Clinical trials: Anticoagulant Drugs
Whole Blood Donation and Leukoreduction
Clinical Investigation to Evaluate the Hemanext® Oxygen Reduction System - Pivotal Trial
The primary goal of Hemanext. is to improve red cell storage through novel storage methods. Based on our review of the pertinent literature, there is substantial evidence suggesting that prolonged exposure to oxygen during…
- Trial name
- NCT03301779
- Testing
- Hemanext Red Blood Cell Processing System
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hemanext
Healthy
Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of BI 655075 Administered Alone or With Dabigatran Etexilate
The primary objective is to investigate the safety, tolerability and pharmacokinetics of BI 655075 following intravenous administration of single rising doses of BI 655075 when administered alone and after administration of…
- Trial name
- NCT01688830
- Testing
- Dabigatran, BI 655075
- Where
- Belgium
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Atrial Fibrillation, Stroke
IMplementation of an RCT to imProve Treatment With Oral AntiCoagulanTs in Patients With Atrial Fibrillation
The purpose of this study is to use a decentralized claims database to determine whether education on stroke prevention in atrial fibrillation (AF) among AF patients and their providers can result in increased use of oral…
- Trial name
- IMPACT-AFib (NCT03259373)
- Testing
- Early Patient-Level and Provider-Level Educational Intervention, Delayed Provider-Level Educational Intervention
- Where
- 4 sites in United States
- Volunteers
- 64,666 people
- Sponsor
- Harvard Pilgrim Health Care
Anticoagulants and Bleeding Disorders, Gastrointestinal Hemorrhage
Comparison of the Effect of Warfarin and Direct Oral Anticoagulants
In this study, it was aimed to compare the frequency of new oral anticoagulants and warfarin usage, and to reveal the rates of recurrent upper gastrointestinal bleeding among patients who applied to our hospital with upper…
- Trial name
- NCT06269302
- Where
- Turkey (Türkiye)
- Volunteers
- 346 people
- Sponsor
- Samsun Education and Research Hospital
Anticoagulants; Increased, Anticoagulant Overdosage
Noninvasive Measurement of Blood Coagulation
The investigators have developed an optical system that measures the coagulation status of patients in vivo in a non-invasive manner.
- Conditions
- Anticoagulants; Increased, Anticoagulant Overdosage, Coagulation Disorder, Blood Clot
- Trial name
- NCT03217799
- Testing
- Measurement of coagulability of blood
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Valvular Heart Disease
RIvaroxaban for Valvular Heart diseasE and atRial Fibrillation Trial -RIVER Trial
RIvaroxaban for Valvular heart diseasE and atRial fibrillation trial (RIVER trial).
- Trial name
- NCT02303795
- Testing
- Rivaroxaban, Warfarin
- Where
- Brazil
- Volunteers
- 1,005 people
- Sponsor
- Hospital do Coracao
Acquired Coagulation Factor Deficiency
Prothrombin Complex Concentrate for Anticoagulant Reversal
Patients on oral anticoagulants need rapid reversal of the anticoagulant effect in case of acute bleeding or emergency surgery. Prothrombin Complex Concentrates are known to provide a fast reversal of the anticoagulant effect…
- Trial name
- NCT00168077
- Testing
- Prothrombin Complex Concentrate
- Where
- 15 sites in Austria, Germany and 6 more
- Volunteers
- 40 people
- Sponsor
- CSL Behring
Atrial Fibrillation, Venous Thromboembolism
Perioperative Anticoagulant Use for Surgery Evaluation Emergency Registry
Among patients who are receiving long-term anticoagulant therapy, whether with a direct oral anticoagulant (DOAC) or vitamin K antagonist (VKA), approximately 3-5% who require treatment interruption for a surgery will do so in an…
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Arterial Vascular Disease
- Trial name
- PAUSE-ER (NCT04195113)
- Where
- 3 sites in Canada
- Volunteers
- 242 people
- Sponsor
- McMaster University
Assessment of Activity of Anti-Xa Factor in Patients Treated With Continuous Veno-venous Hemodiafiltration Receiving Anticoagulant Prophylaxis
Impact of Continuous Veno-venous Hemodiafiltration on Efficacy of Administration of Prophylactic Doses of Enoxaparin or Fondaparinux in Critically Ill Patients.
Dose of anticoagulant prophylaxis in patients with continuous veno-venous hemodiafiltration may be insufficient to keep anti-Xa factor activity in prophylactic range.
- Trial name
- NCT04671160
- Testing
- Assessment the activity of anti-Xa factor.
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Gdansk
Cardiac Disease
Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombotic Events) in Children at Risk Because of Cardiac Disease
A committee will judge the safety and effectiveness of edoxaban and the regular treatment (standard of care). All children in the study will receive free treatment.
- Trial name
- NCT03395639
- Testing
- Edoxaban, Standard of Care (SOC)
- Where
- 48 sites in United States, Austria and 12 more
- Volunteers
- 168 people
- Sponsor
- Daiichi Sankyo
Atrial Fibrillation
Replication of the ROCKET-AF Anticoagulant Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT04593056
- Testing
- Warfarin, Rivaroxaban
- Where
- United States
- Volunteers
- 102,636 people
- Sponsor
- Brigham and Women's Hospital
Venous Thromboembolism
Long-Term Low-Molecular-Weight Heparin Versus Oral Anticoagulants in Deep Venous Thrombosis
The purpose of this study is to evaluate whether low-molecular-weight heparin could be equally or more effective than oral anticoagulation in the long-term treatment of deep venous thrombosis.
- Trial name
- NCT00689520
- Testing
- tinzaparin, acenocoumarol
- Where
- 2 sites in Spain
- Volunteers
- 241 people
- Sponsor
- Hospital Universitari de Bellvitge
Deep Venous Thrombosis
D-Dimer Guided Oral Anticoagulant Treatment (OAT)
This clinical trial will investigate the hypothesis that D-Dimer testing can be successfully used to tailor the duration of OAT in patients after an unprovoked episode of deep venous thrombosis (DVT) using a prospective…
- Trial name
- DDOAT2006 (NCT00895505)
- Testing
- Phenprocoumon, Warfarin-Natrium
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bonn
Mechanical Aortic and/or Mitral Valve Replacement Operation
Patient International Normalised Ratio (INR) Self-Testing Program
The aims of the study are to prove correlation between laboratory and patient self-testing (PST) measurements, estimation of INR variability within a target therapeutic zone and frequency of hemorrhagic and/or thromboembolic…
- Trial name
- NCT00925197
- Testing
- INR self-testing program
- Volunteers
- 206 people
- Sponsor
- University Hospital, Clermont-Ferrand
Atrial Fibrillation, Frailty
Prospective Monitoring of Non-Vitamin K Oral Anticoagulants in Older Adults With Atrial Fibrillation and Frailty
The objective of this study is to establish a near-real-time prospective monitoring program in Medicare, Optum and MarketScan Research data to evaluate the benefit of new cardiovascular disease (CVD) drugs for older adults with…
- Conditions
- Atrial Fibrillation, Frailty, Anticoagulant-induced Bleeding, Stroke
- Trial name
- NCT04878497
- Testing
- Warfarin, Dabigatran, Rivaroxaban
- Where
- United States
- Volunteers
- 1,000,000 people
- Sponsor
- Brigham and Women's Hospital
Ischemic Stroke, TIA
Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events
Transient ischemic attack (TIA) or minor ischemic stroke has a high risk of early recurrent stroke. As the golden standard, aspirin effect modestly on acute ischemic stroke, and slightly increase the risk of intracerebral…
- Trial name
- TRACE (NCT01923818)
- Testing
- rivaroxaban, Aspirin
- Where
- China
- Volunteers
- 3,700 people
- Sponsor
- Xijing Hospital
Craniocerebral Trauma, Cerebral Hemorrhage
Mild Head Injury, Antiplatelets, and Anticoagulants
Approximately 20% of patients with mild head injury presenting to the Emergency Department (ED) is taking antiplatelet agents and 10% is taking oral anticoagulants.
- Trial name
- NCT04741334
- Testing
- direct anticoagulant, antiplatelet drugs, Dicumarols
- Where
- Italy
- Volunteers
- 2,127 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Atrial Fibrillation
A Study to Learn About the Effects of Medicines That Help in Thinning the Blood in People With Atrial Fibrillation (AF) Between 2016 and 2020 in France
The purpose of this study is to look at how many patients with AF had strokes, major bleeding and death in both people who had and had not taken any oral anticoagulant.
- Trial name
- SIFNOS (NCT05838664)
- Testing
- No OAC, VKA, apixaban
- Where
- France
- Volunteers
- 2,140,403 people
- Sponsor
- Pfizer
Atrial Fibrillation, Anticoagulants
Use of Public Health Surveillance Models in the French National Health System Database
Public health surveillance models, previously used for the ongoing detection of occurrence of rare events, could be used to reinforce existing pharmacovigilance systems.
- Conditions
- Atrial Fibrillation, Anticoagulants, Pharmacoepidemiology
- Trial name
- DABI-SURV (NCT02904499)
- Testing
- Dabigatran
- Where
- France
- Volunteers
- 814,446 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Anticoagulant
A Clinical Study to Evaluate the Safety and Pharmacokinetics of CKD-344
A Clinical Trial to evaluate the Pharmacokinetics and safety of CKD-344
- Trial name
- NCT04673695
- Testing
- Lixiana(D006), CKD-344
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical