Clinical trials: Anti-inflammatory Agents
Keratitis, Herpetic
Observation on the Herpes Simplex Keratitis
As is reported, NSAIDs(pranoprofen ,bromfenac) eye drops can suppress herpes simplex virus（HSV-1） reactivation and reduce inflammatory reaction in vitro and in vivo.
- Trial name
- OHSV (NCT03013959)
- Testing
- Pranoprofen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College
Frail Elderly Syndrome, Malnutrition Elderly
Effect of a Combined Exercise and Anti-Inflammatory Nutritional Intervention in Frail Older Adults
The goal of this clinical trial is to evaluate whether a combined intervention of therapeutic exercise and anti-inflammatory nutritional supplementation improves physical performance and reduces systemic inflammation in frail…
- Trial name
- AliFrail (NCT07182292)
- Testing
- Anti-Inflammatory Supplement, Conventional Nutritional Supplement
- Volunteers
- 158 people
- Sponsor
- Fundacion Miguel Servet
Dry Eye Disease (DED)
Anti-inflammatory Effects and Clinical Efficacy of Topical Thealoz Total Eye Drops in Patients With Chronic Dry Eye Disease
The goal of this prospective, open, monocentric study is to evaluate the clinical efficacy of a new preservative-free combination of trehalose, sodium hyaluronate and NAAGA in 30 patients with chronic dry eye disease and…
- Trial name
- NCT07007702
- Testing
- T2769
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Laboratoires Thea
Oxidative Stress, Inflammation
Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols
The purpose of this study is to investigate the possible antioxidant and anti-inflammatory effects of yogurt enriched with polyphenols after 2-week consumption by healthy individuals.
- Trial name
- NCT02494739
- Testing
- Yogurt enriched with polyphenols, Yogurt not enriched with polyphenols
- Where
- Greece
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Thyroid Cancer, Hashimotos Thyroiditis
Hashimotos Thyroiditis and Thyroid Cancer
Thyroid cancer (TC) is the most common endocrine malignancy. The association between inflammation and cancer is well established but the association between thyroiditis (inflammation of thyroid gland) especially Hashimoto's…
- Trial name
- Thyroid Cancer (NCT01428167)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Rheumatoid Arthritis
Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Anti-TNFα Agents
The core and extension studies assessed the safety and efficacy of secukinumab when added to a background therapy in patients with active rheumatoid arthritis who are intolerant to or have had an inadequate response to anti-TNF-α…
- Trial name
- REASSURE (NCT01377012)
- Testing
- Secukinumab (AIN457)
- Where
- 142 sites in United States, Argentina and 14 more
- Volunteers
- 637 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes
Anti-inflammatory Effects of the Fiber
This study will help elucidate the mechanism underlying the cardioprotective and anti-diabetes effect of dietary fiber by exploring a comprehensive set of inflammatory and oxidative stress markers, based on a contemporary…
- Trial name
- NCT02868788
- Testing
- dietary fiber, HFHC meal
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University at Buffalo
Bacterial Infection
Exposure to NSAIDs (Non Steroidal Anti-Inflammatory Drugs) and Severity of Community-acquired Bacterial Infections
NSAIDs are widely consumed, and some are currently available for self-medication with indications 'Pain and Fever' (Cavalié, National Agency for Drug Safety (ANSM), 2014) There is no recommendation to limit their use in bacterial…
- Trial name
- ANAIG (NCT02794831)
- Where
- France
- Volunteers
- 335 people
- Sponsor
- Nantes University Hospital
NSAIDs-induced Small-intestinal Injuries
The Effect of Rebamipide for Non-steroidal Anti-inflammatory Drugs (NSAID) - Induced Small-intestinal Injuries
The purpose of this study is to evaluate the efficacy of rebamipide for NSAID-induced small-intestinal injuries.
- Trial name
- NCT00862628
- Testing
- Rebamipide
- Where
- 2 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Nagoya University
Rheumatoid Arthritis (RA)
L-carnitine Supplementation in Rheumatoid Arthritis Patients
This study aims to evaluate the effect of l-carnitine as add- on therapy for improving the outcome in rheumatoid arthritis patients.
- Trial name
- NCT06753565
- Testing
- Carnitine, Disease-modifying anti-rheumatic drugs
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- German University in Cairo
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
Aspirin for the Treatment of Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD), defined by fatty infiltration of the liver in the absence of excess alcohol consumption, affects an estimated 30% of adults in the United States.
- Trial name
- NCT04031729
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Acute Gout
Canakinumab in the Treatment of Acute Gout Flares and Prevention of New Flares in Patients Unable to Use Non-steroidal Anti-inflammatory Drugs (NSAIDs) and/or Colchicines Including a 12 Week Extension and a 1 Year Open-label Extension Study.
The purpose of this study was to demonstrate that canakinumab given upon acute gout flares relieves the signs and symptoms and prevents recurrence of gout flares in patients with frequent flares of gout for whom non-steroidal…
- Trial name
- β-RELIEVED-II (NCT01080131)
- Testing
- Canakinumab 150 mg, Triamcinolone acetonide 40 mg
- Where
- 108 sites in United States, Canada and 3 more
- Volunteers
- 226 people
- Sponsor
- Novartis Pharmaceuticals
Ischemic Stroke
Anti-inflammatory and Anti-thrombotic Therapy With colcHicine and Low Dose Rivaroxaban for Major Adverse Cardiovascular Events Reduction in Ischemic Stroke
The ARCHIMEDES study (Anti-inflammatory and anti-thRombotic therapy with colCHicine and low dose rIvaroxaban for Major adverse cardiovascular Events reDuction in ischEmic Stroke) will be a randomized, double-blind, 2x2 factorial…
- Trial name
- ARCHIMEDES (NCT06396858)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet, Colchicine 0.5 MG
- Volunteers
- 4,500 people
- Sponsor
- Brazilian Clinical Research Institute
Cyanotic Congenital Heart Disease, Pediatric HD
Propofol vs Sevoflurane in Cyanotic Congenital Heart Disease
The stress response to surgery compromises a series of humoral, metabolic, or cellular reactions. Cardiac surgery with use of cardiopulmonary bypass (CPB) is a major activator of the systemic inflammatory response (SIRS).
- Trial name
- PSI (NCT04125550)
- Testing
- Propofol, Sevoflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Cukurova University
Patients Undergoing Major Abdominal Surgery, Postoperative Confusion
Effect of Remifentanil on Postoperative Cognition Function in Patients Undergoing Major Abdominal Surgery
The purpose of this study is to investigate the effects of two different analgesic methods (Fentanyl vs Remifentanil) during major abdominal surgery on postoperative cognitive status of patients.
- Trial name
- NCT01627873
- Testing
- Remifentanil, Fentanyl
- Where
- Italy
- Volunteers
- 622 people
- Sponsor
- Catholic University of the Sacred Heart
Recurrent Aphthous Stomatitis
A Study on Sumac Mouth Rinse for Treating Recurrent Aphthous Stomatitis
This randomized controlled clinical study aims to evaluate the effectiveness of a Sumac mouth rinse in the management of recurrent aphthous stomatitis (RAS).
- Trial name
- SUMAC-RAS (NCT07229469)
- Testing
- Sumac mouth rinse, Tantum Verde mouth rinse
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Stress, Healthy
The Efficacy of Pasteurised Akkermansia Muciniphila in Healthy Medical Workers
Gut microbiota alterations secondary to chronic stress might serve as a triggering factor towards manifestation of somatic and mental symptoms. The administration of pasteurised A.
- Conditions
- Stress, Healthy, Dietary Supplement
- Trial name
- MENTAkHEALTH (NCT05738746)
- Testing
- Pasteurized Akkermansia muciniphila
- Where
- 2 sites in Poland
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Pre-Eclampsia, Pre-Term
Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes
Women who had an adverse pregnancy outcome (APO), such as preeclampsia, preterm birth, or gestational diabetes, have a higher risk for heart disease.
- Conditions
- Pre-Eclampsia, Pre-Term, Intrauterine Growth Restriction, Hypertension in Pregnancy
- Trial name
- VIA (NCT04633551)
- Testing
- Anti-inflammatory supplement
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Alzheimer Disease
A Multicenter Trial of Rofecoxib and Naproxen in Alzheimer's Disease (NSAID Study)
The primary specific aim of this clinical trial is to determine whether treatment with rofecoxib or naproxen for one year will slow the rate of decline of cognitive function in patients with Alzheimer's disease (AD) as measured…
- Trial name
- NCT00004845
- Testing
- Rofecoxib, Naproxen
- Where
- 40 sites in United States
- Sponsor
- National Institute on Aging (NIA)
Colchicine Adverse Reaction, Atrial Fibrillation New Onset
COlchicine in Cardiac Surgery
Postoperative atrial fibrillation (POAF) is a major complication of cardiac surgery, which could lead to high morbidity and mortality, increase duration of hospital stay and increase the cost of treatment.
- Trial name
- COCS (NCT04224545)
- Testing
- Colchicine Pill
- Where
- 2 sites in Russia
- Volunteers
- 267 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
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