Clinical trials: Antibiotic Resistance, Bacterial
Infection With AmpC Beta-lactamase Producing Enterobacterales
Clinical Comparison of Treatment Strategies in AmpC Beta-lactamase Producing Enterobacterales in a Swiss Tertiary Care Hospital
This study is to investigate the recent epidemiological trends and the treatment outcome in terms of the length of hospital stay, the relevant renal and neurological side effects, risk factors for developing these side effects…
- Trial name
- AmpCstratBasel (NCT04577989)
- Testing
- data collection
- Where
- Switzerland
- Volunteers
- 270 people
- Sponsor
- University Hospital, Basel, Switzerland
Mycoplasma Pneumonia
The Optimization of Mycoplasm Pneumonia Antibiotic Therapy
Mycoplasma pneumoniae, an important pathogen of community acquired pneumonia,are becoming more and more resistant to macrolide. The study aim is to optimize anti-infection therapy.
- Trial name
- NCT01259141
- Testing
- Moxifloxacin, Cephalosporins and azithromycin
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Capital Medical University
Sepsis
Procalcitonin-Guided Antimicrobial Discontinuation
The current study aims to validate the diagnostic use of PCT assessing its capability to individualize and shorten the duration of antibiotic therapy in critically ill patients with suspected or confirmed sepsis.
- Trial name
- NCT00250666
- Testing
- PCT measurement
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Geneva
Gonorrhea
New AntiBiotic Treatment Options for Uncomplicated Anogenital GOnorrhoea
This study evaluates the efficacy of three experimental antibiotics in the treatment of uncomplicated anogenital gonorrhoea. Participants will be randomized to one of four study arms and will receive either one of the three…
- Trial name
- NABOGO (NCT03294395)
- Testing
- Ertapenem 1000 MG, Fosfomycin Oral Suspension, Gentamicin Sulfate, Injectable
- Where
- Netherlands
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- Public Health Service of Amsterdam
Bacterial Colonization
Bacterial Decolonization Within Dyads
The goal of this study is to measure bacterial burden, specifically Staph aureus, and how it spreads between mothers and their infants.
- Trial name
- BADMC (NCT06541145)
- Testing
- Mupirocin, Chlorhexidine baths
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Methicillin-Resistant Staphylococcus Aureus, Recurrence
Patient-Centered Comparative Effectiveness Research (CER) Study of Home-based Interventions to Prevent CA-MRSA Infection Recurrence
The overall goal of the project is to develop and evaluate a home-based intervention to prevent re-infection and transmission of Community-Acquired Methicillin-resistant Staphylococcus aureus (CA-MRSA) in patients presenting to…
- Conditions
- Methicillin-Resistant Staphylococcus Aureus, Recurrence, Staphylococcal Skin Infections, Antibiotic Resistance
- Trial name
- CAMP-2 (NCT02566928)
- Testing
- 2% mupirocin ointment, Chlorhexidine wash, Hygiene protocol
- Where
- 6 sites in United States
- Volunteers
- 278 people
- Sponsor
- Clinical Directors Network
ACS - Acute Coronary Syndrome, Ticagrelor
Modulation of Gut MicroFLORA With Rifaximin to Reduce High Platelet Reactivity in Post-ACS Patients on Ticagrelor
The FLORA-ACS study aims to evaluate the relationship between dysbiosis and high platelet reactivity during treatment with ticagrelor in patients with a history of acute coronary syndromes and investigate the use of rifaximin to…
- Conditions
- ACS - Acute Coronary Syndrome, Ticagrelor, Microbiota, Platelet Aggregation
- Trial name
- FLORA-ACS (NCT07203846)
- Testing
- Rifaximin
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Blood Stream Infections, Adult Cancer Patients
Antimicrobial Resistance and Genomic Profiling of Bacterial Isolates
Sepsis and bloodstream infection (BSI) are among the most serious complications in patients with cancer, in whom disease- and treatment-related immunosuppression markedly increases susceptibility to infection.
- Trial name
- NCT07884942
- Testing
- Identification of bacterial isolates causing blood stream infection and determination of their antibiotic sensitivity, Molecular characterization of bacterial isolates
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Burns
Antimicrobial Resistance of Bacteria in Burn Patients
The purpose of this study is to test the resistance of pathogenic bacteria in infected tissues of burn patients to various antimicrobials and enzyme debriders.
- Trial name
- NCT00794742
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Texas Tech University Health Sciences Center
Bacterial Infections, Antibiotic Resistant Infection
Antibiotic Profile of Pathogenic Bacteria Isolated in Public Hospitals in Northern Jordan
The main aim of the study was to identify the various pathogens associated with surgical site infections and their antibiotic susceptibility in a governmental hospital in northern Jordan.
- Conditions
- Bacterial Infections, Antibiotic Resistant Infection, Surgical Site Infection
- Trial name
- NCT05106803
- Testing
- ciprofloxacin
- Where
- Jordan
- Volunteers
- 24 people
- Sponsor
- Yarmouk University
Malignant Otitis Externa
Microbiological Screening Of Malignant Otitis Externa Patients Presenting at Sohag University Hospitals
This is a prospective study to identify the bacterial and fungal organisms causing Malignant Otitis Externa (MOE) in patients presenting to Sohag University Hospitals.
- Trial name
- MOE Screening (NCT07790679)
- Testing
- ear swab and susceptibility testing
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Critically Ill, Enterobacteriaceae Infections
Infections and Colonization With the Third Group of Enterobacteriaceae in the Intensive Care Unit
There is a lack of data whether colonization and infection with Enterobacteriaceae of the third group (EB3) affect the outcomes for ICU patients.
- Conditions
- Critically Ill, Enterobacteriaceae Infections, Antibiotic Resistant Infection
- Trial name
- EB3REA (NCT04528043)
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Central Hospital, Nancy, France
INFECTIONS, Skin and Subcutaneous Tissue Bacterial Infections
Study of Accuracy of New Diagnostic Technology to Guide Rapid Antibiotic Treatment for Serious Infections
This research will test a new ultra-rapid technology (called ID/AST Accelerate system) that uses a digital microscope to identify bacteria based on their growth patterns.
- Conditions
- INFECTIONS, Skin and Subcutaneous Tissue Bacterial Infections, Healthcare-associated Infection, Infection Due to Resistant Bacteria
- Trial name
- NCT02796716
- Testing
- Testing on new technology called Accelerate ID/AST system
- Where
- United States
- Volunteers
- 2,102 people
- Sponsor
- Denver Health and Hospital Authority
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Bacterial Infection
Incidence of Antibiotic Resistant E.Coli in Patients Undergoing Repeat Prostate Biopsy
The purpose of this study is to discover how often certain bacteria are found in the rectum at the time of a prostate needle biopsy to diagnose prostate cancer.
- Trial name
- NCT00915213
- Where
- 3 sites in United States
- Volunteers
- 136 people
- Sponsor
- University of California, Irvine
Drug Resistance, Multiple, Bacterial Infections
Prediction of Multidrug-resistant Bacterial Infection in Patients with Cirrhosis
The aim of this study is to identify predictive factors of infections caused by multidrug-resistant organisms in patients with cirrhosis and to develop and validate (internally and externally) a predictive model that might be…
- Conditions
- Drug Resistance, Multiple, Bacterial Infections, Liver Cirrhosis
- Trial name
- NCT05641025
- Where
- Argentina
- Volunteers
- 1,774 people
- Sponsor
- Hospital Italiano de Buenos Aires
Bacterial Infections
Effectiveness of Short-Course Versus Standard Antibiotic Therapy in ICU Patients
This study will compare two treatment strategies (standard versus short-course antibiotic therapy) for preventing resistant bacterial infection in patients in the intensive care unit (ICU).
- Trial name
- NCT00410527
- Testing
- Merrem
- Where
- 12 sites in United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Enterobacteriaceae Infections, Multi-antibiotic Resistance
FMT to Eradicate Intestinal Colonization by Carbapenem-resistant Enterobacteriaceae
Antibiotic resistance (AR) is a critical public health threat and one of the greatest challenges of the 21st century. In an estimate of 2019, nearly 700.000 infections and 33.000 attributable deaths from multi-drug-resistant…
- Trial name
- FMT_CRE (NCT05791396)
- Testing
- Donor - FMT
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Infectious Disease, Bacterial Infections
Safety & Efficacy of an Antibacterial Protein Molecule Applied Topically to the Nostrils of Volunteers and Patients
The purpose of this study is to determine whether the antibacterial protein P128 is (i) safe and well tolerated in healthy volunteers and in chronic kidney diseases patients on dialysis, (ii) is it effective in reducing the nasal…
- Trial name
- NCT01746654
- Testing
- P128-0.1 mg, P128-0.3 mg, P128-1.0 mg
- Where
- Singapore
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- GangaGen, Inc.
Infection, Bacterial
Impact of Cefotaxime and Ceftriaxone on the Emergence and Carrying of Multidrug-Resistant Bacteria
Among enterobacteria, the production of ESBL is the first cause of multidrug resistance. The first cases of ESBL-producing enterobacteriaceae (EBLSE) infections were described during the 1980s and subsequently experienced global…
- Trial name
- CROCTX (NCT03903783)
- Testing
- Cefotaxime, Ceftriaxone
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Fondation Hôpital Saint-Joseph