Clinical trials: Antimicrobial Agent
Preoperative Skin Preparation
Evaluation of the Antimicrobial Effectiveness of an Antimicrobial Cloth
Healthy volunteers will receive treatment to two body locations with the investigational product and placebo and the antimicrobial effectiveness of each treatment will be measured.
- Trial name
- NCT03229759
- Testing
- Octenidine Dihydrocloride in aqueous solution, Vehicle Control, Saline Control
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Becton, Dickinson and Company
Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE
A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)
This was a Phase 3 study containing a randomized open-label superiority cohort (Cohort 1) comparing the efficacy and safety of plazomicin with colistin when combined with a second antibiotic (either meropenem or tigecycline) in…
- Conditions
- Bloodstream Infections (BSI) Due to CRE, Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE, Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE, Complicated Urinary Tract Infection (cUTI) Due to CRE
- Trial name
- CARE (NCT01970371)
- Testing
- plazomicin, colistin, meropenem
- Volunteers
- 69 people
- Sponsor
- Achaogen, Inc.
Surgical Skin Preparation
In-vivo Efficacy of Patient Preoperative Prep
The objective of the study is to demonstrate the antimicrobial efficacy of the ZP Preoperative Prep on skin flora of the abdomen and inguinal regions of human subjects.
- Trial name
- NCT02831998
- Testing
- ZuraPrep, ChloraPrep, ZP Vehicle
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Zurex Pharma, Inc.
Complicated Urinary Tract Infection
Safety and Efficacy of IV CXA-101 and IV Ceftazidime in Patients With Complicated Urinary Tract Infections
The purpose of this study is to evaluate the safety and efficacy of intravenous CXA 101 and comparator in complicated urinary tract infection
- Trial name
- NCT00921024
- Testing
- CXA-101, Ceftazidime
- Where
- 21 sites in United States, Germany and 1 more
- Volunteers
- 129 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Malignant Wounds
A Prospective, Open, Non-controlled Clinical Investigation to Evaluate the Performance and Safety of an Antimicrobial Foam Transferring Dressing in Patients With Malignant Wounds
This is a prospective, open, non-controlled clinical investigation to evaluate the performance and safety of using Mepilex Transfer Ag on a malignant wound.
- Trial name
- NCT02431741
- Testing
- Mepilex Transfer Ag
- Where
- 2 sites in Czechia
- Volunteers
- 14 people
- Sponsor
- Molnlycke Health Care AB
Diffuse, Large B-Cell, Lymphoma, Follicular Lymphoma, Grade 3b
Denintuzumab Mafodotin (SGN-CD19A) Combined With RCHOP or RCHP Versus RCHOP Alone in Diffuse Large B-Cell Lymphoma or Follicular Lymphoma
This is a Phase 2 study to evaluate the combination of denintuzumab mafodotin in combination with RCHOP or RCHP compared with RCHOP alone as front-line therapy in patients with diffuse large B-cell lymphoma or follicular lymphoma…
- Conditions
- Diffuse, Large B-Cell, Lymphoma, Follicular Lymphoma, Grade 3b, Transformed Lymphoma / DLBCL
- Trial name
- NCT02855359
- Testing
- denintuzumab mafodotin, rituximab, cyclophosphamide
- Where
- 35 sites in United States, Puerto Rico
- Volunteers
- 24 people
- Sponsor
- Seagen Inc.
Burns
Evaluation of Antimicrobial Soft Silicone, Silver Containing, Foam Dressing, Mepilex Border Ag, in Second Degree Burns
The investigation is designed as an open, non-controlled, post-marketing investigation. Subjects with at least one second degree burn less than 9.5x15 cm in size at 1-3 sites will be included.
- Trial name
- NCT01418482
- Testing
- Mepilex Border Ag
- Where
- 2 sites in Sweden
- Volunteers
- 15 people
- Sponsor
- Molnlycke Health Care AB
Central Venous Catheter Exit Site Infection, Catheter-Related Infections
Comparing CHG I.V. Securement Dressing With Transparent Dressing for Evaluation of Antimicrobial Efficacy
This is a single-center, prospective, randomized controlled clinical trial designed to compare the antimicrobial efficacy of Tegaderm CHG I.V.
- Trial name
- NCT04906512
- Testing
- 3M™ Tegaderm™ CHG I.V. Securement Dressing, 3M™ Tegaderm™ Transparent Film Dressing 1626W
- Where
- China
- Volunteers
- 123 people
- Sponsor
- Solventum US LLC
Microbial Colonization
Evaluation of the Antimicrobial Effectiveness of CHG/IPA
This single site study is a randomized, controlled, partially-blinded design enrolling a minimum of 516 healthy volunteers, where each subject will receive two of the planned study products on the product application sites of the…
- Trial name
- NCT04035161
- Testing
- Investigational Product, Reference Standard, Active Comparator
- Where
- Romania
- Volunteers
- 1,935 people, healthy volunteers welcome
- Sponsor
- Becton, Dickinson and Company
Bacterial Recovery of Skin Flora Post-product Application
In Vivo Preoperative Skin Preparation Persistence Evaluation
Evaluate persistent antimicrobial effectiveness of chlorhexidine gluconate containing products on abdominal and inguinal sites following a saline and wipe challenge.
- Trial name
- NCT03155178
- Testing
- 3M CHG/IPA Prep, ChloraPrep
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Hand Hygiene Effectiveness
Evaluation of Two Hand Hygiene Products in ICUs
This study will evaluate the immediate antimicrobial efficacy and persistence of two hand hygiene products on ICU Health Care Worker's skin flora by measuring bacterial organisms on hands using the hand print method.
- Trial name
- NCT02258412
- Testing
- hand antiseptic with CHG and alcohol, Alcohol hand sanitizer foam
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Surgery
Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Volunteers
Evaluate the effects of Chlorhexidine Gluconate (CHG) cloth on the reduction of bacteria on the skin.
- Trial name
- NCT02526667
- Testing
- Chlorhexidine gluconate, DynaHex-2, Vehicle
- Where
- Romania
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Surgery
Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects
Evaluate the effects of Chlorhexidine Gluconate (CHG) cloth on the reduction of bacteria on the skin.
- Trial name
- NCT02222896
- Testing
- Chlorhexidine Gluconate, Vehicle, DynaHex-2
- Where
- United States
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Febrile Neutropenia
Observational Non-Interventional Study Of Febrile Neutropenia Patients To Evaluate Antibacterial Therapeutical Options
The purpose of this study was to define and classify antibacterial agents used in Turkey for patients with febrile neutropenia.
- Trial name
- NCT00945555
- Testing
- Antibacterial agent for the treatment of febrile neutropenia
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 264 people
- Sponsor
- Pfizer
Urinary Tract Infections, Pyelonephritis
Safety, Tolerability, and Efficacy of MK-7655 (Relebactam) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone for Treating Complicated Urinary Tract Infection (cUTI) (MK-7655-003)
The purpose of this study is to evaluate the efficacy, safety and tolerability of adding 125 mg or 250 mg doses of MK-7655 (relebactam) to imipenem/cilastatin in adults 18 years or older with complicated urinary tract infection…
- Trial name
- NCT01505634
- Testing
- Relebactam 250 mg, Relebactam 125 mg, imipenem/cilastatin 500 mg
- Volunteers
- 302 people
- Sponsor
- Merck Sharp & Dohme LLC
Bacterial Pneumonia
Comparative Study of Ceftaroline vs. Ceftriaxone in Adults With Community-Acquired Pneumonia
The purpose of the study is to determine if the antibiotic ceftaroline is safe and effective in the treatment of community-acquired pneumonia in adults.
- Trial name
- CAP (NCT00509106)
- Testing
- Ceftaroline fosamil for Injection, Ceftriaxone
- Where
- 134 sites in United States, Argentina and 13 more
- Volunteers
- 622 people
- Sponsor
- Forest Laboratories
Atopic Dermatitis
A Randomized, Double-blinded Placebo-controlled Study to Investigate Antimicrobial Efficacy and Safety Following Topical Application of DPK-060
The primary objective of this study was to evaluate microbial density in eczematous lesions during two weeks of twice daily therapy with the investigational product, DPK-060 1% ointment, compared with placebo in patients with…
- Trial name
- NCT01522391
- Testing
- DPK-060 1% ointment
- Where
- Sweden
- Volunteers
- 41 people
- Sponsor
- DermaGen AB
Catheterization
Clinical Performance of a Chlorhexidine Antimicrobial Dressing
Evaluate the clinical performance of a new IV Dressing in Comparison to a standard IV Dressing
- Trial name
- NCT00516906
- Testing
- Chlorhexidine gluconate, Transparent Adhesive Dressing
- Volunteers
- 68 people
- Sponsor
- Solventum US LLC
Tinea Versicolor
A Trial to Evaluate the Safety and Antimicrobial Efficacy of DBI-002 Probiotic in Adults With Tinea Versicolor
A Randomized, Double-Blinded, Aqueous Gel-Controlled Dose Escalating Trial to Study the Safety and Antimicrobial Efficacy of DBI-002 Probiotic vs. Aqueous Gel and Vehicle Gel vs.
- Trial name
- NCT04937920
- Testing
- DBI-002 probiotic gel, Aqueous gel
- Where
- El Salvador
- Volunteers
- 34 people
- Sponsor
- DermBiont, Inc.
Bacterial Infections
Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections
The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin infections in adults.
- Trial name
- cSSSI (NCT00424190)
- Testing
- IV Vancomycin plus IV Aztreonam, Ceftaroline
- Where
- 52 sites in United States, Argentina and 9 more
- Volunteers
- 698 people
- Sponsor
- Forest Laboratories