Clinical trials: Anti-Retroviral Agents
HIV Infections, Coronary Disease
HIV-HEART Aging Study
The HIV/HEART Aging study (HIVH) is an ongoing, prospective, multicentre trial that was conducted to assess the incidence, the prevalence and the clinical course of cardiovascular diseases (CVD) in HIV-infected patients.
- Conditions
- HIV Infections, Coronary Disease, Myocardial Infarction, HIV Encephalopathy
- Trial name
- HIVH (NCT04330287)
- Where
- 5 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Essen
HIV Infection, Adherence
Social Norms and Priming to Improve Adherence to Antiretroviral Therapy and Retention in Care
Interventions incorporating constructs from behavioral economics and psychology have the potential to enhance HIV 'treatment as prevention' (TasP) strategies.
- Trial name
- NCT02938533
- Testing
- Intervention
- Where
- 2 sites in Tanzania
- Volunteers
- 438 people
- Sponsor
- University of California, Berkeley
HIV Infections
Lopinavir/Ritonavir in Combination With Saquinavir Mesylate or Lamivudine/Zidovudine to Explore Metabolic Toxicities in Antiretroviral HIV-Infected Subjects
The objectives of this study are to explore the metabolic toxicities associated with lopinavir/ritonavir (LPV/r) plus saquinavir mesylate (INV) versus LPV/r plus Combivir in antiretroviral naïve subjects and to assess the overall…
- Trial name
- NCT00043953
- Testing
- Lopinavir/ritonavir, Saquinavir mesylate, Lamivudine/zidovudine
- Where
- 11 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Abbott
Retention in Care
Structured Peer-delivered ART and Reentry Community Strategy
The overarching goal of this study is to implement a transition community adherence club strategy (Full-SPARCS) for HIV-positive individuals transitioning from correctional to community settings in South Africa.
- Trial name
- SPARCS (NCT06027671)
- Testing
- Full-SPARCS Intervention
- Where
- South Africa
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV-1-infection
Immunotherapy With Baricitinib and Sirolimus, Alone and in Combination, for the Control of HIV-1 Replication After Antiretroviral Treatment Interruption
Natural HIV controllers (HICs) and post-treatment controllers (PTCs) are rare examples of people living with HIV (PLWH) who achieve control of HIV replication without the need for antiretroviral therapy (ART).
- Trial name
- NCT07081763
- Testing
- Baricitinib 2 MG, Sirolimus 2 MG
- Volunteers
- 191 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1-infection
Efficacy and Safety of Doravirine in the Rapid Initiation
Protocol title: "Efficacy and safety of doravirine in the rapid initiation of highly active antiretroviral therapy (HAART) in HIV-1positive patients without prior treatment."
- Trial name
- RapiDO (NCT07357584)
- Testing
- Doravirine / lamivudine/ Tenofovir Disoproxil Oral Tablet
- Where
- 2 sites in Argentina
- Volunteers
- 100 people
- Sponsor
- Fundación Huésped
Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapy
This phase I trial studies the side effects and the best dose of sunitinib malate in treating human immunodeficiency virus (HIV)-positive patients with cancer receiving antiretroviral therapy.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT00890747
- Testing
- sunitinib malate, pharmacological study, laboratory biomarker analysis
- Where
- 11 sites in United States
- Volunteers
- 42 people
- Sponsor
- National Cancer Institute (NCI)
HIV Infections
The Safety and Effectiveness of Retrovir Plus HIVID Combined With Either Nevirapine or Invirase in the Treatment of HIV Infection
To evaluate the tolerance and immunologic and virologic effects of multidrug combinations of antiretrovirals in patients with HIV infection.
- Trial name
- NCT00002347
- Testing
- Saquinavir, Nevirapine, Zidovudine
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Parexel
HIV Infections, Fanconi Syndrome
Fanconi Syndrome Due to ARVs in HIV-Infected Persons
Cross-sectional cohort study of participants with HIV with or without protocol-defined Fanconi syndrome (confirmed creatinine clearance [CLcr] decline and evidence of proximal tubulopathy).
- Conditions
- HIV Infections, Fanconi Syndrome, Kidney Disease, Renal Impairment
- Trial name
- NCT00499187
- Testing
- Blood Draws
- Where
- 13 sites in United States, Canada
- Volunteers
- 56 people
- Sponsor
- Gilead Sciences
HIV Infection
Hydroxychloroquine for Discordant CD4 Responders on Highly Active Antiretroviral Therapy (HAART)
The purpose of the study is to examine the effects of adding a drug called hydroxychloroquine, usually used to treat rheumatoid arthritis, to patients' usual antiretroviral combination.
- Trial name
- SSAT039 (NCT01232660)
- Testing
- Hydroxychloroquine
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- St Stephens Aids Trust
HIV Infection
Dolutegravir Antiretroviral Strategy to Promote Improvement and Reduce Drug Exposure
HIV-1 infected subjects with CD4 nadir > 200 cells/mm3, no history of virologic failure and plasma HIV RNA <50 copies/mL for at least 48 weeks while on any United States Department of Health and Human Services (DHHS) recommended…
- Trial name
- ASPIRE (NCT02263326)
- Testing
- dolutegravir, lamivudine, Continue current antiretroviral regimen
- Where
- 7 sites in United States
- Volunteers
- 89 people
- Sponsor
- Babafemi Taiwo
HIV, Cardiovascular Disease
Determining the Effect of Abacavir on Platelet Activation
HIV positive patients have a two fold increased risk of developing cardiovascular disease (such as heart attacks and strokes). Cardiovascular disease appears to be due in part to both HIV and the side effects from anti-HIV…
- Trial name
- NCT01886638
- Testing
- Abacavir
- Where
- Australia
- Volunteers
- 23 people
- Sponsor
- Bayside Health
HIV Infections
Observational Study on Patients With HIV/AIDS(OSPWH)
To establish a follow-up cohort of antiretroviral therapy(ART) for patients with HIV/AIDS, to observe the ART efficacy and adverse reactions, complications in the process of ART, as well as mortality and causes of death, so as to…
- Trial name
- OSPWH (NCT04667026)
- Where
- China
- Volunteers
- 15,000 people
- Sponsor
- Guangzhou 8th People's Hospital
HIV Seropositivity
Monitored Antiretroviral Pause in Chronic HIV-Infected Subjects With Long-Lasting Suppressed Viremia
Prospective, open-label, single arm, non-randomized, proof-of-concept study. Eligible patients will sign a written informed consent and will be followed-up at screening, baseline (ART interruption) and at 1, 2, 3, 4, 6, 8, 10…
- Trial name
- APACHE (NCT03198325)
- Testing
- Stop of ART
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- IRCCS San Raffaele
HIV Infections
The Safety and Effectiveness of Nevirapine Plus Lamivudine Plus Other Anti-HIV Drugs
To evaluate the tolerance, safety, and effectiveness of Viramune in preventing clinical AIDS progression events or death when used in combination with Lamivudine and background nucleoside therapy.
- Trial name
- NCT00002368
- Testing
- Nevirapine, Lamivudine
- Where
- 53 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Boehringer Ingelheim
Human Immunodeficiency Virus
Antiretroviral Improvement Among Medicaid Enrollees
This study will evaluate whether a new program will affect how often human immunodeficiency virus (HIV) antiretroviral therapy (ART) prescriptions are filled and whether the program improves the health of people living with HIV.
- Trial name
- AIMS (NCT05477485)
- Testing
- Experimental: AIMS program - patient, No Intervention/Usual care
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
HIV Infections
A Comparison of Two Anti-HIV Triple-Drug Combinations in HIV-Infected Patients
The purpose of this study is to compare the safety and effectiveness of two anti-HIV drug combinations when given to HIV-infected patients who have never been treated with anti-HIV drugs.
- Trial name
- NCT00002168
- Testing
- Indinavir sulfate, Lamivudine, Stavudine
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 200 people
- Sponsor
- Bristol-Myers Squibb
HIV Infections
Blood Levels of Anti-HIV Drugs Used in Combination Regimens in HIV Infected Children
Limited data exist about combination anti-HIV treatment regimens in children, including how those drugs are cleared by the body in children.
- Trial name
- NCT00260078
- Testing
- Atazanavir, Darunavir, Efavirenz
- Where
- 23 sites in United States, Puerto Rico
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv, HIV Infections
Effect of N-803 on B Cell Follicles in Antiretroviral Treated HIV Disease
N-803 has demonstrated ability to reactivate HIV from latency and can activate T cells and NK cells to clear those cells, thus reducing the reservoir.
- Conditions
- Hiv, HIV Infections, AIDS
- Trial name
- NCT04808908
- Testing
- N-803
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota
HIV Infections
Optimisation of Care in Vulnerable HIV Infected Individuals
Antiretroviral therapy is currently the only way to control HIV disease progression in HIV infected subjects and to prevent transmission.
- Trial name
- OPTICARE (NCT03799276)
- Testing
- Opticare study
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
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