Clinical trials: Anti-inflammatory Agents
Acne Vulgaris
Phase II Trial of RA-18C3 in Subjects With Moderate to Severe Acne Vulgaris
This is a 91-day phase II, open label trial of the true human monoclonal antibody RA-18C3 in subjects with moderate to severe acne vulgaris. Ten (10) subjects will receive RA-18C3 via subcutaneous injection.
- Trial name
- NCT01474798
- Testing
- RA-18C3
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Janssen Research & Development, LLC
Skin and Connective Tissue Diseases, Skin Diseases
Pilot Study Assessing the Effect of Tildrakizumab in Vitiligo
Vitiligo is a common acquired depigmentation disorder affecting approximately 2% of the world population. The purpose of this pilot study is to evaluate the effect and the safety of Tildrakizumab in adult participants with…
- Conditions
- Skin and Connective Tissue Diseases, Skin Diseases, Pigmentation Disorder, Hypopigmentation
- Trial name
- TILDVIT-1227 (NCT04971200)
- Testing
- Tildrakizumab
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- Premier Specialists, Australia
Axial Spondyloarthritis
Effects of Nonsteroidal Anti-Inflammatory Drugs in Recurrence of Spondyloarthritis Patients After Remission
The multicenter, randomized controlled trial is to investigate and evaluate the effect of NSAIDs therapy on recurrence in patients with axial spondyloarthritis;
- Trial name
- NCT03425812
- Testing
- To withdraw NSAIDs therapy, To continue NSAIDs therapy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
Anti-Inflammatory Effects of Pioglitazone
There is increasing evidence that inflammation plays a role in progression and destabilization of atherosclerotic plaque. FDG-PET can visualize activated metabolic activity of inflammatory cells.
- Conditions
- Impaired Glucose Tolerance, Type 2 Diabetes Mellitus, Atherosclerosis
- Trial name
- NCT00722631
- Testing
- Pioglitazone, Glimepiride
- Where
- Japan
- Volunteers
- 70 people
- Sponsor
- Kurume University
Chronic Kidney Diseases
Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine
This study is designed to determine the efficacy and safety of colchicine in patients with chronic kidney disease.
- Trial name
- NCT04500665
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Oxidative Stress
EValuation of the Antioxidant and Anti-inflammatory Capacity of Nutraceutical IMMU·SYSTEM Food Supplement (EVAANIS)
The aim of the study is to verify the effectiveness of Nutraceutical IMMU·SYSTEM Dietary supplement in reducing the levels of oxidative stress and inflammation in a sample of healthy adult subjects with high baseline levels of…
- Trial name
- EVAANIS (NCT04912947)
- Testing
- Immusystem
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Complife Italia Srl
HIV Infections
The Anti-HIV Effects of Saquinavir Soft Gelatin Capsules Versus Indinavir in Patients Who Have Used Saquinavir Hard Gelatin Capsules for One Year
To determine, in HIV-infected patients, whether switching to a new soft gelatin capsule formulation of saquinavir or to indinavir following prolonged use of the original hard capsule formulation of saquinavir results in an acute…
- Trial name
- NCT00000848
- Testing
- Indinavir sulfate, Saquinavir
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Covid19, Pneumonia
Comparative Therapeutic Efficacy and Safety of Different Antiviral and Anti Inflammatory Drugs in COVID-19 Patients.
Comparison outcomes of a large cohort of moderate and severe COVID-19 patients received different Antiviral and Anti Inflammatory Drugs.
- Trial name
- NCT04779047
- Testing
- Remdesivir, Hydroxychloroquine, Tocilizumab
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- October 6 University
Alzheimer Disease
Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
The purpose of this trial is to test the ability of the non-steroidal anti-inflammatory medications naproxen and celecoxib to delay or prevent the onset of AD and age-related cognitive decline.
- Trial name
- NCT00007189
- Testing
- Naproxen Sodium (Aleve), Celecoxib (Celebrex)
- Where
- 6 sites in United States
- Volunteers
- 2,625 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Osteoarthritis
Efficacy and Safety of S (+) - Ibuprofen in Osteoarthritis Pain
The purpose of this study is to evaluate the efficacy of S (+) - ibuprofen compared to an active treatment for pain control in individuals diagnosed with osteoarthritis.
- Trial name
- APS003/2020 (NCT04637529)
- Testing
- S (+) - Ibuprofen, Ibuvix® - ibuprofen
- Where
- Brazil
- Volunteers
- 176 people
- Sponsor
- Apsen Farmaceutica S.A.
Papulopustular Rosacea
Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea
Subjects with moderate papulopustular rosacea will be treated either with azelaic acid 15% gel topically plus an anti-inflammatory dose of doxycyline (40mg) daily or with metronidazole 1% gel topically once daily plus an…
- Trial name
- NCT00855595
- Testing
- Azelaic acid (Finacea, BAY39-6251), Metronidazole (Metrogel), Doxycycline (Oracea)
- Where
- 17 sites in United States
- Volunteers
- 207 people
- Sponsor
- LEO Pharma
Pain Management, Anti-Inflammatory Agents, Non-Steroidal
Effectiveness of Anti-Inflammatory Drugs for Preventing Pain Versus Treating Pain During Medical Abortion From 13 to 22 Weeks at Hung Vuong Hospital
The goal of this clinical trial is to assess the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) for prophylactic pain relief compared to on-demand pain relief during medical abortion for pregnancies between 13…
- Conditions
- Pain Management, Anti-Inflammatory Agents, Non-Steroidal, Abortion, Spontaneous
- Trial name
- NCT06696573
- Testing
- Prophylactic NSAID Administration, On-Demand NSAID Administration
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Le Thi Kieu Trang
Obesity, Overweight
Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals
This study evaluates the impact of increased intake of fruits and vegetables and whole grains on markers of inflammation and gut microbial composition.
- Trial name
- NCT02602496
- Testing
- Fruits and Vegetables, Whole Grain, Control
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Submental Fat
Evaluation the Effects of Various Treatments on RZL-012-Induced Adverse Events
This is a Phase 2, open-label, 2-stage, adaptive-design study in which subjects will be randomized into one of 5 treatment groups comprised of RZL-012 with or without additional study treatments:
- Trial name
- NCT05476679
- Testing
- RZL-012, RZL-012+Lidacaine injection prior treatment, RZL-012+Medrol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Raziel Therapeutics Ltd.
Allergic Conjunctivitis
Manuka Eye Droops for Treatment of Allergy
Manuka honey eye drops are used for dry eyes and blepharitis. Manuka honey has been proven to be useful for eczema, atopic dermatitis, wound healing, anti-bacterial, anti-parasitic and anti-inflammatory actions.
- Trial name
- NCT03862053
- Testing
- Manuka honey
- Where
- 2 sites in United States
- Sponsor
- Toyos Clinic
Hypertension
Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members of these drug classes differ in their propensity to such an interaction.
- Trial name
- NCT00631514
- Testing
- acetaminophen, ibuprofen, piroxicam
- Where
- Croatia
- Volunteers
- 88 people
- Sponsor
- University of Split
Cirrhosis, Ascites
Lipopolysaccharide Binding Protein and Development of Infectious Events in Cirrhotic Patients
The purpose of this study is to determine whether plasma levels of lipopolysaccharide binding protein (LBP) are correlated with PBMN pro- and anti-inflammatory cytokine secretion, as well as with the development of severe…
- Conditions
- Cirrhosis, Ascites, Infections
- Trial name
- NCT00760032
- Testing
- Ciprofloxacin
- Where
- Mexico
- Sponsor
- Florencia Vargas-Vorackova
Breast Cancer
Anti-Inflammatory Diet in BRC Patients on Aromatase Inhibitors
This project aims to decrease undesirable side effects and increase qulaity of life of aromatase inhibitors therapy in breast cancer survivors, by anti-inflammatory diet or supplementation.
- Trial name
- AID (NCT06214598)
- Testing
- Supplement, AI diet
- Where
- 2 sites in Serbia
- Volunteers
- 90 people
- Sponsor
- University of Belgrade
Multiple Myeloma
Study of Vorinostat (MK-0683) or Placebo, in Combination With Bortezomib in Participants With Multiple Myeloma (MK-0683-088 AMN)
Study of the efficacy and safety of bortezomib administered in combination with vorinostat in patients with relapsed or refractory multiple myeloma.
- Trial name
- NCT00773747
- Testing
- Vorinostat, bortezomib
- Volunteers
- 637 people
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
The Absorption and Metabolism of Seaweed Polyphenols in Humans
Brown seaweeds are a rich source of phlorotannins, a characteristic class of polyphenols which are unique to seaweeds of this type and can comprise 5 to 15 % of the dried weight.
- Trial name
- SWAFAX (NCT02496806)
- Testing
- Seaweed extract
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Reading
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