Clinical trials: Antidepressant
Major Depressive Disorder, Psychedelic Experiences
Antidepressant Response of DMT Masked With Propofol
The aim of this study is to elucidate if the anti-depressive effect of N,N-dimethyltryptamine (DMT) is based on a biological mechanisms including neuroplasticity and anti-inflammatory effect or due to the subjective psychedelic…
- Trial name
- DMT4D (NCT06927076)
- Testing
- N,N-Dimethyltryptamine, Propofol, no sedation
- Where
- Switzerland
- Volunteers
- 112 people
- Sponsor
- University Hospital, Basel, Switzerland
Depression, Anxiety
Evaluation of the Relevance of Pharmacogenetics in the Prescription Off Antidepressants in a Military Population
The treatment of depression, anxiety disorders and post-traumatic stress disorder (PTSD) is a main public health problem due to the frequency of these pathologies and the very partial effectiveness of the existent therapies.
- Conditions
- Depression, Anxiety, Ptsd
- Trial name
- PSYGEN (NCT04987047)
- Testing
- Blood collection, Questionnaires, Cognitive test battery (optional)
- Where
- 4 sites in France
- Volunteers
- 250 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Depression, Bipolar
Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9)
The goal is to study the effect of lithium compared to cariprazine in patients with depression in a bipolar disease. The main question it aims to answer is: Difference in change between the two groups from baseline to after 8…
- Trial name
- DUAG9 (NCT05913947)
- Testing
- Lithium, Cariprazine
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Aalborg University Hospital
Treatment Resistant Depression
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic…
- Trial name
- TRANSCEND (NCT06423430)
- Testing
- Active-stimulation
- Where
- 26 sites in United States
- Volunteers
- 100 people
- Sponsor
- Abbott Medical Devices
Major Depressive Disorder
Functional and Metabolic Changes in the Course of Antidepressive Treatment
The study will investigate functional and metabolic changes in the course of antidepressive treatments. The investigators will apply different imaging methods to investigate the effects of antidepressive interventions on resting…
- Trial name
- NCT02099630
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Depression, Major Depressive Disorder
Nitrous Oxide for the Treatment of Major Depressive Disorder
The investigators are conducting a randomized controlled trial to evaluate the antidepressant effects of nitrous oxide in people with Major Depressive Disorder (MDD).
- Trial name
- NCT03869736
- Testing
- Nitrous Oxide
- Where
- 2 sites in United States, Australia
- Volunteers
- 81 people
- Sponsor
- Bayside Health
Depression
Combination Therapy of Different Antidepressants With Dietary Supplements
The aim of this clinical trial is to compare the effect of antidepressants in combination with different dietary supplements in patients with depression.
- Trial name
- NCT05931965
- Testing
- L-methylfolate, Vitamin B12, magnesium
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- Riphah International University
Major Depressive Disorder
MRI Studies of Emotion in Depression
The purpose of this study is to research the effects of ketamine on brain function in patients with Major Depressive Disorder (MDD).
- Trial name
- NCT02429011
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Antidepressive Agents, Second-Generation
Antidepressants, Emotions and Personality
Neuroticism is a personality trait described as an enduring tendency to experience negative emotional states and to respond poorly to environmental stress.
- Trial name
- NCT01946607
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Major Depressive Disorder
Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy
This study will attempt to use magnetic resonance imaging (MRI) to take a picture of the brain to learn about changes that occur in the brain during Transcranial Magnetic Stimulation (TMS) in people receiving this treatment for…
- Trial name
- INSCAPE (NCT06043401)
- Testing
- Neuroimaging with Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Depression
Evaluation of Depression Symptoms and Brain Activity Associated With Response to Treatment of Depression
This study will use measurements of depression symptoms and brain activity to determine what factors may influence an individual's response to treatment for depression.
- Trial name
- NCT00200902
- Testing
- Venlafaxine (Effexor), Duloxetine (Cymbalta), Escitalopram (Lexapro), Interpersonal Clinical Interaction (ICI)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of California, Los Angeles
Depression
Org 24448 to Treat Major Depression
This study will evaluate the effectiveness of the experimental drug, Org 24448, for short-term treatment of depression. It will examine the effects of the drug on symptoms, such as low mood and persistent sadness, poor sleep and…
- Trial name
- NCT00113022
- Testing
- Org 24448
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression
AZD6765 for Treatment Resistant Depression
The purpose of this study is to determine whether treatment with AZD6765 will have an antidepressant effect with patients who have treatment resistant depression.
- Trial name
- NCT00491686
- Testing
- AZD6765
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- AstraZeneca
Schizophrenia
Trial for Antidepressant Treatment for Negative Symptom of Schizophrenia With NRG1 Risk Genotype
The project is a double-blind, randomized, placebo controlled clinical trial comparing 3 groups of schizophrenic subjects, who have no less than moderate degree of negative symptoms and carry the homozygous risk genotype (TT) of…
- Trial name
- TANESN (NCT01078870)
- Testing
- Lexapro, Cymbalta
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- National Taiwan University Hospital
Intoxication by Drug
Hemadsorption to Enhance Drug Elimination in Intoxications
In this trial the investigators assess the effectiveness of applying a hemadsorber (cytosorb®) in removing benzodiazepines or tricyclic antidepressants in intoxicated patients admitted to ICU with prolonged impaired…
- Trial name
- MATRIX (NCT06922786)
- Testing
- Hemadsorption filter
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- Universitair Ziekenhuis Brussel
Major Depressive Episode
A Study of Ketamine as an Antidepressant
Recently, interest has emerged in the use of ketamine as an antidepressant. Recent placebo-controlled clinical trials administering a single dose and an open label trial giving repeated doses shown that ketamine is markedly…
- Trial name
- NCT01441505
- Testing
- Ketamine
- Where
- Australia
- Volunteers
- 42 people
- Sponsor
- The University of New South Wales
Bipolar Disorder
Treatment Study of Bipolar Depression
The purpose of this study is to determine whether a single intravenous administration of an N-methyl-D-aspartate antagonist is safe and effective for the acute treatment of bipolar depression.
- Trial name
- NCT00947791
- Testing
- ketamine, midazolam
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Depression
Study to Evaluate the Effectiveness of Certain Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressants During Pregnancy and Evaluate Newborn Outcomes
The purpose of this study is to evaluate if during pregnancy, a common group of antidepressant medications (SSRI's) adequately treats the symptoms of depression and to evaluate if there are any effects of these medications on the…
- Trial name
- NCT00553917
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Indiana University
Interactive Voice Response (IVR)
Treatment Follow-up Study
This study will assess the effectiveness of a medication safety monitoring method utilizing interactive voice response technology for youth recently prescribed anti-depressant medication.
- Trial name
- PhaST (NCT00995696)
- Testing
- PhaST IVR Calls
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Depression
Clinical Trial of Memantine for Major Depression
The purpose of this study is to determine the safety and effectiveness of the drug memantine for treating major depression. Major depression is a serious public health concern that contributes to significant morbidity and…
- Trial name
- NCT00040261
- Testing
- Memantine HCL
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Institute of Mental Health (NIMH)