Clinical trials: Antimicrobial Agent
Healthy
Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics
Evaluate effect of application procedure on efficacy of 2 antiseptics for cleaning skin prior to surgery.
- Trial name
- NCT00692484
- Testing
- Chlorhexidine gluconate, Povidone iodine
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- C. R. Bard
Pressure Ulcer, Venous Ulcer
PuraPly™ Antimicrobial Wound Matrix and Wound Management
The PuraPly Antimicrobial Wound Matrix (PuraPly AM) case series is a prospective, observational study for patients who have received PuraPly AM which consists of a collagen sheet coated with polyhexamethylenbiguanide…
- Conditions
- Pressure Ulcer, Venous Ulcer, Diabetic Ulcer, Surgical Wound
- Trial name
- PuraPlyAM (NCT03070938)
- Testing
- PuraPly™ Antimicrobial Wound Matrix
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Organogenesis
Skin and Soft Tissue Infections, Abscess
The Effect of Irrisept for Irrigation of Skin and Soft Tissue Infections (Irrisept USF Study)
The purpose of this study was to determine whether Irrisept can effectively prevent the progression of skin and soft tissue infections (SSTIs) as compared to treatment by the current Standard of Care.
- Trial name
- NCT01076049
- Testing
- Standard of Care (SoC), Irrisept Delivery System
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Irrimax Corporation
Healthy
Antimicrobial Efficacy of 2% CHG (Chlorhexidine Gluconate)
Pilot study to evaluate and compare activity of preoperative preparation with comparator
- Trial name
- NCT02530541
- Testing
- CHG
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Breast Cancer
Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
The purpose of this randomized Phase III study is to determine whether preoperative focused microwave heat treatment and chemotherapy combined are more effective than preoperative chemotherapy alone in the treatment of large…
- Trial name
- Medifocus301 (NCT01204801)
- Testing
- Focused Microwave Thermotherapy, Chemotherapy (control)
- Where
- 2 sites in United States, Canada
- Volunteers
- 238 people
- Sponsor
- Medifocus, Inc.
Urinary Tract Infections
Diagnosis, Antibiotic Prescribing Practices and Outcomes of cUTI in an Outpatient Setting
This prospective, multicenter, comparative cohort observational study is to determine if Guidance® UTI pathway compared to traditional diagnostic pathways reduces the rates of empiric antibiotic therapy, adverse events, and…
- Trial name
- NCT05091931
- Where
- 2 sites in United States
- Volunteers
- 3,308 people
- Sponsor
- Pathnostics
Acute Wounds
Efficacy Study of a New Antimicrobial Wound Dressing to Treat Wounds Caused by Curettage and Electrodesiccation
The purpose of this pilot clinical study is to compare healing rates, pain levels, and incidence of wound complications including infection with the use of a moist PROCELLERA™ Antimicrobial Wound Dressing when compared to a…
- Trial name
- NCT00816101
- Testing
- Procellera™ Antimicrobial Dressing, Mepilex® Border Lite, Adhesive Bandage
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Vomaris Innovations
Surgery
Preoperative CHG Cloth on Healthy Subjects
Evaluate the effects of CHG cloth on the reduction of bacteria on the skin.
- Trial name
- NCT02291601
- Testing
- Chlorhexidine Gluconate, Vehicle, DynaHex-2
- Where
- United States
- Volunteers
- 879 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Topical Antisepsis
Preoperative Skin Preparation Evaluation
Determine the antimicrobial properties of a proposed new product and an already approved product and a placebo (no drug). Study will be conducted using methods dictated by the FDA.
- Trial name
- NCT00636480
- Testing
- Chlorhexidine gluconate, ChloraPrep One Step, Sterile saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- C. R. Bard
Infections, Bacterial
To Evaluate Plasma and Pulmonary Pharmacokinetics of GSK2140944
Antimicrobial penetration can be assessed through evaluation of antimicrobial concentrations in various lung compartments, including bronchial mucosal tissue, epithelial lining fluid (ELF), and alveolar macrophages (AM).
- Trial name
- NCT01934205
- Testing
- GSK2140944 (Single dose), GSK2140944 (Multiple dose)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gingivitis, Dental Plaque Accumulation
6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health
The goal of this clinical trial is to evaluate the clinical efficacy of an antimicrobial mouthrinse, with a particular focus on its effect on established plaque and the improvement of gum health.
- Trial name
- NCT07414173
- Testing
- Test Mouthrinse, Control Mouthrinse
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
End Stage Renal Disease (ESRD)
Bayston Multicenter Antimicrobial PD Catheter Safety Study
The study was designed to establish the safety of the Bayston Antimicrobial PD catheter that is impregnated with a "cocktail" of three well known anti-microbials
- Trial name
- Bayston (NCT02274896)
- Testing
- PD Catheter group
- Where
- 5 sites in Belgium, Netherlands and 1 more
- Sponsor
- Medical Components, Inc dba MedComp
Acne
Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial Acne
The purpose of the study is to determine the development of microbial resistance when using one of two topical acne therapies for the treatment of facial acne vulgaris.
- Trial name
- NCT00841776
- Testing
- Duac, Ziana gel
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Stiefel, a GSK Company
Chronic Leg Ulcers, Wound Healing
Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers
Some leg ulcers do not seem to respond that well to the standard treatments that we currently use. One reason for this may be that there are high levels of bacteria in the ulcer which may be slowing down the rate of healing.
- Trial name
- NCT00825760
- Testing
- Topical PPA904 gel and light
- Where
- 4 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- Photopharmica
Bacterial Overgrowth
Clinical Evaluation of the Residual Antimicrobial Activity
The purpose of this study is to evaluate the residual antimicrobial efficacy of one test product as defined by the difference between the number of a challenge bacterial species recovered following exposure to the test product…
- Trial name
- NCT04495920
- Testing
- CGB-S-100
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- CAGE Bio Inc.
Antibiotic-Associated Diarrhea
Effect of a Fresh Fermented Dairy Drink Product Consumption on Antibiotic Associated Diarrhea and Gastro-Intestinal Disorders
The purpose of this clinical study is to evaluate the effect of a four-week consumption of a fresh fermented dairy drink containing probiotic strains on Antibiotic-Associated Diarrhea and Gastro-Intestinal disorders in adult…
- Trial name
- NCT02900196
- Testing
- 1 - Fermented dairy drink, 2 - Acidified dairy drink
- Where
- Germany
- Volunteers
- 136 people
- Sponsor
- Danone Global Research & Innovation Center
Bacterial Infections
New Antibiotic to Treat Pediatric Patients With Infections Due to a Specific Bacteria (Vancomycin-Resistant Enterococcus)
This study will treat pediatric patients who have infections that are due to a specific bacteria (Vancomycin-Resistant Enterococcus)
- Trial name
- NCT00035854
- Testing
- Zyvox® / Linezolid
- Where
- 21 sites in United States
- Volunteers
- 13 people
- Sponsor
- Pfizer
Healthcare Associated Infection
Controlled Crossover Study of AIONX Antimicrobial Surface for the Prevention of Healthcare-associated Infections
This is a controlled open label efficacy study of Aionx antimicrobial surface for the prevention of healthcare-associated infections.
- Trial name
- NCT03189043
- Testing
- Antimicrobial Surface
- Volunteers
- 10,000 people
- Sponsor
- Aionx, Inc.
Hematopoietic Stem Cell Transplantation, Bacterial Infections and Mycoses
Safety of a Single Dose of 5 mg of hLF1-11 Given to Autologous Haematopoietic Stem Cell Transplant Recipients
The safety and tolerability of hLF 1-11 has to be established first in HSCT recipients who are at risk of developing, but have not yet developed, infectious complications due to invasive fungal disease.
- Trial name
- NCT00509938
- Testing
- human lactoferrin peptide 1-11
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- AM-Pharma
Healthy Participants
An Investigational Study of Experimental Medication BMS-986278 Given With the Antibiotic Rifampin in Healthy Participants
The purpose of this study is to investigate the effects of experimental medication BMS-986278 given with the antibiotic Rifampin in healthy participants.
- Trial name
- NCT03712540
- Testing
- BMS-986278, Rifampin
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb