Clinical trials: Anti-Bacterial Agents
Cystic Fibrosis
Study to Evaluate the Effect of KB001-A on Time-to-Need for Antibiotic Treatment
The purpose of this study is to confirm and extend the Phase 1-2 KB001 findings of an airway anti-inflammatory effect in CF individuals with chronic Pseudomonas aeruginosa (Pa) airway infection.
- Trial name
- KB001-A (NCT01695343)
- Testing
- KB001-A
- Where
- 67 sites in United States, Australia and 2 more
- Volunteers
- 182 people
- Sponsor
- Humanigen, Inc.
Breast Abscess
Comparison of Efficacy in Treating Breast Abscess, With Systemic Antibiotics Against Local Instillation of Antibiotics Along With Ultrasound Guided Aspiration.
Breast abscess, marked by localized collection of pus, frequently follows mastitis. Its prevalence soars up to 16% in the developing world.
- Trial name
- NCT06594276
- Testing
- Local instillation of antibiotics
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Gujranwala medical college District Headquarters Hospital, Gujranwala
Child Development
Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso
The use of antibiotics has saved millions of human lives, however consumption of antibiotics can select for antibiotic resistant organisms and may lead to changes in commensal microbiome.
- Trial name
- ARMCA (NCT03187834)
- Testing
- Azithromycin, Amoxicillin, Cotrimoxazole
- Where
- 2 sites in United States, Burkina Faso
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Antibiotics
Antibiotic Usage and Resistance; Knowledge and Practices Before and After Educational Sessions
The inappropriate use of antibiotics by patients not only increases the growth of resistant bacterial strains but also, may lead to adverse side effects that range from gastrointestinal disturbances to fatal anaphylactic shock.
- Trial name
- NCT04493008
- Testing
- Experimental: Educational session
- Where
- Egypt
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Misr International University
Side-effect of Antibiotic, Efficacy
Pharmacokinetics and Pharmacodynamics of Linezolid Continuous and Intermittent Administration
The purpose of this study is to evaluate the therapeutic efficacy expressed in pharmacokinetic/pharmacodynamic (PK/PD) indices, the clinical response and the risk of adverse reactions following the continuous and intermittent…
- Conditions
- Side-effect of Antibiotic, Efficacy, Pharmacokinetics, Critical Illness
- Trial name
- NCT05801484
- Testing
- Linezolid continuous infusion
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Cluj Municipal Clinical Hospital
Nontuberculous Mycobacterial Pulmonary Infection
PK and PD of Antibiotics for Treatment of Mycobacterium Abscessus Pulmonary Disease
Investigating the PK and PD indices in patients with M. abscessus complex-PD who will be treated with a currently recommended regimen, minimum inhibitory concentrations of organism, and their relation with clinical outcomes
- Trial name
- NCT05676138
- Testing
- Measuring PK and PD indices in patients who receive conventional treatment
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Urinary Tract Infection Bacterial
Bacteriophage Therapy in Patients With Urinary Tract Infections
This is a phase I/II trial designed to evaluate bacteriophage therapy in patients with urinary tract infections.
- Trial name
- NCT04287478
- Testing
- Bacteriophage Therapy
- Where
- 8 sites in United States
- Volunteers
- 1 people
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Critically-ill Patients
Immunosuppression and Intensive Care Unit-acquired Multidrug-resistant Bacteria
Antimicrobial resistance AMR is an emerging global threat to human health, and intensive care units (ICUs) are a 'hot spot' for the emergence and diffusion of multidrug-resistant (MDR) bacteria.
- Trial name
- TANGERINE (NCT06652126)
- Testing
- Microbiological examinations.
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Lille
Venous Leg Ulcer
Suprasorb®X+PHMB Pro vs Suprasorb®X+PHMB in Treatment of Infected Venous Leg Ulcers
This clinical investigation will be conducted as a multicentre, open-label, randomised in parallel groups, controlled study on patients with infected venous leg ulcers.
- Trial name
- NCT07211243
- Testing
- PHMB-impregnated biocellulose wound dressing with additional polyethylene film on top, compression therapy, systemic antomicrobial therapy (optional), PHMB-impregnated biocellulose wound dressing without additional polyethylene film on top, compression therapy, systemic antomicrobial therapy (optional)
- Where
- 9 sites in Poland
- Volunteers
- 150 people
- Sponsor
- Lohmann & Rauscher
Leukemia, CART Therapy
Early Versus Late Stopping of Antibiotics in Adults With High-risk Hematological Malignancies/Receiving Cellular Therapies and Fever
Pre-neutropenic fever (PNF) (fever following chemotherapy but before developing low white cells) and neutropenic fever (NF) (fever in the setting of low white cells) are very common after chemotherapy for acute leukemia, bone…
- Conditions
- Leukemia, CART Therapy, Transplantation, Stem Cell, Infections, Bacterial
- Trial name
- ELSA-Adult (NCT07051525)
- Testing
- Early antibiotic cessation alert
- Where
- 2 sites in Australia
- Volunteers
- 214 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Periodontitis
Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
Chronic periodontitis is an infectious disease of periodontal support tissues caused by bacterial biofilm, which leads to inflammation and destruction of periodontal support tissues ultimately resulting in tooth loss.In the…
- Trial name
- NCT05530252
- Testing
- Oral biological antimicrobial gel, minocycline hydrochloride ointment, SRP
- Where
- China
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Beijing Stomatological Hospital, Capital Medical University
Pneumonia
STATIN-VAP STATIN-VAP - STATINs and Ventilator-Associated Pneumonia
The objective is to assess the efficacy and safety of oral simvastatin in patients with a suspicion of ventilator-associated pneumonia (VAP).
- Trial name
- NCT01057758
- Testing
- SIMVASTATIN
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cystic Fibrosis
Tobramycin 300 mg Once-a-day (o.d.) Aerosol in Adults With Cystic Fibrosis
The study will include 10 adult patients with cystic fibrosis. The aim of the study is to evaluate whether Tobramycin 300 mg aerosol once-a-day for 28 days can reduce the bacterial load in the airways.
- Trial name
- NCT01608555
- Testing
- tobramycin
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Milan
Lung Infection
Safety and Efficacy of Inhaled Interferon Gamma-1b in Pulmonary MAC Infection
The purpose of this research study is to test the safety and effectiveness of inhaled Interferon gamma-1b (IFN-g 1b), when administered for 48 weeks and in combination with oral antibiotics which may be administered for up to 72…
- Trial name
- NCT00043355
- Testing
- interferon gamma-1b
- Volunteers
- 100 people
- Sponsor
- InterMune
Urethritis, Cervicitis
Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced
The purpose of this on-going study is to study the number of days after antibiotic treatment has commenced (due to infection caused by the sexually transmitted bacteria Chlamydia trachomatis (CT) and Mycoplasma genitalium(Mg)) it…
- Conditions
- Urethritis, Cervicitis, Genital Mycoplasma Infection, Chlamydia Trachomatis
- Trial name
- NCT01661985
- Testing
- Azithromycin, Doxycycline, lymecycline
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Ostergotland County Council, Sweden
Abscess, Cysts
Plasma and Abscess Fluid Pharmacokinetics of Cefpirome and Moxifloxacin After Single and Multiple Dose Administration
Penetration of cefpirome and moxifloaxacin into abscess fluid of humans will be tested. Patients with an abscess scheduled for drainage will receive study drugs (single or multiple dose), pus samples and plasma samples will be…
- Trial name
- NCT00280514
- Testing
- cefpirome and moxifloxacin administration
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Antimicrobial Prophylaxis in Prostate Surgery
Cotrimoxazole Prophylaxis in Transurethral Resection or Greenlight Laser Vaporisation of the Prostate
The optimal duration of antimicrobial prophylaxis (study medication Cotrimoxazole (Trimethoprim/Sulfamethoxazole)) in transurethral resection of the prostate and Greenlight Laser vaporisation of the prostate is investigated by…
- Trial name
- CITrUS (NCT03633643)
- Testing
- oral applications of TMP/SMX 800/160 mg (Nopil forte® tablets)
- Where
- 5 sites in Switzerland
- Volunteers
- 728 people
- Sponsor
- University Hospital, Basel, Switzerland
Urinary Tract Infection (Diagnosis)
Is Methenamine Prophylaxis for Urinary Tract Infection After Midurethral Sling as Effective as Antibiotic Prophylaxis?
Stress urinary incontinence (SUI) affects at least 40% of women in the United States. Synthetic polypropylene mid-urethral slings (MUS) are the gold standard treatment for SUI.
- Trial name
- NCT06810687
- Testing
- Methenamine Hippurate 1g BD, Antibiotic prophylaxis
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
HIV Infections
Effect of Interleukin-2 on HIV Treatment Interruption
Interleukin-2 (IL-2) helps the body make infection-fighting white blood cells, including CD4 and CD8 T cells. One HIV treatment strategy is planned treatment interruption (stopping anti-HIV drugs when CD4 count and level of virus…
- Trial name
- NCT00015704
- Testing
- Aldesleukin
- Where
- 17 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Adult
Effectiveness of AI-Assisted Antibiotic Prescribing
This randomized controlled trial aims to evaluate the impact of providing LLM access to physicians on antibiotic prescribing appropriateness, using a composite outcome instrument, the Antibiotic Prescribing Appropriateness Score…
- Trial name
- NCT07833293
- Testing
- ChatGPT
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lahore University of Management Sciences
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.