Clinical trials: Antiemetic Therapy
Parkinson's Disease
Safety/Efficacy of Tigan® to Control Nausea/Vomiting Experienced During Apokyn® Initiation and Treatment
The purposes of the study are to determine: i. To assess the efficacy of Tigan® (trimethobenzamide) in preventing nausea and vomiting when initiating therapy with Apokyn® (apomorphine) ii.
- Trial name
- NCT00489255
- Testing
- Tigan®
- Where
- 27 sites in United States
- Volunteers
- 117 people
- Sponsor
- Ipsen
Nausea, Vomiting
Protreat-Trial: Prophylactic Antiemetic Treatment of Opioid-induced Nausea and Vomiting (OINV) in Palliative Care
Palliative cancer patients with tumor pain often suffer from nausea and vomiting when starting pain therapy with opioids. The objective of the clinical pilot trial is to evaluate the efficacy and tolerability of palonosetron in…
- Conditions
- Nausea, Vomiting, Pain, Advanced Cancer
- Trial name
- ProTreat (NCT05315999)
- Testing
- Palonosetron Hydrochloride
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Gerhild Becker
Chemotherapy Induced Vomiting, Acute Myeloid Leukemia
Study to Evaluate the Effect of Aprepitant in Children and Adolescents Receiving AML Remission Induction Chemotherapy
The purpose of the study is to find out the efficacy of an anti-emetic drug, Aprepitant as an add-on therapy to prevent vomiting in children and adolescents receiving chemotherapy for leukemia (AML).
- Trial name
- NCT02979548
- Testing
- Aprepitant, Ondansetron, Metoclopramide
- Where
- India
- Volunteers
- 116 people
- Sponsor
- Dr Atul Sharma
Laparoscopic Surgery, Pediatrics
Effect of Palonosetron, Ondansetron and Dexamethasone in the Prevention of Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is an important outcome for the patient; patients generally rate PONV as worse than postoperative pain.
- Conditions
- Laparoscopic Surgery, Pediatrics, Nausea and Vomiting, Postoperative, Antiemetics
- Trial name
- NCT05439798
- Testing
- Ondansetron+Dexamethasone, Palonosetron+Dexamethasone, Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Selcuk University
Cancer of the Cervix
Oral Ondansetron Versus Transdermal Granisetron (Sancuso) for Women With Cervical, Endometrial or Vaginal Cancer Receiving Pelvic Chemoradiation
The goal of this clinical research study is to compare granisetron (when given through a patch) to ondansetron (when taken by mouth) for reducing nausea and vomiting in women with cervical, endometrial, or vaginal cancer having…
- Trial name
- NCT01536392
- Testing
- Granisetron, Ondansetron, Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- M.D. Anderson Cancer Center
Mammary Cancer, PONV
Comparison of Dexamethasone Alone vs in Combination With Pericardium 6 (P6) Electrical Stimulation or Granisetron in the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Breast Cancer Surgery
Breast cancer is one of the three most common cancers worldwide, and the primary treatment method is surgery.Since most patients are non-smokers who use opioids in the postoperative period, which are known risk factors for…
- Trial name
- P6 and PONV (NCT05408676)
- Testing
- electric stimulation therapy
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Fudan University
Non Small Cell Lung Carcinoma, Metastatic Breast Cancer
Non-Interventional Study With Vinorelbine ORAL in Advanced Non-Small Cell Lung Carcinoma(NSCLC) and Metastatic Breast Cancer (MBC)
The purpose of this non-interventional study is to collect data on efficacy and toxicity of the use of Navelbine ORAL in daily routine in Germany (especially after availability of an 80mg capsule).
- Trial name
- NCT00890903
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Pierre Fabre Pharma GmbH
Nausea and Vomiting Post-foregut Surgery
Reletex Versus Standard of Care Therapy for Post-Operative Nausea Control in Patients Undergoing Foregut Surgery
The effect a ReletexTM device has on postoperative nausea and vomiting when used with ondansetron after foregut surgery will be studied.
- Trial name
- Reletex (NCT01510379)
- Testing
- Reletex, IV ondansetron 4 mg q 6 hours for a total of 4 doses, IV promethazine 25 mg q 6 hours prn
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Kyle A Perry
Nausea, Vomiting
A Study to Assess the Anti-Emetic Efficacy of Ginger in Children and Adolescents Receiving Chemotherapy
Ginger root powder is found to be significantly effective,when given as an add-on therapy in reducing chemotherapy induced nausea and vomiting in children and adolescents receiving chemotherapy.
- Trial name
- NCT00940368
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Postoperative Nausea and Vomiting (PONV)
Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients
The proposed randomized clinical trial aims to test and compare the efficacy of chewing gum vs. Intravenous antiemetic ondansetron as rescue treatment for post-operative nausea and vomiting (PONV) among Lebanese female patients…
- Trial name
- NCT07201883
- Testing
- Ondansetron (Zofran), chewing gum, Ondansetron + Chewing gum
- Where
- Lebanon
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
Chemotherapy-induced Nausea and Vomiting
Effectiveness of Laserpuncture and Standard Antiemetic on RINVR Scores in Adolescent Patients Undergoing Chemotherapy
Chemotherapy is a common treatment for treating cancer. Chemotherapy induced nausea and vomiting (CINV) is nausea and vomiting that occurs after chemotherapy.
- Trial name
- NCT06121414
- Testing
- laserpuncture
- Where
- 2 sites in Indonesia
- Volunteers
- 58 people
- Sponsor
- Universitas Indonesia
HIV Infections
Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy
This substudy is an open-label, randomised study comparing the uptake of recombinant interleukin-2 (rIL-2) in HIV-1 infected individuals receiving different combinations of antiemetics and analgesic agents during rIL-2 dosing in…
- Trial name
- NCT00147355
- Testing
- ondansetron, ibuprofen, paracetamol, metoclopramide, ibuprofen, paracetamol, Metoclopramide, codeine phosphate, ibuprofen, paracetamol
- Where
- 16 sites in Argentina, Australia and 1 more
- Volunteers
- 28 people
- Sponsor
- Kirby Institute