Clinical trials: Antimicrobial Prophylaxis
Pancreatic Cystic Lesion
Antibiotic Prophylaxis for EUS-FNA of Pancreatic Cystic Lesions
Large prospective comparative observational study in numerous reference centers in France, comparing infectious complications in patients admitted for pancreatic cystic lesions (PCL) aspiration performed with or without…
- Trial name
- PrePaCyst (NCT06535490)
- Testing
- EUS-FNA, ATBp
- Where
- France
- Volunteers
- 1,702 people
- Sponsor
- Société Française d'Endoscopie Digestive
Infectious Complications Following Prostate Biopsy, Prostate Cancer
A Study Comparing Infectious Complications After Transperineal Prostate Biopsy With or Without Antibiotic Prophylaxis
Prostate biopsy performed through the perineal skin (the area between the testicles and the anus), known as a transperineal biopsy, is currently considered the standard procedure for diagnosing prostate tumors, having replaced…
- Trial name
- NCT07557901
- Testing
- No antibiotic prophylaxis for prostate biopsy, Antibiotic prophylaxis (fosfomycin-trometamol) for prostate biopsy.
- Where
- Slovakia
- Volunteers
- 300 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Surgical Site Infections
Continuous v Bolus Infusion of Cefazolin During Ventral Hernia Repair
Patients undergoing an elective ventral hernia repair will be randomly assigned to receive either bolus infusion or continuous infusion of the cefazolin as the prophylactic antibiotic.
- Trial name
- NCT02666365
- Testing
- Bolus infusion of Cefazolin, Continuous infusion of Cefazolin
- Sponsor
- Milton S. Hershey Medical Center
Antibiotic Prophylaxis, Colorectal Surgery
Intermittent Cefoxitin Administration Versus Loading Bolus Followed by Continuous Infusion for the Prevention of Surgical Site Infection in Colorectal Surgery
The goal of this prospective, multicentre, double-blind, randomized clinical trial is to compare intermittent cefoxitin administration to loading bolus followed by continuous infusion for surgical antibiotic prophylaxis in…
- Trial name
- PROPHYLOXITIN (NCT05755789)
- Testing
- Loading bolus of cefoxitin, Intermittent cefoxitin, Continuous infusion of cefoxitin
- Where
- 19 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Poitiers University Hospital
Healthcare Associated Infection
Controlled Crossover Study of AIONX Antimicrobial Surface for the Prevention of Healthcare-associated Infections
This is a controlled open label efficacy study of Aionx antimicrobial surface for the prevention of healthcare-associated infections.
- Trial name
- NCT03189043
- Testing
- Antimicrobial Surface
- Volunteers
- 10,000 people
- Sponsor
- Aionx, Inc.
Antibiotic Associated Diarrhea, Clostridium Difficile Infection
Probiotic Lactobacillus Reuteri to Prevent Antibiotic-associated Diarrhea and Clostridium Difficile-related Infections in Hospitalized Children
The purpose of this study is to determine if the daily intake of the probiotic Lactobacillus reuteri prevents antibiotic-associated diarrhoea and related Clostridium difficile infections in children and adolescents.
- Conditions
- Antibiotic Associated Diarrhea, Clostridium Difficile Infection, Gastroenteritis
- Trial name
- AADreuter (NCT01295918)
- Testing
- L reuteri in children on antibiotics
- Where
- 2 sites in Bulgaria
- Volunteers
- 100 people
- Sponsor
- St Marina University Hospital, Varna, Bulgaria
Surgical Site Infection (SSI)
Prophylaxis Against Surgical Site Infections Using Local as Well as Systemic Antibiotic
Surgical site infections were defined as infections that developed in the area of an operation within 30 days after surgery. They remained a common problem after surgery and could increase pain, delay wound healing, prolong…
- Trial name
- NCT07478874
- Testing
- Cefazolin plus Gentamicin, Cefazolin
- Where
- Pakistan
- Volunteers
- 284 people
- Sponsor
- Lahore General Hospital
Surgical Site Infection, Microbial Colonization
Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery
The perioperative antibiotic prophylaxis is evidence-based in orthopedic surgery. While its duration ranges from a single dose to three doses throughout the world, the choice of the prophylactic agents is undisputed.
- Conditions
- Surgical Site Infection, Microbial Colonization, Antibiotic Resistant Infection
- Trial name
- BAPTIST (NCT05502380)
- Testing
- Standard antibiotic prophylaxis
- Where
- Switzerland
- Volunteers
- 1,100 people
- Sponsor
- Balgrist University Hospital
Plastic Surgery, Mammaplasty
Single Dose Versus 24 Hours Antibiotic Prophylaxis in Reduction Mammaplasty
Setting: Translacional Surgery Graduation Program - Universidade Federal de São Paulo and Hospital das Clínicas Samuel Libânio - Universidade do Vale do Sapucaí.
- Conditions
- Plastic Surgery, Mammaplasty, Anti-bacterial Agents, Prophylaxis
- Trial name
- NCT04079686
- Testing
- Cephazolin, Sterile saline
- Where
- Brazil
- Volunteers
- 146 people
- Sponsor
- Daniela Francescato Veiga
HIV Prevention
Microbicide/PrEP Acceptability Among Mothers and Male Partners in Africa
The MTN-041 study is a multi-site exploratory study using focus group discussions (FGDs) and in-depth interviews (IDIs) to identify individual, interpersonal, social and cultural factors that may affect potential uptake of two…
- Trial name
- MAMMA (NCT03648931)
- Testing
- Focus Group Discussion (FGD), In-depth Interview (IDI)
- Where
- 4 sites in Malawi, South Africa and 2 more
- Volunteers
- 232 people
- Sponsor
- Microbicide Trials Network
Bladder Cancer
Multicentral Preventive Antibiotics With Cystectomy Within Enhanced Recovery After Surgery
The current usage of antibiotic prophylaxis (AP) in radical cystectomy (RC) is aimed to reducing the incidence of surgical site infections and incidence of unnecessary prescribing of antibiotics.
- Trial name
- MACS (NCT05392634)
- Testing
- Meropenem 1000 mg, Amoxicillin+clavulanic acid 1200 mg or Cefuroksim 1500mg
- Where
- Russia
- Volunteers
- 98 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Infection Secondary to Surgical Procedure
Antibiotic Prophylaxis in Gynecologic Laparoscopy
Laparoscopy is a surgical procedure indicated for most gynecological pathologies and presents numerous advantages over laparotomy, among them lower rates of surgical site infection and less comorbidity feverish.
- Trial name
- NCT01991834
- Testing
- gynecologic laparoscopy, Cefazolin
- Where
- 2 sites in Brazil
- Volunteers
- 114 people
- Sponsor
- Universidade do Vale do Sapucai
Antibiotic-Associated Diarrhea
Probiotics for Prevention of Antibiotic-associated Diarrhea
The purpose of this study is to evaluate if ingestion of a probiotic formula (Jarrow-Dophilus EPS)reduces incidence of diarrhea and improves the quality of life of patients receiving antibiotic therapy.
- Trial name
- NCT00641199
- Testing
- Jarro-Dophilus EPS probiotics
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- University of Saskatchewan
Myelodysplastic Syndromes, Acute Myeloid Leukemia
Efficiency of Antibacterial Prophylaxis in Azacitidine Treated Patients
Infections are a major life-threatening complication in patients with myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML).
- Trial name
- AZABAC (NCT03594149)
- Testing
- Levofloxacin
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Henri Becquerel
Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1
Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract
The exact role of urinary tract infection in the appearance of chronic kidney disease is unclear. Children with congenital malformations of kidney and urinary tract have the higher risk of impairment of renal function.
- Conditions
- Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1, Chronic Kidney Disease
- Trial name
- PREDICT (NCT02021006)
- Testing
- nitrofurantoin, No prophylaxis, Amoxicillin-Potassium Clavulanate Combination
- Where
- Italy
- Volunteers
- 292 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Catheter-Associated Infections, Catheter-Related Infections
Safety and Effectiveness of Novel Nitroglycerin Based Catheter Lock Solution
The objective of this Phase I/II pilot study is to evaluate the safety and effectiveness of a non- antibiotic chelator based lock solution that contains nitroglycerin in combination with sodium citrate and ethanol (NiCE lock…
- Trial name
- NCT02577718
- Testing
- Nitroglycerin-citrate-ethanol (NiCE)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Novel Anti-Infective Technologies, LLC
Inguinal Hernia
Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair
Aim of this study is to measure the effectiveness of topical gentamicin to prevent post-operative infection in inguinal tension-free hernia repair operation.Secondary aim is, if it is effective as a prophylactic agent, to compare…
- Trial name
- NCT01273818
- Testing
- Gentamicin and cefazolin, Cefazolin, Gentamicin
- Where
- Turkey (Türkiye)
- Volunteers
- 276 people
- Sponsor
- Diskapi Teaching and Research Hospital
Endometritis, Wound Infection
Timing of Prophylactic Antibiotics for Cesarean Sections
This is a randomized, double-blinded placebo controlled trial of cefazolin timing before cesarean section fo infection prophylaxis.
- Trial name
- NCT00330278
- Testing
- Cefazolin
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Complication, Infection
Culture-guided Antimicrobial Prophylaxis in Men Undergoing Prostate Biopsy.
This study aims to assess the effectiveness and cost-effectiveness of rectal swab culture-guided antimicrobial prophylaxis to reduce infectious complications after transrectal prostate biopsy.
- Conditions
- Complication, Infection, Prostate Cancer
- Trial name
- pro-SWAP (NCT03228108)
- Testing
- Ciprofloxacin, Trimethoprim/Sulfamethoxazole, Fosfomycin
- Where
- 13 sites in Netherlands
- Volunteers
- 1,538 people
- Sponsor
- Radboud University Medical Center
Urinary Tract Infections
Efficacy Study of Prophylaxis With Fosfomycin Versus Ciprofloxacin Prior Prostate Biopsy
The purpose of this clinical trial is compare the incidence of symptomatic or asymptomatic bacteriuria after transrectal ultrasound guided prostate biopsy using a single dose of fosfomycin 3 g one hour before the biopsy compared…
- Trial name
- BIPROST (NCT01803191)
- Testing
- Fosfomycin 3 g, Ciprofloxacin 500 mg
- Where
- 3 sites in Spain
- Volunteers
- 461 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia