Clinical trials: Antimicrobial Prophylaxis
Intraoperative Nausea-retching-vomiting Episodes, Nausea Scores Will be Evaluated on the Verbal Analog Scale (VAS)
Antibiotic Prophylaxis and Nausea and Vomiting in Cesarean Section Under Regional Anesthesia.
The incidence of intraoperative nausea and vomiting in patients who undergo caesarean section (C/S) under regional anesthesia is approximately 30-80%.
- Trial name
- NCT04697277
- Testing
- Antibiotic prophylaxis timing (before skin incision and after cord clamping) for caesarean section
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Baskent University Ankara Hospital
Induced Abortion, Postaboral Pelvic Inflammatory Disease
To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy
Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when…
- Conditions
- Induced Abortion, Postaboral Pelvic Inflammatory Disease, Sexually Transmitted Infections
- Trial name
- NCT01842100
- Testing
- Universal antibiotic prophylaxis, Screen-and-treat
- Where
- China
- Volunteers
- 2,193 people
- Sponsor
- The University of Hong Kong
Antibiotic Prophylaxis, Voiding Cystourethrogram
Antibiotic Prophylaxis to Prevent Post-procedure UTI After VCUG
The current practice of pre-VCUG antibiotic prophylaxis is highly variable. A recent unpublished survey of Society of Fetal Urologists (SFU) completed by this study team found that 87% of respondents reported having patients who…
- Conditions
- Antibiotic Prophylaxis, Voiding Cystourethrogram, Febrile Urinary Tract Infection
- Trial name
- APPrUV (NCT05438082)
- Testing
- Antibiotic Prophylaxis
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
HIV-1-infection, Pneumocystis Pneumonia
Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria
Cotrimoxazole preventive therapy (CPT) is recommended for prevention of morbidity and mortality due to Pneumocystis pneumonia and other infections in HIV positive patients with low immunity.
- Conditions
- HIV-1-infection, Pneumocystis Pneumonia, Opportunistic Infections, Preventive Therapy
- Trial name
- CoTrimResist (NCT03087890)
- Testing
- Cotrimoxazole
- Where
- 6 sites in Tanzania
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Autoimmune Rheumatic Diseases, Tooth Extraction
Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases
This randomized, double-blind, placebo-controlled clinical trial aims to evaluate whether single-dose amoxicillin prophylaxis administered prior to simple tooth extraction reduces postoperative infection rates inpatients with…
- Conditions
- Autoimmune Rheumatic Diseases, Tooth Extraction, Infection Prevention, Antibiotic Prophylaxis
- Trial name
- PRO-EXOD (NCT07275580)
- Testing
- Amoxicillin
- Where
- Brazil
- Volunteers
- 352 people
- Sponsor
- University of Sao Paulo General Hospital
Inflammation at Mini-screw Insertion Site, Mobility, Mini-screw
Antibiotics Prior to Mini-screw Implant Insertion
The investigators plan to use amoxicillin in capsule form, prepared by a pharmacist, for antibiotic prophylaxis to decrease the failure rate of mini-screw implants temporarily placed in the palate of patients involved in Phase II…
- Trial name
- NCT03582605
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- St. Louis University
Antibiotics Associated Colitis, Pulmonary Infection
Effect of Probiotic Lactobacilli (Lacidofil Cap®) for the Prevention of Antibiotic-Associated Diarrhea
Antibiotic-Associated Diarrhea (AAD) is a common complication of antibiotic use. The frequency of AAD can be high (26 - 60%) or moderate (13-29%) during hospital outbreaks and is relatively infrequent in outpatients.
- Trial name
- NCT01058356
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Pharmbio Korea Co., Ltd.
Rupture of Membranes Prior to Onset of Labor
PROMab Trial: Ampicillin With or Without Gentamicin for Term Prelabour Rupture of Membranes
The goal of this clinical trial is to learn whether adding gentamicin to standard ampicillin prophylaxis can better prevent clinical chorioamnionitis and other maternal and neonatal infectious complications in pregnant women aged…
- Trial name
- PROMab (NCT07563504)
- Testing
- Ampicillin, Ampicillin + gentamicin
- Where
- 3 sites in Malaysia
- Volunteers
- 320 people
- Sponsor
- Sarawak General Hospital
Mycobacterium Avium-intracellulare Infection, HIV Infections
Effects of MAC Preventive Therapy on Disease-Causing Bacteria in HIV-Infected Patients: A Substudy of CPCRA 048
Some people who have taken azithromycin to prevent MAC (Mycobacterium avium Complex, a bacterial infection common in HIV-infected persons) have been found to carry antibiotic-resistant bacteria (germs that grow despite the…
- Conditions
- Mycobacterium Avium-intracellulare Infection, HIV Infections, Pneumococcal Infections
- Trial name
- NCT00000933
- Where
- 15 sites in United States
- Volunteers
- 326 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Postoperative Complications, Third Molar
Complications After Lower Third Molar Surgery
Objectives: The objective of the study was to evaluate the effectiveness of a prophylactic single preoperative dose of amoxicillin in decreasing complications after lower third molar surgery.
- Trial name
- NCT03130933
- Testing
- Lower third molar surgery, Amoxicillin 500 Mg
- Where
- Croatia
- Volunteers
- 400 people
- Sponsor
- University of Zagreb
Perineal Wound Infection
Necessity of Antibiotics for Prevention of Delivery-associated Infections After Spontaneous Vaginal Delivery at Term
The purpose of this study is to determine amoxicillin is effective in the prevention of wound infection in normal labor.
- Trial name
- NCT02131818
- Testing
- Amoxicillin
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Mahidol University
Obese, Antibiotic Prophylaxis
Serum Concentration of CEFOxitin Used for Antibiotic Prophylaxis in Obese Patients Undergoing BARiatric Surgery
Obesity is a pandemic problem in modern societies. Bariatric surgery (gastric by-pass and sleeve gastrectomy) has emerged as an efficient treatment to reduce morbidity and mortality related to obesity.
- Conditions
- Obese, Antibiotic Prophylaxis, Bariatric Surgery Candidate
- Trial name
- CEFOBAR (NCT03306290)
- Testing
- Serum dosage of antibiotic prophylaxis CEFOXITIN
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Tooth Diseases, Tooth Wear
Effects of Antibiotic Prophylaxis on the Healing Parameters Following Surgical Crown Lengthening
The goal of this clinical trial is to test the effects of prophylactic antibiotics in healthy individuals who are in need of surgical crown lengthening.
- Trial name
- SCLABP (NCT05925179)
- Testing
- Surgical crown lengthening, Augmentin
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Biruni University
Complicated Appendicitis, Acute Appendicitis
Antibiotic Instillation in Appendicitis
Appendicitis (inflammation of the wall of the appendix, causing pain and tenderness in the abdomen) has a range of severity that goes from simple to complicated.
- Trial name
- NCT05470517
- Testing
- Ceftriaxone, Intra-peritoneal Fluid Aspiration
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Johns Hopkins All Children's Hospital
Vascular Access Complication, Device Related Infection
Chlorhexidine Caps for CLABSI Prevention in Hemodialysis: a Pilot Randomized Controlled Trial
The goal of this clinical trial is to compare a chlorhexidine antimicrobial barrier cap in patients requiring hemodialysis treatment to the standard hemodialysis caps currently used within the Metro North Kidney Health Service.
- Conditions
- Vascular Access Complication, Device Related Infection, Device Related Sepsis, Catheter Infection
- Trial name
- ECHO-HD (NCT07019610)
- Testing
- ClearGuard HD, B Braun Combi-stopper
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The University of Queensland
Breast Cancer, Chronic Myeloproliferative Disorders
Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant
RATIONALE: A donor stem cell transplant can lower the body's immune system, making it difficult to fight off infection. Giving antibiotics, such as moxifloxacin, may help prevent bacterial infections in patients who have recently…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Infection
- Trial name
- NCT00324324
- Testing
- moxifloxacin hydrochloride
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- OHSU Knight Cancer Institute
Inguinal Hernia
Antibiotic Prophylaxis in Mesh Repair of Inguinal Hernias
Inguinal hernia repairs is clean surgical procedures. However infection may be a concern when prosthetic materials are used. This prospective randomized study has been set to observe if antibiotic prohylaxis is of benefit in mesh…
- Trial name
- NCT01264003
- Testing
- sefazolin
- Volunteers
- 200 people
- Sponsor
- Diskapi Teaching and Research Hospital
Implant Complication, Implant Infection
Local Antibiotics for Breast Implants
The BREAST-AB Trial is a multi-center, randomized, double blind, placebo-controlled trial investigating the efficacy of local application of gentamicin, vancomycin and cefazolin in decreasing all-cause implant explantation after…
- Conditions
- Implant Complication, Implant Infection, Implant Site Infection, Implant Capsular Contracture
- Trial name
- BREAST-AB (NCT04731025)
- Testing
- Gentamicin, Cefazolin and Vancomycin
- Where
- 8 sites in Denmark
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Mikkel Herly
HIV Infections
Safety and Effectiveness of TFV 1% Gel, TDF Tablets, and FTC/TDF Tablets in Preventing HIV in Women
A new approach to HIV prevention currently being studied includes the use of microbicides, substances that kill microbes. Tenofovir disoproxil fumarate (TDF) and emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) are oral…
- Trial name
- NCT00705679
- Testing
- Emtricitabine/tenofovir disoproxil fumarate, Tenofovir disoproxil fumarate, Tenofovir 1% vaginal gel
- Where
- 15 sites in South Africa, Uganda and 1 more
- Volunteers
- 5,029 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Surgical Site Infection
Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections
In a rural hospital in Tanzania the rate of surgical site infections (SSI) was 21.6%. Inappropriate choice of antibiotics and of administration time were determined as sole risk factors in this setting.
- Trial name
- SSI2 (NCT00801099)
- Testing
- Amoxicillin/Clavulanic Acid
- Where
- Switzerland
- Volunteers
- 276 people
- Sponsor
- Swiss Tropical & Public Health Institute