Clinical trials: Anti-inflammatory Agents
Major Depressive Disorder, Depression
Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)
The objective of this clinical trial is to evaluate whether an anti-inflammatory medication, pentoxifylline, reduces depressive symptoms and improves artery function.
- Conditions
- Major Depressive Disorder, Depression, Depressive Symptoms, Cardiovascular Disease (CVD)
- Trial name
- INFLAMED (NCT01625845)
- Testing
- Pentoxifylline, Standard Treatment
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Overweight, Obesity
Pain and Acetaminophen in Women Study
The purpose of this study is to evaluate the influence of acetaminophen on pain response and inflammation.
- Conditions
- Overweight, Obesity, Healthy Adults
- Trial name
- PAWS (NCT04573426)
- Testing
- Acetaminophen, Weight stigma vignette, Control vignette
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Nummular Eczema
Study of Dupilumab to Demonstrate Efficacy in Subjects With Nummular Eczema
Nummular eczema (NE) is an idiopathic chronic inflammatory skin disease that occurs throughout all life periods. Diagnosis is made primarily clinically in correlation with histological findings. Treatment of NE is difficult.
- Trial name
- DUPINUM (NCT04600362)
- Testing
- Experimental: Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Technical University of Munich
Keratoconus
Supplementation With a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients With Keratoconus
The goal of this randomized controlled preliminary study is to assess the effect of daily supplementation with a nutraceutical formulation of a highly-concentrated DHA triglyceride plus minerals on ophthalmological parameters and…
- Trial name
- NCT05756062
- Testing
- Highly-concentrated DHA triglyceride (Tridocosahexanoin-AOX 70%)
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Adverse Events
Strategies for Improving Proton Pump Inhibitors (PPIs) Prescription Associated to Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Background Despite the low prevalence of serious complications associated with non-steroidal anti-inflammatory drugs (NSAIDs) use, there is a widespread use of gastroprotective proton pump inhibitors (PPIs) in order to prevent…
- Trial name
- NCT01128127
- Testing
- Group education, audit-feedback and computer support, Audit-feedback and computer support, Control
- Where
- Spain
- Sponsor
- Servicio Canario de Salud
Pericarditis Acute
Dexamethasone Compared to Non-steroidal Anti-inflammatory Drugs in the Treatment of Acute Pericarditis
The treatment of acute pericarditis is empiric and is based on treatment with medications with anti-inflammatory properties such as non-steroidal anti-inflammatory drugs (NSAID) and corticosteroids.
- Trial name
- Dexa-P (NCT04323280)
- Testing
- Dexamethasone therapy, NSAID therapy
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Cachexia, CKD
A Multimodal Integrated Intervention for Kidney Cachexia
This lay description has been written in conjunction with, and the content approved by our Patient and Public Involvement collaborators.
- Trial name
- MMIEAD (NCT07107087)
- Testing
- Multi-Modal Integrated Intervention Combining Exercise, Anti-inflammatory & Dietary Advice (MMIEAD)
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen's University, Belfast
Impacted Wisdom Teeth
Efficacy Study of IV Ibuprofen vs IV Acetaminophen Post Surgical Extraction
This study will compare how effective a single dose of an intravenous (IV) ibuprofen is when compared to single dose of IV acetaminophen in reducing pain.
- Trial name
- Caldolor (NCT02133326)
- Testing
- Caldolor, Ofirmev
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Tufts University School of Dental Medicine
Acute Post-operative Pain
Ibuprofen Use on Post-operative Pain Following Cholecystectomy
In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.
- Trial name
- NCT06478758
- Testing
- Ibuprofen 400 mg, Acetaminophen 100 MG/ML
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Giresun University
Non-Alcoholic Fatty Liver Disease, Gallstone Disease
Prevention of NAFLD and CVD Through Lifestyle Intervention
Prevention of non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) through lifestyle intervention (MAUCO+) is a clinical trial that aims to improve sarcopenia, aerobic capacity, body composition, and lipid…
- Trial name
- MAUCO+ (NCT05618626)
- Testing
- Physical exercise and dietary intervention for NAFLD
- Where
- Chile
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Oral-facial Pain
Impact of Palmitoylethanolamide (PEA) in the Management of Oro-facial Pain
Pain is the most common symptom faced by dentists, whether acute (pulpitis, acute periodontitis, post-surgical, etc.) or chronic (chronic periodontitis, muscle pain, TMJ disorders, BMS, OLP, etc.).
- Trial name
- NCT05877170
- Testing
- Palmitoyletinolamide
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Catania
CAD - Coronary Artery Disease, Inflamation
Effect of Empagliflozin on Inflammation
Empagliflozin is a drug given to lower glucose. It is used in the treatment of diabetes. However, it was shown to improve symptoms and survival of patients who are suffering from heart failure.
- Conditions
- CAD - Coronary Artery Disease, Inflamation, PCI, SGLT 2 Inhibitors
- Trial name
- EMPANTINFLAM (NCT07292909)
- Testing
- Empagliflozin (SGLT2i)
- Where
- Lebanon
- Volunteers
- 100 people
- Sponsor
- Hotel Dieu de France Hospital
Arthritis Knee, Cryotherapy Effect
Anti Inflammatory Effects of Local Cryotherapy in Knee Arthritis
47 patients with non-septic knee arthritis were treated by local ice (30 min) or cold CO2 (2 min) twice at an 8 hour-interval for 1 day. The synovial fluid was collected just before the first cold application then 24 hours later.
- Trial name
- ALGGAR (NCT03850392)
- Testing
- cryotherapy (Thermogel - Artsana or Cryo+ - Cryonic)
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Glaucoma, Closed-Angle, Glaucoma, Narrow-Angle
Efficacy and Necessity of Anti-inflammatory Drops After Laser Peripheral Iridotomy
The purpose of this study is to evaluate the efficacy and need for prescribing anti-inflammatory topical drops to patients undergoing laser peripheral iridotomy.
- Conditions
- Glaucoma, Closed-Angle, Glaucoma, Narrow-Angle, Glaucoma, Angle-Closure
- Trial name
- NCT02955641
- Testing
- Dexamethasone Disodium Phosphate 0.1%, Nepafenac 0.1%, Hydroxyethylcellulose 0.19%
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Thyroid Diseases, Hypothyroidism
The Effects of an Anti-inflammatory Diet With or Without Curcumin Supplementation on Anthropometric Measurements, Concentrations of Thyroid Hormones, Anti-TPO, and Systemic Inflammation in Plasma and NFK-B in Peripheral Blood Mononuclear Cells in Patients With Hashimato
The goal of this clinical trial is to investigate The effects of an anti-inflammatory diet with or without curcumin supplementation on anthropometric measurements, concentrations of thyroid hormones, anti-TPO, and systemic…
- Conditions
- Thyroid Diseases, Hypothyroidism, Hashimoto Disease
- Trial name
- NCT05975866
- Testing
- curcumin, Anti-inflammatory diet
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- National Nutrition and Food Technology Institute
Ulcerative Colitis
An Investigation of Oral BT051 in Subjects With Moderately to Severely Active Ulcerative Colitis (UC)
This is a randomised, double-blind, placebo-controlled study to assess the safety and tolerability of multiple ascending doses of BT051 in subjects with moderately to severely active ulcerative colitis.
- Trial name
- SCOUT (NCT05084261)
- Testing
- BT051 200 mg, BT051 800 mg, BT051 3200 mg
- Where
- 6 sites in United States, Georgia and 2 more
- Volunteers
- 24 people
- Sponsor
- Adiso Therapeutics
COPD
Anti-inflammatory Effects of Tiotropium in Patients with Stable COPD
This study aims to assess the anti-inflammatory effects after 6 weeks treatment with tiotropium compared to placebo in patients with stable COPD
- Trial name
- ANTIOFLAM (NCT04061161)
- Testing
- Tiotropium Bromide
- Where
- 2 sites in Netherlands
- Volunteers
- 37 people
- Sponsor
- University Medical Center Groningen
Osteo Arthritis Knee, Arthritis
Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis
The purpose of this study is to measure the effectiveness of Sustained Acoustic Medicine (SAM) treatment combined with diclofenac ultrasound coupling gel in patients with stage II and stage III knee osteoarthritis.
- Trial name
- SAM (NCT04391842)
- Testing
- Sustained Acoustic Device with 1% Diclofenac patch
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Tranexamic Acid, Fibrinolysis
Anti-fibrinolytic and Anti-inflammatory Effects of Local Infiltration of Tranexamic Acid in Patients With Calcaneal Fractures
Background. Consensus is lacking regarding the use of tranexamic acid (TXA) in calcaneal fracture surgery. This study aims to investigate the hypothesis that local infiltration of TXA in the post-operation would maintain…
- Conditions
- Tranexamic Acid, Fibrinolysis, Inflammatory, Fracture
- Trial name
- NCT05598086
- Testing
- Tranexamic acid
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Hebei Medical University Third Hospital
Clinical Trial
Supplementation Performance And Exercise With Euterpe Edulis for Men's Enhancement
The study aims to evaluate the effect of supplementation with Euterpe edulis on the physical and mental performance, inflammation, muscle recovery, and muscle strength of healthy men submitted to physical exercises.
- Trial name
- SPAEME (NCT06254170)
- Testing
- Euterpe Edulis juice
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Vila Velha
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.