Clinical trials: Anti-Bacterial Agents
CDI
Precision Antimicrobial STewardship for Clostridioides DIfficile Prevention
To decrease CDI incidence by implementing an electronic health record-integrated CDI-risk classification tool for Clostridioides difficile infection (CDI) to focus a bundle of antimicrobial stewardship (AMS) CDI prevention…
- Trial name
- PASTCDI (NCT05508607)
- Testing
- CDI-risk Classification Tool
- Where
- United States
- Volunteers
- 13,319 people
- Sponsor
- Intermountain Health Care, Inc.
Appendicitis Perforated
Intraperitoneal Administration of Fosfomycin, Metronidazole and Molgramostim Versus Intravenous Antibiotics for Perforated Appendicitis
The objective of this trial is to evaluate if intraoperative intraperitoneal administration of fosfomycin, metronidazole and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) followed by oral…
- Trial name
- NCT03435900
- Testing
- Combination of fosfomycin, metronidazole and rhGM-CSF (administered together intraperitoneally) and three days of antibiotics p.o., Standard antibiotics intravenously
- Where
- 2 sites in Denmark
- Volunteers
- 13 people
- Sponsor
- Herlev Hospital
Peritoneal Dialysis
The Efficacy of Prolonged Antibiotic Therapy for the Prevention of Relapsing Peritonitis in Peritoneal Dialysis Patients With High Dialysis Effluent Bacterial DNA Fragment Levels
Peritoneal dialysis (PD) is the first-line treatment of end stage renal disease (ESRD) in Hong Kong. Despite the advances in antibiotic therapy and connecting system, recurrent peritonitis remains the major cause of peritoneal…
- Trial name
- NCT02593201
- Testing
- Extended antibiotics (cefazolin or ceftazidime), Usual antibiotics (cefazolin or ceftazidime)
- Where
- Hong Kong
- Volunteers
- 358 people
- Sponsor
- Chinese University of Hong Kong
Joint Infection
Can Intraosseous Antibiotics Improve the Results of Irrigation & Debridement and Prosthetic Retention for PJI?
Purpose of Study: In order to improve upon the variable results seen in irrigation and debridement for periprosthetic infection, we ask if the use of intraosseous regional administration of antibiotics at the time of irrigation…
- Trial name
- NCT03713528
- Testing
- Intraoperative Intraosseous Vancomycin
- Where
- 10 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- OrthoCarolina Research Institute, Inc.
Cystic Fibrosis
Trikafta/Kaftrio and Pseudomonas Aeruginosa
The goal of this observational study o is to define whether, how and to what extent treatment with Trikafta/Kaftrio directly affects Pseudomonas aeruginosa in individuals with cystic fibrosis.
- Trial name
- Kaf-Pseudo (NCT05675592)
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Ospedale San Raffaele
Antibiotic-Associated Diarrhea
Ultrasound Diagnosis of Antibiotic Associated Diarrhea
The hypothesis is that there are unique sonographic characteristics of antibiotic-associated diarrhea. We will compare the ultrasound findings in patients who received antibiotics and developed diarrhea to toxin analysis for…
- Trial name
- NCT00658151
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Shaare Zedek Medical Center
Acute Appendicitis
Antibiotics vs Surgery in Acute Appendicitis
The aim of this study is to identify clinical, laboratory, and imaging parameters that can predict the most appropriate treatment strategy in patients diagnosed with acute appendicitis.
- Trial name
- NCT07492329
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines, Antibiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Sebahattin Celik MD
Viral Meningitis, Bacterial Meningitis
Acute Treatment and Long-term Assessment of Adult Infectious Meningitis
Prospective, multicenter, observational clinical registry of adult patients with acute infectious meningitis across approximately 30 public and private hospitals in Brazil.
- Conditions
- Viral Meningitis, Bacterial Meningitis, Fungal Meningitis, Meningitis
- Trial name
- ATLAS-I (NCT07027475)
- Where
- 6 sites in Brazil
- Volunteers
- 624 people
- Sponsor
- Hospital Israelita Albert Einstein
Sepsis, Morality
CRP Versus PCT as Bio-markers for Sepsis and in Guiding Antibiotics in Critically Ill Patients
Sepsis is a life threatening organ dysfunction caused by infection. Severe sepsis is expected to rise due to resistance to antibiotics.
- Trial name
- PCTCRP (NCT04049565)
- Testing
- Procalcitonin biomarker and CRP biomarker
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Pneumonia, Urinary Tract Infections
BetaLACTA® Test for Early De-escalation of Empirical Carbapenems in Pulmonary, Urinary and Bloodstream Infections in ICU
The emergence and rapid worldwide spread of Extended- Spectrum Beta-Lactamase-producing enterobacteriaceae (ESBLE) both in hospital and community, led physicians, and notably intensivists, to prescribe more carbapenems…
- Conditions
- Pneumonia, Urinary Tract Infections, Bloodstream Infection
- Trial name
- BLUE-CarbA (NCT03147807)
- Testing
- betaLACTA® rapid diagnostic test
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthcare-associated Infections, Quality Culture and Leadership in Intensive Care
Perceptions of Leadership in Quality Culture for Infection Prevention Among Intensive Care Nurses and Unit-Based Assessment of Antimicrobial Resistance Indicators in Intensive Care Units
This study aims to examine intensive care nurses' perceptions of leadership in quality culture for infection prevention and to investigate antimicrobial resistance indicators at the intensive care unit level.
- Conditions
- Healthcare-associated Infections, Quality Culture and Leadership in Intensive Care, Infection Prevention and Control
- Trial name
- NCT07782372
- Volunteers
- 127 people
- Sponsor
- Yeliz Sapulu Alakan
Prosthetic Joint Infection
NGS vs Culture Outcomes for Treatment of PJI
This multicenter, randomized controlled trial will compare the use of NGS and traditional culture in directing antimicrobial treatment for patients with periprosthetic joint infection.
- Trial name
- NCT05247281
- Testing
- Culture-based treatment, Next Generation Sequencing (NGS) with Culture
- Where
- 9 sites in United States
- Volunteers
- 250 people
- Sponsor
- Center for Innovation and Research Organization
ARDS, Sepsis
Drug Monitoring of Antibiotics in Critical Care Patients
Infections are critical factors for the survival of critically ill patients. A broad, high-dose and early initial therapy of antibiotics is of particular relevance.
- Trial name
- DRAK (NCT01793012)
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Open tíbia Fracture
Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy
The Beads vs Vac trial is a multi-centre randomized controlled trial of 312 participants with a severe open tibia fracture requiring multiple irrigation and debridement surgeries.
- Trial name
- BeadsvsVac (NCT05615844)
- Testing
- Antibiotic Cement Bead Pouch, Negative Pressure Wound Therapy
- Where
- 35 sites in United States, Canada
- Volunteers
- 312 people
- Sponsor
- University of Maryland, Baltimore
Inhalation Pneumonia
Effect of Diluent Volume on Colistin Inhalation Therapy
The aim of this study is to investigate the impact of different diluent volumes for the same dosage of colistin in mechanically ventilated respiratory patients receiving colistin inhalation therapy.
- Trial name
- NCT06230614
- Testing
- Colistin 1 MU in normal saline 1 ml, Colistin 1 MU in normal saline 2 ml
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University
Pharmacokinetics, Amoxicillin-clavulanate
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)
Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- PADECMO (NCT06426836)
- Testing
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Where
- 3 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- University Hospital, Ghent
Surgical Site Infection
Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery
The purpose of the study is to assess the effectiveness of a single dose of preoperative antibiotic in reducing surgical site infections in certain dermatological procedures.
- Trial name
- NCT04580472
- Testing
- Cephalexin
- Where
- United States
- Volunteers
- 574 people
- Sponsor
- Carilion Clinic
Bacterial Infections
P1 Single and Multiple Ascending Dose (SAD/MAD) Study of IV QPX7728 Alone and Combined With QPX2014 in NHV
QPX7728 is an ultra-broad-spectrum beta-lactamase inhibitor, with activity against numerous beta-lactamases, including class A extended spectrum beta-lactamases (ESBLs), class C cephalosporinases, and extended spectrum class D…
- Trial name
- NCT04380207
- Testing
- QPX7728, QPX2014
- Where
- 2 sites in United States, Australia
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Qpex Biopharma, Inc.
Antibiotic Prophylaxis Surgery
Study of Repeated Cefoxitin Administration in Major Abdominal Surgery Using a Microdialysis Technique
The surgical site infection is one of the most important causes of postoperative morbidity. The appropriate antibiotic prophylaxis is one of the most effective ways to prevent surgical site infections.
- Trial name
- PROPHYLOXITINE (NCT02703857)
- Testing
- cefoxitin
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Poitiers University Hospital
Drug Resistance, Bacterial
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand
The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a…
- Conditions
- Drug Resistance, Bacterial, Bacteremia
- Trial name
- NCT07082465
- Where
- 4 sites in Thailand
- Volunteers
- 108,000 people
- Sponsor
- University of Oxford
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