Clinical trials: Antimicrobial Prophylaxis
Urinary Tract Infection
Can Probiotics be Used in the Prevention of Recurrent UTI in Paediatric Neurogenic Bladder
Although clean intermittent catheterization (CIC) remains the mainstay to ensure complete low-pressure bladder emptying in neurogenic bladder (NB) patients, this forms a vehicle for bacterial entry and colonization of the urinary…
- Trial name
- NCT02044965
- Testing
- Antibiotic, Probiotic
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- London Health Sciences Centre
Prenatal Exposure Delayed Effects, Antibiotic Prophylaxis
Prenatal Antibiotics and Breast Milk / Neonatal IgA
In this biological study, the investigators will evaluate the levels of breast milk IgA, neonatal fecal IgA, and the composition of breast milk and fecal microbiota throughout the first 12 months of life in neonates born to…
- Conditions
- Prenatal Exposure Delayed Effects, Antibiotic Prophylaxis, Dysbiosis, Neonatal Infection
- Trial name
- PAIGAN 1 (NCT05813184)
- Testing
- Antibiotics
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Cesarean Section; Complications, Wound, Dehiscence
The Role of Antimicrobial Foam Dressing in Prevention of Cesarean Section Wound Complications
Post-cesarean section wound infections are responsible for longer hospital stays, readmissions, and ultimately, increased costs to the healthcare system. Silver-containing dressings may prevent wound infections.
- Trial name
- NCT03136159
- Testing
- Silver-impregnated antimicrobial dressing
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- Loyola University
Arrhythmia
Prevention of Arrhythmia Device Infection Trial (PADIT)
The goal of the study is to compare whether a center-wide policy of incremental antibiotic therapy will reduce CIED infection rate compared to a policy of conventional antibiotic prophylaxis in high-risk patients undergoing…
- Trial name
- NCT01628666
- Testing
- Incremental, Conventional
- Where
- Canada
- Volunteers
- 12,814 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Aortic Valve Disease
Prevalence of Cutaneous Enterococci at Femoral Insertion Site in Transcatheter Aortic Valve Implantation (TAVI)
The general rules of antibiotic prophylaxis in surgery or interventional medicine include the choice of an antibiotic active on the bacteria most frequently encountered in surgical site infections.
- Trial name
- Entero-TAVI (NCT04909424)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Clinique Pasteur
Eye Infection, Infection
Effectiveness Study of Zymar Versus Vigamox for Preoperative Sterilization of the Ocular Surface After Loading Dose
The purpose of this study is to analyze the effect of Zymar and Vigamox on ocular surface bacteria. We believe that Zymar will eradicate more ocular surface bacteria than Vigamox.
- Trial name
- NCT00347828
- Testing
- Moxifloxacin ophthalmic solution 0.5%, Gatifloxacin ophthalmic solution 0.3%
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Boston
Simple Hand Lacerations
Antibiotic Prophylaxis for Simple Hand Lacerations
Research Question: In emergency department patients with simple hand cuts, do prophylactic antibiotics reduce the risk of wound infections?
- Trial name
- NCT01155154
- Testing
- cephalexin, clindamycin
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- State University of New York - Downstate Medical Center
Drug Resistance, Bacterial, Postoperative Wound Infection
Local Collagen-Gentamicin and Extra Fixation of the Sternum for Prevention of Sternal Wound Infection in Cardiac Surgery
The aim of the present study is to evaluate a new technique for prevention of sternal wound infection consisting of local application of collagen-gentamicin in addition to routine i.v. antibiotic prophylaxis.
- Trial name
- LOGIX (NCT00484055)
- Testing
- Local application of collagen-gentamicin, Fixation of the sternotomy with more than six wires
- Where
- 2 sites in Sweden
- Volunteers
- 1,358 people
- Sponsor
- Region Örebro County
Surgical Wound Infection
Wound Infections Following Implant Removal
In the Netherlands about 18,000 surgical procedures with implant removal are annually performed after fracture healing, of which 30-80% concern the foot, ankle and lower leg region.
- Trial name
- WIFI (NCT02225821)
- Testing
- Cephalozin, Sodium chloride
- Where
- 21 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Snake Bites
Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite
Clinicians tend to overuse antibiotics in snake bite despite evidence from three previous clinical trials that failed to show a benefit. But, none of these trials was done in India.
- Trial name
- RADIANS (NCT02570347)
- Testing
- Co-amoxiclav, Tetanus toxoid
- Where
- India
- Volunteers
- 66 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Peritoneal Dialysis
The Efficacy of Prolonged Antibiotic Therapy for the Prevention of Relapsing Peritonitis in Peritoneal Dialysis Patients With High Dialysis Effluent Bacterial DNA Fragment Levels
Peritoneal dialysis (PD) is the first-line treatment of end stage renal disease (ESRD) in Hong Kong. Despite the advances in antibiotic therapy and connecting system, recurrent peritonitis remains the major cause of peritoneal…
- Trial name
- NCT02593201
- Testing
- Extended antibiotics (cefazolin or ceftazidime), Usual antibiotics (cefazolin or ceftazidime)
- Where
- Hong Kong
- Volunteers
- 358 people
- Sponsor
- Chinese University of Hong Kong
Surgical Site Infection (SSI), Spine Diseases
Efficacy of Intrawound Vancomycin in Spine Surgery
"This multicenter, prospective, time-cluster randomized controlled trial with blinded endpoint assessment (PROBE design) evaluated the efficacy of intrawound vancomycin powder (2 g) in preventing surgical site infections (SSI)…
- Trial name
- NCT07866157
- Testing
- vancomycin, Standard surgical closure
- Where
- Egypt
- Volunteers
- 416 people
- Sponsor
- Ain Shams University
Clostridium Difficile Infection
Safety and Clinical Effectiveness of Oral Probiotic MIYA-BM to Prevent Recurrent Clostridium Difficile Infections
Patients with confirmed C. difficile infection (CDI) who meet eligibility requirements will be invited to participate. All study patients must receive treatment for CDI with metronidazole or vancomycin.
- Trial name
- NCT01077245
- Testing
- MIYA-BM Fine Granules (CBM588)
- Sponsor
- Osel, Inc.
Lung Transplantation
Film Array Pneumonia Plus Panel® Multiplex PCR for Early Adaptation of Antibiotic Prophylaxis During Lung Transplantation
Postoperative pneumonia significantly worsens the prognosis for patients undergoing lung transplantation (LT). It is therefore recommended to use antibiotic prophylaxis after LT, although the specific types of antibiotics or the…
- Trial name
- FilmArray-TP (NCT07792018)
- Testing
- Early adapation of antibiotic prophylaxis according to FAPP results.
- Volunteers
- 98 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Staphylococcal Infections, Methicillin-resistant Staphylococcus Aureus
Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty
This study will evaluate the safety and effectiveness of daptomycin, an antibiotic compared to another one which is vancomycin when given around the time of joint replacement surgery.
- Trial name
- NCT01196169
- Testing
- Daptomycin, Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Mountain Home Research & Education Corporation
Hospital Acquired Infection
Effect of Copper Impregnated Textiles on Healthcare Associated Infections and Antibiotic Use
This is a prospective Infection Control study comparing rates of antibiotic usage and infections in the General Intensive Care Unit (GICU) in beds with copper impregnated linens versus regular linens.
- Trial name
- NCT02351895
- Testing
- Copper impregnated linen
- Where
- United States
- Volunteers
- 1,302 people
- Sponsor
- Eastern Virginia Medical School
Dental Caries in Children, Dental Plaque
Targeting of Preventive Treatment for Adolescents at Risk of Oral Diseases
The aim of the study is to identify adolescent patients that are at risk of developing oral diseases, and to assess if targeted preventive oral treatment with antibacterial dual-light therapy as an adjunctive treatment method can…
- Conditions
- Dental Caries in Children, Dental Plaque, Tooth Decay, Periodontitis
- Trial name
- LumoPrevent (NCT06286501)
- Testing
- Lumoral Treatment, Standard, personalized oral health care
- Where
- Finland
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wellbeing Services County of Pirkanmaa
Antibiotic Side Effect, Eyelid; Wound
Topical Antibiotic Prophylaxis for Eyelids
The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery.
- Conditions
- Antibiotic Side Effect, Eyelid; Wound, Eyelid Diseases, Surgical Wound Infection
- Trial name
- NCT03199911
- Testing
- Topical Antibiotic Product, Topical Non-Antibiotic Ointment
- Where
- United States
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Surgical Site Infection
Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections
In a rural hospital in Tanzania the rate of surgical site infections (SSI) was 21.6%. Inappropriate choice of antibiotics and of administration time were determined as sole risk factors in this setting.
- Trial name
- SSI2 (NCT00801099)
- Testing
- Amoxicillin/Clavulanic Acid
- Where
- Switzerland
- Volunteers
- 276 people
- Sponsor
- Swiss Tropical & Public Health Institute
Diarrhea
Recombinant Human Lactoferrin Administered Orally for the Prevention of Antibiotic Associated Diarrhea in Adult Patients
The purpose of the study is to Evaluate the Efficacy and Safety of Recombinant Human Lactoferrin Administered Orally for the Prevention of Antibiotic Associated Diarrhea in Adult Patients.
- Trial name
- NCT01382199
- Testing
- Lactoferrin
- Volunteers
- 340 people
- Sponsor
- Ventria Bioscience