Clinical trials: Antimicrobial Agent
Wounds
A Clinical Study of An Antimicrobial Gauze Dressing
The purpose of this study is to determine if a new antimicrobial gauze dressing is better than the current method of dressing open wounds with plain sterile gauze.
- Trial name
- NCT00203489
- Testing
- KERLIX A.M.D. Gauze
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Tyco Healthcare Group
Infectious Diseases, Antimicrobial Drug Resistance
A Phase 1 Study of the Safety and Tolerability of Single and Multiple Ascending Doses of BWC0977 in Healthy Volunteers
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of single and multiple intravenous doses of BWC0977 when administered to healthy adult volunteers.
- Trial name
- NCT07029932
- Testing
- BWC0977
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bugworks Research Inc.
Dialysis Catheter Infections
Efficacy Study to Evaluate B-Lock™ as an Antimicrobial Lock Solution in Dialysis Patients With a CVC
Hypothesis: B-Lock is a safe and effective catheter lock solution that will maintain catheter patency and reduce Central Line Associated Blood Stream Infections (CLABSI) in dialysis patients using a central venous catheter (CVC)…
- Trial name
- NCT01989091
- Testing
- B-Lock, Heparin 5,000 U/mL
- Where
- 21 sites in Hungary, Poland
- Volunteers
- 270 people
- Sponsor
- Great Lakes Pharmaceuticals Inc.
Diabetic Foot Infection
Nu-3 Gel for Infected Diabetic Foot Ulcers
The goal of this clinical trial is to test a topical drug in patients with mild infections of their diabetic foot ulcer. The main questions it aims to answer are: What strength does the drug need to be in order to make the…
- Trial name
- NCT06020235
- Testing
- 5% Nu-3 gel, 10% Nu-3 gel
- Volunteers
- 60 people
- Sponsor
- Lakewood-Amedex Inc
Infection Secondary to Surgical Procedure
Antimicrobial Efficacy of ALT005 Ophthalmic Prep Solution in Healthy Volunteers
This is an open-label, randomized, single-dose, placebo-controlled efficacy study to assess the antimicrobial efficacy of ALT005 ophthalmic prep solution following dermal administration in healthy volunteers.
- Trial name
- NCT01531699
- Testing
- ALT005 Ophthalmic Prep Solution, saline control, Betadine ophthalmic prep solution
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Altacor Ltd.
Pressure Ulcers, Venous Ulcers
Prospective PuraPly™ AM Case Series Study
The PuraPly AM case series is a prospective, observational study for patients who have received PuraPly AM which consists of a collagen sheet coated with polyhexamethylene biguanide hydrochloride (PHMB) and is intended for the…
- Conditions
- Pressure Ulcers, Venous Ulcers, Diabetic Ulcers, Surgical Wounds
- Trial name
- NCT03070925
- Testing
- PuraPly™ Antimicrobial Wound Matrix
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Organogenesis
Cervical Caries
Nobio Antimicrobial Particles Effect in a Split Mouth Model
The study purpose is to evaluate the antimicrobial effect of Nobio particles incorporated within Novidia Dental Bonding and Flowable Composite versus standard of care within a split mouth model.The study population will include…
- Trial name
- NCT03501784
- Testing
- Nobio particles incorporated within Novidia Dental Bonding, Filtek bond and flow composite
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Nobio Ltd.
Microbial Colonization
Evaluation of the Antimicrobial Effectiveness of CHG/IPA
This single site study is a randomized, controlled, partially-blinded design enrolling a minimum of 516 healthy volunteers, where each subject will receive two of the planned study products on the product application sites of the…
- Trial name
- NCT04035161
- Testing
- Investigational Product, Reference Standard, Active Comparator
- Where
- Romania
- Volunteers
- 1,935 people, healthy volunteers welcome
- Sponsor
- Becton, Dickinson and Company
Helicobacter Pylori Infection
Evaluation of SQ109 Plus PPI in Urea Breath Test-Positive Volunteers
Helicobacter pylori infection of the gastric epithelium is the most common bacterial infection worldwide. Its global prevalence is estimated at 50%, though the burden falls disproportionately on the developing world, where the…
- Trial name
- NCT01252108
- Testing
- SQ109
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sequella, Inc.
Bacterial Recovery of Skin Flora Post-product Application
In Vivo Preoperative Skin Preparation Persistence Evaluation
Evaluate persistent antimicrobial effectiveness of chlorhexidine gluconate containing products on abdominal and inguinal sites following a saline and wipe challenge.
- Trial name
- NCT03155178
- Testing
- 3M CHG/IPA Prep, ChloraPrep
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Blood Stream Infection, Blood Stream Infections
Evaluation of Diagnostic Accuracy and Clinical Performance of the UllCORE Bloodstream Infection (BSI) Test
This study is designed to evaluate the clinical performance of the UllCORE Bloodstream Infection (BSI) Test, an investigational molecular diagnostic test intended to detect microorganisms and selected antimicrobial resistance…
- Conditions
- Blood Stream Infection, Blood Stream Infections, Sepsis, Fungemia
- Trial name
- B-RAPID (NCT07859852)
- Testing
- UllCORE BSI Test
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 1,500 people
- Sponsor
- Deepull Diagnostics S.L.
Chronic Wound
Evaluating Wound Healing With Next Science Gel & Wash.
This is a 12-week, single-site, open-label prospective study in adult with a chronic wound diagnosis. Subjects will be randomized in equal numbers to either the control treatment arm, antimicrobial control treatment arm, or Next…
- Trial name
- NCT03738579
- Testing
- Next Science Group, Control Group, Antibacterial Control Group
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Next Science TM
Hand Hygiene Effectiveness
Evaluation of Two Hand Hygiene Products in ICUs
This study will evaluate the immediate antimicrobial efficacy and persistence of two hand hygiene products on ICU Health Care Worker's skin flora by measuring bacterial organisms on hands using the hand print method.
- Trial name
- NCT02258412
- Testing
- hand antiseptic with CHG and alcohol, Alcohol hand sanitizer foam
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Ventral Hernia, Incisional Hernia
Antimicrobial Hernia Repair Device Clinical Study
This prospective clinical study will evaluate the safety and efficacy of the Cook® Antimicrobial Hernia Repair Device containing an antimicrobial to reinforce soft tissue during ventral or incisional hernia repair in…
- Trial name
- AMEX (NCT02401334)
- Testing
- Cook® Antimicrobial Hernia Repair Device
- Where
- 4 sites in Canada, United Kingdom
- Volunteers
- 24 people
- Sponsor
- Cook Group Incorporated
Surgery
Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Volunteers
Evaluate the effects of Chlorhexidine Gluconate (CHG) cloth on the reduction of bacteria on the skin.
- Trial name
- NCT02526667
- Testing
- Chlorhexidine gluconate, DynaHex-2, Vehicle
- Where
- Romania
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Surgery
Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects
Evaluate the effects of Chlorhexidine Gluconate (CHG) cloth on the reduction of bacteria on the skin.
- Trial name
- NCT02222896
- Testing
- Chlorhexidine Gluconate, Vehicle, DynaHex-2
- Where
- United States
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Febrile Neutropenia
Observational Non-Interventional Study Of Febrile Neutropenia Patients To Evaluate Antibacterial Therapeutical Options
The purpose of this study was to define and classify antibacterial agents used in Turkey for patients with febrile neutropenia.
- Trial name
- NCT00945555
- Testing
- Antibacterial agent for the treatment of febrile neutropenia
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 264 people
- Sponsor
- Pfizer
Wound Healing, Wound Infection
Efficacy Study of a Bioelectric Dressing to Treat Wounds Caused by Curettage and Electrodesiccation
The purpose of this study is to determine whether a bioelectric wound dressing, a silver-coated dressing, or a silver-foam dressing are effective in the treatment of wounds resulting from curettage and electrodesiccation of skin…
- Trial name
- NCT01004055
- Testing
- Procellera™ Antimicrobial Wound Dressing, ACTICOAT™ Antimicrobial Barrier Dressing, Mepilex® Ag Silver Foam Dressing
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Vomaris Innovations
Urinary Tract Infection Bacterial
Bacteriophage Therapy in Patients With Urinary Tract Infections
This is a phase I/II trial designed to evaluate bacteriophage therapy in patients with urinary tract infections.
- Trial name
- NCT04287478
- Testing
- Bacteriophage Therapy
- Where
- 8 sites in United States
- Volunteers
- 1 people
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Venous Leg Ulcer
Suprasorb®X+PHMB Pro vs Suprasorb®X+PHMB in Treatment of Infected Venous Leg Ulcers
This clinical investigation will be conducted as a multicentre, open-label, randomised in parallel groups, controlled study on patients with infected venous leg ulcers.
- Trial name
- NCT07211243
- Testing
- PHMB-impregnated biocellulose wound dressing with additional polyethylene film on top, compression therapy, systemic antomicrobial therapy (optional), PHMB-impregnated biocellulose wound dressing without additional polyethylene film on top, compression therapy, systemic antomicrobial therapy (optional)
- Where
- 9 sites in Poland
- Volunteers
- 150 people
- Sponsor
- Lohmann & Rauscher