Clinical trials: Anti-inflammatory Agents
Influenza, Lower Respiratory Tract Infection
Anti-inflammatory Effects of Macrolide Treatment in Influenza Lower Respiratory Tract Infections
Influenza lower respiratory tract infection (LRTI) is a major cause of morbidity and mortality worldwide. While viral replication can be suppressed by antiviral treatment, excessive inflammatory responses, which are increasingly…
- Trial name
- NCT01779570
- Testing
- Macrolide treatment
- Where
- 2 sites in Hong Kong
- Volunteers
- 68 people
- Sponsor
- Chinese University of Hong Kong
Chronic Obstructive Pulmonary Disease
Low-dose Theophylline as Anti-inflammatory Enhancer in Severe Chronic Obstructive Pulmonary Disease
The main objective of the study is to determine the effects of low-dose oral theophylline added to combination treatment with long-acting β-agonist (LABA) and inhaled corticosteroid (ICS) in patients with severe Chronic…
- Trial name
- ASSET (NCT01599871)
- Testing
- theophylline
- Where
- 10 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Son Espases
Chronic Obstructive Pulmonary Disease
A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD
The purpose of this study is to evaluate the dose-response relationship of different doses of CHF6001 and to identify the optimal dose (s) in terms of benefit/risk ratio for further development in the target patient population.
- Trial name
- PIONEER (NCT02986321)
- Testing
- CHF6001, Budesonide
- Volunteers
- 1,130 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Inflammatory Bowel Diseases
Anti Tumor Necrosis Factor Alpha Agents and Surgical Stress Response
Background: The immunologic response to stress is regulated by the cytokines. Anti-Tumor Necrosis Factor-α agents are antibodies directed against a key cytokine in the process angiogenesis and collagen synthesis.
- Trial name
- NCT01974869
- Testing
- Anti-tumor necrosis factor alpha agents
- Where
- 4 sites in Denmark
- Volunteers
- 47 people
- Sponsor
- El-Hussuna, Alaa, M.D.
Dermatitis, Atopic
Non-steroid, Atopic Dermatitis Phase IIb 12-week Trial; Topical WBI-1001 Cream
Welichem Biotech has developed a small molecule drug candidate, WBI-1001, that selectively targets the pathogenic features of inflammatory skin diseases, including atopic dermatitis (a form of eczema).The purpose of this clinical…
- Trial name
- NCT01098734
- Testing
- WBI-1001
- Where
- 5 sites in Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Welichem Biotech Inc.
Crohn's Disease, Ulcerative Colitis
Medico-economic Evaluation of the Therapeutic Drug Monitoring of Anti-TNF-α Agents in Inflammatory Bowel Diseases
Since their appearance more than a decade ago, anti-tumor necrosis factor (TNF) inhibitors have demonstrated beneficial activity in the treatment of inflammatory bowel diseases (IBD).
- Trial name
- ATAIM (NCT02508012)
- Testing
- Immuno monitoring
- Where
- France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Montpellier
ACS - Acute Coronary Syndrome
Multi-omics Characterization and Model Construction of Colchicine Anti-inflammatory Therapy Efficacy in ACS Patients
The aim of this prospective cohort study was to investigate the multi-omics characteristics of the efficacy of colchicine treatment in patients with ACS and to construct a model of efficacy.
- Trial name
- MCM-CATE-ACS (NCT07064109)
- Testing
- Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Atherosclerosis
Monocyte Activation in Preclinical Atherosclerosis
The study of proinflammatory and anti-inflammatory cytokines and chemokines expression profiles in human monocytes to identify new effective biomarkers that have the best diagnostic potential in asymptomatic atherosclerosis.
- Trial name
- MAPA (NCT02126280)
- Testing
- In vitro estimation of individual reactivity of monocytes
- Where
- Russia
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Institute for Atherosclerosis Research, Russia
Spinal Cord Injury, Depression
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Inflammation and Depression Following SCI
Spinal cord injury (SCI) has been shown to be associated with impairment to the autonomic nervous system in the form of reduced activity of a key nerve known as the vagus nerve.
- Trial name
- NCT06493071
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Ulcerative Colitis
Tailored Anti-Inflammatory (A-I) Diet for Americans With Ulcerative Colitis (UC)
The purpose of this study is to test the effect of an anti-inflammatory diet that incorporates native foods of the American diet on disease remission in American patients with Ulcerative Colitis (UC) and to identify biomarkers of…
- Trial name
- NCT06784323
- Testing
- Catered diet, Diet guidance sessions, Dietary counseling
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of Miami
Peptic Ulcer
Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers
The aim of this study is to study the natural history of the ulcer healing while on proton pump inhibitors (PPI) and the ulcer recurrence without acid suppression therapy of Non-steroidal Anti-inflammatory Drugs (NSAID)…
- Trial name
- NCT00153712
- Where
- China
- Volunteers
- 391 people
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Disease
Casein Glycomacropeptide in Healthy Subjects
Casein glycomacropeptide (CGMP) has anti-inflammatory properties in experimental rodent colitis and using human in vitro inflammation models. Its use as a food ingredient has proven safe and with no influence on dietary intake.
- Trial name
- NCT02832700
- Testing
- Casein glycomacropeptide
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Severe Obesity
Pigeon Peas (Cajanus Cajan) : a Natural Anti-inflammatory Facilitating Weight Loss in Obese Patients Returning to Sport?
Adult obesity is due to an excess of body fat. This corresponds to all the fat in the body (or adipose tissue). It is opposed to the lean mass which corresponds to the weight of muscles, organs and viscera.
- Trial name
- OBESICA (NCT05493592)
- Testing
- Standardized physical activity protocol associated with the consumption of Cajanus cajan (EXACAJAN)
- Where
- Martinique
- Volunteers
- 124 people
- Sponsor
- University Hospital Center of Martinique
Traumatic Brain Injuries
Anti-inflammatory Effect of MgSO₄ in Patients With Moderate Traumatic Brain Injury by Measurming Nucleotide-binding Oligomerization Domain-Like Receptor Pyrin Domain-containing 3 (NLRP3) Inflammasome-a Multiprotein Complex
The primary objective of this study is to evaluate the biochemical efficacy of Magnesium Sulfate (MgSO₄) as an anti-inflammatory therapeutic agent in patients suffering from moderate traumatic brain injury (TBI) at Assiut…
- Trial name
- NCT07763665
- Testing
- Magnesium sulfate (MgSO4), Normal Saline
- Volunteers
- 64 people
- Sponsor
- Assiut University
Tooth, Impacted, Tooth Diseases
Ibuprofen Liquid Capsules 2 x 200 mg Efficacy and PK/PD Study in Surgical Removal of Impacted Third Molars
This is a single centre, three-arm randomised, double-blind, double-dummy, parallel group, single-dose, active and placebo-controlled efficacy and pharmacokinetics/ pharmacodynamics study to evaluate the efficacy and safety of 2…
- Conditions
- Tooth, Impacted, Tooth Diseases, Stomatognathic Diseases
- Trial name
- NCT05484401
- Testing
- Ibuprofen 200Mg Oral Cap, Ibuprofen 200Mg Oral Tablet
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Macular Thickening, Macular Edema
Effect of Topical Nepafenac in Macular Thickening Related to Pan-retinal Photocoagulation
The purpose of this study is to determine whether topical nepafenac (qid) is effective in preventing and treating macular thickening related pan-retinal photocoagulation in patients with diabetic retinopathy.
- Trial name
- NEPAF (NCT00801905)
- Testing
- Nepafenac, Lubricant
- Where
- 2 sites in Mexico
- Volunteers
- 50 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Trigger Finger
Effect of Therapeutic Ultrasound Versus Anti-inflammatory Drugs in the Treatment of Trigger Finger
to determine the effect of US on pain intensity in TF patients 2) to determine the effect of US on number of daily finger triggering in TF patients.
- Trial name
- NCT05467501
- Testing
- Theraputic ultrasound
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eslam Elsayed Ali Shohda
Symptomatic Irreversible Pulpitis
Efficacy of Block Injection of an Anti Inflammatory Medicine in Patients With Mandibular Dental Pain
The aim of this study is to determine whether inferior alveolar nerve block of ketorolac and lidocaine would improve the success rate in teeth with symptomatic irreversible Pulpitis.
- Trial name
- IANB (NCT03410212)
- Testing
- Ketorolac Tromethamine
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azad University of Medical Sciences
Postoperative Pain
The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery
The effects of none-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase inhibitors (Coxibs) on the formation of bone and fracture healing have been a matter of debate since long.
- Trial name
- NCT00733421
- Testing
- etoricoxib, tramadol
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Effect of Drug
Comparison of the Anti-Inflammatory Efficacy of Preemptive Dexamethasone and Etoricoxib
Impaction of mandibular third molars is a commonly encountered problem in oral surgery; patients frequently visit dental OPDs with complains related to the impacted molars, and in almost all situations, surgical removal of these…
- Trial name
- NCT05142098
- Testing
- Dexamethasone, Etoricoxib 60 mg
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
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