Clinical trials: Anxiety, Generalized
Autism, Asperger's Syndrome
Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders
Autism spectrum disorders affect as many as 1 out of 150 children and are related to significant impairment in social, adaptive, and school functioning.
- Conditions
- Autism, Asperger's Syndrome, Generalized Anxiety Disorder, Social Phobia
- Trial name
- NCT01178385
- Testing
- Cognitive-behavioral therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Bipolar Disorder, Panic Disorder
Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD
The specific aim of this study is to evaluate the efficacy, tolerability, and safety of quetiapine SR monotherapy and divalproex sodium ER monotherapy in comparison to placebo in the treatment of ambulatory bipolar disorder with…
- Conditions
- Bipolar Disorder, Panic Disorder, Generalized Anxiety Disorder
- Trial name
- NCT00579280
- Testing
- quetiapine SR, divalproex sodium ER
- Where
- 3 sites in United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Social Anxiety Disorder
Effect of D-cycloserine Plus Cognitive Behavioral Therapy on People With Social Phobia
This study will assess the effectiveness of D-cycloserine combined with cognitive-behavior therapy in treating people with social anxiety disorder.
- Trial name
- NCT00515879
- Testing
- D-cycloserine, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Boston University Charles River Campus
Generalized Anxiety Disorder
An Efficacy and Safety Study of Vortioxetine (Lu AA21004) in Treating Generalized Anxiety Disorder
The purpose of this study is to determine the safety and efficacy of vortioxetine, once daily (QD), in treating Generalized Anxiety Disorder.
- Trial name
- NCT00734071
- Testing
- Vortioxetine
- Where
- 33 sites in United States
- Volunteers
- 304 people
- Sponsor
- Takeda
Anxiety Disorders,Generalized Anxiety Disorder
A Study of Escitalopram in the Treatment of Children and Adolescents With Generalized Anxiety Disorder
This is a study in minors (7 to 17 years old) diagnosed with generalized anxiety disorder (GAD) and evaluated using standard questionnaires as having at least moderate severity of GAD.
- Trial name
- NCT03924323
- Testing
- Escitalopram
- Where
- 39 sites in United States
- Volunteers
- 273 people
- Sponsor
- AbbVie
Anxiety Disorders
Effectiveness of Long-Term Versus Short-Term Treatment of Generalized Anxiety Disorder With Venlafaxine XR
This study will assess the effectiveness of venlafaxine XR, randomized to either venlafaxine XR or placebo in preventing the relapse of generalized anxiety disorder after 6 months of treatment versus 12 months of treatment.
- Trial name
- NCT00183274
- Testing
- Venlafaxine XR
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- University of Pennsylvania
Major Depression, Generalized Anxiety Disorder
Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepines
The hypothesis of this study is that symptoms of anxiety, depression and insomnia; and indices of psychosocial function will all improve, while BZ use will decrease significantly during a twelve-week trial period of substituting…
- Trial name
- NCT01244711
- Testing
- quetiapine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Weill Medical College of Cornell University
Generalized Anxiety Disorder
Pregabalin in the Treatment of Patients With Generalized Anxiety Disorder (GAD).
The primary objective of this study is to evaluate the efficacy of pregabalin as compared to placebo in the treatment of patients with general anxiety disorder (GAD).
- Trial name
- NCT00413010
- Testing
- pregabalin
- Where
- 68 sites in United States, Czechia and 6 more
- Volunteers
- 356 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
Memantine Treatment for Obsessive-compulsive Disorder and Generalized Anxiety Disorder
The objective of this study was to obtain preliminary open-label data on the efficacy and tolerability of memantine, an anti-glutamatergic medication with a unique pharmacodynamic profile, in individuals with OCD and individuals…
- Trial name
- NCT00674219
- Testing
- Memantine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Los Angeles
Anxiety Disorders
Proof of Concept in Patients With Generalized Anxiety Disorder (GAD)AZD7325
The purpose of this research study is to determine whether AstraZeneca's drug AZD7325 is safe and effective in the treatment of generalized anxiety disorder.
- Trial name
- NCT00807937
- Testing
- AZD7325, Lorazepam
- Where
- 51 sites in United States
- Volunteers
- 369 people
- Sponsor
- AstraZeneca
Pharmacokinetics
Biomarker Changes and Anxiolytic Effects-Phase 2
This study will examine the utility of plasma and urinary based biomarkers for the anxiolytic properties of kava. The investigators will conduct a one week, double blind, randomized placebo controlled trial of kava, dosed at…
- Trial name
- KavaPK (NCT04565145)
- Testing
- Kava Dietary Supplement
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Social Anxiety Disorder
12-Week Study of Pristiq (Desvenlafaxine) Social Anxiety Disorder
This study is designed to evaluate the efficacy and safety of Pristiq® in treatment of the symptoms of Generalized Social Anxiety Disorder (SAD).
- Trial name
- NCT01316302
- Testing
- Pristiq
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- The Medical Research Network
Anxiety Disorders Generalized
A Pilot fMRI Study of TMS in Late-Life Severe Worry
Investigators will test a novel intervention through experimental therapeutic approach using fMRI-directed Intermittent Theta Burst Stimulation (iTBS), a high frequency TMS paradigm, for the treatment of severe, uncontrollable…
- Trial name
- TINA (NCT03577106)
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Carmen Andreescu
Anxiety Generalized, Quality of Life
A Problem Solving Intervention for Hospice Caregivers
Hospice care is conceptualized as quality compassionate care for people facing a life-limiting illness, with services that cover clinical care, pain management, and emotional and spiritual support tailored to patients' and…
- Conditions
- Anxiety Generalized, Quality of Life, Depression
- Trial name
- NCT03712410
- Testing
- PISCES
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- George Demiris, PhD
Generalized Anxiety Disorder
Stress Reduction Techniques and Anxiety: Therapeutic and Neuroendocrine Effects
Current therapies for Generalized Anxiety Disorder (GAD) have limited effectiveness. This study measures the efficacy of two different approaches to reducing anxiety and stress.
- Trial name
- NCT01033851
- Testing
- Mindfulness Based Stress Reduction, Stress Management Education
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Massachusetts General Hospital
Generalized Anxiety Disorder
Randomized Trial of Adult Participants With Generalized Anxiety Disorder
The purpose of this study is to compare the efficacy of troriluzole versus placebo in participants with generalized anxiety disorder.
- Trial name
- NCT03829241
- Testing
- Troriluzole
- Where
- 53 sites in United States
- Volunteers
- 881 people
- Sponsor
- Biohaven Pharmaceuticals, Inc.
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts
The investigators are conducting this study to learn more about the cognitive and attentional processes among individuals with three types of repetitive negative thinking (RNT): mental rituals (as seen in obsessive compulsive…
- Conditions
- Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
- Trial name
- NCT04225624
- Testing
- Emotion Regulation Therapy - Attention Regulation (AR-ERT), Supportive Psychotherapy (SPT)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Pain, Postoperative
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery.
- Trial name
- NCT03577730
- Testing
- Caffeine Citrate, Dextrose Water
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Michigan
Generalized Anxiety Disorder
Empower Neuromodulation System - Pilot Study for Anxiety Treatment
This study evaluates the effects of peripheral nerve stimulation on anxiety levels in participants with Generalized Anxiety Disorder (GAD).
- Trial name
- NCT04901481
- Testing
- Empower Neuromodulation System
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Theranova, L.L.C.
Anxiety Disorders
Expectation of Unpleasant Events in Anxiety Disorders
Fear and anxiety are normal responses to a threat. However, anxiety is considered abnormal when the response to the threat is excessive or inappropriate.
- Trial name
- NCT00055224
- Testing
- Threat of shock
- Where
- United States
- Volunteers
- 921 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)