Clinical trials: Antithrombotic Therapy
Atrial Fibrillation, Atrial Flutter
Cardiovascular Registry of Atrial Fibrillation
Follow a representative sample of Latin American patients diagnosed with atrial fibrillation to set data on demographic characteristics, documenting antithrombotic therapy, describe the INR control level of VKA users…
- Trial name
- LACROSS (NCT04456842)
- Testing
- Patient Registry Data
- Where
- 17 sites in Argentina, Brazil and 2 more
- Volunteers
- 2,016 people
- Sponsor
- Brazilian Clinical Research Institute
Coronary Artery Ectasia, Acute Coronary Syndromes (ACS)
Multicenter Trial of Antithrombotic Strategies in Acute Coronary Syndrome With Coronary Artery Ectasia
Coronary artery ectasia (CAE) is a condition in which a coronary artery becomes abnormally dilated, measuring at least 50% larger than the adjacent normal segment.
- Conditions
- Coronary Artery Ectasia, Acute Coronary Syndromes (ACS), STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
- Trial name
- OVER-TIME II (NCT07511257)
- Testing
- Aspirin 100 mg, Clopidogrel 75 mg, Rivaroxaban 15 mg
- Where
- Mexico
- Volunteers
- 326 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Acute Coronary Syndromes
EYESHOT (EmploYEd Antithrombotic Therapies in Patients With Acute Coronary Syndromes HOspitalized in iTalian Coronary Care Units)
This register will evaluate the use of different antithrombotic therapies, combinations of different drugs routinely used during any stage of hospital admission, with their timing, dosage and mode of administration, in patients…
- Trial name
- EYESHOT (NCT02015624)
- Where
- 203 sites in Italy
- Volunteers
- 2,597 people
- Sponsor
- Heart Care Foundation
Acute Coronary Syndrome
Percutaneous Coronary Intervention Followed by Antiplatelet Monotherapy in the Setting of Acute Coronary Syndromes
Phase-3, randomized, multicenter, parallel-group study with blind evaluation of endpoints and intention-to-treat analysis. The general purpose of the study is evaluate the non-inferiority hypothesis for ischemic events and the…
- Trial name
- NEOMINDSET (NCT04360720)
- Testing
- Antiplatelet Monotherapy
- Where
- 50 sites in Brazil
- Volunteers
- 3,410 people
- Sponsor
- Hospital Israelita Albert Einstein
Acute ST Elevation Myocardial Infarction
How Effective Are Antithrombotic Therapies in Primary Percutaneous Coronary Intervention
The purpose of this study is to compare unfractionated heparin (UFH) and bivalirudin in the performance and subsequent outcomes of Primary percutaneous coronary intervention. This will be a pragmatic trial.
- Trial name
- HEAT-PPCI (NCT01519518)
- Testing
- unfractionated heparin, Bivalirudin
- Where
- United Kingdom
- Volunteers
- 1,829 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Bleeding, Ischemic Stroke
The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet
The purpose of this study is to determine whether Plasma Factor VIII Levels are related to the treatment of bleeding in ischemic stroke（IS）.
- Trial name
- NCT02677818
- Where
- China
- Sponsor
- Zhujiang Hospital
COVID-19, Venous Thromboembolism
Prevention of Arteriovenous Thrombotic Events in Critically-Ill COVID-19 Patients Trial
The researchers wanted to learn how to help sick patients who are in the hospital because of COVID-19. They are trying to find out the best way that is safe to stop blood clots that could be dangerous from forming in patients…
- Conditions
- COVID-19, Venous Thromboembolism, Arterial Thrombosis
- Trial name
- COVID-PACT (NCT04409834)
- Testing
- Unfractionated Heparin IV, Enoxaparin 1 mg/kg, Clopidogrel
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- The TIMI Study Group
Device Related Infection, Antithrombotic Drugs
Antithrombotic Therapy in Patients Undergoing CIED Surgery - HEMATOMA NO MORE Registry
Hundreds of thousands patients undergo implantation or replacement of cardiac implantable electronic devices (CIEDs) annually in Europe, and up to 50% of these subjects receive antiplatelet agents or oral anticoagulants.
- Conditions
- Device Related Infection, Antithrombotic Drugs, Cardiac Arrhythmia, Surgery--Complications
- Trial name
- NCT03067909
- Testing
- CIED surgery
- Where
- Italy
- Volunteers
- 1,450 people
- Sponsor
- Azienda Ospedaliera Universitaria Senese
Thromboembolism
SALTO - Epidemiological Study on Compliance and Treatment Satisfaction
Patients that are on total knee/hip replacement initiate prophylaxis treatment on the hospital ground. Once they leave the hospital, as outpatients they continue with the treatment at least during two consecutive weeks.
- Trial name
- SALTO (NCT00911001)
- Testing
- No Drug
- Where
- Spain
- Volunteers
- 480 people
- Sponsor
- Bayer
Atrial Fibrillation, Coronary Artery Disease
LAAO With DAPT Versus Antithrombotic Therapy
This study will retrospectively review and compare clinical outcomes between left atrial appendage occlusion with dual antiplatelet therapy versus conventional antithrombotic therapy in patients with atrial fibrillation…
- Trial name
- NCT03310801
- Testing
- ACP or Watchman
- Volunteers
- 480 people
- Sponsor
- Korea University Anam Hospital
Upper Gastrointestinal Bleeding
Anticoagulation With Enhanced Gastrointestinal Safety (AEGIS) Trial
This is a pragmatic, single center, feasibility pilot cluster randomized trial with embedded individual randomization to evaluate implementation strategies to increase the use of evidence-based practices to reduce upper…
- Trial name
- AEGIS (NCT05085405)
- Testing
- Clinician notification, Clinician Notification with Nurse Facilitation, Clinician Notification / Patient Activation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Cervical Artery Dissection
Antithrombotic Treatment Strategies in Cervical Artery Dissection
The goal of this clinical randomised controlled trial is to compare two treatment strategies - antiplatelet treatment strategy versus anticoagulation treatment strategy - in patients with acute, ischemic Cervical Artery…
- Trial name
- TREAT-CAD 2 (NCT07639892)
- Testing
- Antiplatelet Treatment Strategy, Anticoagulation Treatment Strategy
- Volunteers
- 1,100 people
- Sponsor
- University Department of Geriatric Medicine FELIX PLATTER
Acute Coronary Syndrome
Bleeding Risk Assessment System for Antithrombotic Therapy of ACS
Antithrombotic therapy is the cornerstone of the management of patients with acute coronary syndrome (ACS), which result in lower risk of mortality and ischemic events.
- Trial name
- NCT04162808
- Where
- China
- Volunteers
- 6,379 people
- Sponsor
- Beijing Anzhen Hospital
Severe Aortic Valve Stenosis
Personalized, CT-guided Antithrombotic Therapy Versus Lifelong Single Antiplatelet Therapy to Reduce Thromboembolic and Bleeding Events in Non-atrial Fibrillation Patients After Transcatheter Aortic Valve Implantation
The POPular ATLANTIS trial aims to investigate CT-guided antithrombotic therapy compared to lifelong single antiplatelet therapy after a transcatheter aortic valve implantation (TAVI) procedure.
- Trial name
- POP ATLANTIS (NCT06168370)
- Testing
- CT guided strategy
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- St. Antonius Hospital