Clinical trials: Anti-inflammatory Agents
Frozen Shoulder, Adhesive Capsulitis
Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis
Patients aged 18-75 years who present to a tertiary rehabilitation hospital with shoulder pain and restricted range of motion, and who consent to participate, will be included in the study.
- Conditions
- Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain, NSAID (Non-Steroidal Anti-Inflammatory Drug)
- Trial name
- NCT07493226
- Testing
- Propionic acid deriaves, acetic acid derivatives, oxicam derivatives
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Major Depressive Disorder, Inflammatory Response
Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders
The goal of this clinical trial is to study how physical exercise works when applied to patients diagnosed with Major Depressive Disorder (MDD).
- Trial name
- CARE-MIND (NCT06450704)
- Testing
- Physical Exercise, Antidepressant medication (ADM)
- Where
- 5 sites in Spain
- Volunteers
- 124 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Psoriatic Arthritis
A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug
This is a Phase 3 multicenter study that included two periods. Period 1 was designed to compare the safety, tolerability, and efficacy of upadacitinib 15 mg once daily (QD) and 30 mg QD versus placebo in participants with…
- Trial name
- SELECT - PsA 2 (NCT03104374)
- Testing
- Upadacitinib
- Where
- 165 sites in United States, Australia and 17 more
- Volunteers
- 642 people
- Sponsor
- AbbVie
Asthma
Anti-Inflammatory Lipid Mediators in Asthma
The purpose of this study is to demonstrate the efficacy and safety of 10-nitro-9(E)-octadec-9-enoic acid (CXA-10) in obese adult asthmatics.
- Trial name
- ALMA (NCT03680976)
- Testing
- CXA-10
- Where
- United States
- Sponsor
- Sally E. Wenzel MD
Knee Osteoarthritis (OA)
The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis
Our purpose is to expand upon the results of the pilot study performed at David Grant Medical Center (DGMC) which showed that concomitant non-steroidal NSAID use in adults with knee osteoarthritis (OA) undergoing a three-shot…
- Trial name
- NCT06911359
- Testing
- Participants are given Ibuprofen 400 mg to take for 7 days on the day they receive a dextrose prolotherapy (DPT) injection. These procedures are repeated every 3-5 weeks for a total of 3 times.
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- David Grant U.S. Air Force Medical Center
Acute Gouty Arthritis
Canakinumab in the Treatment of Gouty Arthritis Flare(s) and Prevention of New Flares in Patients With Chronic Kidney Disease
The purpose of this study is to confirm the efficacy and safety results obtained in a chronic kidney disease (CKD) subgroup of patients participating in Phase III studies in a larger, independent patient population with difficult…
- Trial name
- NCT01593527
- Testing
- ACZ885, Triamcinelone acetonide
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis, Diet, Healthy
The Effect of a Plant-based Diet on the Active Rheumatoid Arthritis Activity.
The increase in autoimmune diseases in Western countries has been linked to environmental factors, and diet is considered a modifier of rheumatoid arthritis (RA).
- Conditions
- Rheumatoid Arthritis, Diet, Healthy, Inflammatory Response
- Trial name
- NCT05911880
- Testing
- Plant-based diet for 14 days in patients with rheumatoid arthritis.
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Periodontal Diseases, Periodontitis
The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.
Periodontal disease is an infectious pathology that consists of the destruction of the gums and supporting structures around the teeth. There are several mechanisms involved in this process.
- Trial name
- NCT04404335
- Testing
- Crevicular fluid analysis by using ELISA testing.
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Chronic Obstructive Pulmonary Disease
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of CHF6297 in Healthy Subjects and Patients With COPD
CHF6297 is a potent and selective inhibitor of human MAP kinase p38 being developed as an anti-inflammatory agent for the treatment of inflammatory airways diseases.
- Trial name
- CHF6297 FIH (NCT02815488)
- Testing
- CHF6297 (Part 1 - SAD), CHF6297 (Part 2 - MAD), CHF6297 (Part 3)
- Where
- 2 sites in United Kingdom
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Pain, Postoperative
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
Laparoscopic colorectal surgery (LCS) has gained wide acceptance in the treatment of various pathology from diverticular disease to colon cancer.
- Trial name
- NCT02086123
- Testing
- Epidural Analgesia, Parenteral Analgesia (Intravenous)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Irvine
Necrotic Teeth With Apical Periodontitis
Evaluation of the Aloe Vera Anti-inflammatory Effect on Apical Periodontitis.
The goal of this clinical trial is to evaluation aloe vera as intracanal medication anti-inflammatory also inter-appointment pain incidence compared with calcium hydroxide.
- Trial name
- NCT07826091
- Testing
- Aloe vera gel, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Ain Shams University
Alzheimer's Disease
Effects of an Anti-Inflammatory Drug in Alzheimer's Disease
The purpose of this study is to evaluate the effects of the drug cyclophosphamide (CY) on inflammation and immune responses in individuals with Alzheimer's Disease (AD).
- Trial name
- NCT00013650
- Testing
- Cyclophosphamate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
In-stent Restenosis
Anti-inflammatory Therapy for Recurrent In-stent Restenosis
This study is aimed at making a comparison of the safety and efficacy of standard drug therapy (control group), standard drugs combined with lose-dose colchicine therapy (colchicine group) and standard drug combined with…
- Trial name
- NCT06090890
- Testing
- Colchicine, Prednisone, Aspirin
- Where
- 4 sites in China
- Volunteers
- 252 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Alzheimer Disease
Insulin-Sensitizing Anti-Inflammatory Small Molecule for Investigative Treatment of Dementia
This study seeks to measure changes in cognition through verbal and visual test procedures and changes in biomarkers of Alzheimer's disease and inflammatory and metabolic parameters that can be measure in the central nervous…
- Trial name
- NCT05227820
- Testing
- NE3107
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Neurological Associates of West Los Angeles
Rheumatoid Arthritis
A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
The purpose of this study was to assess efficacy, including inhibition of radiographic progression, and safety with upadacitinib versus placebo and versus an active comparator, adalimumab, in adults with with moderately to…
- Trial name
- SELECT-COMPARE (NCT02629159)
- Testing
- Adalimumab, Upadacitinib
- Where
- 370 sites in United States, Argentina and 42 more
- Volunteers
- 1,629 people
- Sponsor
- AbbVie
Allergic Asthma
Optimization of Asthma Treatment Through Exhaled NO for Increased Asthma-Related Quality of Life (NOAK)
The purpose of this study is to determine whether use of exhaled NO (nitric oxide) to regulate the anti-inflammatory treatment leads to increased asthma-related quality of life in patients with allergic asthma
- Trial name
- NCT00421018
- Testing
- Single corticosteroid inhalers and Singulair
- Where
- Sweden
- Volunteers
- 187 people
- Sponsor
- Karolinska Institutet
Sleep Disordered Breathing
Inflammatory Response to Anti Inflammatory Therapy in Children With Sleep Disordered Breathing
This study will assess in a double blind placebo controlled fashion the effects of a 12 week course of oral montelukast/placebo on polysomnographic and radiological findings and will characterize the systemic (serum,urine) and…
- Trial name
- NCT00299910
- Testing
- Montelukast
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Soroka University Medical Center
Ulcerative Colitis, Crohn's Disease
Anti-inflammatory Effect of Agaricus Blazei Murill in Inflammatory Bowel Disease (IBD)
Examine whether daily oral ingestion of a immunomodulatory mushroom extract (AndoSanTM) in patients with ulcerative colitis (UC) and Crohn's disease (CD), experience clinical, biochemical and genetical improvement in their…
- Conditions
- Ulcerative Colitis, Crohn's Disease, Inflammatory Bowel Disease
- Trial name
- NCT01496053
- Testing
- AndoSan, Sugar Extract
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Psoriatic Arthritis, Rheumatoid Arthritis
Activating the Cholinergic Anti-Inflammatory Pathway in Healthy Volunteers and People With Inflammatory Arthritis
This study is designed to investigate whether non-invasive ultrasound (US) that is optimized for stimulation and can elicit an anti-inflammatory response in people with Inflammatory Arthritis as compared to a sham intervention.
- Conditions
- Psoriatic Arthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- NCT06555562
- Testing
- Ultrasound Stimulation, Non-active ultrasound stimulation
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Surf Therapeutics
Cystic Fibrosis
Effect of Losartan in Cystic Fibrosis (CF)-NIH Grant #133240
The goal of this study is to execute a small clinical proof of concept trial: To examine the effects of losartan on mucociliary clearance (MCC) in patients not eligible for CFTR rescue therapies
- Trial name
- NCT03435939
- Testing
- Losartan
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Kansas Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.