Clinical trials: Antibiotic Resistance, Microbial
Antibiotic Resistant Infection, COVID-19
The Impact of Covid-19 Hospital Care on the Prevalence of MDRO in Indonesia
The effect of the COVID-19 pandemic on the emergence and spread of antibiotic-resistant bacteria is largely unknown, especially in low-resource settings.
- Trial name
- NCT05293483
- Where
- 2 sites in Indonesia
- Volunteers
- 1,110 people
- Sponsor
- Erasmus Medical Center
Multi-antibiotic Resistance
Screening of Multidrug Resistant Bacteria, and the Clinical Implication for the Patient
The goal of this observational study is to evaluate the screening for multidrug resistant bacteria in patients admitted to hospitals in Scania.
- Trial name
- NCT06370299
- Testing
- (exposure of) MDR carriage
- Volunteers
- 10,000 people
- Sponsor
- Region Skane
Infant, Premature, Diseases
Probiotics On Resistant Bacteria Colonization In Preterm Receiving Antibiotics
In this study, the investigators investigated the effect of probiotic use on colonization of resistant microorganisms in newborn preterm infants receiving antibiotics.
- Trial name
- NCT02178267
- Testing
- Lactobacillus reuteri (biogai AB, Sweden)
- Volunteers
- 51 people
- Sponsor
- Baskent University
Patients With Complicated Urinary Tract Infections Caused by P. Aeruginosa, Pseudomonas Aeruginosa
Safety and Efficacy Study of Ftortiazinon in the Treatment of Patients With Complicated Urinary Tract Infections Caused by P. Aeruginosa
This study is planned to evaluate the safety and efficacy of the drug Ftortiazinon in combination with the drug Maxipime® in comparison with placebo in combination with the drug Maxipime® in the treatment of hospitalized adult…
- Conditions
- Patients With Complicated Urinary Tract Infections Caused by P. Aeruginosa, Pseudomonas Aeruginosa, Pseudomonas Infections, Urinary Tract Infections
- Trial name
- NCT03638830
- Testing
- Ftortiazinon (tablets 300 mg) full dose + Maxipim
- Where
- 5 sites in Russia
- Volunteers
- 777 people
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Urinary Tract Infection Complicated, Acute Pyelonephritis
CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria
The purpose of this study is to evaluate the effects of CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) compared to Meropenem for treating hospitalized patients with complicated urinary tract infections, including acute pyelonephritis…
- Trial name
- PLEA (NCT03477422)
- Testing
- CSE-1034 (Ceftriaxone + Sulbactam + EDTA), Meropenem
- Where
- 17 sites in India
- Volunteers
- 230 people
- Sponsor
- Venus Remedies Limited
Urinary Tract Infection
Microbiological Characterization and Antibiotic Resistance Profiling of Providencia Spp,: An Emerging Pathogen Isolated From Urinary Tract Infections
Aims of the Research: 1. Isolation and identification of Providencia spp. from UTIs. 2. Genotypic confirmation of Providencia isolates. 3. Determination of antimicrobial sensitivity patterns of isolated Providencia spp. 4.
- Trial name
- NCT07204769
- Testing
- Antibiotic sensitivity
- Where
- Egypt
- Volunteers
- 241 people
- Sponsor
- Assiut University
Cesarean Section; Infection, Perineal Infection
Effect of Copper on the Healing of Obstetric Wounds
The most common complication of vaginal delivery is perineal tearing with a prevalence of 85% and 70% will need suturing. The caesarean section rate worldwide is rising and the rate in Croydon University Hospital is in the region…
- Conditions
- Cesarean Section; Infection, Perineal Infection, Wound Infection, Surgical Site Infection
- Trial name
- ECHO (NCT03284749)
- Testing
- Copper impregnated wound dressing, Normal wound dressing, Copper impregnated maternity pads
- Where
- United Kingdom
- Volunteers
- 774 people
- Sponsor
- Croydon Health Services NHS Trust
Periodontal Disease, Periodontitis
Antibiotic Resistance Genes in Periodontitis
Antimicrobial resistance (AMR) is a major global public health concern, and the oral microbiome may serve as an important reservoir of antibiotic resistance genes (ARGs).
- Conditions
- Periodontal Disease, Periodontitis, Antibiotic Resistance Genes
- Trial name
- NCT07887204
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Intestinal Bacteria Flora Disturbance
Multi-Antibiotic Resistance Carriage in Gut Flora
Prevalence Study evaluating the acquisition of carriage of multidrug-resistant Gram-negative bacteria (MDRGNB) in the gut flora in volunteers of French Armed Forces staying from 4 to 6 months outside France.
- Trial name
- MARC (NCT01591538)
- Where
- France
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Da Volterra
Infection
Allergy Antibiotics And Microbial Resistance
ALBAMA study is designed to find out if the effects of Penicillin allergy assessment pathway (PAAP) intervention is on penicillin prescribing
- Trial name
- ALABAMA (NCT04108637)
- Testing
- penicillin allergy assessment pathway
- Where
- United Kingdom
- Volunteers
- 823 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Helicobacter Pylori Infection
Rabeprazole Based Sequential-Concommitant Hybrid Therapies for H. Pylori Infections
This prospective controlled randomized open-label clinical trial is designed to determine the optimal eradication rate of rabeprazole based sequential-concommitant hybrid therapies for adults infected with Helicobacter pylori in…
- Trial name
- NCT01566643
- Testing
- RA5-RACM7, RA3-RACM7, RA7-RACM7
- Where
- Taiwan
- Volunteers
- 231 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Antibiotic Resistance, Ocular Surface Microbiome
Antibiotic Resistance In Eye Surgeries
In this study, the investigators seek to determine the effect of antibiotic use post-surgery on antimicrobial resistance. The investigators will be studying adults (aged 18 or older) who will undergo eye surgery at University of…
- Conditions
- Antibiotic Resistance, Ocular Surface Microbiome, Gut Resistome
- Trial name
- ARIES (NCT04750655)
- Testing
- Moxifloxacin (Topical)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Francisco
Hospital Acquired Infections
Clinical Trial to Reduce Antibiotic Resistance in European Intensive Cares
Colonization of patients with Antimicrobial Resistant Bacteria (AMRB) like Methicillin Resistant Staphylococcus Aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE) and Extended-Spectrum Beta-Lactamases (ESBL)…
- Trial name
- MOSAR-ICU (NCT00976638)
- Testing
- Chromogenic surveillance, Molecular surveillance
- Where
- 13 sites in France, Greece and 6 more
- Volunteers
- 14,318 people
- Sponsor
- UMC Utrecht
Gram-negative Bacterial Infections
Surveillance Study - Incidence of Antibiotic Resistance in Serial Gram-negative Bloodstream Isolates
This research is important because it allows for the determination of resistance rates to antibiotics that may not be frequently tested by the clinical microbiology laboratory at University of Pittsburgh Medical Center…
- Trial name
- NCT00394784
- Where
- United States
- Sponsor
- University of Pittsburgh
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
Microbiome
Effect of a Probiotic or Postbiotic on Gut Microbiome During Antibiotic Treatment
This study assesses the effects of a probiotic or postbiotic on gut microbiome during antibiotic treatment.
- Trial name
- POTATO-2 (NCT07594860)
- Testing
- Probiotic, Postbiotic
- Where
- Greece
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Vaccine
Impact of Vaccines on Antimicrobial Microbial Resistance
Vaccination is a potentially critical component of efforts to arrest development and dissemination of antimicrobial resistance (AMR), though little is known about vaccination impact within low-income and middle-income countries.
- Trial name
- IVAR (NCT06450379)
- Where
- Malawi
- Volunteers
- 13,200 people, healthy volunteers welcome
- Sponsor
- Malawi Liverpool Wellcome Programme
Antimicrobial Resistance
A Multicentre Study of Wastewater and Antibiotic Resistance in Care Homes.
This study aims to model the relationship between the prevalence of ESBL-E and CPE carriage among nursing home residents and their respective concentrations in wastewater discharged from the facility.
- Trial name
- E-FLUENT (NCT07234331)
- Where
- 2 sites in France
- Volunteers
- 1,600 people
- Sponsor
- Nantes University Hospital
Pneumonia, Pneumococcal, Community-acquired Pneumonia
Quantitative Polymerase Chain Reaction for Improved Detection of Pneumococci in CAP "CAPTAIN"
The purpose of this study is to evaluate the added diagnostic value of a quantitative polymerase chain reaction targeting the lytA gene in detecting pneumococci in patients with community-acquired pneumonia.
- Trial name
- CAPTAIN (NCT03315403)
- Testing
- LytA targeted quantitative polymerase chain reaction (qPCR)
- Where
- 2 sites in Netherlands
- Volunteers
- 922 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Periodontitis
Long-term Safety of Minocycline in Patients With Gum Disease
This study will look at the safety of using the study medicine for a long time. It will see if the germs get used to the medicine, making it not work as well, if it's used by people with gum disease for a long time.
- Trial name
- NCT00668746
- Testing
- Minocycline HCl microspheres
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- OraPharma