Clinical trials: Antimicrobial Susceptibility Testing
Helicobacter Pylori Infection, Antibiotic Resistant Infection
Non-invasive Test-guided Tailored Therapy Versus Empiric Treatment for Helicobacter Pylori Infection.
The aim of our study will be to assess in an open-label, multicenter, randomized controlled trial whether a tailored therapy guided by a non-invasive antibiotic susceptibility test on stool samples achieves higher Helicobacter…
- Conditions
- Helicobacter Pylori Infection, Antibiotic Resistant Infection, Antibiotic Resistant Strain
- Trial name
- THD-HP (NCT04107194)
- Testing
- Pantoprazole 40mg, Amoxicillin 1000 MG, Clarithromycin 500mg
- Where
- Italy
- Volunteers
- 362 people
- Sponsor
- University of Bari
Bloodstream Infection
Genotypic Versus Phenotypic Susceptibility Testing of Positive Blood Cultures
This study is designed as a prospective, randomized, open-label trial evaluating antimicrobial utilization, clinical outcomes, and healthcare costs among patients with positive blood cultures.
- Trial name
- NCT03744728
- Testing
- Accelerate PhenoTest™ BC kit, Standard of Care
- Where
- United States
- Volunteers
- 774 people
- Sponsor
- Accelerate Diagnostics, Inc.
Antibiotic Susceptibility Reporting
Discontinuation of Antibiotic Susceptibility Testing on Enterococcus Faecalis Positive Urine Cultures in Hospitalized Patients: an Impact on Antibiotic Prescriptions? (FaecaCible)
The objective of the study is to evaluate the impact of not reporting antibiotic susceptibility tests on antibiotic consumption for Enterococcus faecalis positive urine cultures in adult hospitalized patients.
- Trial name
- FaecaCible (NCT05743192)
- Testing
- Stop performing an antibiotic susceptibility test
- Where
- France
- Volunteers
- 217 people
- Sponsor
- Central Hospital, Nancy, France
Prosthetic Joint Infection, Prosthetic Infection
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections
The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patient outcomes and reduce the…
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Hip Prosthesis Infection, Knee Prosthesis Infection
- Trial name
- NCT04488458
- Testing
- MIC or MBEC+MIC based treatment algorithm
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori Rescue Treatment
With increasing antibiotic resistance and unsatisfactory results of empiric eradication regimens, tailored therapy may be the best choice to achieve high efficacy for rescue treatment.
- Trial name
- NCT03413020
- Testing
- esomeprazole, bismuth Potassium Citrate, amoxicillin
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection
Genotypic Resistance Guided Versus Susceptibility Testing Guided Therapy for the First-line Eradication of H. Pylori
We aimed to (1) compare the efficacy of genotypic resistance guided sequential therapy vs. susceptibility testing guided therapy in the first-line therapy (2) assess the long term impact of eradication therapy on the antibiotic…
- Trial name
- NCT03556254
- Testing
- GGT, SGT
- Where
- Taiwan
- Volunteers
- 560 people
- Sponsor
- National Taiwan University Hospital
Antimicrobial Susceptibility Testing, Triple Therapy
Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment
Helicobacter pylori (H. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer.
- Trial name
- NCT03139253
- Testing
- amoxicillin, clarithromycin, tinidazole
- Volunteers
- 120 people
- Sponsor
- Yanqing Li
Gram-negative Bacteremia
Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia
RAPIDS-GN is a multi-center, prospective, randomized, controlled trial to evaluate the following strategies for patients with confirmed gram-negative bacillus bacteremia (GNB): 1.
- Trial name
- RAPIDS-GN (NCT03218397)
- Testing
- Accelerate PhenoTest™ BC Kit, Standard Culture and AST
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Helicobacter Pylori Infection
Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy
Increasing drug resistance presents a significant challenge to the efficacies of common empiric eradication regimens for Helicobacter pylori treatment in the mainland of China.
- Trial name
- NCT03708848
- Testing
- Esomeprazole, Bismuth Potassium Citrate, Clarithromycin
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Helicobacter Pylori Infection, Antimicrobial Susceptibility Testing
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the First-line Helicobacter Pylori Eradication.
The purpose of this study is to assess efficacy of 10-day antimicrobial susceptibility test guided triple therapy for the first-line treatment of Helicobacter pylori infection, then comparing it with 14-day empirical tailored…
- Trial name
- NCT03571230
- Testing
- two sensitive antibiotics(amoxicillin, clarithromycin, metronidazole, tinidazole, levofloxacin, furazolidone and tetracycline), two antibiotics based on personal medication history(amoxicillin,clarithromycin,furazolidone), one proton pump inhibitor(PPI)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shandong University
Bacteremia
Rapid Antimicrobial Susceptibility Testing with MIC Directly from Positive Blood Cultures with ASTar
The investigators want to investigate the clinical impact of early antimicrobial susceptibility results for gram negative bacilli isolated from blood cultures on antimicrobial choices and early switches of antimicrobial therapy.
- Trial name
- RASTA (NCT06218277)
- Testing
- ASTAR
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- University Hospital, Ghent
Urinary Tract Infections
Selective Reporting for Antibiotic Susceptibility Testing and GPs' Prescribing of Broad-spectrum Antibiotics in Women With E. Coli UTIs
The control of antibiotic resistance requires a reduction in inappropriate prescriptions of broad-spectrum antibiotics (amoxillin-clavulanate (AMC), fluoroquinolones (FQ), third-generation cephalosporins (C3G)), particularly for…
- Trial name
- ABC-MG (NCT06067386)
- Testing
- Dissemination of a selective reporting for antibiotic susceptibility testing, Standard antibiotic susceptibility testing report
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Nantes University Hospital
Bacteremia
Clinical Performance and Reproducibility of the Accelerate PhenoTest™ Blood Culture (BC) Kit With New Antibiotic Wave I Updates
This is a performance and reproducibility study to validate new or updated antimicrobials on the Accelerate PhenoTest™ BC kit. The data from this study will be used to support the submission to the FDA for clearance in the US and…
- Trial name
- NCT04295915
- Testing
- Specimens that meet inclusion criteria
- Where
- 3 sites in United States
- Volunteers
- 731 people, healthy volunteers welcome
- Sponsor
- Accelerate Diagnostics, Inc.
Urinary Tract Infections
ADAPT-AST (Adaptive Antimicrobial Susceptibility Testing)
The goal of this study is to improve the way urinary tract infections (UTIs) are tested for antibiotic resistance. The main questions it aims to answer are: Can the investigators use a method called Bayesian causal inference to…
- Trial name
- ADAPT-AST (NCT06297837)
- Where
- United Kingdom
- Volunteers
- 500,000 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Sepsis With Escherichia Coli
Rapid Detection of Bacterial Resistance by MALDI-TOF MS and Antibiotic Savings
This study aims at determining within a short time (<3h) the susceptibility to clinical isolates of E. coli to the major antibiotics directly from positive blood cultures.
- Trial name
- MALDI-TRAc (NCT02860247)
- Volunteers
- 103 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pseudomonas
Impact of Modifications to the Rendering of the Antibiogram on the Prescriptions of Meropenem in Pseudomonas Bacteremia
Modification of the rendering of the antibiogram at the Strasbourg University Hospital in November 2019 with the appearance of the concept of "standard dose" or "high dose" sensitivity.
- Trial name
- Mero-Pyo (NCT06113107)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Bacteremia
Impact of Performing a Rapid Antibiotic Susceptibility Test on Antibiotic Therapy Adaptation in Adult Patients with Enterobacterales Bacteremia
Bacteremia is defined as the presence of bacteria in the blood. They can potentially lead to life-threatening septic shock. Effective probabilistic antibiotic therapy must therefore be initiated immediately after blood cultures…
- Trial name
- MHR-Blood (NCT06425367)
- Testing
- Antibiotic susceptibility testing
- Where
- France
- Volunteers
- 960 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Periodontal Diseases
Antibacterial and Anti-biofilm Activity of Frankincense Extract Against Porphyromonas Gingivalis
Boswellia sacra Flueck. oleoresin extract (frankincense) was traditionally used in the treatment of different diseases as respiratory, rheumatoid arthritis, and bacterial infections.
- Trial name
- NCT04705714
- Testing
- Frankincense Extract
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Helicobacter Pylori Infection
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the Rescue Treatment of Helicobacter Pylori Infection
The purpose of this study is to assess efficacy of 14-day antimicrobial susceptibility test guided quadruple therapy for the rescue treatment of Helicobacter pylori infection, then comparing it with 14-day personal medication…
- Trial name
- NCT03565484
- Testing
- susceptibility guided therapy, personal medication history guided therapy, salvage treatment for failed eradication
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shandong University
Therapeutic Duration, Helicobacter Pylori
Optimal Duration of Antimicrobial Susceptibility Test (AST) Guided Rescue Therapy for Helicobacter Pylori Infection
Strongly evidence supports that H. pylori eradication is an effective approach to reduce the incidence of those pathologies. However, due to the increasing resistance rates to antibiotics, failures of H.
- Conditions
- Therapeutic Duration, Helicobacter Pylori, Antimicrobial Susceptibility Test, Eradication
- Trial name
- NCT02934048
- Testing
- 7-day triple regimen guided by AST, 10-day triple regimen guided by AST, 14-day triple regimen guided by AST
- Volunteers
- 700 people
- Sponsor
- Shandong University