Clinical trials: Anti-inflammatory Agents
Asthma
Change of Airway Hyperresponsiveness to Mannitol and Methacholine in Patients With Asthma
Control of airway inflammation is the cornerstone of asthma management. The aim of the present pilot study was to assess whether, and in which magnitude, a leukotriene receptor antagonist (LTRA) added to a basic treatment of…
- Trial name
- NCT01725360
- Testing
- montelukast
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- Cantonal Hospital, Baselland
Acute Kidney Injury
AKI in Thoracic and Abdominal Surgery
The study will investigate the role of NSAIDs in the development of AKI in patients undergoing high-risk abdominal or thoracic surgery.
- Trial name
- NCT02553174
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Milton S. Hershey Medical Center
Oral Health Promotion and Anti-inflammatory Effects of Fermented Lingonberry Juice Gel.
The aim of this clinical study is to investigate whether FLJ gel has effects on oral health, such as reducing BOP or plaque, and whether it affects the reduction of aMMP-8.
- Trial name
- NCT07737574
- Testing
- Fermented lingonberry juice gel
- Sponsor
- Hanna Lahteenmaki
Gastrointestinal Hemorrhage, Stomach Ulcer
Pharmacogenetics of Gastrointestinal Bleeding
Gastrointestinal bleeding is a severe adverse effect occurring in subjects secondary to the use of nonsteroidal anti-inflammatory drugs (NSAIDs). The enzyme CYP2C9 is responsible for the elimination of several NSAIDs.
- Conditions
- Gastrointestinal Hemorrhage, Stomach Ulcer, Non-steroidal Anti-inflammatory Drug Sensitivity
- Trial name
- NCT00190255
- Testing
- CY2PC9 genotyping
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psoriasis, Systemic Inflammation
Anti-Inflammatory Effects of Time-Restricted Feeding
Background: Time-restricted feeding (TRF) means that a person eats only during certain hours of the day. In other studies, researchers have found that fasting can improve immune system function in healthy people.
- Trial name
- NCT04728165
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Decompensated Heart Failure, Cytokine Storm
Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart Failure
Assess the anti-inflammatory effects of short-term Copaxone therapy on patients with acute decompensated heart failure. Trial Design An open-label, randomized, prospective trial of patients hospitalized due to acute…
- Conditions
- Acute Decompensated Heart Failure, Cytokine Storm, Inflammatory Response, Heart Failure
- Trial name
- Copaxone (NCT06003972)
- Testing
- Copaxone, guideline directed medical therapy (GDMT)
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- Hadassah Medical Organization
Rheumatic Arthritis
Capability of Tofacitinib or Etanercept to Accelerate Tapering of NSAID and Treat-to-target Guided De-escalation of Corticosteroids in RA Patients
Patients with active rheumatic arthritis (RA) and lack of efficacy of at least one csDMARD (Disease-modifying anti-rheumatic drug) treatment will be randomized to receive either Tofacitinib (TOFA) or etanercept (ETA).
- Trial name
- AcceleRAte (NCT04485325)
- Testing
- Tofacitinib, Etanercept
- Where
- 6 sites in Germany
- Volunteers
- 92 people
- Sponsor
- Dr. Frank Behrens
Autism Spectrum Disorder, Autism
GAIP ASD Research Study
This clinical research study evaluates the safety and preliminary effects of AdiaVita (umbilical cord blood-derived stem cells and exosomes) combined with glutathione versus glutathione alone in people aged 3 and older with…
- Conditions
- Autism Spectrum Disorder, Autism, ASD, Autism Spectrum Disorder (ASD)
- Trial name
- NCT07622316
- Testing
- Umbilical Cord Blood-Derived Stem Cells and Exosomes, Glutathione
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Greater Atlanta Integrative Pediatrics
Lupus Erythematosus, Systemic, Musculoskeletal Pain
Using the Cholinergic Anti-Inflammatory Pathway to Treat Systemic Lupus Musculoskeletal Pain
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune, inflammatory disease and musculoskeletal pain is one of the most common symptoms.
- Trial name
- NCT02822989
- Testing
- Vagus nerve stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwell Health
Gastric Ulcers, Duodenal Ulcers
Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)
The purpose of this study is to evaluate the efficacy of TAK-438, once daily (QD), compared to AG-1749 (Lansoprazole) in patients with a history of gastric or duodenal ulcer who require long-term therapy of non-steroidal…
- Trial name
- NCT01452750
- Testing
- TAK-438, Lansoprazole
- Where
- 102 sites in Japan
- Volunteers
- 642 people
- Sponsor
- Takeda
Pneumonia, Viral
Low Dose Anti-inflammatory Radiotherapy for the Treatment of Pneumonia by COVID-19
Low radiation doses produce anti-inflammatory effects, which may be useful in the treatment of respiratory complications of COVID-19.
- Trial name
- NCT04380818
- Testing
- Low-dose radiotherapy, Hydroxychloroquine Sulfate, Ritonavir/lopinavir
- Where
- 3 sites in Spain
- Volunteers
- 106 people
- Sponsor
- Grupo de Investigación Clínica en Oncología Radioterapia
COVID-19
Anti-inflammatory Drug Algorithm for COVID-19 Home Treatment
The newly recognised disease COVID-19 is caused by the Severe-AcuteRespiratory-Syndrome Coronavirus 2 (SARS-CoV-2), which rapidly spread globally in late 2019, reaching pandemic proportions.
- Trial name
- COVER3 (NCT05249790)
- Testing
- Recommended treatment schedule, Usual care
- Sponsor
- Mario Negri Institute for Pharmacological Research
Ovulation, Ovulation Inhibition
Can Ibuprofen Delay Ovulation in Natural Cycle-IVF?
During natural cycle in vitro fertilisation, no gonadotropin stimulation is used to stimulate oocyte production. Ovulation is induced with HCG (human chorionic gonadotropin) and the follicle is retrieved 36 hours later.
- Conditions
- Ovulation, Ovulation Inhibition, Ovulation Inhibition/Drug Effects, Pregnancy
- Trial name
- Ibudelay (NCT02571543)
- Testing
- Ibuprofen
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Dysphagia, Dysphonia
The Effect of IV NSAID's and Corticosteroids on Dysphasia and Dysphonia Following ASDF
This study is to assess the efficacy of intra-operative intravenous non-steroidal anti-inflammatory drug (Ketorolac) versus intravenous (dexamethasone) administration on dysphagia and dysphonia after anterior cervical discectomy…
- Trial name
- NCT04650893
- Testing
- Intravenous Ketorolac, Intravenous Dexamethasone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Rheumatoid Arthritis
A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)
The study objective of Period 1 of this study is to compare the safety and efficacy (signs and symptoms) of upadacitinib 30 mg once daily (QD) alone and upadacitinib 15 mg QD alone versus continuing MTX alone adults with…
- Trial name
- NCT02706951
- Testing
- Methotrexate, Upadacitinib
- Where
- 153 sites in United States, Argentina and 23 more
- Volunteers
- 648 people
- Sponsor
- AbbVie
Gingivitis, Dental Plaque
Antiplaque, Antigingivitis and Anti-inflammatory Effects of Myrrh Mouthwash
Myrrh-based mouthwash has the potential to be a suitable alternative to the gold standard chlorhexidine mouthwash for dental plaque and gingivitis reduction.
- Trial name
- NCT04723732
- Testing
- Myrrh mouthwash, Chlorhexidine mouthwash, Normal saline
- Where
- Saudi Arabia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Healthy Volunteers
Bioavailability of Xanthones From Mangosteen
Mangosteen is a tropical tree. The peel of mangosteen fruit is used in traditional medicine. The purpose of this study was to determine the bioavailability of the xanthones from mangosteen juice in adult human subjects.
- Trial name
- NCT01425047
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mark Failla
Non-Cystic Fibrosis Bronchiectasis
Effect of Long-term, High-dose N-acetylcysteine on Exacerbations of Bronchiectaisis
Objective: To evaluate whether long-term oral N-acetylcysteine as an expectorant drug can reduce the frequency of acute exacerbations of patients with non-cystic fibrosis bronchiectasis and improve their quality of life.
- Trial name
- BENE (NCT02088216)
- Testing
- N-acetylcysteine, On-demand treatment
- Where
- China
- Volunteers
- 161 people
- Sponsor
- Qilu Hospital of Shandong University
Warfarin and NSAID
Warfarin and Non-Steroidal Anti-Inflammatory Drugs (NSAID) Customized Alert
The hypothesis is that a newly formatted electronic alert that requires the prescriber to pause and enter a specific "reason for override" on this alert, will cause prescribers in the intervention group to be significantly less…
- Trial name
- NCT00880932
- Testing
- Electronic Alert
- Where
- United States
- Volunteers
- 1,865 people
- Sponsor
- University of Pennsylvania
Coronavirus, Severe Acute Respiratory Syndrome
Anti-Coronavirus Therapies to Prevent Progression of Coronavirus Disease 2019 (COVID-19) Trial
ACT is a randomized clinical trial to assess therapies to reduce the clinical progression of COVID-19.
- Trial name
- ACTCOVID19 (NCT04324463)
- Testing
- Colchicine, Interferon-Beta, Aspirin
- Where
- 66 sites in Brazil, Canada and 10 more
- Volunteers
- 6,667 people
- Sponsor
- Population Health Research Institute
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