Clinical trials: Anti-inflammatory Agents
Memory Decline, Cognitive Decline
Anti-inflammatory Probiotics in Cognitive Functioning
The goal of this study is to explore the potential impact of an anti-inflammatory probiotic mixture of psychobiotics including Bifidobacterium longum Rosell®-175 and Lactobacillus helveticus Rosell®-52 on cognitive functions in…
- Conditions
- Memory Decline, Cognitive Decline, Cognitive Aging
- Trial name
- CoProM (NCT07165977)
- Where
- Poland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Rheumatoid Arthritis
Effects of Atorvastatin on Disease Activity and HDL Cholesterol Function in Patients With Rheumatoid Arthritis
This research evaluates the effects of a cholesterol-lowering medication, atorvastatin, on both arthritis activity and the ability of high-density lipoprotein cholesterol (HDL-C, sometimes referred to as "good cholesterol") to…
- Trial name
- NCT00356473
- Testing
- Atorvastatin
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Schizophrenia
Combination of NMDA-enhancing and Anti-inflammatory Treatments for Schizophrenia
Previous studies found that some NMDA-enhancing agents were able to improve clinical symptoms of patients with chronic schizophrenia.
- Trial name
- NCT04917302
- Testing
- NMDAE plus AIFA
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- China Medical University Hospital
Axial Spondyloarthritis
Continuing Versus Withdrawing Adalimumab in Maintaining Remission in Non-Radiographic Axial Spondyloarthritis
The objective of this multicenter, randomized, double-blind study was to evaluate the efficacy and safety of continuing versus withdrawing therapy with adalimumab 40 mg given every other week SC in maintaining remission in…
- Trial name
- NCT01808118
- Testing
- adalimumab
- Volunteers
- 673 people
- Sponsor
- AbbVie
Pituitary Adenoma, Surgery
Pain Management After Transnasal Transsphenoidal Surgery for Pituitary Adenomas
We hypothesize that the effects of non-steroidal anti-inflammatory drugs (NSAIDS) for pain relief among patients with pituitary adenomas undergoing transnasal transsphenoidal surgeries are non-inferior to tramadol.
- Conditions
- Pituitary Adenoma, Surgery, Pain
- Trial name
- NCT04611685
- Testing
- NSAID, Tramadol
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Peking Union Medical College Hospital
Osteoarthritis, Knee, Osteoarthritis, Hip
Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
The primary objective of the study is to evaluate the efficacy of fasinumab compared to placebo, when administered for up to 24 weeks in patients with pain due to osteoarthritis (OA) of the knee or hip.
- Trial name
- FACT OA2 (NCT03304379)
- Testing
- Fasinumab, Diclofenac, Celecoxib
- Where
- 71 sites in United States
- Volunteers
- 1,650 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis, Knee
Intra-articular Tenoxicam Versus Triamcinolone Acetonide in Knee Osteoarthritis Management
Knee osteoarthritis is a very common joint condition that leads to pain, stiffness, and difficulty with daily activities, particularly in middle-aged and older adults.
- Trial name
- NCT07194135
- Testing
- Tenoxicam, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Sepsis - to Reduce Mortality in the Intensive Care Unit
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis
Sepsis is a severe, life-threatening condition caused by an abnormal host response to infection, which includes systemic inflammation, oxidative stress, and increasing organ dysfunction.
- Trial name
- NCT07655791
- Testing
- Nicotinamide 1000 mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Solar Elastosis
Histologic Response to UVA and UVB Exposure During the Use of Sunscreen
Anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent…
- Trial name
- NCT01892150
- Testing
- Sunscreen
- Where
- Thailand
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Migraine
Safety and Efficacy of Eletriptan for the Treatment of Migraine in Subjects Unsuccessfully Treated With Nonsteroidal Anti-inflammatory Drugs
To assess the safety and efficacy of eletriptan for the treatment of migraine in subjects who had not been adequately treated with non-steroidal antiinflammatory drugs (NSAIDs)
- Trial name
- NCT00634985
- Testing
- eletriptan
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Myofascial Pain Syndrome of the Upper Trapezius
Comparison of NSAID Patch Given in Monotherapy and NSAID Patch in Combination With Transcutaneous Electric Nerve Stimulation, Heating Pad, or Topical Capsaicin in the Treatment of Patients With Myofascial Pain Syndrome of the Upper Trapezius: A Pilot Study
Myofascial pain syndrome (MPS) is a common clinical problem of musculoskeletal pain and various treatment modalities have been introduced.
- Trial name
- NCT01884116
- Testing
- NSAID patch, NSAID patch + transcutaneous electric nerve stimulation, NSAID patch + heating pad
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Hypertension, Abdominal Aortic Aneurysm
Study on Anti-inflammatory Effect of Anti-hypertensive Treatment in Patients With Small AAA's and Mild Hypertension
Inflammation of the blood vessel plays an important role in the development and growth of a dilated abdominal aorta. An elevated blood pressure leads to an increase in inflammation, therefore blood pressure lowering is an…
- Trial name
- PISA (NCT01425242)
- Testing
- Aliskiren, Amlodipine
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Amsterdam UMC, location VUmc
Rib Fractures, Pain, Acute
Blue Light as an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma
The main goal of this clinical trial is to learn if light therapy improves pain and inflammation in adults with painful rib fractures.
- Trial name
- BLAASTT (NCT06626334)
- Testing
- Bright Blue Light, Bright Full-Spectrum (White) Light, Usual Ambient Light
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rebecca E Kotcher, MD
Remitting-Relapsing Multiple Sclerosis
TMP001 in Relapsing-remitting Multiple Sclerosis
The purpose of this study is to assess the impact of TMP001 in the treatment of patients with relapsing-remitting multiple sclerosis (RRMS).
- Trial name
- NCT02686788
- Testing
- TMP001
- Where
- 5 sites in Germany
- Volunteers
- 9 people
- Sponsor
- Dr. Frank Behrens
Hypertension
Anti Inflammatory Treatment of Hypertension
To investigate the anti-inflammatory effect of amlodipine and levamlodipine in the treatment of hypertension
- Trial name
- NCT04740840
- Testing
- Levamlodipine, Amlodipine
- Volunteers
- 200 people
- Sponsor
- Affiliated Hospital of North Sichuan Medical College
Cystoid Macular Edema, Cataract
Anti-inflammatory Efficacy for Prophylaxis of Cystoid Macular Edema (CME) After Phacoemulsification
To compare the anti-inflammatory efficacy of ketorolac of tromethamine 0.4% and nepafenac 0.1% eye drops for prophylaxis of cystoid macular edema (CME) after small-incision cataract extraction.
- Trial name
- NCT02084576
- Testing
- Nepafenac, Ketorolac
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Oftalmologico de Brasilia
Anti-Inflammatory Agents, Non-Steroidal, Pain, Postoperative
Effect of Parecoxib on Postoperative Shoulder Pain After Gynecological Laparoscopy.
This prospective, double blind, placebo-controlled, parallel group study will be conducted in the first affiliated hospital of Sun yat-sen university in Guangzhou, China.
- Conditions
- Anti-Inflammatory Agents, Non-Steroidal, Pain, Postoperative, Laparoscopy
- Trial name
- NCT01393925
- Testing
- parecoxib
- Where
- China
- Volunteers
- 126 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Osteoarthritis
A Prospective Observational Study on Discontinuation of Medication of Shinbaro Capsule
This study investigates how gastrointestinal toxicity affects discontinuation of medication given to patients with osteoarthritis in routine clinical practice.
- Trial name
- NCT02064634
- Where
- South Korea
- Volunteers
- 6,700 people
- Sponsor
- Green Cross Corporation
Ureteral Stent Placement, Kidney Stone
NSAIDs Stent Study
This is a pilot study to (1) evaluate the effect of Ketorolac on inflammatory response and its impact on stent related symptoms in patients undergoing stent placement procedure and (2) assess feasibility of recruitment…
- Trial name
- NCT03638999
- Testing
- Ketorolac Trometamol 30Mg/1mL Injection, Normal saline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Washington University School of Medicine
HIV Infections, Cytomegalovirus
A Study to Evaluate the Anti-inflammatory Effects of Letermovir (Prevymis) in Adults With Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV) Who Are on Suppressive Antiretroviral Therapy, Plus Its Effect on Chronic Inflammation, HIV Persistence and Other Clinical Outcomes.
This was an open-label, controlled study, conducted at US sites to evaluate the anti-inflammatory effectiveness of the study drug letermovir in adults with HIV and asymptomatic cytomegalovirus (CMV) who were on antiretroviral…
- Conditions
- HIV Infections, Cytomegalovirus, CMV
- Trial name
- ELICIT (NCT04840199)
- Testing
- Letermovir Oral Tablet
- Where
- 15 sites in United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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