Clinical trials: Antibiotic
Hematologic Malignancy, Febrile Neutropenia
Early Neutropenic Fever De-escalation of Antibiotics Study
This is a randomized, open label clinical trial among individuals with hematologic conditions. The trial aims to evaluate the safety and clinical outcomes of de-escalating antibiotic therapy among stable individuals diagnosed…
- Conditions
- Hematologic Malignancy, Febrile Neutropenia, Antibiotic Stewardship
- Trial name
- END (NCT06278896)
- Testing
- Cessation of antibiotics
- Volunteers
- 260 people
- Sponsor
- Brigham and Women's Hospital
Periradicular Disease
Comparing the Antibacterial Effect of 810 nm Diode Laser and Photodynamic Therapy
The aim of this study was to compare the Antibacterial Efficacy of Diode Laser 810nm and Photodynamic therapy in reducing bacterial microflora in endodontic retreatment of teeth with periradicular lesion.
- Trial name
- NCT02555488
- Testing
- diode laser, Methylene blue
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Bone and Joint Infection, Antibiotic Reaction
Evaluation of the Tolerance of Ceftaroline and Ceftobiprole in the Management of BJI / PJI
Staphyloccous aureus and coagulase negative staphylocci are responsible of a large marjority of PJI. Regarding the high rate of methicillin resistance, current guidelines recommend the use of a glycopeptide, and most frequently…
- Trial name
- NCT04409769
- Testing
- Description of use of ceftaroline and ceftobiprole
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Hospices Civils de Lyon
Antibiotic Resistance, Antibiotic Use
Antibiotics, Antibiotic Resistance, and Prescribing Practices Among Periodontists: Cross Sectional KAP Study
Antibiotic resistance is a global health threats that require attention from all healthcare providers. In Periodontology, antibiotic is prescribed in many clinical situations.
- Conditions
- Antibiotic Resistance, Antibiotic Use, Periodontitis
- Trial name
- NCT06371560
- Testing
- Questionnaire
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis
Antibacterial Activity of Calcium Hydroxide and Betamethasone in Apical Periodontitis
Apical periodontitis is a chronic inflammatory disease caused by bacterial infection of the root canal system. Although mechanical cleaning and shaping reduce most microorganisms, bacteria may persist in areas that are difficult…
- Trial name
- NCT07351682
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Duygu Degirmencioglu
MDR-TB, Tuberculosis Multi Drug Resistant Active
Feasibility of the Application of a New Six-month Treatment for Multidrug-resistant Tuberculosis (MDR-TB) Patients in France (FAST-MDR)
The FAST-MDR trial is an externally-controlled, multicentre trial with one prospective arm, evaluating the non-inferiority of the effectiveness of BPaLM in the interventional arm versus the effectiveness of the long, conventional…
- Conditions
- MDR-TB, Tuberculosis Multi Drug Resistant Active, Antibiotic Resistance, Mycobacterium Tuberculosis
- Trial name
- FAST-MDR (NCT07486024)
- Testing
- Bedaquiline Oral Tablet
- Where
- 5 sites in France
- Volunteers
- 55 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteomyelitis
Antibiotic Device for Osteomyelitis of the Extremities Pivotal Trial - Genex With Gentamicin.
The purpose of this trial is to determine if genex with gentamicin (genex G) an antibiotic loaded bone void filler, works to treat and is a safe option as part of the surgical treatment of osteomyelitis in the extremities.
- Trial name
- ADOPT GG (NCT07270380)
- Testing
- genex with gentamicin (genex G)
- Where
- 4 sites in United States
- Volunteers
- 139 people
- Sponsor
- Biocomposites Ltd
Antibiotic, Oral Health Care
Parental Views on Antibiotics in Dentistry
This study aims to assess parents' knowledge of antibiotic use and its relationship with their children's oral health.
- Conditions
- Antibiotic, Oral Health Care, Parents, Pediatric Dentistry
- Trial name
- NCT07112079
- Where
- Turkey (Türkiye)
- Volunteers
- 1,610 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Respiratory Infections
Improving Antibiotic Use in Acute Care Treatment
Purpose The emergence and rapid rise in antibiotic resistance among common bacteria are adversely affecting the clinical course and health care costs of community-acquired infections.
- Trial name
- IMPAACT (NCT00144040)
- Testing
- Physician & patient education on appropriate antibiotic use, Rapid C-reactive protein testing to guide antibiotic treatment
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- US Department of Veterans Affairs
Acute Appendicitis
Acute Appendicitis and Microbiota - Etiology of Appendicitis and Antibiotic Therapy Effects
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a routine procedure.
- Trial name
- MAPPAC (NCT03257423)
- Testing
- Ertapenem followed by levofloxacin and metronidazole, Moxifloxacin, Appendectomy
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Turku University Hospital
Antimicrobial Stewardship, Antibiotics Causing Adverse Effects in Therapeutic Use
A Multimodal Intervention to Optimise Antimicrobial Use in Residential Aged Care Facilities (ENGAGEMENT Study)
The antimicrobial stewardship ENGAGEMENT study aims to deliver a bundle of interventions, including education of GPs and nursing staff, guideline implementation and telehealth support for 18 residential aged care facilities…
- Trial name
- ENGAGEMENT (NCT04705259)
- Testing
- Antimicrobial Stewardship ENGAGEMENT bundle
- Where
- 4 sites in Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Pneumonia, Bacterial
Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative and / or Gram-positive Bacterial Colonization
To demonstrate the safety and efficacy of adjunctive therapy with the Amikacin Fosfomycin Inhalation System (AFIS) versus aerosolized placebo in mechanically ventilated patients with Gram-negative and / or Gram-positive bacterial…
- Trial name
- NCT02218359
- Testing
- Amikacin Fosfomycin Inhalation Solution
- Sponsor
- Cardeas Pharma
Antibiotic Resistant Infection, COVID-19
The Impact of Covid-19 Hospital Care on the Prevalence of MDRO in Indonesia
The effect of the COVID-19 pandemic on the emergence and spread of antibiotic-resistant bacteria is largely unknown, especially in low-resource settings.
- Trial name
- NCT05293483
- Where
- 2 sites in Indonesia
- Volunteers
- 1,110 people
- Sponsor
- Erasmus Medical Center
Pulp Necrosis, Root Canal Infection
Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection
This research study is being done to find out if a natural ingredient called frankincense can clean infected root canals as effectively as the standard cleaning solution currently used in dentistry.
- Conditions
- Pulp Necrosis, Root Canal Infection, Apical Periodontitis
- Trial name
- FSHRCD: RCT (NCT07823868)
- Testing
- Sodium hypochlorite 3%, Frankincense-based irrigant
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Dental College
Penicillin Allergy
Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients
The proposed research project will retrospectively review the anesthetic records over the past 5 years and identify patients who present with a history of penicillin allergy or allergy to an antibiotic in the penicillin family.
- Trial name
- NCT02036840
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- Joseph D. Tobias
Acne Vulgaris, Pediatrics
Subantimicrobial Doxycycline in Acne
Antibiotic resistance is a public health problem that worsens the more physicians prescribe standard dose antibiotics for acne. Regardless of race, acne vulgaris is one of the most common dermatologic conditions among pediatric…
- Trial name
- NCT05399290
- Testing
- Doxycycline Hyclate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Infectious Keratitis, Adjuvant Treatment Bacterial Infectious Keratitis
Effect of Sodium Chloride 5% Solution as an Adjuvant Treatment With Antimicrobial Therapy in the Treatment of Bacterial Infectious Keratitis
This study aims to detect the effect of sodium chloride 5% solution as an adjuvant treatment with antimicrobial therapy in treatment of bacterial infectious keratits and to assess whether NaCl 5% accelerates epithelial healing…
- Conditions
- Infectious Keratitis, Adjuvant Treatment Bacterial Infectious Keratitis, Sodium Chloride 5% Solution
- Trial name
- keratitis (NCT07452588)
- Testing
- Sodium chloride 5% solution, quinolones
- Volunteers
- 40 people
- Sponsor
- Sohag University
Pulp Necrosis
Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar
This randomized clinical study evaluates the antibacterial effectiveness and postoperative pain following root canal irrigation using the Triton irrigation protocol in necrotic mandibular molars.
- Trial name
- NCT07435883
- Testing
- triton irrigation protocol, conventional irrigation group
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- sara hosny mostafa
Acute Otitis Media
Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children
This is a randomized, controlled trial studying the effects of various antimicrobial treatments on the intestinal microbiome of small children.
- Trial name
- AOMMi (NCT02935374)
- Testing
- Amoxicillin, Amoxicillin-Potassium Clavulanate, Macrolide
- Where
- Finland
- Volunteers
- 73 people
- Sponsor
- University of Oulu
Postoperative Pain
Assessment of Pain and Antibacterial Activity of Chitosan Versus Sodium Hypochlorite as Irrigant in Infected Canal
A randomized clinical trial that aims to study the effect of chitosan nanoparticles (CS-np) versus sodium hypochlorite as a root canal irrigant on postoperative pain and antibacterial activity against E.faecalis in infected root…
- Trial name
- NCT03719261
- Testing
- chitosan nanoparticles, Sodium Hypochlorite
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University