
Antimicrobial Resistance in Hospitals From Meta, Colombia
Introduction: Healthcare-associated infections cause a burden in morbidity and mortality, and they increase the financial cost of care.
- Trial name
- NCT06044272
- Testing
- Factors associated
- Where
- Colombia
- Volunteers
- 10,000 people
- Sponsor
- Hospital Departamental de Villavicencio
Dental Caries, Periodontal Diseases
Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect
a double-blind cross-over in vivo study was performed to measure the salivary concentration of Xylitol released from the two chewing gums containing different amount of the polyol.
- Trial name
- NCT03971981
- Testing
- 100% Xylitol Gum, 22% Xylitol Gum
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Urinary Tract Infections
Effectiveness of Preurodynamic With Posturodynamic Levofloxacin on the Incidence of UTI
This study aims to compare the effectiveness of preoperative single dose of levofloxacin with postoperative levofloxacin for three days on the incidence of urinary tract infections (UTI) after urodynamic examination.
- Trial name
- NCT05219877
- Testing
- Pre-urodynamic Levofloxacin, Post-urodynamic Levofloxacin
- Where
- Indonesia
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Antibiotics, Severe Burn
Determining Drug Levels of Beta-lactam Antibiotics in Severe Burned Patients
At antibiotic stewardship of the University Hospital of Schleswig-Holsten it was noticed that there are much less studies measuring drug levels in severe burned patients than are required.
- Conditions
- Antibiotics, Severe Burn, Intensive Care
- Trial name
- MSBV (NCT03335137)
- Testing
- Drug Level Monitoring
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University Hospital Schleswig-Holstein
Cystic Fibrosis
A Study Comparing Continuous Infusion Antibiotics to Standard Treatment for Lung Infections in Cystic Fibrosis
Cystic fibrosis (CF) is an inherited disorder which results in increased thickness of secretions, especially in the lungs. By adulthood, the majority of patients with CF will have a bacteria living in their lungs, called…
- Trial name
- CISTIC (NCT01667094)
- Testing
- Intermittent, short infusion Ceftazidime, Continuous infusion Ceftazidime, Intermittent, short infusion Meropenem
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- The Alfred
Surgical Site Infection
Efficacy Study to Evaluate Antimicrobial Effectiveness of ZuraPrep™ (ZX-ZP-0055)
This is a randomized, paired-comparisons design where each subject receives two of the planned treatments.
- Trial name
- NCT02296645
- Testing
- ZuraPrep, ChloraPrep
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Zurex Pharma, Inc.
Trachoma
Partnership for Rapid Elimination of Trachoma
Trachoma, an ocular infection caused by C. trachomatis, is the second leading infectious cause of blindness worldwide. Years of repeated infection with C.
- Trial name
- PRET (NCT00792922)
- Testing
- Azithromycin
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Inflammation, Necrosis
Antimicrobial Pulpotomy of Primary Molars
There is a lack of evidence of the long-term successful outcomes of antimicrobial endodontic treatment for primary teeth. This study intended to evaluate (by survival analysis) the effectiveness of an antimicrobial pulpotomy…
- Trial name
- NCT01010451
- Testing
- Antimicrobial pulpotomy, Calcium hydroxide pulpectomy
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Underdosing of Aminoglycosides, Critical Illness
An International Survey on Aminoglycoside Practices in Critically Ill Patients: AMINO III Survey
This is an international observational cohort study on current aminoglycoside practices in intensive care units. Clinical and demographic data, dosing and therapeutic drug monitoring data will be collected during the first week…
- Trial name
- NCT02850029
- Testing
- Observational study, no intervention
- Where
- 85 sites in Australia, Chile and 3 more
- Volunteers
- 964 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Lyme Disease, Lyme Neuroborreliosis
PEMF Therapy to Treat Lingering Symptoms of Lyme Disease After Treatment With Antibiotics
Overview PEMF Therapy for relief or reduction of lingering symptoms after antibiotic treatment of Lyme disease of participants in the UK.
- Conditions
- Lyme Disease, Lyme Neuroborreliosis, Lyme Arthritis, Unknown Origin Fever
- Trial name
- PEMF (NCT04577053)
- Testing
- Scientific Consciousness Interface Operations (SCIO) Class II FDA approved medical device
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kasey Phifer
Perineal Wound Infection
Necessity of Antibiotics for Prevention of Delivery-associated Infections After Spontaneous Vaginal Delivery at Term
The purpose of this study is to determine amoxicillin is effective in the prevention of wound infection in normal labor.
- Trial name
- NCT02131818
- Testing
- Amoxicillin
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Mahidol University
Risk Factor
Digestive Colonisation by Highly Resistant Bacteria (CODBAHRE)
The aim of this study is to identify in hospitalized patients, the risk factors associated with the digestive colonisation by emergent extensively drug-resistant bacteria (eXDR), to optimize their detection and the medical care…
- Trial name
- CODBAHRE (NCT04085380)
- Where
- France
- Volunteers
- 2,396 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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