Clinical trials: Anti-inflammatory Agents
Acute Post-operative Pain
Ibuprofen Use on Post-operative Pain Following Cholecystectomy
In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.
- Trial name
- NCT06478758
- Testing
- Ibuprofen 400 mg, Acetaminophen 100 MG/ML
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Giresun University
Axial Spondyloarthritis (AxSpA), Aerobic Exercise
Effect of Aerobic Exercises on Axial Spondyloarthropathy
This study aimed to examine whether aerobic exercises, in addition to home exercises, have anti-inflammatory effects, which are evaluated by disease activity, acute phase reactants, and cytokine levels in axial spondyloarthropathy
- Conditions
- Axial Spondyloarthritis (AxSpA), Aerobic Exercise, Disease Activity
- Trial name
- NCT06699238
- Testing
- Home Exercise, Aerobic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Yeşim Ozge Gunduz Gul
Warfarin and NSAID
Warfarin and Non-Steroidal Anti-Inflammatory Drugs (NSAID) Customized Alert
The hypothesis is that a newly formatted electronic alert that requires the prescriber to pause and enter a specific "reason for override" on this alert, will cause prescribers in the intervention group to be significantly less…
- Trial name
- NCT00880932
- Testing
- Electronic Alert
- Where
- United States
- Volunteers
- 1,865 people
- Sponsor
- University of Pennsylvania
Healthy
The Absorption and Metabolism of Seaweed Polyphenols in Humans
Brown seaweeds are a rich source of phlorotannins, a characteristic class of polyphenols which are unique to seaweeds of this type and can comprise 5 to 15 % of the dried weight.
- Trial name
- SWAFAX (NCT02496806)
- Testing
- Seaweed extract
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy
Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France
The purpose of this study is to assess in general population NSAID and gastroprotective agent utilization and compliance in elderly people.
- Trial name
- NCT01211652
- Where
- 3,510 sites in France
- Volunteers
- 8,186 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Fatty Liver
Resveratrol in Patients With Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) and fatty liver hepatitis (NASH) are very common in the Western world and strongly associated with obesity. No known effective treatment is known.
- Trial name
- LIRMOI3 (NCT01464801)
- Testing
- Resveratrol
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- University of Aarhus
Breast Cancer
Comparative Effectiveness of Acupuncture and Nonsteroidal Anti-inflammatory Drugs for the Management of Aromatase Inhibitor Induced Arthralgia Among Breast Cancer Survivors
Hormone therapy is used to treat women with hormone receptor-positive breast cancer and aromatase inhibitor (AI) is administered after menopause.
- Trial name
- NCT04511832
- Testing
- Diclofenac
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- China Medical University Hospital
Candidiasis
Efficacy and Safety of LAS41003 in the Treatment of Intertriginous Candida Infections
The aim of this study is to determine the efficacy and safety of once daily topical application of the combinational cream LAS41003 compared to the corresponding mono-substances in the treatment of candida infections in…
- Trial name
- NCT01102387
- Testing
- LAS41003, LAS189962, LAS189961
- Where
- 6 sites in Germany
- Volunteers
- 137 people
- Sponsor
- Almirall, S.A.
Acute Aortic Syndrome
Additive Anti-inflammatory Action for Aortopathy & Arteriopathy
Acute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity.
- Trial name
- NCT04398992
- Testing
- observation
- Where
- 34 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Nanjing Medical University
Rheumatoid Arthritis
A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis
A Canadian study to evaluate early use of adalimumab after methotrexate failure in early rheumatoid arthritis. The study hypothesis will verify if adalimumab effectively reduces joint damage in more participants when introduced…
- Trial name
- RADAR (NCT01162421)
- Testing
- adalimumab, Methotrexate
- Volunteers
- 77 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Gastric Ulcer, Duodenal Ulcer
Long Term Study to Investigate the Efficacy & Safety of D961H (Esomeprazole) for the Prevention of NSAIDs-induced Ulcer
The purpose of this study is to assess the Safety and tolerability of D961H (Esomeprazole) 20 mg once daily for up to 52 weeks of treatment involving patients with a history of gastric and/or duodenal ulcers receiving daily…
- Conditions
- Gastric Ulcer, Duodenal Ulcer, Rheumatoid Arthritis, Osteoarthritis
- Trial name
- NCT00595517
- Testing
- Esomeprazole 20 mg
- Where
- 3 sites in Japan
- Volunteers
- 395 people
- Sponsor
- AstraZeneca
Anemia, Sickle Cell
Antioxidant Therapy to Reduce Inflammation in Sickle Cell Disease
The purpose of this study is to determine whether alpha-lipoic acid and acetyl-L-carnitine will lower systemic inflammation in patients with Sickle Cell Disease by reducing oxidative stress, which will result in a decrease in the…
- Trial name
- NCT01054768
- Testing
- alpha-lipoic acid and acetyl-L-carnitine, Control
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Age Related Macular Degeneration
Evaluation of Wet Age-Related Macular Degeneration (AMD) Genetic Profile Interactions With Ranibizumab Treatment Outcomes
Age Related Macular Degeneration (AMD) is the leading cause of blindness in North America. This condition causes a progressive loss of central vision, the part of your vision that allows you to read, drive and see images in sharp…
- Trial name
- NCT01363570
- Testing
- Ranibizumab
- Where
- 2 sites in Canada
- Volunteers
- 70 people
- Sponsor
- McMaster University
Hidradenitis Suppurativa
Evaluation of Sonelokimab for the Treatment of Patients With Active Moderate to Severe Hidradenitis Suppurativa
This is a study to demonstrate the clinical efficacy and safety of the nanobody® sonelokimab administered subcutaneously (sc) compared with placebo in the treatment of adult participants with moderate to severe hidradenitis…
- Trial name
- NCT05322473
- Testing
- Sonelokimab (M1095), Adalimumab
- Where
- 57 sites in United States, Bulgaria and 5 more
- Volunteers
- 234 people
- Sponsor
- MoonLake Immunotherapeutics AG
Rheumatoid Arthritis
Safety and Efficacy Vagal Nerve Stimulation in Patients With Rheumatoid Arthritis
This is a 12 week open label pilot study to determine the efficacy and safety of a surgically implanted, electrically active vagal nerve stimulation device in patients with active rheumatoid arthritis.
- Trial name
- NCT01552941
- Testing
- Cyberonics VNS System
- Where
- 4 sites in Bosnia and Herzegovina, Croatia and 1 more
- Volunteers
- 18 people
- Sponsor
- SetPoint Medical Corporation
Macular Thickening, Macular Edema
Effect of Topical Nepafenac in Macular Thickening Related to Pan-retinal Photocoagulation
The purpose of this study is to determine whether topical nepafenac (qid) is effective in preventing and treating macular thickening related pan-retinal photocoagulation in patients with diabetic retinopathy.
- Trial name
- NEPAF (NCT00801905)
- Testing
- Nepafenac, Lubricant
- Where
- 2 sites in Mexico
- Volunteers
- 50 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants, Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants
Ibuprofen Inhibits Human Sweet Taste
The sweet taste receptor, TAS1R2-TAS1R3, is expressed both orally, where it signals sweet taste, and extraorally in the intestine and pancreas, where it may affect glucose absorption and metabolism.
- Trial name
- NCT06291337
- Testing
- Inhibition of Sweet Taste by Ibuprofen Oral Rinses, Inhibition of Sweet Taste by Naproxen Oral Rinses
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Post-Surgical Ocular Pain, Post-Surgical Ocular Inflammation
Dextenza Within Upper Lid Canaliculus Compared With Lower Lid Canaliculus Following Bilateral Cataract Extraction Surgery With PCIOL.
Assessing DEXTENZA efficacy when placed within the upper eyelid canaliculus as opposed to the lower eyelid canaliculus.
- Trial name
- NCT04592081
- Testing
- Dextenza 0.4Mg Ophthalmic Insert
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kerry Assil, MD
Macular Oedema, Cataract Surgery
Comparing Efficacy of Bromfenac 0.09%, Nepafenac 0.3% and Diclofenac 0.1% in Patients After Cataract Surgery
The goal of this clinical trial is to learn which of the drugs bromfenac 0.09%, nepafenac 0.3% and diclofenac 0.1% has better efficacy in treatment and prevention of cystoid macular oedema after cataract surgery.
- Conditions
- Macular Oedema, Cataract Surgery, NSAID (Non-Steroidal Anti-Inflammatory Drug)
- Trial name
- BND (NCT07178639)
- Testing
- Bromfenac 0.09 % Ophthalmic Solution, Nepafenac 0.3% Oph Susp, diclofenac 0.1% ophthalmic susp.
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Nemocnice Kolín
Relapsing Remitting Multiple Sclerosis
A Study of Orally Administered BGC20-0134 (Structured Lipid) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS)
To determine the efficacy and safety of an oral drug (BGC20-0134) in patients with relapsing remitting multiple sclerosis. Specifically, the cumulative number of new gadolinium enhancing lesions after 24 weeks of treatment with…
- Trial name
- NCT01037907
- Testing
- Pleneva TM BGC20-0134
- Where
- 35 sites in Belgium, France and 4 more
- Volunteers
- 173 people
- Sponsor
- Boston Scientific Corporation
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