Clinical trials: Antibiotic Prophylaxis
Urological System Complication of Procedure, Urinary Tract Infections
Effectiveness of Single Dose Fosfomycin and Single Dose Levofloxacin as Pre-urodynamic Antibiotic for UTI Prevention
The goal of this clinical trial is to compare the use of single dose fosfomycin and single dose levofloxacin as pre-urodynamic antibiotic prophylaxis for urinary tract infection prevention post-urodynamic in patients with lower…
- Trial name
- NCT06017479
- Testing
- Fosfomycin 3000 MG, Levofloxacin 500mg
- Where
- Indonesia
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Clostridium Difficile Infection
Microbiota or Placebo After Antimicrobial Therapy for Recurrent C. Difficile at Home (MATCH)
The purpose of this study is to determine whether Fecal Microbiota Therapy (FMT) is effective vs. placebo in the prevention of C. difficile infection recurrence.
- Trial name
- MATCH (NCT03005379)
- Testing
- Fecal Microbiota Therapy (FMT)
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- VA Office of Research and Development
Infections
Pharmacokinetics and Safety of Cefazolin 3gm DUPLEX in Adults
This study is designed to evaluate the pharmacokinetics (PK) of a single 3 gm dose of cefazolin from a DUPLEX container, in adult subjects (weighing >/= 120 kg) scheduled for surgery.
- Trial name
- 3gCefPK (NCT05205486)
- Testing
- Cefazolin 3gm for Injection USP and Dextrose Injection USP
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- B. Braun Medical Inc.
Prostate Cancer, Urinary Tract Infection
Antibiotic Prophylaxis for Urinary Catheter Removal After Radical Prostatectomy
The aim of this study is to determine whether antibiotics prophylaxis at the time of urinary catheter removal decreases the number of symptomatic urinary tract infections in patients after radical prostatectomy.
- Conditions
- Prostate Cancer, Urinary Tract Infection, Clostridium Difficile
- Trial name
- Abx (NCT02247960)
- Testing
- Ciprofloxacin
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Rochester
Pancreatic Cancer, Pancreas Cancer
Does Cefoxitin or Piperacillin-Tazobactam Prevent Postoperative Surgical Site Infections After Pancreatoduodenectomy?
The purpose of this study is to figure out which commonly used antibiotic, cefoxitin or piperacillin-tazobactam, is better at decreasing the rate of surgical site infections after pancreatoduodenectomy.
- Conditions
- Pancreatic Cancer, Pancreas Cancer, Pancreatic Diseases
- Trial name
- NCT03269994
- Testing
- Cefoxitin, Piperacillin-tazobactam
- Where
- 32 sites in United States, Canada
- Volunteers
- 967 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Surgical Site Infection
De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children
The overall objective of this study is to identify the best strategy to eliminate unnecessary antibiotic use after surgery in pediatric surgical procedures considered low-risk for an SSI.
- Trial name
- OPerAtiC (NCT04366440)
- Testing
- Order set review and modification with facilitation, Order set review and modification
- Where
- 10 sites in United States
- Volunteers
- 18,267 people
- Sponsor
- Washington University School of Medicine
Penicillin Allergy
Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients
The proposed research project will retrospectively review the anesthetic records over the past 5 years and identify patients who present with a history of penicillin allergy or allergy to an antibiotic in the penicillin family.
- Trial name
- NCT02036840
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- Joseph D. Tobias
Diarrhea Travelers, Antibiotic Resistant Infection
Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea
The purpose of this study is to determine if the use of prophylactic bismuth subsalicylate (BSS) has an effect on the acquisition of travelers' diarrhea (TD) or antimicrobial resistance (AMR) genes in fecal samples among…
- Trial name
- NCT03535272
- Testing
- Bismuth subsalicylate
- Where
- United States
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Pancreatic Fistula
eXtended Antibiotic Prophylaxis for Intermediate- and High-risk Glands After Pancreatoduodenectomy to Reduce CR-POPF
The purpose of this clinical trial is to investigate if prolonged antibiotics after pancreatoduodenectomy can prevent the development of a pancreatic fistula and related complications.
- Trial name
- NCT05753735
- Testing
- Piperacillin/Tazobactam, Amoxicillin/ Clavulanic acid
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Case Comprehensive Cancer Center
Clostridium Difficile
Bezlotoxumab as Secondary Prophylaxis for C. Difficile in High-risk Hospitalized Patients Exposed to Antibiotics.
This study will examine whether the human monoclonal antibody, bezlotoxumab administered AFTER acute Clostridioides difficile (C.diff) has resolved, but during a period of subsequent antibiotic therapy, will eliminate the high…
- Trial name
- NCT03937999
- Testing
- Bezlotoxumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Montefiore Medical Center
Anthrax
Velocity 2: An Anthrax Vaccine and Antibiotics Clinical Study
This study is designed to evaluate the pharmacokinetic (PK) profiles of ciprofloxacin or doxycycline when administered orally, prior to, and following, the intramuscular (IM) administration of a two-dose schedule of AV7909…
- Trial name
- NCT04067011
- Testing
- Ciprofloxacin 500Mg Tablet, Doxycycline 100Mg Tablet, AV7909
- Where
- 4 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Fractures, Closed, Wounds and Injuries
Antibiotic Prophylaxis in Orthopaedic Traumatology
It has been established that providing antibiotic prophylaxis after closed fracture fixation with implants or prosthetic devices has beneficial effects.
- Trial name
- NCT00610987
- Testing
- cefazolin
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- University of Missouri-Columbia
Surgical Site Infection
Continuous Antibiotic Prophylaxis in Colorectal Surgery
We propose to randomise patients due to undergo colorectal surgery to standard antibiotic prophylaxis or an interventional antibiotic prophylaxis regimen and assess surgical wound infection rates.
- Trial name
- Colo-Pro (NCT02445859)
- Testing
- Cefuroxime 4 hourly bolus
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Leeds