Clinical trials: Antiretroviral Therapy, Highly Active
HIV Infections, Hypertriglyceridemia
The Effect of Fish Oil Plus Fenofibrate on Triglyceride Levels in People Taking Highly Active Antiretroviral Therapy (HAART)
The purpose of this study is to determine the effectiveness of fish oil supplements combined with the drug fenofibrate in treating elevated triglyceride levels in people taking anti-HIV drugs.
- Trial name
- NCT00076518
- Testing
- Fenofibrate, Fish Oil
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1
PI or NNRTI as First-line Treatment of HIV in West Africa - the PIONA Trial
BACKGROUND: Since 1996 the combination of three or more drugs has been the mainstay of human immunodeficiency virus (HIV) treatment.
- Trial name
- PIONA (NCT01192035)
- Testing
- Efavirenz or Nevirapine, Ritonavir-boosted lopinavir
- Where
- Guinea-Bissau
- Volunteers
- 400 people
- Sponsor
- University of Aarhus
HIV Infections
Stopping and Restarting Anti-HIV Drugs in Children and Adolescents With Low Blood Levels of HIV
Some patients taking anti-HIV drugs as part of highly active antiretroviral therapy (HAART) do not show any HIV in the blood; however, some HIV will remain hidden in the body and, if the drugs are stopped, will return to the…
- Trial name
- NCT00016783
- Where
- 17 sites in United States, Puerto Rico
- Volunteers
- 39 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
The Effect of Anti-HIV Therapy on Fat Metabolism in HIV-Positive Patients
The purpose of this study is to see how taking certain anti-HIV drugs affects the way the body metabolizes fat. This study will evaluate patients who are enrolled in CPCRA 058 (the FIRST [Flexible Initial Retrovirus Suppressive…
- Trial name
- NCT00001102
- Where
- 15 sites in United States
- Volunteers
- 460 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Observational Cohort of HIV Infected Adults and Children in the PHPT Network Hospitals in Thailand
Since 2004, the Thai Ministry of Public Health has massively scaled up antiretroviral treatment programs to provide therapy to more than 80,000 patients with partial support of the Global Fund to fight AIDS, Tuberculosis and…
- Trial name
- NCT00433030
- Where
- 38 sites in Thailand
- Volunteers
- 2,816 people
- Sponsor
- Institut de Recherche pour le Developpement
HIV Infections
The Effectiveness of Ritonavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients
To determine whether administration of a highly active antiretroviral treatment regimen consisting of ritonavir (ABT-538), zidovudine (AZT), and lamivudine (3TC) is associated with the restoration of delayed type hypersensitivity…
- Trial name
- NCT00001075
- Testing
- Ritonavir, Lamivudine, Zidovudine
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Maraviroc Intensification and Peripheral Blood Monocyte HIV DNA Levels
High levels of HIV infection within blood monocyte/macrophages (a type of white cells in the bloodstream) increases risk of dementia in HIV-infected individuals.
- Trial name
- NCT00987948
- Testing
- maraviroc (Selzentry)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Hawaii
HIV Infections
Effect of Nutritional Intervention on the Lipid Profile of HIV-Positive Patients Who Start HAART: a Randomized Trial
Highly active antiretroviral therapy (HAART) in HIV-positive patients is associated with the development of dyslipidemia, a risk factor for cardiovascular events.
- Trial name
- NCT00429845
- Testing
- Nutritional
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
HIV Infection
Safety, Tolerability and Immunogenicity Induced by the THV01 Treatment in Patients Infected With HIV-1 Clade B and Treated With Highly Active Antiretroviral Therapy (HAART).
The objectives of this Phase I/II trial is to evaluate the safety, tolerability and immunogenicity of THV01 compared to placebo in HIV-1 infected patients on HAART (highly active antiretroviral therapies).
- Trial name
- NCT02054286
- Testing
- THV01-1, THV01-2
- Where
- 11 sites in Belgium, France
- Volunteers
- 38 people
- Sponsor
- Theravectys S.A.
AIDS-related Kaposi's Sarcoma
A Study of Selumetinib in Patients With Kaposi's Sarcoma
Cancer is a leading cause of death in individuals living with human immunodeficiency virus (HIV), and Kaposi's sarcoma (KS) remains the commonest HIV-associated cancer.
- Trial name
- SCART (NCT01752569)
- Testing
- Selumetinib
- Where
- 6 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Acquired Immunodeficiency Syndrome
PI Vs. NNRTI Based Therapy for HIV Advanced Disease
Ritonavir boosted protease inhibitor based therapy will have equivalent antiviral efficacy over 48 weeks compared to NNRTI based therapy in patients who are antiretroviral therapy naïve and initiate therapy with CD4 counts ≤…
- Trial name
- NCT00162643
- Testing
- zidovudine+lamivudine+lopinavir/ritonavir, zidovudine + lamivudine + efavirenz
- Where
- 5 sites in Mexico
- Volunteers
- 300 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran