Clinical trials: Anxious-Depressive
Distress, Psychological, Depression - Major Depressive Disorder
Relief From Stress Via Social Protection in Senegal
Despite the growing prevalence of mental health disorders in low- and middle-income countries, significant barriers to seeking and accessing mental health services persist.
- Conditions
- Distress, Psychological, Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD)
- Trial name
- RESTORE (NCT06698471)
- Testing
- Community worker training, Referral to Health System
- Where
- Senegal
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Mild Cognitive Impairment, Depressive Symptoms
HEPPI: Efficacy of a Cognitive-Emotional Intervention for Homebound Older Adults
The main goal of this research is to assess the efficacy of a 10-week home-delivered cognitive-emotional intervention program for homebound older adults presenting Mild Cognitive Impairment (MCI) and depressive and/or anxiety…
- Conditions
- Mild Cognitive Impairment, Depressive Symptoms, Anxiety State
- Trial name
- HEPPI (NCT05499767)
- Testing
- HEPPI
- Where
- Portugal
- Volunteers
- 199 people
- Sponsor
- University of Coimbra
Depression - Major Depressive Disorder, Anxiety
Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans
This project will integrate pharmacological and psychophysiological methodology to mechanistically investigate, in humans, the role of N/OFQ in laboratory phenotypes of both disorders.
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Stress
- Trial name
- NCT06786637
- Testing
- Nociceptin Receptor Antagonist (LY-2940094), DS8R Biphasic Constant Current Stimulator
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression - Major Depressive Disorder, Anxiety
Clinical Impact of an Anti-Inflammatory Diet in Anxiety and Depression With AI
The goal of this clinical trial is to evaluate the effectiveness of an anti-inflammatory dietary intervention on physical health, mental health, and cognitive functioning in individuals with clinically diagnosed anxiety and/or…
- Trial name
- NCT07398040
- Testing
- Anti-inflammatory diet, Control
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad de Zaragoza
Major Depressive Disorder (MDD, Anxiety Disorder, Generalized
Serotonin Variants & Gut Microbiota in Mental Health
This observational pilot study investigates whether a broad panel of genetic variants relevant to the serotonin pathway (including serotonergic system, methylation cycle, intestinal barrier integrity, and inflammatory response…
- Conditions
- Major Depressive Disorder (MDD, Anxiety Disorder, Generalized, Stress Disorders, Post-Traumatic, Panic Disorder
- Trial name
- NCT07634458
- Testing
- SNP Genotyping and Gut Metagenomics
- Volunteers
- 30 people
- Sponsor
- Neurobiologix
Post-Acute COVID-19 Syndrome, Biofeedback, Psychology
Prevention of Long Covid Syndrome
Biofeedback equipment is classified by the Food and Drug Administration (FDA) as medical device class II and this type of equipment/treatment has shown evidence regarding stress management in post-Covid-19 syndrome.
- Conditions
- Post-Acute COVID-19 Syndrome, Biofeedback, Psychology, Quality of Life, Depressive Symptoms
- Trial name
- NCT05793736
- Testing
- Biofeedback training, Treatment as usual
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- University of Cagliari
Stress, Psychological, Depression
The Efficacy of a Mobile Application for Treating Depression and Anxiety Symptoms
This was a 12-week, parallel randomised controlled trial, including a 6-week follow-up. The trial compared a group of university students (N = 84) receiving a mobile CBT application intervention ("Feel Stress Free") to a…
- Conditions
- Stress, Psychological, Depression, Anxiety
- Trial name
- NCT03032952
- Testing
- "Feel Stress Free" mobile application
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University College, London
Breast Cancer
Epigenetics and Psychoneurologic Symptoms in Women With Breast Cancer
This study examines the relationship among epigenetic alterations and the development and persistence of psychoneurologic symptoms (cognitive dysfunction, depressive symptoms, anxiety, fatigue, sleep disturbance, and pain) in…
- Trial name
- NCT01411943
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Virginia Commonwealth University
Depression, Dysthymic Disorder
Rumination Focus Cognitive Behavior Therapy
1. To investigate the efficacy and acceptability of a guided internet-delivered transdiagnostic intervention targeting repetitive negative thinking for individuals with elevated levels of depression and generalized anxiety…
- Conditions
- Depression, Dysthymic Disorder, Panic Disorder, Social Phobia
- Trial name
- iRFCBT (NCT03507114)
- Testing
- Rumination-Focused CBT (RFCBT)
- Where
- Romania
- Volunteers
- 90 people
- Sponsor
- West University of Timisoara
Perinatal Depression, Depression, Postpartum
Thinking Healthy Program-Technology Assisted (THP-TA)
Background The Thinking Healthy Program (THP) is an evidence based task-shifted low intensity psychosocial intervention, recommended by the World Health Organization for the treatment of perinatal depression.
- Trial name
- THP-TA (NCT05353491)
- Testing
- Technology assisted Thinking Healthy Program (THP-TA), Standard Thinking Healthy Program
- Where
- Pakistan
- Volunteers
- 980 people
- Sponsor
- Human Development Research Foundation, Pakistan
Multiple Sclerosis (MS) - Relapsing-remitting, Anxiety
Psychological Interventions for Multiple Sclerosis: Effects on Anxiety, Depression, and Cognition.
This study evaluated the efficacy of two structured psychological interventions in individuals with relapsing-remitting multiple sclerosis (RRMS).
- Conditions
- Multiple Sclerosis (MS) - Relapsing-remitting, Anxiety, Depression, Cognitive Impairment
- Trial name
- MS-PSY (NCT07273604)
- Testing
- Cognitive Behavioral Therapy (CBT), Psychophysiological Regulation Therapy (PRT)
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Moisés Bermúdez Hernández
Anxiety Disorders, Depressive Disorder
A Prospective Study of Anxiety, Depression, and Bipolar Disorder in People
This study aims to understand how anxiety disorders, depressive disorders, and bipolar disorder change over time and to identify patterns that may help with earlier recognition, diagnosis, and prediction of future symptoms.
- Conditions
- Anxiety Disorders, Depressive Disorder, Bipolar Disorder (BD)
- Trial name
- NCT07903246
- Where
- China
- Volunteers
- 2,690 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Pain, Mental Health Disorder
Therapeutic Writing for Adults Suffering From Chronic Pain and Comorbid Mental Health Disorders
The goal of this observational study is to understand the effects and experiences of therapeutic writing interventions in adult women with chronic pain and co-occurring mental health conditions.
- Conditions
- Chronic Pain, Mental Health Disorder, Psychiatric &Amp;Amp;or Mood Disorder, Psychiatric Comorbidities
- Trial name
- TWfCP&MH (NCT07058532)
- Testing
- Therapeutic Writing Intervention in Pain Rehabilitation
- Where
- Finland
- Sponsor
- Toni Salikka
Pancreas Adenocarcinoma
Analysis Of The Anxiety-Depressive Pattern, Quality Of Life And Assessment Of Personality in Patients With Pancreatic Ductal Adenocarcinoma (PACT24)
The aim of this study is the evaluation of psychological aspects, such as anxiety-depressive patterns, quality of life, personality and other psychopathological syndromes of patients who receive a diagnosis of pancreatic cancer…
- Trial name
- NCT04396093
- Testing
- psychological support
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Michele Reni
Coronary Heart Disease
Unstable Angina Pectoris in Comorbidity With Anxiety-depressive Syndrome
Introduction: Today it is necessary to emphasize that coronary heart disease is often associated with anxiety disorders. Research over the years has shown several and sometimes surprising links between coronary heart disease and…
- Trial name
- NCT04599621
- Testing
- Collection of blood samples to determine the level of certain cytokines (TNF-α, IL-1β, IL-4 and IL-10),Collection of blood samples to determine the level of uric acid
- Where
- Uzbekistan
- Volunteers
- 3 people
- Sponsor
- Samarkand State Medical Institute
Depression, Suicide
Youth Depression and Suicide Research Network
The objective of this study is to build the Texas Youth Depression and Suicide Research Network to support the development of a Network Participant Registry and characterization of systems and interventions to examine statewide…
- Conditions
- Depression, Suicide, Suicidal Ideation, Suicide, Attempted
- Trial name
- YDSRN (NCT04572321)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Mental Health Disorders in Adolescents, Emotional Dysregulation
Dog-Assisted Therapy in Adolescents Attending a Child and Adolescent Mental Health Day Hospital
This study aimed to evaluate the feasibility and effectiveness of a dog-assisted therapy program integrated into a Child and Adolescent Mental Health Day Hospital, as well as to explore participants' subjective experiences.
- Conditions
- Mental Health Disorders in Adolescents, Emotional Dysregulation, Anxiety Disorders, Depressive Disorders
- Trial name
- DAT-MH-DH (NCT07663916)
- Testing
- Experimental: Experimental: Dog-assisted therapy + Treatment as usual, Active Comparator: Treatment as usual
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Clinic of Barcelona
Substance-Related Disorders, Depressive Disorder
Research on Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders
Adolescent substance abuse results in significant negative outcomes and extraordinary costs for youths, their families, communities, and society.
- Conditions
- Substance-Related Disorders, Depressive Disorder, Anxiety Disorder
- Trial name
- NCT01117753
- Testing
- OutPatient Treatment for Adolescents (OPT-A), Treatment As Usual
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Medical University of South Carolina
Chronic Condition, Chronic Pain
RIVER At Home Ketamine Protocols
Multiple site studies with the recruitment of other sub-investigators and sites. It's sobering to consider how chronic illness makes us more vulnerable to suicidal thoughts and behavior.
- Conditions
- Chronic Condition, Chronic Pain, Chronic Disease, Major Depressive Disorder
- Trial name
- NCT06070766
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 50,000 people
- Sponsor
- RIVER Foundation
Depression, Anxiety
Consultation-Liaison Intervention for Patients with Depression and Anxiety in Primary Care
The CoLiPri study is a cluster randomized controlled trial funded by the Swiss National Science Foundation to evaluate the clinical and cost effectiveness as well as the implementation of a complex consultation-liaison…
- Trial name
- CoLiPri (NCT04233853)
- Testing
- CoLiPri intervention, Usual primary care enhanced
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- University of Zurich