Clinical trials: Anti-Bacterial Agents
Sepsis
Procalcitonin-guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients
This clinical trial is aimed to show a procalcitonin-guided treatment algorithm may shorten duration of antibiotic therapy safely and cost-effectively in sepsis patients of Korean ICU.
- Trial name
- PRODA (NCT02202941)
- Testing
- Procalcitonin guided treatment, Conventional treatment
- Where
- 4 sites in South Korea
- Volunteers
- 62 people
- Sponsor
- Seoul National University Hospital
Simple Diverticular Disease
Randomized Clinical Trial for the Uncomplicated Diverticulitis in Right Colon
The aim of the present study was to evaluate whether antibiotics is mandatory for the treatment of acute uncomplicated right-sided diverticulitis.
- Trial name
- NCT02314013
- Testing
- Cephalosporin + Metronidazole
- Where
- South Korea
- Volunteers
- 132 people
- Sponsor
- Dongtan Sacred Heart Hospital
Pyelonephritis Acute
Patient-Directed Antimicrobial Duration in Acute Uncomplicated Pyelonephritis
This pilot study will randomize 40 female patients with acute uncomplicated pyelonephritis to receive standard duration of therapy versus patient-directed antimicrobial duration (PDAD).
- Trial name
- NCT06127160
- Testing
- Cephalexin
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Brett A Faine
Multi-antibiotic Resistance
Pathway From Functional Disability to Antimicrobial Resistance in Nursing Home Residents
Multidrug-resistant organisms (MDROs) are endemic in nursing homes (NHs) with prevalence rates surpassing those in hospitals. The aim of the study is to design and evaluate the effectiveness of a multi-component intervention to…
- Trial name
- NCT02909946
- Testing
- Multi-modal Infection Control Program
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- University of Michigan
Acute Respiratory Tract Infections
Optimisation of Antibiotic Prescription in Acute Noncomplicated Respiratory Tract Infections in Children (OptimAP Study)
Background: High-volume antibiotic prescribing in primary care is a major driver of antibiotic resistance. Education of physicians and patients can lower prescribing levels, but it frequently relies on highly trained staff.
- Trial name
- OptimAP (NCT05166369)
- Testing
- Communication skills training, Mobile phone application on RTI
- Where
- 4 sites in Spain
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Complicated Appendicitis, Perforated Appendicitis
Antibiotic Duration in Post-appendectomy Abscess
This is a randomized study of patients 2-17 years old who are diagnosed with perforated appendicitis and develop an abscess after laparoscopy that is subsequently drained.
- Trial name
- NCT03795194
- Testing
- ampicillin/clavulanate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Phoenix Children's Hospital
Sepsis
Evaluation of Usage Patterns and Outcomes in Patients Receiving Ceftolozane/Tazobactan (C/T) in Brazilian Hospitals
Ceftolozane/Tazobactan (C/T) is a recent option to manage multidrug resistant gram-negative infections in hospital patients. Despite several randomized controlled trials describing safety and efficacy of C/T, real world evidence…
- Trial name
- NCT05267483
- Testing
- No intervention
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education
Meningitis
Daptomycin in Pediatric Patients With Bacterial Meningitis
5 Children > 3months and < 16 years with Gram-positive meningitis will receive a single dose of daptomycin 24 hours after the first dose of ceftriaxone.
- Trial name
- NCT01522105
- Testing
- Daptomycin
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Leg Ulcer, Venous Leg Ulcer
Safety and Tolerability of Single and Multiple Doses of SoftOx Biofilm Eradicator (SBE) in Chronic Leg Wounds
Single-centre clinical study investigating the safety and tolerability of randomised, double-blinded, placebo-controlled ascending single doses of topically applied SoftOx Biofilm Eradicator (SBE) in patients with chronic leg…
- Trial name
- NCT05710094
- Testing
- SoftOx Biofilm Eradicator (Groups 1 to 7), Sterile isotonic saline (Groups 1 to 4)
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- SoftOx Solutions AS
Pancreatic Cystic Lesion
Antibiotic Prophylaxis for Endoscopic Ultrasound Guided Fine Needle Aspiration of Pancreatic Cystic Lesions
The purpose of this study is to determine whether the use of antibiotic prophylaxis is appropriate when performing a pancreatic cyst fine needle aspiration guided by endoscopic ultrasonography.
- Trial name
- NCT02261896
- Testing
- Ciprofloxacin
- Where
- Spain
- Volunteers
- 226 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cholangitis
Comparisons of Intravenous Ceftriaxone With Intravenous Moxifloxacin in ERCP
Background and aims: The use of prophylactic antibiotics before endoscopic retrograde cholangiopancreatography (ERCP) is recommended by all major international gastroenterological societies, especially in the presence of an…
- Trial name
- NCT02098486
- Testing
- Moxifloxacin, ceftriaxone
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Kangbuk Samsung Hospital
Infections
Efficacy and Safety of Antimicrobial Durations Treatment of Infections Associated With Osteosynthesis Material
Infections associated with osteosynthesis material are among the most feared and challenging complications of trauma surgery and can lead to total function loss or limb amputation when complete recovery is to be expected without…
- Trial name
- DURATIOM (NCT05294796)
- Testing
- Short course of antibiotherapy, Long course of antibiotherapy
- Where
- 29 sites in Spain
- Volunteers
- 364 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Cellulitis, Erysipelas
Duration of ANtibiotic Therapy for CEllulitis
Cellulitis is among the most common infections leading to hospitalization, yet the optimal duration of therapy remains ill defined.
- Trial name
- DANCE (NCT02032654)
- Testing
- Flucloxacillin
- Where
- 11 sites in Netherlands
- Volunteers
- 151 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sepsis, AKI
Effect of Antibiotic Choice On ReNal Outcomes (ACORN)
Sepsis is one of the most common causes of acute illness and death in the United States. Early, empiric broad-spectrum antibiotics are a mainstay of sepsis treatment.
- Conditions
- Sepsis, AKI, Neurotoxicity
- Trial name
- ACORN (NCT05094154)
- Testing
- anti-pseudomonal cephalosporin, anti-pseudomonal penicillin
- Where
- United States
- Volunteers
- 2,634 people
- Sponsor
- Vanderbilt University Medical Center
Patients Receiving Antimicrobial Therapy
Impact of Infectious Diseases Specialists on the Appropriateness of Antimicrobial Therapy in Surgical and Medical Wards
CONTEXT: Antibiotics are frequently used in hospital but the appropriateness of prescriptions ranged between 25-50%. The intervention of infectious disease specialists (IDS) could improve the appropriateness of prescriptions and…
- Trial name
- ATBREFSURMED (NCT01136200)
- Testing
- Infectious disease specialist advice
- Where
- France
- Volunteers
- 264 people
- Sponsor
- Henri Mondor University Hospital
Community-acquired Pneumonia
Adequate Duration of Antibiotic Treatment in Community-acquired Pneumonia With High Risk Class and Adequate Initial Clinical Response
Non-inferiority, multicenter, prospective double-blind, randomized clinical trial of two parallel groups. The randomization between the 2 study groups will be carried out according to a scheme generated by a computer program, in…
- Trial name
- 2017-001406-15 (NCT03609099)
- Testing
- Moxifloxacin
- Where
- 5 sites in Spain
- Volunteers
- 424 people
- Sponsor
- David Garcia Cinca
Staphylococcal Infection
Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA"
The purpose of this study is to determine the optimal outpatient treatment strategy of uncomplicated skin and soft tissue infection (SSTI) in areas of the United States where the prevalence of Community-Acquired…
- Trial name
- NCT00729937
- Testing
- Cephalexin, Clindamycin, Trimethoprim-sulfamethoxazole
- Where
- 5 sites in United States
- Volunteers
- 2,265 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Respiratory Tract Diseases, Nosocomial Infections
Impact of Antibiotic Treatment on Outcome in Patients With Ventilator-Associated Tracheobronchitis
The aim of this study is to determine whether antibiotic treatment could reduce mechanical ventilation duration in patients with nosocomial tracheobronchitis acquired under mechanical ventilation.
- Trial name
- NCT00122057
- Testing
- antibiotic treatment
- Where
- France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Lille
Surgical Wound Infection
Study of the Efficacy of Preoperative Cefuroxime Prophylaxis to Prevent Surgical Site Infection in Herniated Disk Surgery
The purpose of the study is to determine whether a single, pre-operative dose of cefuroxime is effective in preventing surgical site infection in patients undergoing surgery for herniated disk
- Trial name
- NCT00530400
- Testing
- cefuroxime
- Where
- 2 sites in Switzerland
- Volunteers
- 1,369 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Community-acquired Pneumonia
Clinical Reassessment Versus Procalcitonin in Order to Shorten Antibiotic Duration in Community-acquired Pneumonia
CLINPCT study is a prospective, randomized, controlled, open intervention clinical trial including adult patients admitted in the emergency department with community-acquired pneumonia.
- Trial name
- CLINPCT (NCT01723644)
- Testing
- the clinical reassessment arm, the procalcitonin arm
- Where
- 15 sites in France
- Volunteers
- 286 people
- Sponsor
- Nantes University Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.