Clinical trials: Antibiotic Duration
Pneumonia
Procalcitonin Use in Pneumonia Patients in the Critical Care Setting
The goal of the study is to determine the impact of procalcitonin (PCT)-guided therapy on duration of antibiotic therapy in critical care unit (CCU) patients with suspected pneumonia at Mayo Clinic Health System Eau Claire.
- Trial name
- NCT01788488
- Testing
- Use of procalcitonin as biomarker to guide therapy
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Mayo Clinic
Infections, Urinary Tract, Nephrolithiasis
Preoperative Prophylactic Antibiotic Duration in Moderate to High Risk Ureteroscopy
The goal of this non-inferiority randomized controlled trial: is to test the hypothesis that the that there is no additional benefit from a longer course (7 days) versus a shorter course (2 days) of pre-operative antibiotics in…
- Trial name
- NCT06149455
- Testing
- Duration of antibiotics
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Obstructive Pulmonary Disease
Short Antibiotic Treatment Versus Duration Guided by Markers of Inflammation in the Treatment of AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. In a recent study, we showed that administration of levofloxacin is superior to placebo in the treatment of decompensation of COPD; it…
- Trial name
- AECOPD (NCT02067780)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
Fractures, Closed, Wounds and Injuries
Antibiotic Prophylaxis in Orthopaedic Traumatology
It has been established that providing antibiotic prophylaxis after closed fracture fixation with implants or prosthetic devices has beneficial effects.
- Trial name
- NCT00610987
- Testing
- cefazolin
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- University of Missouri-Columbia
To Reduce Duration of Antibiotics Exposure in Patients With COPD Hospitalized in Intensive Care Unit With Pneumonia
An Antibiotic Protocol Guided by a Multimodal Approach in AECOPD With Pneumonia in Intensive Care
Investigators propose to conduct a multicenter, prospective, randomized, controlled, assessing the interests of an antibiotic protocol guided by the combined use of serum procalcitonin (PCT) and a broad-panel respiratory…
- Trial name
- BPCTréa2 (NCT06301841)
- Testing
- experimental
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Caen
Sepsis
Procalcitonin as a Tool to Shorten Antibiotic Therapy in the ICU
Recently, biomarkers like procalcitonin have been studied in order to help physicians to decrease the duration of the antibiotic therapy.
- Trial name
- NCT01494675
- Testing
- procalcitonin measurement
- Where
- Brazil
- Volunteers
- 81 people
- Sponsor
- Hospital Israelita Albert Einstein
Community-Acquired Pneumonia
Improved Use of Antibiotic Guidelines in Hospital Environment
The purpose of this study is to determine if the use of antibiotic guidelines and thus antibiotics can be improved through a description of possible barriers leading to tailored interventions.
- Trial name
- NCT00512772
- Where
- 2 sites in Belgium
- Volunteers
- 823 people
- Sponsor
- KU Leuven
Orthopedic Devices Associated With Misadventures, Infection, Surgical Site
Short Against Long Antibiotic Therapy for Infected Orthopedic Sites
The investigators will perform two concomitant RCTs, depending on the presence of infected osteosynthesis material at enrolment: SALATIO 1. Infected implant not removed (or new material inserted): Randomization 6 vs.
- Conditions
- Orthopedic Devices Associated With Misadventures, Infection, Surgical Site, Antibiotic Side Effect
- Trial name
- SALATIO (NCT05499481)
- Testing
- Antibiotic
- Where
- Switzerland
- Volunteers
- 495 people
- Sponsor
- Balgrist University Hospital
Sepsis
Sepsis Alert Routine Implementation in the Emergency Department
This study evaluates the impact of a structured sepsis alert routine, that has been implemented in the Emergency Department (ED) of Karolinska University Hospital Huddinge, Sweden.
- Trial name
- SARIED (NCT07020598)
- Volunteers
- 3,389 people
- Sponsor
- Region Stockholm
Community-acquired Pneumonia
Clinical Reassessment Versus Procalcitonin in Order to Shorten Antibiotic Duration in Community-acquired Pneumonia
CLINPCT study is a prospective, randomized, controlled, open intervention clinical trial including adult patients admitted in the emergency department with community-acquired pneumonia.
- Trial name
- CLINPCT (NCT01723644)
- Testing
- the clinical reassessment arm, the procalcitonin arm
- Where
- 15 sites in France
- Volunteers
- 286 people
- Sponsor
- Nantes University Hospital
Bloodstream Infection, Gram Negative Infections
Antibiotic Duration and Outcomes in High-Risk Febrile Neutropenia Patients
The goal of this clinical trial is to learn if a personalized duration of antibiotic therapy, based on clinical stability, is as effective as a standard duration of at least 10 days in hospitalized patients with hematologic…
- Conditions
- Bloodstream Infection, Gram Negative Infections, Bacteraemia Caused by Gram-Negative Bacteria, Febrile Neutropenia (FN)
- Trial name
- PERaSTrA (NCT07372131)
- Testing
- Clinical Stability-Driven Antibiotic Discontinuation Strategy, Standard of Care Antibiotic Duration
- Where
- Italy
- Volunteers
- 172 people
- Sponsor
- Valeria Cento
Bacteremia
BALANCE on the Wards: A Pilot RCT
The burden of bloodstream infections is large and increasing over time. Antibiotic overuse continues to drive increased rates of antimicrobial-resistant pathogens across Canada.
- Trial name
- BALANCE-Wards (NCT02917551)
- Testing
- 7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment
- Where
- 6 sites in Canada
- Volunteers
- 134 people
- Sponsor
- Sunnybrook Health Sciences Centre
Bronchiectasis
Bacterial Load Guided Therapy for Severe Bronchiectasis Exacerbations
From the British Thoracic Guidelines1 and a PUBMED search there are no randomised controlled trials exploring optimum antibiotic duration for chest infections.
- Trial name
- BLTBrIV (NCT02047773)
- Testing
- Duration, Colomycin, Meropenem
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Edinburgh
Cystic Fibrosis
Duration of Antibiotics in Infective Exacerbations of Cystic Fibrosis
Cystic Fibrosis patients attending with infective exacerbations will be enrolled into the study. The trial is a double blinded, randomised trial with patients randomised to 10,14 or 21 days of antibiotic therapy, comprising of…
- Trial name
- NCT01044719
- Testing
- Ceftazidime, Tobramycin, Meropenem
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- Imperial College London
Pyelonephritis Acute, Kidney Transplantation Recipients
Duration of Antibiotic Therapy in Acute Kidney Graft Pyelonephritis (AGPN): Effect on the Risk of Recurrence
The aim of this study is to evaluate the impact of the duration of antibiotic therapy on the risk of recurrence in kidney graft pyelonephritis.
- Trial name
- DUTRAPYL (NCT06848816)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Central Hospital, Nancy, France
Urinary Tract Infection
Febrile Urinary Tract Infection Randomized Short Treatment Trial
The purpose of this study is to determine whether a 7-day duration of antibiotic treatment of febrile urinary tract infection (FUTI) is non inferior to 14-day standard duration of treatment in unselected population presenting at…
- Trial name
- FUTIRST (NCT00809913)
- Testing
- short treatment (ciprofloxacin)
- Where
- 6 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Leiden University Medical Center
Gram Negative Bacteremia
Duration of Antibiotics for the Treatment of Gram-negative Bacilli Bacteremia
The investigators plan an open label randomized controlled trial to compare short-course antibiotic therapy (<=7 days) versus longer treatment (>7 days).
- Trial name
- NCT01737320
- Testing
- short-course antibiotic treatment, accepted prolonged antibiotic treatment
- Where
- 3 sites in Israel, Italy
- Volunteers
- 604 people
- Sponsor
- Rabin Medical Center
Complicated Urinary Infection
Urinary Tract Infection Study With the Antibiotic Levofloxacin Given at a Higher Dose Over a Shorter Period of Time
The purpose of the study is to compare the safety and effectiveness of the antibiotic levofloxacin by administering a higher dose of levofloxacin and using a shorter course of therapy.
- Trial name
- NCT00245791
- Testing
- Levofloxacin
- Where
- 3 sites in Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Critically Ill Patients, Infection
Central Venous Catheter-Related Infection
Intravascular devices are an integral component of modern-day medical practice. Infection is one of the leading complications of intravascular catheters and is associated with an increased mortality, prolonged hospitalization and…
- Trial name
- NCT00533988
- Testing
- Antimicrobial impregnated catheter (5593)
- Volunteers
- 118 people
- Sponsor
- University of Witwatersrand, South Africa
Sepsis, Adult Disease
Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Baylor S&W
The purpose of this study is to demonstrate that addition of the Monocyte Width Distribution (MDW) parameter to current standard of care improves a clinician's ability to recognize sepsis in the Emergency Department, resulting in…
- Conditions
- Sepsis, Adult Disease, Emergency Department, Severe Sepsis
- Trial name
- NCT04291417
- Testing
- CBC-DIFF Monocyte Volume Width Distribution (MDW)
- Where
- United States
- Volunteers
- 1,700 people
- Sponsor
- Beckman Coulter, Inc.