Clinical trials: Anti-inflammatory Agents
Severe Asthma
The Inflammatory Profile of Exacerbations in Patients With Severe Asthma Receiving Tezepelumab: The TezEx Study
Tezepelumab is a treatment that is approved by NICE (National Institute for Health and Care Excellence, https://www.nice.org.uk/) for patients with severe asthma, that remains poorly controlled despite high dose inhaled…
- Trial name
- TezEx (NCT06666504)
- Testing
- Prospective Data Analysis
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Postoperative Ileus
Pilot Study: Anti-inflammatory Effect of Peroperative Stimulation of the Vagus Nerve
Hypothesis: Electrical stimulation of the abdominal vagus nerve has an anti-inflammatory effect and represents a new therapeutic approach to shorten postoperative ileus.
- Trial name
- NCT01572155
- Testing
- Vagus stimulation 1, Vagus stimulation 2
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- KU Leuven
Sprain
Etoricoxib in Acute Ankle Ligament Sprains
The aim of the study is to measure the effectiveness of treatment over 7 days with commonly used anti-inflammatory medications namely etoricoxib and diclofenac (Voltaren) on reducing the severity of pain, swelling and loss of…
- Trial name
- NCT00954785
- Testing
- Ankle brace, Diclofenac 50 mg tds, Etoricoxib 120 mg mane
- Where
- 2 sites in South Africa
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Cape Town
Rheumatoid Arthritis
Anti-TNF Agents for the Treatment of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic disease that leads to inflammation and progressive joint damage. RA is a systemic inflammatory autoimmune disorder affecting almost 1% of the United States population.
- Trial name
- NCT00837434
- Testing
- Etanercept, Adalimumab
- Where
- 7 sites in United States
- Volunteers
- 63 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pain, Quality of Life
Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life
Pericoronitis is a painful inflammatory condition which is well known for its negative impact on quality of life of those affected.
- Trial name
- NCT03745599
- Testing
- Diclofenac, Flurbiprofen, Benzydamine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Near East University, Turkey
Endometriosis
The Role of a Mediterranean Diet in Patients With Endometriosis: a Feasibility Trial
This study aims to test if making changes to diet can affect the pelvic pain associated with endometriosis. One group will follow a Mediterranean diet for 12 weeks while the control group will continue with their current diet.
- Trial name
- MDIE (NCT05411549)
- Testing
- Diet Modification to Adopt Mediterranean Diet
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Acute Ischemic Stroke, Acupuncture
Acupuncture Intervention to Improve Neurological Function and Anti-inflammatory Effect in Acute Ischemic Stroke (ANAIS)
This study will have acupuncture intervention in acute ischemic stroke patients and evaluate the effect in neurological function improving by National Institutes of Health Stroke Scale (NIHSS), Modified Rankin Scale (mRS)…
- Trial name
- ANAIS (NCT03097055)
- Testing
- Traditional Acupuncture, Minimal Acupuncture
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- China Medical University, Taiwan
Painful Diabetic Peripheral Neuropathy
Effect Of Pregabalin Treatment In Patients With Diabetic Nerve Pain Who Currently Use A Non-Steroid Anti-Inflammatory Drug (NSAID) For Another Pain
This study is to test the effectiveness of pregabalin in treating nerve pain caused by diabetes. The suitable subjects will be patients who also use an non-steroid anti-inflammatory drug for another pain which is not related to…
- Trial name
- NCT01455415
- Testing
- pregabalin
- Where
- 61 sites in United States, Czechia and 2 more
- Volunteers
- 306 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Obesity
An Anti-inflammatory Diet Effect on Metabolic, Inflammatory and Immune Status of Obese Younger Adults
Diet has a major role in the etiology of obesity, and there is a growing body of evidence suggesting that a variety of dietary factors can modulate obesity-induced chronic low-grade inflammation and thus the course of…
- Trial name
- NCT03987776
- Testing
- Anti-inflammatory energy-restricted diet, Control energy-restricted diet
- Where
- Croatia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Pulmonary Disease, Chronic Obstructive
A Study To Investigate The Ability To Use 18FDG PET Scanning To Monitor The Effectiveness Of New Drugs In COPD Patients
It is hypothesised that there is a difference between the uptake of a radioactive substance ([18F]fluorodeoxyglucose (FDG)) in the lungs of patients with Chronic Obstructive Pulmonary Disease (COPD) and healthy volunteers.
- Trial name
- NCT00472264
- Testing
- PET imaging
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Gastric Ulcer, Duodenal Ulcer
Nexium Capsules Non-steroidal Anti-inflammatory Drug (NSAID) Specific Clinical Experience Investigation
The purpose of this investigation is to collect following data in patients given Nexium capsule (Nexium) for long term in usual-post-marketing therapy to prevention of recurrence of gastric ulcer or duodenal ulcer with…
- Trial name
- NCT01562600
- Where
- 46 sites in Japan
- Volunteers
- 1,634 people
- Sponsor
- AstraZeneca
Skin Diseases, Metabolic, Skin Care
Safety and Effectiveness Evaluation of the Apotech® Diabetic Body Moisturizer
Safety and effectiveness evaluation of a new moisturizer formulation with antioxidant, anti-inflammatory and anti-microbial effects in the prevention of diabetics dry skin and complications.
- Trial name
- Apotech (NCT03192592)
- Testing
- Body moisturizer
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- ANS Pharma
Colorectal Neoplasms
Yield and Safety of Colonoscopy in Patients Older Than 80 Years
The aim of the study is to study the risk of colorectal cancer and polyps in people older than 80 years compared to the younger age group.
- Trial name
- NCT00590434
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Midwest Biomedical Research
Functional Dyspepsia
Helicobacter Eradication Relief of Dyspeptic Symptoms
A double-blind clinical trial investigating if a sub-group of functional dyspeptic patients without any use of NSAID or gastric erosions could have a better evolution of their dyspeptic symptoms after Helicobacter eradication…
- Trial name
- HEROES-12 (NCT00404534)
- Testing
- Amoxicillin, Clarythromycin, Omeprazole for ten days
- Where
- Brazil
- Volunteers
- 407 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Healthy
Tolerability, Safety and Pharmacokinetic Study Of Methosulide in Healthy Adult Subjects
The purpose of this study is to determine the safety and tolerability, and to evaluate the pharmacokinetic characteristics and food effect of Methosulide after oral administration in healthy adult subjects.
- Trial name
- NCT02374684
- Testing
- Methosulide
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Hubei Biological Medicine Industrial Technology Institute Co., Ltd.
Post-Surgical Ocular Pain, Post-Surgical Ocular Inflammation
Dextenza Within Upper Lid Canaliculus Compared With Lower Lid Canaliculus Following Bilateral Cataract Extraction Surgery With PCIOL.
Assessing DEXTENZA efficacy when placed within the upper eyelid canaliculus as opposed to the lower eyelid canaliculus.
- Trial name
- NCT04592081
- Testing
- Dextenza 0.4Mg Ophthalmic Insert
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kerry Assil, MD
Schizophrenia, Schizoaffective Disorder
RCT of Methotrexate Added to Treatment As Usual in Schizophrenia
The aim of the this study is to evaluate the effectiveness of methotrexate added to treatment as usual on positive and negative symptoms, cognitive and social functioning and quality of life of patients suffering from…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- RECOVERY (NCT02074319)
- Testing
- Methotrexate
- Where
- 4 sites in Pakistan
- Volunteers
- 92 people
- Sponsor
- Pakistan Institute of Living and Learning
Osteoarthritis, Knee
Parabens Flocculation on the Anti Inflammatory Effects of Corticosteroid Injections for Total Knee Arthroplasty
The purpose of this study is to identify whether corticosteroid use with anesthetics containing preservatives (parabens) reduces clinical effectiveness of the anti-inflammatory agent Up to 100 patients, both male and female…
- Trial name
- 5160373 (NCT03445611)
- Testing
- corticosteroid solution with lidocaine containing parabens., corticosteroid solution with lidocaine containing no paraben
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Ulcerative Colitis
Saffron as Anti Inflammatory In Patients With Inflammatory Bowel Disease
Nutritional Saffron supplement has been widely used as food supplement and has known anti-depressant and anti-inflammatory activities. The investigators use saffron extract in Egyptian patients with ulcerative colitis for 8 weeks.
- Trial name
- NCT05715099
- Testing
- Saffron
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Minia University
Myofascial Pain Syndromes
Myofascial Pain:Acupuncture Versus Trigger Point Injection Combined With Dipyrone and Cyclobenzaprine
CONTEXT AND OBJECTIVE: Myofascial syndrome is the most frequent condition of chronic pain. The objective of the present study was to compare the analgesic action of acupuncture and trigger point injection combined with…
- Trial name
- ACP (NCT00635037)
- Testing
- bupivacaine and acupuncture
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
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