Clinical trials: Anti-inflammatory Agents
Acute Herpes Zoster
Efficacy of Electroacupuncture for Acute Herpes Zoster-Associated Pain and Biomarker Evaluation
Background: Herpes zoster (HZ) is an acute dermatological condition caused by the varicella-zoster virus. Its onset is characterized by severe pain, imposing significant physical and psychological burdens on patients.
- Trial name
- NCT07515885
- Testing
- Acupuncture, Valacyclovir, pregabalin and mecobalamin
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Dexiong Han
Stroke, Acute
Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke
The primary aim of this study is to find out which of 4 different doses of minocycline are safe and well tolerated so that we will know the optimal dose to test in future patients.
- Trial name
- MINOS (NCT00630396)
- Testing
- Minocycline
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- David Hess, MD
Color Changes During Tooth Formation
Effect of an Anti-inflammatory on Tooth Sensitivity Caused by Bleaching
Perhaps the use of a more selective anti-inflammatory drug, capable of inhibiting enzyme specific for pain may be more effective in preventing the tooth sensitivity caused by the inflammatory response produced by in-office…
- Trial name
- NCT01300780
- Testing
- Etoricoxib
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Eloisa Andrade de Paula
Chronic Rhinosinusitis Without Polyps
Thermosensitive Gel Nasal Spray With Exosomes, Azelastine, and Interferon for Acute Phase of Chronic Sinusitis
This study tests a new nasal spray for adults (18-65 years) with chronic sinusitis experiencing an acute phase. The spray contains a temperature-sensitive gel that turns into a soft gel inside the nose to slowly release three…
- Trial name
- CRS (NCT07635459)
- Testing
- Exosomes, Azelastine, and Interferon alpha-2b, Azelastine and Interferon alpha-2b
- Volunteers
- 108 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Inflammatory Bowel Diseases
Atorvastatin in Patients With Ulcerative Colitis
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease characterized by diffused inflammation of the colon and rectum mucosa; however, the exact underlying mechanisms of UC remain poorly understood.
- Trial name
- NCT05561062
- Testing
- Atorvastatin 80mg
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Asthma
The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma
We hypothesize that simvastatin in combination with ICS might have synergistic anti-inflammatory effects on airway inflammation in asthmatic patients
- Trial name
- NCT00792337
- Testing
- simvastatin, B1-6-12
- Where
- Thailand
- Volunteers
- 53 people
- Sponsor
- Mahidol University
Fever, Hyperthermia
The Fever and Antipyretic in Critically Illness Evaluation Study
The purpose of this multination multicenter observational study is to determine the impact of fever and antipyretic on outcomes in critically ill patients.
- Trial name
- FACE (NCT00940654)
- Testing
- Antipyretic therapy
- Where
- 2 sites in Japan, South Korea
- Volunteers
- 1,426 people
- Sponsor
- Japanese Society of Intensive Care Medicine
Multiple Sclerosis
Anti-Inflammatory Type II Monocyte Induction by Glatiramer Acetate (Copaxone) Treatment of Multiple Sclerosis
The purpose of this study is to determine whether glatiramer acetate (Copaxone) will induce anti-inflammatory type II monocyte development during treatment of MS, and if these antigen presenting cells (APC) will promote Th2 and…
- Trial name
- NCT00819195
- Testing
- Glatiramer acetate
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Endometriosis
Pilot Study on a Dietary Supplement With EndoGen™ as Adjunct Therapy in Women With Endometriosis
Current treatments for endometriosis, such as NSAIDs and hormone therapies, are meant for long-term use but often cause side effects, including stomach, liver, heart, and kidney issues; allergies; and hormonal problems like…
- Trial name
- NCT07228975
- Testing
- MetrioFen Gocce
- Where
- 7 sites in Italy
- Volunteers
- 36 people
- Sponsor
- Endok s.r.l.
Arthritis, Rheumatoid
Safety and Tolerability Study of MBS2320 in Healthy Subjects and Subjects With Rheumatoid Arthritis
Rheumatoid arthritis (RA) affects 1 percent of the population worldwide and up to 40 percent of patients don't respond to current treatments.
- Trial name
- NCT02480946
- Testing
- MBS2320, Methotrexate
- Where
- 3 sites in United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Modern Biosciences Ltd
Heartburn
Esomeprazole And Symptomatic Response In Patients With Or Without An Elevated Risk For Non-Steroidal Anti-Inflammatory Drug (NSAID)-Associated GI Damage
The purpose of this study is to compare the treatment effect in patients with upper gastro-intestinal complaints with an elevated risk for NSAID-associated GI-damage to those without an elevated risk for NSAID-associated damage…
- Trial name
- Synchronise (NCT00524329)
- Volunteers
- 1,220 people
- Sponsor
- AstraZeneca
Asthma Acute
Anti-inflammatory Effect of Nocturnal NIPPV on Acute Asthma
INTRODUCTION: Asthma is a disease characterized by inflammation of the airway and secondary contraction of smooth muscle. Treatment for the crisis consist in the use of local and / or systemic bronchodilators and…
- Trial name
- NCT03154762
- Testing
- NIPPV, CPAP
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Hypercholesterolemia, Chronic Nephropathy
Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy
The purpose of this study is to determine whether, in patients with chronic proteinuric nephropathy and dyslipidemia, ezetimibe-simvastatin combined therapy is more effective than statin alone to achieve the optimum lipid…
- Trial name
- VICTORY (NCT00861731)
- Testing
- simvastatin, EZE/simvastatin
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliero Universitaria di Sassari
Postoperative Pain
Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management
This study aims to evaluate the influence of genetic polymorphisms on the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following endodontic treatment.
- Trial name
- NCT06937853
- Testing
- Ibuprofen 600 mg, diclofenac sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Phase 1, Bioequivalence
Pharmacokinetic, Safety and Tolerability Study of Altebrel in Healthy Male Subjects
This study aims to demonstrate pharmacokinetic (PK) similarity of biosimilar candidate Altebrel relative to etanercept reference product (Enbrel®) and evaluate safety and tolerability of Altebrel, in a crossover fashion in…
- Trial name
- NCT03273088
- Testing
- Etanercept
- Where
- Iran
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- AryoGen Pharmed Co.
Multiple Sclerosis
High-intensity Training and Its Effects on Neuroplasticity
Regular physical activity is known to reduce the risk for some neurodegenerative disorders and their symptoms. Several studies have shown positive effects of therapeutic exercise interventions on motor- and cognitive function as…
- Trial name
- TRAINUVIMAB (NCT03652519)
- Testing
- Exercise Training
- Where
- Switzerland
- Volunteers
- 72 people
- Sponsor
- Klinik Valens
Trauma
The Anti-inflammatory Effects of High-fat Nutrition; Towards a Clinical Application
Patients undergoing major surgery, trauma and burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual.
- Trial name
- NCT00468507
- Testing
- nutritional intervention with Respifor and Diasip
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Periodontal Diseases, Gingivitis
The Effect of Vitamin D Supplementation on the Anti-inflammatory Response in Periodontal Diseases
A review of the literature revealed that while there are studies investigating the relationship between vitamin D and periodontal disease, there are no studies investigating the anti-inflammatory effect of vitamin D on…
- Conditions
- Periodontal Diseases, Gingivitis, Vitamin D Deficiency
- Trial name
- NCT07636733
- Testing
- Non-surgical periodontal treatment, Vitamin D administration, Oral Hygiene Education and Patient Motivation
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Crohn Disease
A Culturally Tailored Dietary Intervention to Treat Crohn's Disease
The goal of the study is to test the efficacy of a dietary intervention in inducing clinical response and remission for patients with Crohn's disease in a randomized controlled trial.
- Trial name
- DAIN (NCT05627128)
- Testing
- DAIN
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 150 people
- Sponsor
- University of Massachusetts, Worcester
Reflux Esophagitis, Gastric Ulcer
A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal Ulcer
This is an open label, parallel group, multi-centre, phase III study to assess the safety and efficacy of D961H in maintenance therapy following initial healing therapy in Japanese paediatric patients with reflux esophagitis, and…
- Conditions
- Reflux Esophagitis, Gastric Ulcer, Duodenal Ulcer
- Trial name
- NCT03553563
- Testing
- D961H capsule 10mg, D961H sachet 10mg
- Where
- 15 sites in Japan
- Volunteers
- 50 people
- Sponsor
- AstraZeneca
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