Clinical trials: Antithrombotic
NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI), Acute Myocardial Infarction (AMI)
Treatment With Aspirin Alone Versus Aspirin in Combination With Fondaparinux Before Early Coronary Assessment in Patients With Non-ST-Elevation Myocardial Infarction
The main goal of this study is to compare two treatments in patients with a specific type of heart attack called Non-ST-elevation Myocardial Infarction (NSTEMI).
- Trial name
- FOXY (NCT06710184)
- Testing
- Aspirin, Fondaparinux Sodium
- Where
- 10 sites in Denmark
- Volunteers
- 5,076 people
- Sponsor
- University of Aarhus
Covid19
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis
A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge
- Trial name
- NCT04650087
- Testing
- Apixaban 2.5 MG
- Where
- 121 sites in United States
- Volunteers
- 1,291 people
- Sponsor
- Thomas L. Ortel
Hypertension
Doxazosin and Ramipril in Hypertension
Randomized double-blind parallel group study in patients with mild-to-moderate hypertension to evaluate the effects beyond the blood pressure lowering effect of treatment for 12 weeks with ramipril or doxazosin on hemostatic…
- Trial name
- DoRa (NCT02901977)
- Testing
- Ramipril, Doxazosin
- Where
- Sweden
- Volunteers
- 71 people
- Sponsor
- Karolinska Institutet
Stroke of Basilar Artery, Optical Coherence Tomography
Optical Coherence Tomography Guided Antithrombotic Treatment After Endovascular Thrombectomy of the Posterior Circulation
Evidence regarding the role of early (<24 hours) antithrombotics post-revascularization with either intravenous thrombolysis (IVT), endovascular thrombectomy (EVT), or a combination of both remains scarce.
- Conditions
- Stroke of Basilar Artery, Optical Coherence Tomography, Antithrombotics, Endovascular Thrombectomy
- Trial name
- NCT04121611
- Testing
- Unfractionated heparin, Acetylsalicylic Acid (ASA)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sunnybrook Health Sciences Centre
Venous Thromboembolic Disease
Best Antithrombotic Therapy in Patients With Acute Venous ThromboEmbolism While Taking Antiplatelets
Venous thromboembolism (VTE) and atherosclerotic cardiovascular disease share common risk factors and frequently coexist in the same patients.
- Trial name
- BAT-VTE (NCT05627375)
- Testing
- Full-dose anticoagulant therapy (AC), Antiplatelet therapy (AP)
- Where
- 28 sites in France
- Volunteers
- 1,400 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Skin Graft Complications
Antithrombotics and Complications in Skin Grafts
Patients who were referred to cutaneous surgery and needed full thickness or split skin grafting and using antitrombotic or non-antitrombotic therapies were observed.
- Trial name
- NCT04231305
- Where
- Denmark
- Volunteers
- 172 people
- Sponsor
- Aalborg University Hospital
Antithrombotic Therapy, Perioperative Care
Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy
The purpose of this pragmatic interventional study is to evaluate whether a protocol-based management of antithrombotic drugs can reduce a composite of perioperative outcomes in patients with chronic antithrombotic therapy before…
- Conditions
- Antithrombotic Therapy, Perioperative Care, Perioperative Outcomes
- Trial name
- NCT04852406
- Testing
- Protocol-based management of perioperative antithrombotic therapy, Routine management of perioperative antithrombotic therapy
- Where
- China
- Volunteers
- 526 people
- Sponsor
- Peking University First Hospital
Atrial Fibrillation
COhort of antithrOmbotic Use and cLinical Outcomes in Patients With Atrial Fibrillation (COOL-AF) Phase 2
Atrial fibrillation (AF) is a leading cause of cardiovascular mortality and morbidity. Asian patients with AF have a higher rate of major bleeding including intracranial hemorrhage (ICH) compared to non-Asians.
- Trial name
- NCT06396299
- Testing
- No intervention
- Where
- 33 sites in Thailand
- Volunteers
- 4,000 people
- Sponsor
- Mahidol University
Atrial Fibrillation, Acute Coronary Syndromes
DUAL Antithrombotic Therapy in Patients With AF and ACS
The study aims to show inferiority of rivaroxaban plus ticagrelor when compared to rivaroxaban plus clopidogrel in terms of safety.
- Trial name
- NCT04023630
- Testing
- Rivaroxaban 15 MG Oral Tablet, Clopidogrel 75 Mg Oral Tablet, Ticagrelor 90 MG Oral Tablet
- Volunteers
- 4,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracranial Hemorrhages, Stroke
Risk of Intracranial Hemorrhage in Users of Oral Antithrombotic Drugs
The true incidence and risks of intracranial hemorrhage (ICH) in patients on various antithrombotic treatments remain unknown. Here a nationwide study is conducted to investigate the risk for and incidence rates of ICH in users…
- Trial name
- RICH (NCT02481011)
- Testing
- antithrombotic drugs
- Where
- Norway
- Volunteers
- 22,111 people
- Sponsor
- St. Olavs Hospital
Colorectal Polyps
Prospective Comparison of Cold Polypectomy and Conventional Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents
1. Background: The ideal method to remove small colorectal polyps in patients who are taking antithrombotic agents is unknown. 2.
- Trial name
- NCT01553565
- Testing
- Cold polypectomy
- Where
- Japan
- Volunteers
- 160 people
- Sponsor
- Showa Inan General Hospital
Thrombosis
Antithrombotic Activities of Sotagliflozin vs. Empagliflozin
The availability of Sodium-glucose cotransporter-2 inhibitors (SGLT2-i) has dramatically altered the management of heart failure (HF) patients, independently of their ejection fraction and glycemic status.
- Trial name
- SOTATHROMBUS (NCT06618976)
- Testing
- Sotagliflozin, Empagliflozin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Venous Thromboembolism, Embolism and Thrombosis
Factor IX Inhibition in Thrombosis Prevention (The FIXIT Trial)
The purpose of this study is to determine whether TTP889 prevents venous thromboembolism following surgery to repair hip fracture.
- Conditions
- Venous Thromboembolism, Embolism and Thrombosis, Hip Fractures
- Trial name
- NCT00119457
- Testing
- TTP889
- Where
- 21 sites in Czechia, Denmark and 2 more
- Volunteers
- 300 people
- Sponsor
- vTv Therapeutics
Chronic Renal Failure
Evaluation of Two New Innovative Haemostasis Tests: Measurement of the Active Form of GTP-bound Rap1b (aRap1b) in Platelets and the Pro and Antithrombotic Balance of Circulating Endothelial Microvesicles (patEMV) (INNOV-CKD Test)
The aim of this PROJECT is to develop two biomarkers to assess the thrombotic and hemorrhagic risk of patients with chronic renal failure (CKD) treated with antiplatelet drugs following the occurrence of an acute coronary…
- Trial name
- INNOV-CKD test (NCT05765630)
- Testing
- BLOOD SAMPLES
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hip Fracture, Antithrombotic Therapy
Assessing the Effectiveness and Safety of Pericapsular Nerve Group (PENG) Block in Hip Fracture Patients on Antithrombotic Therapy
PENG block will be done on patients with hip fracture either receiving antithrombotic therapy or not under ultrasound guidance
- Conditions
- Hip Fracture, Antithrombotic Therapy, PENG Block
- Trial name
- PENG Block (NCT06582667)
- Testing
- PENG block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Non-valvular Atrial Fibrillation (NVAF), Venous Thromboembolism (VTE)
Precision Antithrombotic Therapy
The goal of this observational study is to systematically analyze the relationship between trough/peak concentrations of novel oral anticoagulants (NOACs) and antiplatelet drugs with clinical events, aiming to provide high-level…
- Conditions
- Non-valvular Atrial Fibrillation (NVAF), Venous Thromboembolism (VTE), MI(Myocardial Infarction), Ischemic Stroke
- Trial name
- NCT07654634
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Transcatheter Aortic Valve Replacement, Antithrombotic Therapy
Antithrombotic Strategy Based on Clinical Events and 4D-CT for Patients After TAVR
This is a multicenter, open-label, randomized controlled study meant to test the superior efficacy of oral anticoagulation (OAC) therapy versus single antiplatelet therapy (SAPT) in patients after TAVR.
- Conditions
- Transcatheter Aortic Valve Replacement, Antithrombotic Therapy, Bioprosthetic Valve Thrombosis
- Trial name
- NCT05375474
- Testing
- Oral anticoagulation therapy, Single antiplatelet therapy
- Where
- China
- Volunteers
- 650 people
- Sponsor
- China National Center for Cardiovascular Diseases
Type-2 Diabetes Mellitus, Coronary Artery Disease
Ticagrelor Versus Clopidogrel in Type 2 Diabetic Patients
The purpose of this study is to determine whether treatment with ticagrelor + aspirin is more effective than treatment with clopidogrel + aspirin in patients with type-2 diabetes.
- Trial name
- NCT01823510
- Testing
- Ticagrelor + Aspirin, Clopidogrel + Aspirin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Juan J Badimon
Transcatheter Aortic Valve Replacement
Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes
To assess whether a rivaroxaban-based anticoagulation strategy, following successful TAVR, compared to an antiplatelet-based strategy, is superior in reducing death or first thromboembolic events (DTE).
- Trial name
- GALILEO (NCT02556203)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Acetylsalicylic Acid (ASA), Clopidogrel
- Where
- 140 sites in United States, Austria and 15 more
- Volunteers
- 1,653 people
- Sponsor
- Bayer
Aortic Valve Replacement, Antithrombotic Therapy
Apixaban for the Prevention of Latent Biological Valve Thrombosis
Background: The optimal antithrombotic strategy early after aortic valve replacement surgery with a biological valve remains controversial due to lack of high-quality evidence.
- Conditions
- Aortic Valve Replacement, Antithrombotic Therapy, Bioprosthetic Valve Thrombosis, Rapid Deployment Valves
- Trial name
- NCT06184113
- Testing
- Aortic valve replacement surgery, Computed tomography, Echocardiography
- Where
- Croatia
- Volunteers
- 166 people
- Sponsor
- Clinical Hospital Centre Zagreb