Clinical trials: Antimicrobial Prophylaxis
Relationship Dynamics, Pre-exposure Prophylaxis (PrEP) Adherence
CHARISMA Expansion Study
The CHARISMA Expansion Study is a two-arm, randomized (1:1), controlled study of a behavioral intervention-the Community Health clinic model for Agency in Relationships and Safer Microbicide Adherence (CHARISMA)-to reduce social…
- Trial name
- CHARISMA (NCT04092114)
- Testing
- Control, CHARISMA Intervention
- Where
- South Africa
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- RTI International
Stomach Neoplasms
No Antimicrobial Prophylaxis for Laparoscopic Distal Gastrectomy
The aim of this study is to evaluate the feasibility and safety of no use of antimicrobial prophylaxis during laparoscopic distal gastrectomy for gastric carcinoma.
- Trial name
- KSWEET-01 (NCT02200315)
- Testing
- No Antimicrobial prophylaxis
- Where
- 3 sites in South Korea
- Volunteers
- 98 people
- Sponsor
- Korean South West East Gastric Surgery Group
Infection
Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate
Prostate biopsy is usually conducted transrectal, ultrasonography guided. Since the area is not sterile, infection can be induced during the procedure.
- Trial name
- NCT00480376
- Testing
- ofloxacin, gentamicin
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- HaEmek Medical Center, Israel
Antibiotic Prophylaxis, Colorectal Surgery
Intermittent Cefoxitin Administration Versus Loading Bolus Followed by Continuous Infusion for the Prevention of Surgical Site Infection in Colorectal Surgery
The goal of this prospective, multicentre, double-blind, randomized clinical trial is to compare intermittent cefoxitin administration to loading bolus followed by continuous infusion for surgical antibiotic prophylaxis in…
- Trial name
- PROPHYLOXITIN (NCT05755789)
- Testing
- Loading bolus of cefoxitin, Intermittent cefoxitin, Continuous infusion of cefoxitin
- Where
- 19 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Poitiers University Hospital
Elective Cesarean Section
Antibiotic Prophylaxis Before Surgery Versus After Cord Clamping in Elective Cesarean Delivery - a Double-blind, Prospective, Randomized Placebo-controlled Trial
In this prospective, randomized, placebo controlled trial the investigators were able to demonstrate the usefulness of prophylactic cefazolin in elective caesarean section versus placebo, irrespective of the timing of…
- Trial name
- NCT01248078
- Testing
- Keflex, saline solution
- Where
- Austria
- Volunteers
- 1,112 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dysphagia, Peristomal Wound Infection
The Influence of Oral Hygiene on Local Wound and Systemic Infection in Patients With Percutaneous Endoscopic Gastrostomy Placement
Percutaneous endoscopic gastrostomy (PEG) is commonly used for long term enteral feeding of patients with severe dysphagia. The most common complication is peristomal wound infection.
- Trial name
- PEG (NCT00859235)
- Testing
- Chlorhexidine gluconate 0.2%, Plain water
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Neonatal Infections Colonize With Group B Streptococci
Interest of the Detection of Hyper-virulent Clone ST17 of Group B Strep (GBS) for the Prevention of Neonatal GBS Meningitis
The main objective of this study : Demonstrate that GBS (group B streptococci) "ST-17" colonize and persist to 60 days twice in the digestive tract of newborns that strains of GBS non-ST-17.
- Trial name
- Col-Strepto B (NCT01719510)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 949 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Appendicitis
Laparoscopic Appendectomy for Uncomplicated Appendicitis: Does Antimicrobial Prophylaxis Really Matter?
To compare surgical site infection (SSI) rate in patients undergoing laparoscopic appendectomy for acute uncomplicated appendicitis and treated with single dose regime of antibiotics versus group of patients undergoing…
- Trial name
- NCT02404064
- Testing
- cefamezin 1g IV, metronidazole 500 mg IV
- Volunteers
- 288 people
- Sponsor
- HaEmek Medical Center, Israel
Mycobacterium Avium-Intracellulare Infection, HIV Infections
A Study to Examine the Effects of Stopping Preventive Therapy for Disseminated Mycobacterium Avium Complex (DMAC) in HIV-Positive Patients
The purpose of this study is to evaluate the effects of stopping preventive therapy for DMAC in HIV-positive patients who (1) have been treated for DMAC for at least 12 months and are now free of any signs of DMAC for at least 16…
- Trial name
- NCT00000907
- Where
- 24 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Induced Abortion, Postaboral Pelvic Inflammatory Disease
To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy
Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when…
- Conditions
- Induced Abortion, Postaboral Pelvic Inflammatory Disease, Sexually Transmitted Infections
- Trial name
- NCT01842100
- Testing
- Universal antibiotic prophylaxis, Screen-and-treat
- Where
- China
- Volunteers
- 2,193 people
- Sponsor
- The University of Hong Kong
Hysterectomy
Tinidazole Versus Cefazolin Antibiotic Prophylaxis of Vaginal and Abdominal Hysterectomy
Purpose: to compare the efficacy of tinidazole and cefazolin on the prophylaxis of the febrile and infectious morbidity after vaginal or abdominal hysterectomy.
- Trial name
- NCT00787553
- Testing
- cefazolin, tinidazole, cefazolin plus tinidazole
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- University of Campinas, Brazil
Ventilator-associated Pneumonia, Cardiac Arrests With Shockable Rhythm
Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications
Mild therapeutic hypothermia is currently recommended in management of cardiac arrests with shockable rhythm. In mechanically ventilated patients who were resuscitated after out-of-hospital cardiac arrests, mild therapeutic…
- Conditions
- Ventilator-associated Pneumonia, Cardiac Arrests With Shockable Rhythm, Mild Therapeutic Hypothermia, Preventive Antibiotics
- Trial name
- ANTHARTIC (NCT02186951)
- Testing
- Amoxicillin - clavulanic acid
- Where
- 16 sites in France
- Volunteers
- 197 people
- Sponsor
- University Hospital, Limoges
Head and Neck Cancer
Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Head and Neck Cancer to Prevent Aspiration Pneumonia
Patients with locally advanced head and neck cancer treated with chemo-radiotherapy have (during and shortly after this treatment) a high risk of developing pneumonia by aspiration.
- Trial name
- PANTAP (NCT01598402)
- Testing
- amoxicillin/clavulanic acid suspension
- Where
- 6 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Obese, Antibiotic Prophylaxis
Serum Concentration of CEFOxitin Used for Antibiotic Prophylaxis in Obese Patients Undergoing BARiatric Surgery
Obesity is a pandemic problem in modern societies. Bariatric surgery (gastric by-pass and sleeve gastrectomy) has emerged as an efficient treatment to reduce morbidity and mortality related to obesity.
- Conditions
- Obese, Antibiotic Prophylaxis, Bariatric Surgery Candidate
- Trial name
- CEFOBAR (NCT03306290)
- Testing
- Serum dosage of antibiotic prophylaxis CEFOXITIN
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Microbial Colonization, Antibiotic Side Effect
Timing of Maternal Antibiotic Prophylaxis During a Cesarean Section and the Early Infant Gut Microbiome
In this study, investigators seek to determine whether the timing of antibiotics given to mothers during an elective C-section affects the composition of their infant's gut microbiome.
- Conditions
- Microbial Colonization, Antibiotic Side Effect, Cesarean Section Complications
- Trial name
- CSBabyBiome (NCT06030713)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Colorectal Neoplasms
Trial of Antibiotic Prophylaxis in Elective Laparoscopic Colorectal Surgery: Oral and Systemic Versus Systemic Antibiotics
The purpose of this study is to determine optimal prophylactic antibiotics administration method in elective laparoscopic colorectal surgery.
- Trial name
- NCT00508690
- Testing
- cefmetazole, kanamycin/metronidazole
- Where
- 5 sites in Japan
- Volunteers
- 584 people
- Sponsor
- Japan Multinational Trial Organization
Elective Colorectal Surgery
Intravenous Versus Combined Oral and Intravenous Antimicrobial Prophylaxis for the Prevention of Surgical Site Infection in Elective Colorectal Surgery
To assess the effects of a combined antimicrobial prophylaxis using oral ornidazole (the day before surgery) and intravenous cephalosporin (before surgical incision) with that of intravenous cephalosporin alone (standard of care)…
- Trial name
- COMBINE (NCT02618720)
- Testing
- ornidazole
- Where
- France
- Volunteers
- 920 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infection
Prophylaxis Of Wound Infections- Antibiotics in Renal Donation
The aim of this study is to see whether antibiotics given at the start of laparoscopic kidney donation surgery prevent infection.
- Trial name
- POWAR (NCT02089568)
- Testing
- Co-Amoxiclav, Normal Saline
- Where
- United Kingdom
- Volunteers
- 284 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Surgical Site Infection
Study for Antibiotic Impregnated Calcium Sulfate Beads as Prophylaxis for Surgical Site Infection
The CDC quotes a rate of wound infection of 2-5% for inpatient surgery. Patients undergoing a vascular operation, however, are generally at an increased risk of wound infection with rates often close to 5-10%.
- Trial name
- NCT03308253
- Testing
- Stimulan Rapid Cure, Vancomycin, Tobramycin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Infection
Antibiotic Prophylaxis for Transrectal Prostate Biopsy
This study is being conducted in men scheduled to undergo transrectal ultrasound-guided prostate biopsy (TRUSP). Traditionally prior to prostate biopsy, an antibiotic, ciprofloxacin, has been given to men to prevent…
- Trial name
- NCT01659866
- Testing
- Ciprofloxacin, trimethoprim-sulfamethoxazole, cefuroxime
- Where
- United States
- Volunteers
- 563 people, healthy volunteers welcome
- Sponsor
- Northwestern University