Clinical trials: Antimicrobial Prophylaxis
Diabetes Mellitus, Type 2, Pre-diabetes
Regular Use of aPDT in the Management and Prevention of Periodontitis Symptoms in Diabetic Patients
This is an investigator-initiated clinical study to establish easy referral and access for diabetic patients from primary health care to oral health care facilities for preventive oral care, periodontal assessment, and treatment…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Periodontal Diseases, Periodontitis
- Trial name
- APDT-T2D (NCT06486012)
- Testing
- Lumoral Treatment, Standard oral hygiene
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Wellbeing Services County of Pirkanmaa
The Patients Who Receive Percutaneous Endoscopic Gastrostomy, Peristomal Wound Infection After the Operation of PEG
Tailored Antibiotics Prophylaxis for Percutaneous Endoscopic Gastrostomy
Tailored antibiotic prophylaxis according to the individual throat swab culture could reduce the peristomal infection rate
- Conditions
- The Patients Who Receive Percutaneous Endoscopic Gastrostomy, Peristomal Wound Infection After the Operation of PEG, Prophylactic Antibiotics Before PEG
- Trial name
- PEG (NCT01237730)
- Testing
- cefuroxime, Tailored antibiotic
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Cheng Kung University
GBS
The Implementation of Real-time PCR - Intrapartum GBS (Group B Streptococcus) Colonization to Reduce Antibiotic Prophylaxis
The implementation of real-time PCR for detection of intrapartum GBS (group B Streptococcus) colonization as a way to reduce antibiotic prophylaxis usage.
- Trial name
- NCT03936816
- Testing
- GBS vaginal double swab
- Where
- Israel
- Volunteers
- 303 people
- Sponsor
- Carmel Medical Center
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Carbapenemase-Producing Enterobacteriaceae (CPE), Healthcare-Associated Infections (HAIs)
Effect of Daily Chlorhexidine Bathing and Antibiotic/PPI Stewardship on Prevention of CPE Transmission and Infection
This multicenter, cluster-randomized crossover trial aims to evaluate the effectiveness and safety of a bundled intervention-including daily chlorhexidine bathing and targeted antimicrobial and proton pump inhibitor (PPI)…
- Trial name
- NCT07039955
- Testing
- Daily Chlorhexidine Bathing, Antimicrobial and PPI Stewardship Program, Standard Bathing
- Where
- 3 sites in South Korea
- Volunteers
- 5,760 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Cleft Palate
The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair
Cleft Lip and Palate surgical repair is one of the most common procedures performed by Plastic and Reconstructive Surgeons in the World.
- Trial name
- Cleft Palate (NCT02688634)
- Testing
- Amoxicillin
- Where
- 2 sites in United States
- Sponsor
- University of Florida
Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence
Secondary Prevention of Clostridioides Difficile Using Vancomycin
Re-exposure to systemic antibiotics (i.e., antibiotics absorbed into the bloodstream) is common after a Clostridioides difficile infection (CDI) and is the strongest risk factor for a recurrent episode.
- Conditions
- Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence, Clostridoides Difficile Associated Disease
- Trial name
- SPORES-V (NCT06979609)
- Testing
- Oral Vancomycin Prophylaxis
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Vancomycin Resistant Enterococci Infection, Clostridium Difficile Infection
Hospital Design and Risk of Nosocomial Infections: A Prospective Controlled Trial
With the construction of a new medical teaching ward with features designed to reduce hospital-acquired infections, we hypothesized that the design of the new ward was the major factor that contributed to the improved outcomes…
- Conditions
- Vancomycin Resistant Enterococci Infection, Clostridium Difficile Infection, Nosocomial Infection, Methicillin Resistant Staphylococcus Aureus Infection (MRSA)
- Trial name
- NCT00563186
- Testing
- Admission to a novel hospital ward
- Where
- Canada
- Volunteers
- 1,514 people
- Sponsor
- University of Calgary
Infection Control, Antibiotic Prophylaxis
The Effect of Antibiotic Prophylaxis Associated With Dental Implant Surgery
The overall aim of the study is to investigate whether routine administration of antibiotic prophylaxis 1 hour prior to implant surgery may prevent postoperative infection and implant loss in healthy or substantially healthy…
- Trial name
- NCT03412305
- Testing
- Amoxicillin
- Where
- Sweden
- Volunteers
- 474 people
- Sponsor
- Malmö University
Graft-versus-host Disease Prevention
Fecal Transplant +/- Gut Decontamination in Preventing Acute Graft Versus Host Disease in Patients Given Broad-Spectrum Antibiotics
This phase II trial studies how well a fecal microbiota transplant with or without total gut decontamination works in preventing graft versus host disease in patients exposed to broad-spectrum antibiotics.
- Trial name
- NCT03862079
- Testing
- Best Practice, Fecal Microbiota Transplantation, Nystatin
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Osteosynthesis, Infection Prevention
Use of a Taurolidine Containing Antimicrobial Wash to Reduce Prosthetic Device Infection After Trauma Surgery
A taurolidine-based antimicrobial solution, was evaluated for its safety and efficacy in preventing infections associated with prosthetic materials, such as joint replacements, plates, nails, and screws.
- Trial name
- Prosafeti (NCT06919770)
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- University of Kiel
Infection Prosthesis Hip and Knee, Infection, Prosthesis Related
Results of Extended Versus Single Dose Antibiotic Prophylaxis In Orthopedic Revision Arthroplasty in Nijmegen.
The goal of this randomized control trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
- Conditions
- Infection Prosthesis Hip and Knee, Infection, Prosthesis Related, Joint Infection, Infection, Surgical Site
- Trial name
- REViSION (NCT06402591)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 751 people
- Sponsor
- Radboud University Medical Center
Radical Cystectomy, Surgical Site Infection
Optimized Perioperative Antibiotic Prophylaxis in Radical Cystectomy
Cystectomy with urinary diversion (ileal conduit, orthotopic ileal bladder substitute, continent catheterizable pouch) is the best treatment option for patients with muscle-invasive bladder cancer.
- Conditions
- Radical Cystectomy, Surgical Site Infection, Urologic Cancer, Perioperative/Postoperative Complications
- Trial name
- PAPRAC (NCT03305627)
- Testing
- Short PAP, Extended PAP
- Where
- 2 sites in Switzerland
- Volunteers
- 196 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Bariatric Surgery
Tissue and Plasma Pharmacokinetics of Cefazolin in Antibiotic Prophylaxis in Bariatric Surgery
With 6.5 million obese recorded in France in 2009, obesity is a major public health: it is a chronic disease associated with many respiratory, cardiac, metabolic, musculoskeletal complications.
- Trial name
- Cefasleeve (NCT01537380)
- Testing
- Cefazoline
- Where
- France
- Volunteers
- 117 people
- Sponsor
- Nantes University Hospital
Fracture of Hip, Total Hip Arthroplasty
Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a Fracture
Aim: To compare the effect of one single dose versus multiple doses of prophylactic antibiotics administered within 24 hours, on the development of PJI after surgery in patients undergoing primary THA due to an acute fracture or…
- Conditions
- Fracture of Hip, Total Hip Arthroplasty, Prosthetic-joint Infection, Fracture Acetabular
- Trial name
- ProHipQ-F (NCT05530174)
- Testing
- Antibiotic dosage practice
- Where
- 36 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Soren Overgaard
Osteoarthritis, Knee
Antibiotic Loaded Bone Cement in Prevention of Periprosthetic Joint Infections in Primary Total Knee Arthroplasty
Introduction: The current evidence on the efficacy of Antibiotic Loaded Bone Cement (ALBC) in reducing the risk of periprosthetic joint infections (PJI) after primary joint reconstruction is insufficient.
- Trial name
- ALBA (NCT04135170)
- Testing
- ALBC vs plain bone cement
- Where
- Norway
- Volunteers
- 9,172 people, healthy volunteers welcome
- Sponsor
- The Norwegian Arthroplasty Register
Assisted Reproductive Technology, Antibiotic Prophylaxis
Prophylactic Antibiotics Prior to Embryo Transfer (PAPET): RCT
The objective of this study is to determine the impact on clinical pregnancy rate of withholding routine prophylactic antibiotic therapy during IVF.
- Conditions
- Assisted Reproductive Technology, Antibiotic Prophylaxis, Embryo Transfer
- Trial name
- PAPET (NCT03386227)
- Testing
- Withholding antibiotic prophylaxis
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Breast Cancer, Chronic Myeloproliferative Disorders
Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant
RATIONALE: A donor stem cell transplant can lower the body's immune system, making it difficult to fight off infection. Giving antibiotics, such as moxifloxacin, may help prevent bacterial infections in patients who have recently…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Infection
- Trial name
- NCT00324324
- Testing
- moxifloxacin hydrochloride
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- OHSU Knight Cancer Institute
Shoulder Infections
Acne crème to Reduce Propionibacterium Acnes Load in Primary Shoulder Surgery
60 patients undergoing first time open shoulder surgery (Latarjet, prosthesis) will be prospectively included in this study. The investigators will do a randomized controlled trial, choosing with a single-blinded protocol 30…
- Trial name
- NCT03949751
- Testing
- Acne Crème Plus
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Balgrist University Hospital
Propionibacterium Infection
Antimicrobial Prophylaxis for Skin Colonization With Propionibacterium Acnes in Primary Open Shoulder Surgery
INESS Antibiotic Prophylaxis in Orthopedic Guide recommends the use of Cefazolin at induction for all orthopaedic procedure with implantation of internal fixation device. With the increasing rate of identified P.
- Trial name
- PAPA (NCT02996656)
- Testing
- Cefazolin, Ceftriaxone
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- Université de Montréal