Clinical trials: Anticoagulant Drugs
Atrial Fibrillation
The Effectiveness of Interactive Nursing Education Program Through Health Belief Model Based and Informative Technology-assisted on Atrial Fibrillation Patients Receiving Oral Anticoagulant
This study examined patients on taking oral anticoagulants (OACs) are often prescribed for Atrial fibrillation (AFib) to determine the effectiveness of a multiple interactive health education program, which was developed based on…
- Trial name
- NCT05145634
- Testing
- Patient education related oral anticoagulants (OACs)
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Venous Thromboembolism
Treatment Patterns and Bleeding Risk of Anticoagulants in Patients With Venous Thromboembolism in Korea
This study is a retrospective, observational, nationwide population-based cohort study utilizing the South Korea's Health Insurance and Review Assessment Service (HIRA) database.
- Trial name
- NCT05022563
- Testing
- Parenteral anticoagulant, Warfarin, Apixaban
- Where
- 2 sites in South Korea
- Volunteers
- 55,759 people
- Sponsor
- Pfizer
Anticoagulant-induced Bleeding, Warfarin Sodium Causing Adverse Effects in Therapeutic Use
AI-based Social Software to Manage wARfarin Therapy
The investigators have demonstrated that social software could improve warfarin therapy quality by Human management. however,the efficiency of management will decline if patients' number expands huge.
- Trial name
- AI-SMART (NCT03870581)
- Testing
- AI-based social software management model, Human-based social software management model
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Wuhan Asia Heart Hospital
Respiratory Insufficiency, Circulatory Failure
Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support
A three-arm randomized controlled non-inferiority pilot study comparing anticoagulation strategies using unfractionated heparin, argatroban and enoxaparin for extracorporeal membrane oxygenation support conducted as an…
- Conditions
- Respiratory Insufficiency, Circulatory Failure, Thromboembolism, Bleeding
- Trial name
- CASUAL-ECMO (NCT06442267)
- Testing
- Enoxaparin Injectable Solution, Argatroban, 1 Mg/mL Intravenous Solution, Unfractionated heparin
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Thrombosis, Anticoagulant-induced Bleeding
Reversal of the Antithrombotic Action of New Oral Anticoagulants
The main goal of this study is to improve safety and efficiency of clinical practice with the new generation of oral anticoagulants. 1.
- Conditions
- Thrombosis, Anticoagulant-induced Bleeding, Anticoagulant Overdosage, Hemorrhage
- Trial name
- REVANT (NCT01478282)
- Testing
- Rivaroxaban, Dabigatran
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Gines Escolar
Idiopathic Pulmonary Fibrosis
AntiCoagulant Effectiveness in Idiopathic Pulmonary Fibrosis
This study will test the effectiveness of warfarin in patients with IPF. Approximately 256 patients will be randomized 1:1 to either warfarin or placebo.
- Trial name
- ACE-IPF (NCT00957242)
- Testing
- warfarin
- Where
- 22 sites in United States
- Volunteers
- 145 people
- Sponsor
- Duke University
Prevention & Control
Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease
The primary objectives of this study are: To determine whether rivaroxaban 2.5 mg twice daily (bid) + aspirin 100 mg once daily (od) compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction…
- Trial name
- COMPASS (NCT01776424)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Aspirin, Pantoprazole
- Where
- 565 sites in United States, Argentina and 31 more
- Volunteers
- 27,395 people
- Sponsor
- Bayer
Healthy
Evaluation of Pharmacokinetic and Pharmacodynamic Characteristics of Indobufen, an Anticoagulant Agent
This study is designed to evaluate the pharmacokinetic and pharmacodynamic characteristics of indobufen in healthy subjects.
- Trial name
- NCT01232023
- Testing
- Indobufen
- Where
- 2 sites in South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Anticoagulants, Quality of Life
Quality of Life and Efficacy Evaluation of Patient Self-monitoring Their Oral Anticoagulation Therapy
The purpose of this study is to determine whether self-management of oral anticoagulation therapy with warfarin has an effect on patient's quality of life following a specific training program led by pharmacists.
- Conditions
- Anticoagulants, Quality of Life, Drug Monitoring, Pharmacy
- Trial name
- ESCAPE (NCT01033279)
- Testing
- Self-monitoring and adjustment of oral anticoagulation
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Montreal Heart Institute
Anticoagulated Patients
Short-term Interruption Versus Continuous Anticoagulation in Colorectal Polypectomy
This study is designed to find out if it is safe to keep taking blood-thinning medicine during the removal of polyps from the colon or rectum.
- Trial name
- POLYPHEM (NCT07185295)
- Testing
- To maintain anticoagulant therapy during the polypectomy of colorectal lesions
- Where
- 10 sites in Spain
- Volunteers
- 481 people
- Sponsor
- Outcomes'10
Lymphoma, Acute Lymphoblastic Leukemia
A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase
The purpose of this study is to compare the effect of a blood thinning drug called Apixaban versus no administration of a blood thinning drug, in preventing blood clots in children with leukemia or lymphoma.
- Trial name
- NCT02369653
- Testing
- Apixaban, No systemic anticoagulant prophylaxis
- Where
- 96 sites in United States, Australia and 10 more
- Volunteers
- 512 people
- Sponsor
- Bristol-Myers Squibb
Atrial Fibrillation (AF), Stroke (in Patients With Atrial Fibrillation)
DOAC or VKA in Patients With AF and Stroke While on DOAC - a Pilot Trial
People with atrial fibrillation who have a stroke while receiving a DOAC are at increased risk of experiencing another stroke. Physicians do not know the best medication to prevent another stroke in this group of people.
- Trial name
- SWITCH-AF (NCT07011095)
- Testing
- VKA, Direct Oral Anticoagulant (DOAC)
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Respiratory Distress Syndrome, Adult, Extracorporeal Membrane Oxygenation
PGE1 as Additive Anticoagulant in ECMO-Therapy
Bleeding complications and thromboembolic complications are frequent during extracorporeal membrane oxygenation (ECMO). Retrospective data suggest that platelet inhibition using prostaglandins, in this case PGE1, may reduce…
- Trial name
- ECMO_PGE1 (NCT02895373)
- Testing
- Alprostadil, 0.9% sodium chloride solution
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Thomas Staudinger
Healthy Volunteers
A Study of Pharmacokinetics, Safety and Tolerability of Dimolegin (DD217)
In the course of the clinical study, the pharmacokinetics, pharmacodynamics, safety and tolerability of Dimolegin (DD217) 10 mg enteric-coated tablets after single administration to healthy volunteers at increasing doses were…
- Trial name
- NCT05181241
- Testing
- Dimolegin
- Where
- Russia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- PharmaDiall Ltd.
Cardiac Disease
Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombotic Events) in Children at Risk Because of Cardiac Disease
A committee will judge the safety and effectiveness of edoxaban and the regular treatment (standard of care). All children in the study will receive free treatment.
- Trial name
- NCT03395639
- Testing
- Edoxaban, Standard of Care (SOC)
- Where
- 48 sites in United States, Austria and 12 more
- Volunteers
- 168 people
- Sponsor
- Daiichi Sankyo
Aortic Valve Stenosis
Anticoagulant Versus Dual Antiplatelet Therapy for Preventing Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement
This trial is to compare the efficacy of NOAC(Novel Oral Anticoagulants) with edoxaban vs. dual antiplatelet therapy (DAPT) for prevention of leaflet thrombosis (documented by cardiac CT imaging) and cerebral embolization…
- Trial name
- ADAPT-TAVR (NCT03284827)
- Testing
- NOAC, DAPT
- Where
- 5 sites in Hong Kong, South Korea and 1 more
- Volunteers
- 235 people
- Sponsor
- Duk-Woo Park, MD
Correction of Cancer-related Coagulopathy With Novel Oral Anticoagulant (Edoxaban)
Edoxaban for the Treatment of Coagulopathy in Patients With Active Cancer and Acute Ischemic Stroke: a Pilot Study. (ENCHASE Study)
Purpose: Cancer-related hypercoagulability plays an important role in the development of cancer-related stroke. With rapidly aging population and increasing cancer prevalence, cancer related stroke has become an important stroke…
- Trial name
- ENCHASE (NCT03570281)
- Testing
- Edoxaban, Enoxaparin
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Deep Venous Thrombosis
D-Dimer Guided Oral Anticoagulant Treatment (OAT)
This clinical trial will investigate the hypothesis that D-Dimer testing can be successfully used to tailor the duration of OAT in patients after an unprovoked episode of deep venous thrombosis (DVT) using a prospective…
- Trial name
- DDOAT2006 (NCT00895505)
- Testing
- Phenprocoumon, Warfarin-Natrium
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bonn
Myeloma, Venous Thromboembolism
Evaluation of the Use of Apixaban in Prevnetion of Thromboembolic Disease in Patients With Myeloma Trated With iMiDs
To evaluate: the incidence of venous thromboembolic event (VTE) the incidence of hemorrhagic complications, In a population of patients with myeloma who are treated with IMiDs and require thromboprophylaxis for 6 months, using an…
- Trial name
- MYELAXAT (NCT02066454)
- Testing
- Apixaban
- Where
- 19 sites in France
- Volunteers
- 108 people
- Sponsor
- University Hospital, Grenoble
Heart Failure
Risk Factors of Outcomes Associated With Disease Progression in Patients With Atrial Fibrillation and Heart Failure (HF) Who Are Receiving a Direct Oral Anticoagulant (Rivaroxaban)
Evaluation of the risk factors associated with Heart Failure (HF) worsening (measured by hospitalizations and emergency visits because of HF exacerbations) in Spanish patients with Atrial Fibrilation and HF treated with…
- Trial name
- FARAONIC (NCT03455439)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- Spain
- Volunteers
- 552 people
- Sponsor
- Bayer