Clinical trials: Anti-inflammatory Agents
Arthritis, Rheumatoid
Methotrexate and Statins With Methotrexate Alone in the Treatment of Rheumatoid Arthritis
The objective of the study is to compare the efficacy of combination of Methotrexate and Statins with Methotrexate alone in the treatment of Rheumatoid Arthritis.
- Trial name
- NCT04177173
- Testing
- Simvastatin 20 mg, Methotrexate 10 mg
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- King Edward Medical University
Asthma, Exercise-Induced
A Study to Investigate the Effects of PT027 (Budesonide/Albuterol Sulfate) Metered-dose Inhaler Compared With Placebo on Exercise-Induced Bronchoconstriction in Adult Patients With Asthma
The purpose of this Phase III, multicentre, randomized, double-blind, single-dose, 2-period, crossover study is to assess the efficacy and safety of PT027 (budesonide/albuterol sulfate) metered-dose inhaler compared with placebo…
- Trial name
- BREATH (NCT06245551)
- Testing
- Budesonide/albuterol metered-dose inhaler 160/180 μg
- Where
- 6 sites in Russia
- Volunteers
- 64 people
- Sponsor
- AstraZeneca
Adverse Effects in the Therapeutic Use of Analgesic, Antipyretic and Anti-Inflammatory Drug, Unspecified
A Prospective Study on the Comparison of Postoperative Pain According to the Use of Cocktail Therapy in Laminoplasty
This study is the first prospective randomized controlled trial to analyze the effects and safety of multimodal cocktail injections after cervical laminoplasty
- Trial name
- NCT06113497
- Testing
- Cocktail injection
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Crohn's Disease
Vagus Nerve Stimulation a New Approach in the Treatment of Crohn's Disease
The purpose of this study is to determine whether (VNS) Vagus Nerve Stimulation , is effective in the treatment of Crohn's disease.
- Trial name
- VNS (NCT01569503)
- Testing
- vagus nerve stimulation (VNS)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Grenoble
Necrotizing Enterocolitis
Anti-inflammatory Treatment at the Onset of Necrotizing Enterocolitis (NEC) in Preterm Infants
Despite modern medical advances, necrotizing enterocolitis (NEC) remains a significant problem in neonatal intensive care units (ICUs).
- Trial name
- steroids/NEC (NCT01156480)
- Testing
- hydrocortisone
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Endeavor Health
Inflammation, Spinal Cord Injuries
Anti-inflammatory Diet Consultation for Those With Neuromuscular Disability
This study investigated the effects of a 2-part dietary consultation on adherence to an anti-inflammatory diet in individuals with neuromuscular disability.
- Conditions
- Inflammation, Spinal Cord Injuries, Multiple Sclerosis, Muscular Dystrophies
- Trial name
- NCT05881122
- Testing
- Mad Dog Dietary Consultation
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Brock University
Malaria, Bacteremia
Empirical ANtibiotic THErapy in Adults Hospitalised With Malaria
While World Health Organization (WHO) guidelines recommend empirical antibacterial therapy as the standard of care in all African children with severe falciparum malaria, there are fewer data to guide the management of adults…
- Conditions
- Malaria, Bacteremia, Sepsis
- Trial name
- ANTHEM (NCT03224052)
- Where
- Burma
- Volunteers
- 20 people
- Sponsor
- Menzies School of Health Research
Root Canal Obturation
Postoperative Pain After Root Canal Obturation With Sealer Containing Prednisolone.
The study design is a multicentric randomized controlled clinical trial. 238 subjects (teeth) requiring a primary or a secondary root canal treatment will be enrolled in 2 groups (119 in each group).
- Trial name
- NCT04935736
- Testing
- root canal sealer : CORTISOMOL SP, root canal sealer : SEALITE REGULAR
- Where
- 8 sites in France
- Volunteers
- 243 people
- Sponsor
- ACTEON Group
Rheumatoid Arthritis
Ultrasound Neuroimmune Modulation in Adults With Rheumatoid Arthritis
This two-stage, multicenter clinical trial is designed to evaluate the feasibility, safety, and preliminary efficacy of splenic ultrasound stimulation to activate immune-neuromodulation (SUSTAIN) in patients with rheumatoid…
- Trial name
- SUSTAIN (NCT07293871)
- Testing
- Active treatment
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Surf Therapeutics
Parkinson Disease
A Trial to Test the Use of Dapansutrile, an Anti-inflammatory Medication, in People With Parkinson's Disease
In Parkinson's disease (PD), there is inflammation in the brain, the gut and the blood, which is thought to contribute to the development and progression of the disease.
- Trial name
- DAPA-PD (NCT07157735)
- Testing
- dapansutrile
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Cancer
Study to Assess the Safety and Tolerability of MBF-118 in Healthy Volunteers
This is a single center, randomised, double blind, placebo controlled clinical study to assess the safety and tolerability of MBF-118 in healthy volunteers.This clinical phase I trial is divided in two stages and involves, first…
- Trial name
- NCT05921916
- Testing
- MBF-118 oral capsules
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medibiofarma S.L.
Acute Myocardial Infarction
Post-MI PET Scan Imaging of Inflammation
Restoring the patency of the coronary vessels and providing the ischemic myocardium with reperfused blood can cause additional tissue damage.
- Trial name
- NCT02281305
- Testing
- Colchicine
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- G.Gennimatas General Hospital
Analgesia and Anti-inflammatory of Osteoarthritis
A Trial of HRF2105 Patch in Relieving Pain of Osteoarthritis
The study is being conducted to evaluate the efficacy, and safety of HRF2105patch in relieving pain of Osteoarthritis.
- Trial name
- NCT06047483
- Testing
- HRF2105 patch, Loxoprofen patch
- Volunteers
- 90 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Generalized Chronic Periodontitis
Garcinia Mangostana L.Pericarp Gel as a Local Drug Delivery in Treatment of Chronic Periodontitis
A single-center, randomized controlled clinical trial was done to assess the periodontal status of the individuals and the presence of red complex microorganisms (RCM) such as Treponema denticola, Porphyromonas.gingivalis and…
- Trial name
- NCT02880397
- Testing
- Garcinia mangostana
- Volunteers
- 50 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Dry Eye Disease
Evaluation of Anti-Inflammatory Treatment in Dry Eye Patients
The purpose of this study was to determine if difluprednate ophthalmic emulsion is effective in reducing the ocular symptoms of dry eye disease, as measured by a global Visual Analog Scale (VAS) discomfort score.
- Trial name
- NCT01276223
- Testing
- Difluprednate 0.05% ophthalmic emulsion, Difluprednate vehicle
- Where
- United States
- Volunteers
- 722 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Renal Colic
Oral NSAI Versus Paracetamol or Placebo as a Second Line Treatment for Renal Colics
Outpatients treatment with NSAI in renal colics has not been well investigated and there is no clear recommendations regarding this matter.
- Trial name
- ONSAIP-RC (NCT02304783)
- Testing
- Piroxicam, paracetamol
- Where
- Tunisia
- Volunteers
- 1,400 people
- Sponsor
- University of Monastir
Postoperative Pain
The Effect of Anti-inflammatory Cryoagent on the Level of Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis.
The aim of this study is comparative between: 1. Intra-radicular cryotherapy using cold anti-inflammatory {ketorolac tromethamine at 2-5C}. 2.
- Trial name
- NCT06584188
- Testing
- anti-inflammatory ketorolac tromethamine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pneumonia
PET Imaging of Endotoxin-induced iNOS Activation
The overall purpose of this research is to gain understanding of the basic responses of the lung to inflammation. Inflammation is the way our bodies react to irritation or injury, and involves red, warm, and often painful…
- Trial name
- NCT01407796
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin), [18F](+/-)NOS
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Gastric Ulcers, Duodenal Ulcers
Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)
The purpose of this study is to evaluate the safety of TAK-438, once daily (QD), during long-term concomitant non-steroidal anti-inflammatory drug (NSAID) therapy in patients with a history of gastric or duodenal ulcer who…
- Trial name
- NCT01456260
- Testing
- TAK-438, Lansoprazole
- Where
- 97 sites in Japan
- Volunteers
- 406 people
- Sponsor
- Takeda
Type 2 Diabetes
An Investigation Into The Anti-hypertensive And Potential Anti-inflammatory Actions Of Dapagliflozin
This is a single center, prospective, randomized, placebo -controlled, parallel design and double blind study to evaluate oxidative stress, inflammation and hypertension markers and mediators before and after treatment with…
- Trial name
- NCT02433678
- Testing
- dapagliflozin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University at Buffalo
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