Clinical trials: Anxiety Disorders
Anxiety Disorder, Cancer
MDMA-assisted Therapy in People With Anxiety Related to Advanced Stage Cancer
This is a pilot study intended to find out if 3,4-methylenedioxymethamphetamine (MDMA) is safe and can help people with advanced stage cancer and anxiety arising from the cancer diagnosis.
- Trial name
- NCT00252174
- Testing
- Stage 1 Active Methylenedioxymethamphetamine, Stage 1 Low dose Methylenedioxymethamphetamine, Psychotherapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Depression, Postpartum, Anxiety Disorders
Inhaled Oxytocin and HPA Axis Reactivity
Mothers who were enrolled in the Mood, Mother and Infant study will be eligible to participate in the 6-year follow-up maternal visit.
- Conditions
- Depression, Postpartum, Anxiety Disorders, Stress, Psychological
- Trial name
- NCT03593473
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of North Carolina, Chapel Hill
Anxiety Disorders
Anxiety in Older Veterans
Anxiety leads to poor quality of life, avoidance of activities, decreased social engagement, functional decline, and disability in older patients.
- Trial name
- BREATHE (NCT02400723)
- Testing
- Progressive Muscle Relaxation, Diaphragmatic Breathing
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- VA Office of Research and Development
Burnout, Professional, Anxiety
Feasibility of a Yoga- and Mindfulness-Based Intervention for Resident Physicians
The investigators aim to initiate and complete the first investigation of the effect of a yoga-based program on resident physicians' psychological health using a randomized controlled trial to assess feasibility of the program in…
- Conditions
- Burnout, Professional, Anxiety, Depression, Stress
- Trial name
- NCT03687450
- Testing
- RISE yoga-based program
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Anxiety Disorders and Symptoms, Depression
Positive Valence System Enhancement Treatment for Anxiety and Depression: Clinical Efficacy and Neural Changes
The proposed project aims to test the efficacy and neural correlates of a behavioral treatment program comprised of positive activity interventions in a sample of individuals seeking treatment for anxiety or depression.
- Trial name
- NCT02330627
- Testing
- Positive Valence System Treatment
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of California, San Diego
Anxiety Disorders in Youth With Autism, Asperger's Syndrome, and Pervasive Developmental Disorder Not Otherwise Specified
Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
Comorbid anxiety disorders affect as many as 80% of youth with autism spectrum disorders, causing substantial distress and impairment over and above the autism spectrum diagnosis alone.
- Trial name
- NCT01177969
- Testing
- Cognitive-Behavioral Therapy, Wait-list
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Anxiety, Anorexia Nervosa
Treatment of Anxiety and Anorexia Nervosa in Adolescents
Adolescents with anorexia nervosa frequently have associated anxiety, and standard medications used for anxiety are unhelpful when patients are malnourished.
- Trial name
- TAANA (NCT01933243)
- Testing
- Fish oil
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Andrea Bonny
Mental Health Issue, Alcohol Use Disorder
Acceptability and Feasibility of Cognitive Behavioral Therapy for Treatment-Seeking (CBT-TS) With Deaf Individuals
The current study aims to assess the acceptability and feasibility of an adapted version of Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS) for use with signing Deaf adults.
- Conditions
- Mental Health Issue, Alcohol Use Disorder, Depression, Anxiety
- Trial name
- NCT05520190
- Testing
- Cognitive Behavioral Therapy for Treatment Seeking (CBT-TS)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Rochester
Traumatic Brain Injury, Chronic Pain
One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change
Mild traumatic brain injury (mTBI) is the signature wound of Veterans returning from the operations in Iraq and Afghanistan (i.e., OIF/OEF/OND), with up to 20 percent experiencing persistent post-concussive symptoms.
- Conditions
- Traumatic Brain Injury, Chronic Pain, Post Traumatic Stress Disorder, Depression
- Trial name
- NCT04143243
- Testing
- ACT on Life, Education, Resources, and Support
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- VA Office of Research and Development
Stress, Anxiety
Effects of Open-label Placebos on COVID-related Psychological Health
This project aimed to test the efficacy of a telehealth-administered placebo without deception intervention on stress, anxiety, and depression related to the COVID-19 pandemic.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT05035550
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Anxiety, Depression
Effectiveness of CES on Emotional and Cellular Wellbeing
The investigators aim to use a CES (cranial electrotherapy stimulation) intervention to improve emotional well-being by reducing symptoms of anxiety and depression and to assess for changes in markers of cellular health …
- Trial name
- NCT03369418
- Testing
- Alpha-Stim Active, Alpha-Stim Inactive
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Social Anxiety
1/2 A Multi-site Systems Intervention for Unemployed Persons With Social Anxiety
Social anxiety disorder is a highly prevalent condition that interferes with employment. Prior research indicates that social anxiety disorder interferes with work attainment.
- Trial name
- NCT02633267
- Testing
- Vocational Services as usual plus Cognitive Behavioral Therapy (CBT), Usual Vocational Services
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Michigan
Anxiety, Anxiety Disorders
Generalized Anxiety Disorder Adjunct Study
This study is being carried out to see if extended release quetiapine fumarate (Seroquel®XL) when added to standard selective serotonin reuptake inhibitor (SSRI) / serotonin-norepinephrine reuptake inhibitor (SNRI) therapy is…
- Conditions
- Anxiety, Anxiety Disorders, Anxiety Neuroses, Anxiety States
- Trial name
- NCT00534599
- Testing
- quetiapine fumarate XR
- Where
- 53 sites in United States
- Volunteers
- 409 people
- Sponsor
- AstraZeneca
Generalized Anxiety Disorder
GATE: Generalized Anxiety - A Treatment Evaluation
The purpose of this randomized study is to examine the comparative efficacy of yoga, cognitive behavioral therapy, and stress education, a previously employed control condition, for patients with Generalized Anxiety Disorder.
- Trial name
- NCT01912287
- Testing
- Cognitive Behavioral Therapy, Stress Education, Yoga
- Where
- 2 sites in United States
- Volunteers
- 226 people
- Sponsor
- NYU Langone Health
Anxiety, Cardiovascular Disease
Exercise and Pharmacotherapy for Anxiety in Cardiac Patients
Coronary heart disease (CHD) is the leading cause of death in the United States; more than 600,000 Americans suffer a fatal cardiac event each year.
- Trial name
- NCT02516332
- Testing
- Lexapro, Supervised Aerobic Exercise
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Duke University
Critical Illness, Family Members
Addressing Palliative Care Needs Among Intensive Care Unit Family Members
The quality of palliative care is highly variable for many patients treated in intensive care units (ICUs) and their family members.
- Conditions
- Critical Illness, Family Members, Psychological Distress, Informal Caregivers
- Trial name
- ICUconnect (NCT03506438)
- Testing
- Needs-focused mobile app, Usual care
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Duke University
Anxiety Disorders, Post Traumatic Stress Disorder
Increasing Treatment Efficacy Using SMART Methods for Personalizing Care
The proposed study will determine the feasibility, tolerability, and acceptability of a study that tests: 1) personalized treatment delivery (i.e., module sequencing and treatment discontinuation timing) aimed at increasing the…
- Conditions
- Anxiety Disorders, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT04642898
- Testing
- Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shannon E. Sauer-Zavala
Depressive Disorder, Depression
Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress
The purpose of this study is to assess the tolerability, safety, and efficacy of brexpiprazole (2.0 mg/day) as adjunctive therapy in adult subjects with a diagnosis of MDD with and without anxious distress
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders
- Trial name
- NCT02196506
- Testing
- Brexpiprazole +ADT
- Where
- 47 sites in United States, Germany and 3 more
- Volunteers
- 837 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Anxiety Disorder
Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety
Objective: The overall aim of this protocol is to examine the effect of pharmacological manipulations of affective and cognitive processes on anxiety and task performance.
- Trial name
- NCT02153944
- Testing
- Propranolol, Methylphenidate
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- National Institute of Mental Health (NIMH)
Knee Arthropathy, Hip Arthropathy
Preoperative Acupuncture for Total Knee or Hip Arthroplasty
Open-label, randomized controlled trial to determine the effect of preoperative acupuncture on preoperative anxiety and postoperative pain for high-anxiety patients undergoing total hip or knee arthroplasty.
- Conditions
- Knee Arthropathy, Hip Arthropathy, Anxiety
- Trial name
- (Acupuncture) (NCT06099223)
- Testing
- Acupuncture needles
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hartford Hospital