Clinical trials: Anti-Bacterial Agents
Non-healing Wound
Antibiotic Tumescent For Chronic Wounds
Chronic non-healing wounds are becoming an increasingly more common problem. Eligible, consenting patients with chronic wounds in the lower extremities, upper extremities or trunk, will either continue to the standard of care or…
- Trial name
- TAI (NCT06327113)
- Testing
- CeFAZolin Injectable Solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Bacteremia, Transplant Recipient
Outcomes of Empiric Antibiotic Therapy Based on Hospital Antibiograms in Organ Transplant Recipients with Bacteraemia
The purpose of this observational study is to examine how using the hospital cumulative antibiogram to guide empirical antibiotic therapy affects outcomes in patients with bloodstream infections who have undergone solid organ…
- Trial name
- NCT06874920
- Testing
- No intervention (observational study)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Osteomyelitis Tibia, Tibial Fractures
Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial
This prospective randomized clinical trial will compare outcomes between patients treated primarily with a prophylactic antibiotic coated nail and those treated with traditional standard of care intramedullary (IM) nailing.
- Conditions
- Osteomyelitis Tibia, Tibial Fractures, Open Tibia Fracture
- Trial name
- NCT05421741
- Testing
- Antibiotic coated intramedullary Nail, Standard Intramedullary Nail
- Where
- 15 sites in United States
- Volunteers
- 242 people
- Sponsor
- Wake Forest University Health Sciences
Cataracts
A Comparison of Prophylactic Antibacterial Efficacy of Besivance vs. VIGAMOX Prior to Cataract Surgery
To compare antibacterial efficacy of Besivance versus VIGAMOX for decreasing bacteria of the conjunctiva and lid margins in cataract patients prior to surgery after both 1 hour and 3 days of treatment.
- Trial name
- NCT01296542
- Testing
- Moxifloxacin Ophthalmic, Besifloxacin Ophthalmic
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bucci Laser Vision Institute
Postoperative Pain
Assessment of Pain and Antibacterial Activity of Chitosan Versus Sodium Hypochlorite as Irrigant in Infected Canal
A randomized clinical trial that aims to study the effect of chitosan nanoparticles (CS-np) versus sodium hypochlorite as a root canal irrigant on postoperative pain and antibacterial activity against E.faecalis in infected root…
- Trial name
- NCT03719261
- Testing
- chitosan nanoparticles, Sodium Hypochlorite
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Halitosis
Adjunctive Effect of Photodynamic Therapy on Halitosis
The present study aims to evaluate bad breath in patients undergoing gingival treatment combined with tongue scraping and laser and to assess its potential benefits for both periodontal and microbiological condition.
- Trial name
- NCT06764342
- Testing
- Full-mouth scaling combined with antimicrobial photodynamic therapy, full-mouth scaling
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Pain, Symptomatic Irreversible Pulpitis
The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste
In our study, we used nitrofurantoin as a root canal medication in patients suffering from symptomatic irreversible pulpitis in alleviating pain compared with double antibiotic paste.
- Trial name
- NCT05600023
- Testing
- Nitrofurantoin, Double Antibiotic
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Septic Shock, Acute Renal Failure
Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock
The objective of this study is to determine the feasibility of conducting a large scale randomized controlled trial comparing standard and renally adjusted dosage of antibiotics in the septic shock patients with acute renal…
- Trial name
- NCT00816790
- Testing
- Piperacillin/Tazobactam
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Fraser Health
Apexification, Apexogenesis
Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma
Children often damage their front teeth. In approximately 6% of cases, the nerve inside the affected tooth dies (becomes 'non-vital') and natural root development stops.
- Conditions
- Apexification, Apexogenesis, Pulp Necrosis, MTA
- Trial name
- NCT01817413
- Testing
- Mineral trioxide aggregate, Revascularisation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Liverpool
Bacteremia
IL-10 Stratifying Tool for Towards Antibiotic Selection for MRSaB
Patients with MRSaB have high therapeutic failure rates and mortality rates. Recent studies have shown that an elevated IL-10 level is an independent risk factor of mortality.
- Trial name
- NCT02660346
- Testing
- Daptomycin, Vancomycin, Ceftaroline
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Sharp HealthCare
Thoracic Surgery, Antibiotic Prophylaxis
Prevention of Infections in Cardiac Surgery
There is clinical equipoise about the question of whether antibiotic prophylaxis should be given for a short period or an extended period of time as reflected by inconsistencies in major guidelines, current practices at Canadian…
- Trial name
- PICS (NCT02285140)
- Testing
- Cefazolin, Vancomycin
- Where
- 4 sites in Canada
- Volunteers
- 5,989 people
- Sponsor
- Hamilton Health Sciences Corporation
Infectious Disease
Perception of Smell and Taste During Antibiotic Treatment
Antibiotic use may be associated with effects on the perception of smell and taste. These effects are poorly known. The mechanisms can be very diverse, and the effect can be very variable depending on the type of antibiotic used…
- Trial name
- OGUSTA (NCT03893279)
- Testing
- Smell and Taste and questionnaire
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Hospices Civils de Lyon
Fracture Lower Leg, Diabetes
Extended Oral Antibiotic Prophylaxis in Diabetic Fracture Patients
The goal of this clinical trial is to learn if taking an antibiotic pill for 7 days after surgery reduces the risk of wound infection in adults with poorly controlled diabetes who have surgery to fix a broken bone in the leg…
- Conditions
- Fracture Lower Leg, Diabetes, Fracture Fixation, Internal
- Trial name
- NCT07561541
- Testing
- Cefadroxil 500 mg Capsules, Clindamycin, Bactrim DS
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Diverticular Disease of Colon
Percutaneous Drainage Versus Antibiotic Therapy for Acute Diverticulitis With Abscess.
the management of diverticular abscesses is guided by consensus-based recommendations from the WSES guidelines, the American College of Physicians, and the American Gastroenterological Association, all of which acknowledge the…
- Trial name
- NCT07352605
- Testing
- Arm 1 (Control Arm) - Percutaneous drainage plus antibiotics: Image-guided (CT or ultrasound) percutaneous drainage performed within 48 hours of randomization with intravenous bro, Arm 2 (Experimental Arm) - Antibiotics alone: Intravenous broad-spectrum antibiotics: piperacillin-tazobactam 4 g/0.5 g q6h (dosage to be adjusted based on renal function) according to the recent lite
- Volunteers
- 50 people
- Sponsor
- Azienda Sanitaria di Firenze
Appendicitis
Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children
OBJECTIVE The aim of this study is to compare the effectiveness of initial non-operative treatment strategy (reserving appendectomy for those not responding or with recurrent disease) with immediate appendectomy in children from…
- Trial name
- APAC (NCT02848820)
- Testing
- Augmentin + Gentamicin, Appendectomy
- Where
- 15 sites in Netherlands
- Volunteers
- 302 people
- Sponsor
- Ramon Gorter
Urinary Tract Infections in Children
Urinary Tract Infection In Assiut University Children Hospital
Antibiotic Sensitivity Pattern and Demographic Characteristics of Urinary Tract Infection In Assiut University Children Hospital
- Trial name
- NCT06625554
- Volunteers
- 75 people
- Sponsor
- Assiut University
Clostridioides Difficile Infection
Clostridioides Difficile: Understanding Responses and Treatment Effects
The goal of this observational study is to learn how different treatments for Clostridioides difficile infection (CDI) work, and which biological mechanisms are involved in recovery.
- Trial name
- CURE-CDI (NCT07374094)
- Testing
- Antibiotic treatment, Fecal microbiota transplantation (FMT)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Chronic Periodontitis
Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis
Summary The aim of this study is to evaluate through clinical, microbiological and immunological parameters using PLGA microspheres (lactic-co-glycolic acid polyacid) containing doxycycline in periodontal therapy in smokers with…
- Trial name
- NCT02726646
- Testing
- Doxycycline, Mechanical debridement
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Appendicitis Acute
Polymerase Chain Reaction (PCR) and Cultivation of the Peritoneal Fluid at Operation for Appendicitis and Postoperative Enteral Antibiotic Treatment
Patients diagnosed with acute appendicitis receives antibiotics during the operation, and only patients where the surgeon suspects a complicated appendicitis with spread inflammation to the abdominal cavity receive antibiotics…
- Trial name
- PACPAT (NCT04713527)
- Testing
- Cultivation and PCR within 24 hours, Enteral antibiotics
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Southern Denmark
Meningitis, Children, Only
National Bacterial Meningitis Study in Children and Newborns
Bacterial meningitis is a major cause of morbidity and mortality in childhood. Antibiotic treatment recommendations are based on epidemiological and susceptibility data.
- Conditions
- Meningitis, Children, Only, Pneumococcal Conjugate Vaccine, Meningococcal Vaccines
- Trial name
- NCT04664569
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
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