Clinical trials: Anti-inflammatory Agents
Immune Reconstitution Inflammatory Syndrome, Immune Reconstitution Syndrome
Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) Treatment Trial
Tuberculosis is the most common opportunistic infection (OI) in HIV-infected persons worldwide, including in South East Asia. Significant numbers of patients experience tuberculosis-related paradoxical immune reconstitution…
- Conditions
- Immune Reconstitution Inflammatory Syndrome, Immune Reconstitution Syndrome, Tuberculosis, HIV-infection/Aids
- Trial name
- NCT01442428
- Testing
- Dexamethasone, Atorvastatin, Naproxen
- Where
- 3 sites in Thailand
- Sponsor
- University of Minnesota
Low Back Pain
Radial Extracorporeal Shock Wave Therapy for Chronic Non-specific Low Back Pain
This study tests the hypothesis that radial extracorporeal shock wave therapy (rESWT) in combination with the non-steroidal anti-inflammatory drug Celecoxib and the antispasmodic drug Eperisone (hereafter, "C-E drug therapy") is…
- Trial name
- NCT03337607
- Testing
- rESWT, Celecoxib, Eperisone
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Neuralgia, Shingles
Dose-Finding Study of REN-1654 in Patients With Post-Herpetic Neuralgia
The purpose of this study is to gain initial safety and efficacy data on the experimental agent REN-1654 in patients with painful post-herpetic neuralgia (PHN).
- Conditions
- Neuralgia, Shingles, Peripheral Nervous System Disease
- Trial name
- NCT00099528
- Testing
- REN-1654
- Where
- 16 sites in United States
- Volunteers
- 90 people
- Sponsor
- Renovis
Inflammation
Anti-inflammatory Actions of Osteopathic Manipulative Treatment
This study evaluates the hypothesis that osteopathic manipulative treatment (OMT) and non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) elicit anti-inflammatory actions through activation of the…
- Trial name
- OMT_taVNS (NCT04177264)
- Testing
- Occipito-Atlantal Decompression (OA DC), Splenic Lymphatic Pump Technique (SpLPT), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Burrell College of Health Sciences
Rheumatoid Arthritis, Psoriasis
The Anti-inflammatory Effects of Harkány Medicinal Water
The study aims to provide evidence on the effectiveness of Harkány medicinal water in psoriatic and rheumatoid arthritis patients using subjective and objective methods.
- Trial name
- NCT04275206
- Testing
- Harkány medicinal water
- Where
- Hungary
- Volunteers
- 350 people
- Sponsor
- University of Pecs
Osteoarthritis, Knee
Parabens Flocculation on the Anti Inflammatory Effects of Corticosteroid Injections for Total Knee Arthroplasty
The purpose of this study is to identify whether corticosteroid use with anesthetics containing preservatives (parabens) reduces clinical effectiveness of the anti-inflammatory agent Up to 100 patients, both male and female…
- Trial name
- 5160373 (NCT03445611)
- Testing
- corticosteroid solution with lidocaine containing parabens., corticosteroid solution with lidocaine containing no paraben
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Aspirin Hypersensitivity, NSAIDs Hypersensitivity
Nasal Provocation Test With Lysine-Acetylsalicylate (ASA) in Patients With Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Hypersensitivity
This study aims to compare the efficacy of nasal provocation test with Lysine-Acetylsalicylate in patients with history of NSAIDs hypersensitivity between mucocutaneous symptoms and respiratory symptoms and laboratory outcomes.
- Trial name
- NCT00815126
- Testing
- Lysine-ASA Nasal ProvocationTest
- Where
- Thailand
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Schizophrenia, Schizoaffective Disorder
Withania Somnifera: an Immunomodulator and Anti-inflammatory Agent for Schizophrenia
Withania somnifera (WSE; Ashwagandha in Ayurveda) extracts have been used as an adaptogen or to build resistance to stress or diseases in indigenous medical systems in India for centuries.
- Trial name
- NCT01793935
- Testing
- Sensoril®
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- K.N. Roy Chengappa
Non-steroidal Anti-inflammatory Drugs, Pleurodesis
Non-steroidal Anti-inflammatory Drugs in Pleurodesis
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use.
- Conditions
- Non-steroidal Anti-inflammatory Drugs, Pleurodesis, Pneumothorax, Pain Management
- Trial name
- KETOTHORAX (NCT06731647)
- Testing
- pleurodesis procedures, KETOPROFEN(RP19583)
- Where
- France
- Volunteers
- 358 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Relapsing Remitting Multiple Sclerosis
A Study of Orally Administered BGC20-0134 (Structured Lipid) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS)
To determine the efficacy and safety of an oral drug (BGC20-0134) in patients with relapsing remitting multiple sclerosis. Specifically, the cumulative number of new gadolinium enhancing lesions after 24 weeks of treatment with…
- Trial name
- NCT01037907
- Testing
- Pleneva TM BGC20-0134
- Where
- 35 sites in Belgium, France and 4 more
- Volunteers
- 173 people
- Sponsor
- Boston Scientific Corporation
Tuberculosis
TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial
Background: Non-Steroid Anti-Inflammatory Drugs (NSAIDs) reduce pain and inflammation by inhibiting cyclooxygenase, an enzyme in the pathway for formation of prostaglandins and thromboxane.
- Trial name
- NCT02060006
- Testing
- Meloxicam 7.5mg daily for 8 weeks
- Where
- South Africa
- Volunteers
- 200 people
- Sponsor
- University of Stellenbosch
Inflammatory Bowel Diseases
Dietary Intervention for Inflammatory Bowel Disease Remission
1. To compare adding dietary intervention based on MD to dietary intervention based on IBD-AID on induction of disease remission of IBD patients receiving pharmacotherapy. 2.
- Trial name
- NCT05920187
- Testing
- Mediterranean diet and Anti-inflammatory diet
- Volunteers
- 80 people
- Sponsor
- Assiut University
Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate
Investigating the Anti-inflammatory Effects of Frondanol in Adults With Inflammatory Bowel Disease
This is a pilot, prospective, double-blinded, two-arm, randomized controlled trial of the efficacy of Frondanol in comparison to placebo in decreasing bowel inflammation in patients with a clinical diagnosis of inflammatory bowel…
- Conditions
- Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate, Crohn Colitis
- Trial name
- NCT05194007
- Testing
- Frondanol
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 13 people
- Sponsor
- Mohammed Bin Rashid University of Medicine and Health Sciences
Dental Plaque
Comparison of the Clinical and Microbiological Effects of CHX and HOCl Containing Mouthwashes
This study compared two mouthwashes, containing hypochlorous acid (HOCl) or chlorhexidine (CHX), for their effects on dental plaque accumulation, gum bleeding, tooth staining, and bacteria in dental plaque.
- Trial name
- NCT06589193
- Testing
- Hypochlorous acid 0.02% mouthwash, Chlorhexidine gluconate 0.2% mouthwash
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baskent University
COVID-19, Virus Diseases
Anti-inflammatory Clarithromycin for Improving COVID-19 Infection Early
Recent information appearing from different countries suggest that treatment of Coronavirus disease 2019 (COVID-19) with hydroxychloroquine or with a combination of hydroxychloroquine and azithromycin has either an indifferent…
- Conditions
- COVID-19, Virus Diseases, Corona Virus Infection
- Trial name
- ACHIEVE (NCT04398004)
- Testing
- Clarithromycin
- Where
- 9 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Cardiopulmonary Bypass, Inflammation
Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
Each year over a million patients worldwide undergo cardiac surgery requiring cardiopulmonary bypass (CPB). CPB is associated with significant morbidity including the transfusion of allogenic blood products, inflammation and…
- Conditions
- Cardiopulmonary Bypass, Inflammation, Fibrinolysis, Surgery
- Trial name
- BRAC (NCT00223704)
- Testing
- HOE 140, Aminocaproic Acid
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University
Type 2 Diabetes, Obesity
Exploring the Anti-inflammatory Properties of Cannabis and Their Relevance to Insulin Sensitivity
This study tests the effects of cannabinoid levels in blood on inflammation and insulin sensitivity both acutely and chronically in individuals across the weight spectrum.
- Conditions
- Type 2 Diabetes, Obesity, Cannabis Use, Insulin Sensitivity
- Trial name
- SONIC (NCT04114903)
- Testing
- Study A: Single use of cannabis flower product, Study B: Ad libitum cannabis use for four weeks or no cannabis use
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- University of Colorado, Boulder
Obsessive-Compulsive Disorder
Neuroinflammation in Patients With OCD
The goal of this study is to examine whether measurements of inflammation from brain scanning and blood tests can predict how much benefit patients with obsessive-compulsive disorder (OCD) will have from treatment with an…
- Trial name
- NCT04786548
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- New York State Psychiatric Institute
Multimodal Analgesia, Nonsteroidal Anti-inflammatory Drugs
NSAID vs. Narcotics
This will be a single-center, prospective observational study. The study will compare post-operative pain scores and narcotic consumption between two groups of patients - one cohort will receive ibuprofen (Motrin) and Percocet…
- Trial name
- NCT02915055
- Testing
- Ibuprofen 600 mg, standard oxycodone/acetaminophen
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Cystic Fibrosis
Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers
Inflammation clearly contributes to the progression of the cystic fibrosis (CF) lung disease, and administration of the anti-inflammatory agent high-dose ibuprofen retards the rate of decline of pulmonary function.
- Trial name
- NCT00531882
- Testing
- Pioglitazone, Simvastatin, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
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