Clinical trials: Anti-inflammatory Agents
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Type 2 Diabetes, Diabetes
The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy Volunteers
This study, conducted at the Phoenix Indian Medical Center, Phoenix, Arizona, will determine whether reducing subclinical inflammation lessens insulin resistance in healthy, obese volunteers.
- Trial name
- NCT00339833
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Acne Vulgaris
Phase II Trial of RA-18C3 in Subjects With Moderate to Severe Acne Vulgaris
This is a 91-day phase II, open label trial of the true human monoclonal antibody RA-18C3 in subjects with moderate to severe acne vulgaris. Ten (10) subjects will receive RA-18C3 via subcutaneous injection.
- Trial name
- NCT01474798
- Testing
- RA-18C3
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Janssen Research & Development, LLC
Postoperative Bariatric Surgery
Use Of Esomeprazole In Postoperative Bariatric Surgery Patients Users And Non-Users Of Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)
Phase IV, open-label, multicenter, non-randomized, with 2 non-comparative investigational arms study, carried out in morbid obesity patients who had undergone gastric bypass surgery for body weight reduction
- Trial name
- NCT00608712
- Testing
- Esomeprazole
- Volunteers
- 140 people
- Sponsor
- AstraZeneca
Gonarthrosis, Coxarthrosis
Radiotherapy 3 vs 6 Gy in Gonarthrosis and Coxarthrosis
This is a non-inferiority study in which the investigators compare two low-dose radiotherapy schemes, which are recommended from DEGRO Clinical Practice Guidelines (3 Gy vs 6 Gy) for the treatment of osteoarthritis and other…
- Trial name
- RAGOCO (NCT04424628)
- Testing
- Low dose radiotherapy A, Low dose radiotherapy B
- Where
- Spain
- Volunteers
- 338 people
- Sponsor
- Fundacion GenesisCare
Psoriasis, Systemic Inflammation
Anti-Inflammatory Effects of Time-Restricted Feeding
Background: Time-restricted feeding (TRF) means that a person eats only during certain hours of the day. In other studies, researchers have found that fasting can improve immune system function in healthy people.
- Trial name
- NCT04728165
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma
Withania Somnifera for Moderate-to-Severe Persistent Asthma
This randomized, double-blind, placebo-controlled study evaluated Withania somnifera root powder as a complementary therapy in adults with moderate-to-severe persistent asthma receiving standard asthma treatment.
- Trial name
- WISTA (NCT07787507)
- Testing
- Withania somnifera Root Powder, Standard Asthma Treatment
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Aligarh Muslim University
Gingivitis, Dental Plaque
Antiplaque, Antigingivitis and Anti-inflammatory Effects of Myrrh Mouthwash
Myrrh-based mouthwash has the potential to be a suitable alternative to the gold standard chlorhexidine mouthwash for dental plaque and gingivitis reduction.
- Trial name
- NCT04723732
- Testing
- Myrrh mouthwash, Chlorhexidine mouthwash, Normal saline
- Where
- Saudi Arabia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Gingivitis
The Effects of Green Tea and Salvadora Persica L. in Patients With Gingivitis
Gingivitis is an inflammatory condition of the gingival tissue, most commonly caused by bacterial infection.The plaque control is considered the most important preventive factor concerning caries, gingivitis, and periodontitis…
- Trial name
- NCT06211309
- Testing
- co.mouthwas, Kin, Distilled water
- Where
- Iraq
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Postoperative Complications, Cataract
Safety and Efficacy Study of Topical Bromfenac Versus Placebo to Treat Ocular Inflammation After Cataract Surgery
The primary objective of this study was to investigate the efficacy of bromfenac sodium ophthalmic solution 0.09% for treatment of post-operative ocular inflammation in subjects who undergo cataract extraction and intraocular…
- Trial name
- NCT00198445
- Testing
- Bromfenac
- Where
- 39 sites in United States
- Volunteers
- 527 people
- Sponsor
- Bausch & Lomb Incorporated
Asthma
The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma
We hypothesize that simvastatin in combination with ICS might have synergistic anti-inflammatory effects on airway inflammation in asthmatic patients
- Trial name
- NCT00792337
- Testing
- simvastatin, B1-6-12
- Where
- Thailand
- Volunteers
- 53 people
- Sponsor
- Mahidol University
Rheumatoid Arthritis
Pentoxifylline as Anti-Inflammatory in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a long-term inflammatory condition that leads to gradual damage of joints lined by synovial membranes, along with various potential effects outside of the joints.
- Trial name
- NCT06998628
- Testing
- Methotrexate, Pentoxifylline
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Fever, Hyperthermia
The Fever and Antipyretic in Critically Illness Evaluation Study
The purpose of this multination multicenter observational study is to determine the impact of fever and antipyretic on outcomes in critically ill patients.
- Trial name
- FACE (NCT00940654)
- Testing
- Antipyretic therapy
- Where
- 2 sites in Japan, South Korea
- Volunteers
- 1,426 people
- Sponsor
- Japanese Society of Intensive Care Medicine
Anterior Cruciate Ligament (ACL) Tears
Early Treatment for Acute ACL Tear
This research study is the first of its kind and will allow health care professionals and researchers to answer many questions about the reasons why anterior cruciate ligament (ACL) injury leads to knee pain and disability and…
- Trial name
- AAA (NCT01692756)
- Testing
- Kenalog
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Cale Jacobs
Colchicine Adverse Reaction, Atrial Fibrillation New Onset
COlchicine in Cardiac Surgery
Postoperative atrial fibrillation (POAF) is a major complication of cardiac surgery, which could lead to high morbidity and mortality, increase duration of hospital stay and increase the cost of treatment.
- Trial name
- COCS (NCT04224545)
- Testing
- Colchicine Pill
- Where
- 2 sites in Russia
- Volunteers
- 267 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Acute Decompensated Heart Failure, Cytokine Storm
Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart Failure
Assess the anti-inflammatory effects of short-term Copaxone therapy on patients with acute decompensated heart failure. Trial Design An open-label, randomized, prospective trial of patients hospitalized due to acute…
- Conditions
- Acute Decompensated Heart Failure, Cytokine Storm, Inflammatory Response, Heart Failure
- Trial name
- Copaxone (NCT06003972)
- Testing
- Copaxone, guideline directed medical therapy (GDMT)
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- Hadassah Medical Organization
Low Back Pain, Acute
Interfascial Infiltration for Acute Unspecific Low Back Pain in the Emergency Department
Pain relief and functional impairment have been shown to remain poor to moderate over weeks after emergency department discharge, in patients who seek ED management for acute nontraumatic, nonradicular low back pain.
- Trial name
- PreSosLumbago (NCT03968185)
- Testing
- Interfascial infiltration, Standard medical treatment
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Dyspepsia
Total Antioxidant Effects of Esomeprazole in Dyspeptic Patients Receiving Non-steroidal Anti-inflammatory Drugs
The principal investigator hypothesizes that participants receiving NSAID drugs with dyspeptic symptoms have increased production of gastric levels of free radicals.
- Trial name
- NCT00443963
- Testing
- Esomeprazole Magnesium
- Where
- United States
- Sponsor
- Medstar Health Research Institute
Obesity
Effects of n-3 Intake on Lipid Profile, Biochemical and Inflammatory Markers in Subjects With Obesity
Obesity is a chronic disease characterized by the excessive accumulation of adipose tissue that is harmful to health. Dietary habits modification through a caloric restriction, macronutrient distribution including linoleic and…
- Trial name
- NCT04901052
- Testing
- n-3 supplementation group
- Where
- 2 sites in Mexico
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Malignant Pleural Effusion, Pleural Effusion
The First Therapeutic Intervention in Malignant Pleural Effusion Trial
Fluid caused by cancer cells may accumulate in the lining of the lung. Draining the fluid with a chest tube may relieve pain and shortness of breath.
- Trial name
- TIME-1 (NCT00896285)
- Testing
- Large bore chest drain + NSAID based analgesic regimen, Small bore chest drain + NSAID based analgesic regimen, Large bore chest drain + opiate based analgesic regimen
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, Davis
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