Clinical trials: Antibiotic Resistance
Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection
Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections
Antimicrobial resistance is a major global problem, particularly in hospital-acquired infections (HAIs). Gram-negative bacilli (GNB), including Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, are among the…
- Conditions
- Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection, Severe Infection, Pseudomonas Aeruginosa
- Trial name
- OPTIMISE (NCT05210387)
- Testing
- Duration of therapy
- Where
- 29 sites in Brazil
- Volunteers
- 107 people
- Sponsor
- Hospital Moinhos de Vento
Community Members
Using Social Influencers for Public Health Education on Antibiotic Use and Antimicrobial Resistance
This study aims to compare the effectiveness of health education facilitated by neighborhood food and beauty establishments with that facilitated by clinics in increasing the public's knowledge of antibiotic use and antimicrobial…
- Trial name
- NCT06998576
- Testing
- Animated educational video on antibiotic use
- Where
- Singapore
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Bloodstream Infections, Enterobacteriaceae Infections
ANTIBIOTIC-RESISTANT ENTEROBACTERALES BLOODSTREAM INFECTIONS AND RISK FACTORS IN PATIENTS ADMITTED TO THE INTENSIVE CARE UNIT
In this study, we first aimed to reveal the resistance profile of Enterobacteriales bloodstream infections at our center. We evaluated data from patients with ESBL, colistin, and carbapenem resistance and identified resistance…
- Conditions
- Bloodstream Infections, Enterobacteriaceae Infections, Intensive Care (ICU), Antibiotic Resistant Infection
- Trial name
- NCT07172932
- Where
- Turkey (Türkiye)
- Volunteers
- 314 people
- Sponsor
- Ankara City Hospital Bilkent
Pneumonia, Next-generation Sequencing
Monitoring of Antimicrobial Resistance Based on Metagenomics Analyses in Pneumonia Patients
Monitoring of antimicrobial resistance (AMR) based on metagenomics analyses in pneumonia patients is critical for optimizing clinical diagnosis and treatment and improving clinical prognosis.
- Conditions
- Pneumonia, Next-generation Sequencing, Microbiome, Antimicrobial Resistance
- Trial name
- NCT06566898
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shanghai General Hospital, China
Bacteremia, Sepsis
Rapid Blood Culture Identification Panel in Pediatric Patients in Guatemala
The purpose of this study is to assess the clinical impact of a rapid multiplex PCR blood culture identification panel on time to optimal antimicrobial therapy when compared to conventional microbiological culture methods in…
- Trial name
- NCT05314816
- Testing
- Blood culture identification panel
- Where
- Guatemala
- Volunteers
- 479 people
- Sponsor
- University of Colorado, Denver
Drug Resistance, Microbial, Biomarkers
INterest of the Negative Predictive Value of Integrons in the reduCtion of Large Broad-spectrum anTibiotics Consumption for Urinary Tract infectionS
Urinary tract infections (UTI), mainly driven by Gram-negative bacteria (GNB) are a frequent cause of hospitalization and the second cause of antibiotic prescription after lower respiratory tract infections.
- Conditions
- Drug Resistance, Microbial, Biomarkers, Urinary Tract Infections (UTI's), Antibacterial Agents
- Trial name
- INVICTUS (NCT07675018)
- Testing
- Detection of integrons, Gold standard
- Where
- 7 sites in France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Limoges
MRSA, VRE
Benefits of Universal Glove and Gowning
This study will test if doctors, nurses and other people who take care of patients in hospitals wearing gloves and gown for all contact with patients in an intensive care unit (ICU) will: Decrease the chance of patients getting…
- Trial name
- BUGG (NCT01318213)
- Where
- United States
- Volunteers
- 19,856 people
- Sponsor
- University of Maryland, Baltimore
Bacterial Infections
Effectiveness of Short-Course Versus Standard Antibiotic Therapy in ICU Patients
This study will compare two treatment strategies (standard versus short-course antibiotic therapy) for preventing resistant bacterial infection in patients in the intensive care unit (ICU).
- Trial name
- NCT00410527
- Testing
- Merrem
- Where
- 12 sites in United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Antibiotics
Building a Novel Antibiotic Stewardship Intervention for Nursing Homes
The OASIS Collaborative is an organizational intervention aimed at reducing unnecessary antibiotic use in skilled nursing facilities.
- Trial name
- OASIS (NCT02874872)
- Testing
- OASIS Collaborative
- Volunteers
- 2,942 people
- Sponsor
- University of Wisconsin, Madison
Infection
A Pilot Trial to Determine the Efficacy of Lactobacillus Rhamnosus for Reducing Colonization by Methicillin-resistant Staphylococcus Aureus (MRSA) (PROSE)
The purpose of this study is to investigate the feasibility, safety and efficacy of oral probiotic, Lactobacillus rhamnosus versus oral placebo for reducing colonization by MRSA.
- Trial name
- PROSE (NCT01112995)
- Testing
- Lactobacillus rhamnosus
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Wisconsin, Madison
NAsal MEthicillin-resistant Staphylococcus
NAsal MEthicillin-resistant Staphylococcus (NAMES): a Prospective Study to Assess the Impact of Antibiotic Therapy on Nasal Colonization with Methicillin-resistant Staphylococcus Aureus (MRSA) Inhospitalized Children
Antimicrobial resistance (AMR) is recognized as one of the major threats to global health [1], causing up to 25.000 deaths in the European Union every year, longer hospitalizations and increased healthcare costs.
- Trial name
- NAMES (NCT06872099)
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Malnutrition Severe, Antibiotic Resistance
First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition
Children with severe malnutrition who are admitted sick to hospitals have a high mortality(death rate), usually because of infection.
- Conditions
- Malnutrition Severe, Antibiotic Resistance, Antibiotic Toxicity
- Trial name
- FLACSAM (NCT03174236)
- Testing
- Ceftriaxone, Benzyl penicillin, Metronidazole
- Where
- 8 sites in Kenya, Uganda
- Volunteers
- 2,000 people
- Sponsor
- University of Oxford
Intestinal Multi-drug Resistant Organism Colonization
Further MT for Antibiotic-Resistant Bacterial Colonization
The purpose of this study is to better understand the effectiveness and safety of microbiome therapies (MT) as a treatment for patients with Multidrug Resistant Organism (MDRO) colonization after an infection.
- Trial name
- FAIR (NCT05835206)
- Testing
- Microbiome Therapeutic
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emory University
MRSA - Methicillin Resistant Staphylococcus Aureus Infection
Vascular Surgical Antibiotic Prophylaxis Study (VSAPS 2)
The current recommended antibiotic, Cefazolin, treatment for vascular surgery, provides coverage only for Methicillin-Sensitive Staphylococcus Aureaus (MSSA), other gram-positive bacteria, and some gram-negative bacteria which…
- Trial name
- NCT01612052
- Testing
- Antibiotic Prophylaxis
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Antibiotic Use
Generating Collective Solutions to Reduce Unnecessary Antibiotic Use in Vietnam
The study aims to develop community-based interventions targetting inappropriate antibiotic dispensing and use behaviours in rural Vietnam and has 3 research components.
- Trial name
- NCT04358289
- Testing
- Basic antimicrobial stewardship education, Participatory action research group in commune health center and community, Antimicrobial stewardship program in hospitals
- Where
- Vietnam
- Volunteers
- 3,315 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Increased Drug Resistance, Infectious Diseases
Reducing Inappropriate Antibiotic Prescribing by Primary Care Clinicians
Hypotheses and Specific Aims: The continued emergence of antibiotic-resistance in the outpatient setting underlines the need to responsibly manage antimicrobial prescribing.
- Trial name
- NCT01099943
- Testing
- Intervention: Education, Decision Support Tools
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Multidrug Resistant Bacterial Infection
Antibiotics Resistance Gene in Healthcare Workers
Multidrug resistant bacteria (MDR) pose a threat to the safety of patients worldwide. Drug resistant bacteria are commonly present in hospital environments and can cause infections, often leading to outbreaks within hospitals.
- Trial name
- ARGH (NCT06228248)
- Testing
- metagenomics
- Where
- 8 sites in China
- Volunteers
- 250 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Urinary Tract Infections
Urinary Tract Infection in Pregnancy
to describe the profile of uropathogenic E coli from Egyptian pregnant women with UTIs and a symptomatic bacteriuria. to determine the susceptibility pattern of our local isolated UPEC strains which is essential for optimal…
- Trial name
- NCT04244526
- Testing
- Talking a urine sample
- Volunteers
- 155 people
- Sponsor
- Assiut University
Pneumonia
Phase I Single-blind Clinical Trial to Evaluate the Safety and Local Immune Activation of a Toll-like Receptor 5 Agonist (FLAMOD) Administered by Aerosol
This is a single-blind, randomized, placebo-controlled, dose-escalation phase I monocentric trial assessing a single administration of FLAMOD by aerosol in healthy subjects.
- Trial name
- NEBUFLAG (NCT06681402)
- Testing
- FLAMOD
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Soft Tissue Infections
Placebo Controlled Study of Antibiotic Treatment of Soft Tissue Infection
This study is to determine whether antibiotic therapy is needed for patients with non-life threatening soft tissue infections. Most patients with these soft tissue infections are presently treated with antibiotics.
- Trial name
- NCT00187759
- Testing
- cephalexin
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of California, San Francisco