Clinical trials: Antimicrobial Prophylaxis
HIV Prevention
Griffithsin-based Rectal Microbicide for PREvention of Viral ENTry (PREVENT)
This is the first-in-human clinical study to see if a single dose of an investigational enema made from a modified plant protein called Q-Griffithsin is safe, tolerated, and acceptable for use by healthy adults 18-45 years of age…
- Trial name
- PREVENT (NCT04032717)
- Testing
- Q-Griffithsin (Q-GRFT) enema
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Rhonda Brand
Pancreatic Surgery, Antibiotic Prophylaxis
Impact of Antibiotic Prophylaxis Change on Surgical Site Infections After Pancreaticoduodenectomy
Patients undergoing pancreaticoduodenectomy after preoperative biliary drainage are at increased risk of surgical site infections (SSI) due to bile colonization.
- Conditions
- Pancreatic Surgery, Antibiotic Prophylaxis, Surgical Site Infection (SSI), Surgical Site Infection Prevention
- Trial name
- ICADI (NCT07531420)
- Where
- France
- Volunteers
- 117 people
- Sponsor
- Central Hospital, Nancy, France
Diarrhea Caused by Drug, Abdominal Pain
Combined Lactobacilli (Reuteri LMG P-27481 and GG ATCC 53103) to Prevent Antibiotic Associated Symptoms in Children
This is a prospective multicenter pediatric double-blind, randomized placebo-controlled, parallel group clinical trial intended to evaluate the efficacy, safety and tolerability of a combined probiotic (LGG and L.
- Trial name
- NCT04836013
- Testing
- combined Lactobacilli
- Where
- Italy
- Volunteers
- 216 people
- Sponsor
- Università degli Studi dell'Insubria
Early-Onset Neonatal Sepsis
PROcalcitonin and Presepsin-guided Decision for Antibiotic Prophylaxis of EOS
The goal of this randomized controlled study is to compare the outcome of preterm infants who will receive the standard antibiotic prophylaxis for EOS or Procalcitonin/Presepsin-guided antibiotic prophylaxis of early onset sepsis…
- Trial name
- PROPOSE (NCT05796115)
- Testing
- Procalcitonin/Presepsin guided antibiotic prophylaxis for EOS, Antibiotic prophylaxis for EOS
- Volunteers
- 266 people
- Sponsor
- University of Florence
Congenital Heart Disease
Vancomycin and Cefoxitin During Pediatric Cardiopulmonary Bypass
The aim of this study will be to evaluate vancomycin and cefoxitin blood levels during elective cardiopulmonary bypass (CPB) surgery in four pre-determined pediatric strata: neonates, infants, children weighting less than 40 kg…
- Trial name
- VANCOCEF (NCT02839486)
- Testing
- vancomycin pharmacokinetics, cefoxitin pharmacokinetics
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Cystectomy, Bladder Cancer Requiring Cystectomy
Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis
The aim of this trial is to test whether postoperative antibiotics targeted towards bacteria in the urine can reduce the risk of infection after surgical removal of the bladder (cystectomy) compared to a standardised antibiotic…
- Conditions
- Cystectomy, Bladder Cancer Requiring Cystectomy, Postoperative Infections, Antibiotic Prophylaxis
- Trial name
- REINFORCE (NCT06709196)
- Testing
- Pivmecillinam, Amoxicillin clavulanic acid, Amoxicillin
- Where
- 5 sites in Denmark
- Volunteers
- 248 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Antibiotic-Associated Diarrhea, Clostridium Difficile-Associated Diarrhea
Efficacy and Safety Study in the Prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridium Difficile-Associated Diarrhea (CDAD) in Hospitalized Adult Patients Exposed to Nosocomial Infection
The purpose of this study is to evaluate the efficacy and safety of Bio-K+ CL-1285 in the prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridum difficile-Associated Diarrhea (CDAD) in hospitalized patients exposed to…
- Trial name
- NCT00958308
- Testing
- BIO-K+ CL-1285®
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Bio-K Plus International Inc.
Antibiotic-associated Diarrhea
Dose Response Effect of Probiotics for the Prevention of Antibiotic-associated Diarrhea in Chinese Adults
The purpose of this study is to determine the dose response effect of probiotic capsules for the prevention of antibiotic-associated diarrhea (AAD).
- Trial name
- NCT01143623
- Testing
- Probiotic
- Where
- China
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Open tíbia Fracture, Osteomyelitis Tibia
Intramedullary Calcium Sulfate Antibiotic Depot
The goal of this randomized clinical trial is to study the best treatment for open lower leg fractures to prevent infection. The main questions it aims to answer is if treating tibia fracture patients with a calcium sulfate…
- Conditions
- Open tíbia Fracture, Osteomyelitis Tibia, Tibial Fractures
- Trial name
- NCT05766670
- Testing
- Vancomycin Hydrochloride, Gentamicin, Standard Intramedullary Nail
- Where
- 12 sites in United States
- Volunteers
- 242 people
- Sponsor
- Wake Forest University Health Sciences
Surgical Wound Infection
Duration of Postoperative Antibiotic Prophylaxis in Facial Fractures
Facial fractures make up a significant proportion of injuries in trauma patients. Treatment of these fractures often results in standard surgical interventions.
- Trial name
- NCT01583062
- Testing
- Amoxicillin/clavulanic acid
- Where
- Switzerland
- Volunteers
- 217 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pleural Effusion, Pleurisy
Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy
This is a prospective study to assess the efficacy and safety of a single dose of cefazolin 2g IV for the prophylaxis of surgical site and pleural space infections in patients undergoing medical thoracoscopy.
- Conditions
- Pleural Effusion, Pleurisy, Empyema
- Trial name
- APT (NCT02446782)
- Testing
- Cefazolin, saline
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Urinary Tract Infection
Usefulness of Antimicrobial Prophylaxis in Children With Isolated Vesico-Ureteral Reflux.
Randomized, prospective, multicenter study in order to assess the usefulness of antimicrobial prophylaxis in children with isolated vesico-ureteral reflux (grade III or less).
- Trial name
- NCT00200616
- Testing
- Antimicrobial prophylaxis
- Where
- France
- Volunteers
- 232 people
- Sponsor
- Nantes University Hospital
Bacteraemia, Endocarditis
An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures
Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens.
- Trial name
- NCT02783404
- Testing
- Amoxicillin, Amoxicillin-Potassium Clavulanate
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- University of Santiago de Compostela
HIV Infections
A Pilot Study for Toxicity Evaluation of HIV Rectal Microbicides
The purpose of this study is to determine if detectable changes in permeability of the lining of the colon are caused by either application of HIV microbicide gels or medical procedures, such as flexible sigmoidoscopy.
- Trial name
- NCT00389311
- Testing
- Normosol-R, Nonoxynol-9, Gastrointestinal instrumentation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Urolithiasis, UTI
Antibiotic Prophylaxis With Routine Ureteral Stent Removal
This study will be a single-institutional randomized, single-blinded prospectively controlled clinical trial of a single dose of Ciprofloxicin 500mg antibiotic tablet as prophylaxis at the time of office flexible cystoscopy with…
- Trial name
- STENTABX (NCT02944825)
- Testing
- Ciprofloxacin, trimethoprim/sulfamethoxazole, No Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Hemodialysis
Prophylactic Antibiotic Treatment in Hemodialysis
The purpose of this study is to assess the efficacy of prophylactic antibiotic treatment on blood stream infections and severe culture negative infections, in patients on newly started hemodialysis(HD), with a central venous…
- Trial name
- PANTHEM (NCT05248620)
- Where
- 7 sites in Denmark
- Volunteers
- 800 people
- Sponsor
- Zealand University Hospital
Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence
Secondary Prevention of Clostridioides Difficile Using Vancomycin
Re-exposure to systemic antibiotics (i.e., antibiotics absorbed into the bloodstream) is common after a Clostridioides difficile infection (CDI) and is the strongest risk factor for a recurrent episode.
- Conditions
- Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence, Clostridoides Difficile Associated Disease
- Trial name
- SPORES-V (NCT06979609)
- Testing
- Oral Vancomycin Prophylaxis
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Prostate Biopsy, Antibiotic
Transperineal MRI-TRUS Fusion Guided Prostate Biopsy With vs Without Antibiotic Prophylaxis
Prostate biopsy is indicated in patients with suspected prostate cancer and has been traditionally performed through the rectum using antibiotic prophylaxis.
- Trial name
- NORAPP (NCT04146142)
- Testing
- Transperineal prostate biopsy with or without antibiotic prophylaxis
- Where
- 2 sites in Germany, Norway
- Volunteers
- 550 people
- Sponsor
- Oslo University Hospital
Recurrent Urinary Tract Infections, Antibiotic Prophylaxis
D Mannose for Prevention and Treatment of RUTIs
The aim of this review is to address clinical reliability, efficacy and safety of long-term treatment with oral D Mannose for the prevention of recurrent urinary tract infections (RUTIs) in females.
- Conditions
- Recurrent Urinary Tract Infections, Antibiotic Prophylaxis, Antibiotic Resistance
- Trial name
- mannoseRUTIs (NCT03790254)
- Testing
- systematic review
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Bacteremia
A New Antibiotic Prophylaxis Regimen to Prevent Bacteremia Following Dental Procedures
The aim of this study is to evaluate the efficacy of prophylactic dosage with amoxicillin (AMX), amoxicillin-clavulanate (AMX-CLV), and a combination of amoxicillin-clavulanate and a chlorhexidine mouthwash (AMX-CLV-CHX) in the…
- Trial name
- NCT02115776
- Testing
- Amoxicillin-Potassium Clavulanate, Amoxicillin, Chlorhexidine
- Where
- 2 sites in Spain
- Volunteers
- 266 people
- Sponsor
- University of Santiago de Compostela