Clinical trials: Anticoagulant
Obscure Gastrointestinal Bleeding, Iron-Deficiency Anemia
Endoscopic Evaluation for Iron Deficiency Anemia in Patients on Antithrombotic Therapy
This is a single-center, randomized pilot study evaluating the feasibility and safety of two management strategies for patients on antithrombotic therapy who present with obscure gastrointestinal bleeding (OGIB).
- Conditions
- Obscure Gastrointestinal Bleeding, Iron-Deficiency Anemia, Antithrombotic Therapy
- Trial name
- BEACON-IDA (NCT07089030)
- Testing
- Standard endoscopic evaluation, Conservative Medical Management
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
Pulmonary Embolism
Deferment of Imaging for Pulmonary Embolism
Background. Management of patients with suspected Pulmonary Embolism (PE) is problematic if diagnostic imaging is not available.
- Trial name
- NCT00381511
- Testing
- low molecular weight heparin
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico
Direct Oral Anticoagulants (DOACs)
LED Application Following Dental Extraction in Patients Taking Direct Oral Anticoagulants.
The DENT-DOAC trial is a single-blinded RCT investigating the effectiveness of LED application following dental extractions in patients taking direct oral anticoagulants (DOACs) .
- Trial name
- DENT-DOAC (NCT06971081)
- Testing
- LED light
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Pulmonary Embolism
Prophylaxis Against DVTs After Primary Hip and Knee Replacement Surgery
The purpose of this research is to find a better way to prevent the post operative development of clots in the deep veins of the legs (also called Deep Vein Thrombosis or DVT).
- Trial name
- DVT (NCT00767559)
- Testing
- warfarin, Fondaparinux:
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- The New England Baptist Hospital
Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis
DOAC in Unusual Site Venous Thrombosis
Unusual site venous thromboembolism (VTE) refers to thrombosis occurring in venous districts outside the veins of the lower extremities and the pulmonary arteries, and includes splanchnic vein thrombosis (SVT), cerebral vein…
- Conditions
- Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein Thrombosis
- Trial name
- DUST (NCT03778502)
- Testing
- Direct Oral Anticoagulants
- Where
- 24 sites in United States, Canada and 8 more
- Volunteers
- 358 people
- Sponsor
- University of Malta
Traumatic Intracranial Haemorrhage
Timing to Restart Direct Oral Anticoagulants After Traumatic Intracranial Haemorrhage
Older people falling from a standing height is the most common cause of hospital admission for head injury. Up to 1 in 3 patients admitted are taking a tablet medication which thins the blood, known as an oral anticoagulant.
- Trial name
- RESTARTtlCrH (NCT06322953)
- Testing
- Direct-Acting Oral Anticoagulants (used as per local standard practice)
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,084 people
- Sponsor
- Walton Centre NHS Foundation Trust
Thrombosis, Cancer
Safety of Perioperative Anticoagulation Management in People With Active Cancer Undergoing Cancer-Related Surgery or Procedures (ACE-HIGH Study)
The purpose of this study is to help find how safe current practices are when managing blood thinners in people with cancer who are having surgery or medical procedures.
- Conditions
- Thrombosis, Cancer, Thrombosis, Deep Vein, Atrial Fibrillation (AF)
- Trial name
- ACE-HIGH (NCT07372716)
- Testing
- standardized perioperative anticoagulation management Guideline
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Ottawa Hospital Research Institute
Covid19, Venous Thromboembolism
Medically Ill Hospitalized Patients for COVID-19 THrombosis Extended ProphyLaxis With Rivaroxaban ThErapy: The MICHELLE Trial
The Michelle trial is expected to provide high-quality evidence around the role of extended thromboprophylaxis in COVID-19 and will help guide medical decisions in clinical practice.
- Trial name
- MICHELLE (NCT04662684)
- Testing
- Rivaroxaban 10 MG
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- Science Valley Research Institute
Atrial Fibrillation
Real-World Comparative Observational Study in Non-Valvular Atrial Fibrillation Patients Using Oral Anticoagulants
The purpose of this study is to compare the risk of major bleeding event among nonvalvular atrial fibrillation patients treated with warfarin, apixaban, dabigatran and rivaroxaban.
- Trial name
- NCT02754154
- Testing
- Warfarin, Apixaban, Dabigatran
- Volunteers
- 321,182 people
- Sponsor
- Bristol-Myers Squibb
Anticoagulants and Bleeding Disorders
Anticoagulation and Antiplatelet Management During Perioperative Period
the investigators hypothesize that patients do not understand these therapies, and that they are poorly undertaken. In some cases, the anesthesiologist does not understand correctly the indication of the treatment due to lack of…
- Trial name
- OMAHA (NCT03871283)
- Where
- Belgium
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Anticoagulants and Bleeding Disorders, Tissue Adhesion
Safety of Anticoagulant Therapy After Tissue Glue for Gastric Varices
This study aimed to clarify the safety of anticoagulant therapy after glue injection for cirrhotic variceal bleeding patients with portal vein thrombosis.
- Conditions
- Anticoagulants and Bleeding Disorders, Tissue Adhesion, Gastric Varices Bleeding
- Trial name
- NCT05545475
- Testing
- Low molecular weight heparin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Acute Myocardial Infarction, Left Ventricular Thrombosis
Apixaban Versus Warfarin in Patients With Left Ventricular (LV) Thrombus
Patients with acute ST-segment elevation myocardial infarction (STEMI) have an elevated risk of stroke, most of which are cardio-embolic in origin as a result of left ventricular (LV) thrombus formation.
- Conditions
- Acute Myocardial Infarction, Left Ventricular Thrombosis, Anticoagulants and Bleeding Disorders
- Trial name
- NCT03232398
- Testing
- Apixaban Oral Tablet [Eliquis], Warfarin
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Venous Thromboembolism; Deep Vein Thrombosis; Pulmonary Embolism; Anticoagulants
VTE and the Related Factors Associated With Higher Rates of PE After a DVT in Southwestern China
Little is known about the current management status of venous thromboembolism (VTE) in Southwestern China. We aimed to investigate the status of anticoagulant administration in VTE in Southwestern China and assess the potential…
- Trial name
- NCT05464901
- Volunteers
- 500 people
- Sponsor
- Wei Huang
Anticoagulants and Bleeding Disorders
Bleeding Oral Anticoagulant Analyzer (BOA)
The quality of the reversion of these serious hemorrhagic accidents under oral anticoagulants depends on the adequate use of reversion products but also on the speed of obtaining hemostasis data allowing to evaluate the…
- Trial name
- BOA (NCT05026281)
- Testing
- Quantra analyzer
- Where
- 6 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Venous Thromboembolism
WHITE Study: WHIch Decision After a First Venous ThromboEmbolism?
The WHITE study is a multicenter, multinational, investigators-initiated, observational, prospective study conducted in a consecutive series of ambulatory patients who had completed the recommended or practicable period of…
- Trial name
- WHITE (NCT04646993)
- Where
- Czechia
- Volunteers
- 1,200 people
- Sponsor
- Arianna Anticoagulazione Foundation
Hemorrhage, Surgical, Hemorrhage Postoperative
Safe and Timely Antithrombotic Removal - Direct Oral Anticoagulants Apixaban & Rivaroxaban (STAR-D)
Prospective, Multicenter, Double-blind, Randomized, Study to Evaluate DrugSorb-ATR Removal of Apixaban and Rivaroxaban to Reduce Likelihood of Serious Bleeding in Patients Undergoing Urgent Cardiothoracic Surgery
- Conditions
- Hemorrhage, Surgical, Hemorrhage Postoperative, Blood Loss, Surgical, Blood Loss, Postoperative
- Trial name
- STAR-D (NCT05093504)
- Testing
- DrugSorb-ATR system
- Where
- 27 sites in United States
- Volunteers
- 9 people
- Sponsor
- CytoSorbents, Inc
Under Oral Anticoagulation Patients
Evaluation of the Contribution of a Pre-consultation Questionnaire on the Therapeutic Education
To assess the value of a dedicated knowledge questionnaire, filled by the patient prior consultation. Indeed, it could allow to target specific shortcomings of patients first, and help the cardiologist to prioritize the other…
- Trial name
- EDUCONSULT (NCT02907151)
- Testing
- Survey
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Montpellier
Anticoagulant
A Clinical Study to Evaluate the Safety and Pharmacokinetics of CKD-344 in Healthy Volunteers
A Clinical Trial to evaluate the Pharmacokinetics and safety of CKD-344
- Trial name
- NCT04867200
- Testing
- Lixiana(D006), CKD-344
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Atrial Fibrillation
RAPID AFib Decision Aid for Stroke Prevention in Atrial Fibrillation
The goal of this pilot clinical trial is to evaluate the utility of a new electronic patient decision aid for stroke prevention therapy in patients with atrial fibrillation.
- Trial name
- NCT05900414
- Testing
- Electronic patient decision aid, Information
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Antiphospholipid Syndrome in Pregnancy, Anticoagulants
HYDROxychloroquine in Syndrome Primary AntiPhospholipid
Antiphospholipid syndrome (APS) is defined by thrombosis or obstetric complication (≥ 3 spontaneous miscarriages or fetal death or prematurity <34 weeks gestation-related amenorrhea (SA)) associated with antiphospholipid…
- Trial name
- HYDROSAPL (NCT04275778)
- Testing
- Plaquenil 200Mg Tablet
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris