Clinical trials: Anxious-Depressive
Social Anxiety Disorder, Major Depressive Disorder
Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder
This placebo-controlled study is designed to determine the efficacy, safety, and tolerability of vortioxetine in the treatment of adults with Major Depressive Disorder (MDD) that is comorbid with Social Anxiety Disorder (SAD).
- Trial name
- NCT02294305
- Testing
- Vortioxetine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Medical Research Network
Major Depression, Unipolar Depression
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder
Background: Medications to treat major depression act on a brain chemical called serotonin, which binds to receptors on brain cells.
- Conditions
- Major Depression, Unipolar Depression, Depression, Anxiety Disorder
- Trial name
- NCT01313403
- Testing
- Antidepressant (SSRI)
- Sponsor
- National Institute of Mental Health (NIMH)
Postpartum Pain, Postpartum Depression
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery
Patients presenting for normal spontaneous vaginal delivery who have a neuraxial anesthestic will be randomized to receive preservative free morphine or saline placebo after delivery.
- Conditions
- Postpartum Pain, Postpartum Depression, Opioid Consumption
- Trial name
- NCT04017442
- Testing
- Preservative Free Morphine, Saline
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Clinical Depression, Clinical Anxiety
Efficacy of Psychological Intervention for Children With Cancer
The study will be conductued at the Pediatric Oncology Department of the Children's Hospital, PIMS Islamabad, over the peroid of six months.
- Conditions
- Clinical Depression, Clinical Anxiety, Quality of Life
- Trial name
- NCT06620445
- Testing
- Interventiion or CBT Group
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Pakistan Institute of Medical Sciences
Autism Spectrum Disorder, Depressive Disorder
Feasibility, Acceptability, and Preliminary Effectiveness of Cognitive Behavioral Therapy for Depression in Autistic Youth in Clinical Settings
The goal of this clinical trial is to learn if Cognitive Behavioral Therapy for Depression in Autistic Youth (CBT-DAY) can improve depressive symptoms and related mechanisms in autistic youth aged 11-17 years with depression…
- Conditions
- Autism Spectrum Disorder, Depressive Disorder, Anxiety Disorders
- Trial name
- CBT-DAY (NCT07755137)
- Testing
- CBT-DAY (Cognitive Behavioral Therapy for Depression in Autistic Youth), Treatment-as-Usual (TAU)
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Children's Hospital Los Angeles
Fibromyalgia, Psychological Trauma
Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia
Fibromyalgia (FM) is a generalized, widespread chronic pain disorder and has an estimated prevalence of 2%-4% in the general population.
- Conditions
- Fibromyalgia, Psychological Trauma, Depressive Symptoms, Anxiety
- Trial name
- NCT04084795
- Testing
- Eye Movement Desensitization and Reprocessing therapy, transcranial Direct Current Stimulation
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Parc de Salut Mar
Medication Adherence, Depressive Symptoms
Testing THRIVE 365 for Black Sexual Minority Men (On The Daily)
The primary goal of this study is to test a minority stress model of psychological health outcomes for Black sexual minority men (BSMM) while using and not using a novel intervention named THRIVE 365.
- Conditions
- Medication Adherence, Depressive Symptoms, Anxiety Symptoms, Emotion Regulation
- Trial name
- OTD (NCT05376397)
- Testing
- iTHRIVE 365
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Mental Health Issue, Substance Use Disorders
Improving Maternal Mental Health & SUD Screening and Treatment
The purpose of the study is to compare a text message-based mental health and substance use screening and referral to a treatment program, called Listening to Women and Pregnant and Postpartum People (LTWP), to standard of care…
- Conditions
- Mental Health Issue, Substance Use Disorders, Postpartum Depression, Postpartum Anxiety
- Trial name
- NCT05764213
- Testing
- Listening to Women & Pregnant and Postpartum People
- Where
- United States
- Volunteers
- 10,469 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Post-Traumatic Stress Disorder (PTSD), Depressive Symptoms
Trauma-Focused Cognitive Behavioral Therapy in Unaccompanied Refugee Minors With PTSD in Greece: An RCT
This single-blinded, multicentered, randomized controlled trial aims to evaluate the effectiveness of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) compared to Treatment-as-Usual (TAU) in reducing post-traumatic stress…
- Conditions
- Post-Traumatic Stress Disorder (PTSD), Depressive Symptoms, Anxiety Symptoms, Somatic Symptoms
- Trial name
- TF-CBT (NCT06975280)
- Testing
- Trauma - Focused Cognitive Behavioral Therapy, Treatment as Usual (TAU)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Theodora Anastasiou
Postpartum Depression (PPD)
An Online Self-compassion Intervention for Anxiety and Depression in Fathers of Infants: A Feasibility Study
To investigate the feasibility, acceptability, and preliminary effectiveness of an online mindfulness and self-compassion intervention for the mental health in fathers experiencing paternal perinatal depression (PPD).
- Trial name
- NCT07077759
- Testing
- Online self-compassion intervention
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Major Depression
Computerized Information-Processing Bias Retraining in Depressed Adolescents
This study will examine how well a novel four-session computerized program, designed to help adolescents learn to interpret ambiguous situations less negatively, reduces symptoms of depression and decreases negative…
- Trial name
- NCT01147913
- Testing
- Computerized Information-Processing Bias Retraining, Attention Control Training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment, Depressive Symptoms
Homebound Elderly People Psychotherapeutic Intervention
This study aims to develop, implement, and assess the feasibility, acceptability, and preliminary efficacy of a 10-week structured and individualized cognitive-emotional intervention program for homebound older adults with Mild…
- Conditions
- Mild Cognitive Impairment, Depressive Symptoms, Anxiety State
- Trial name
- HEPPI (NCT04967378)
- Testing
- HEPPI
- Where
- Portugal
- Volunteers
- 51 people
- Sponsor
- University of Coimbra
Major Depressive Disorder, Anxiety
The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depression
To measure the effects of Microbial Ecosystem Therapeutics (MET)-2 on symptoms of depression and anxiety using pre- and post-treatment scores for overall depression and anxiety
- Trial name
- NCT04602715
- Testing
- MET-2
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- NuBiyota
Depressive Disorder, Anxiety
Adjunctive Resonance-Based Chinese Five-Element Music Intervention for Depressive Disorders and Anxiety Symptoms in Male Inpatients
This randomized controlled trial will evaluate the effectiveness of Resonance-Based Chinese Five-Element Music Intervention (RFEMI) as an adjunct to pharmacotherapy in male inpatients with depressive disorders.
- Conditions
- Depressive Disorder, Anxiety, Randomised Controlled Trial
- Trial name
- RCFMI (NCT07653113)
- Testing
- Resonance-Based Chinese Five-Element Music Intervention(RFEMI) plus pharmacotherapy group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- University of Malaya
Major Depressive Disorder, Mood Disorder
Laughter Yoga Intervention for People With Major Depressive Disorder
The present study will adopt a non-blinded parallel-group randomized controlled trial design that involves a Laughter Yoga group (intervention) and a treatment-as-usual group (Control).
- Conditions
- Major Depressive Disorder, Mood Disorder, Depression
- Trial name
- NCT03163940
- Testing
- Laughter Yoga
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Major Depressive Disorder, General Anxiety Disorder
Emotional Brain Networks & Cognitive Functioning in Depression and Anxiety
This study aims to 1) examine common and specific emotional and cognitive dysfunctions between Major Depression and generalized anxiety disorder; 2) Examine emotional and cognitive dysfunctions between the two disorders and…
- Trial name
- NCT03084042
- Testing
- fMRI
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Cognitive Therapy, Depression, Postpartum
RCT of Automated Conversational Agent vs. Treatment as Usual for the Management of Perinatal Mood
The purpose of this study is to investigate the efficacy of an evidence-based smartphone application (app) for the management of mood compared to treatment as usual alone among 135 women who have been discharged post-delivery…
- Conditions
- Cognitive Therapy, Depression, Postpartum, Mental Health, Depression
- Trial name
- NCT03646539
- Testing
- Use of smartphone application (app), Treatment as usual
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Subjects, Depressive Disorder and Anxiety Disorders
Study Of Safety, Blood Levels, And Brain Receptor Occupancy Of GSK163090 Using PET Imaging In Healthy Males
The purpose of this study is to look at how much of a new drug, GSK163090, binds to proteins in the brain and how much stays in the blood over a range of different doses.
- Trial name
- NCT00435695
- Testing
- GSK163090
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Major Depression, Generalized Anxiety
Neural Mechanisms of Real-world Emotions and Internalizing
This study utilizes mobile health methods, including smartphone technology, subjective self-reports measures of emotion, behavioral tasks, functional Magnetic Resonance Imaging (fMRI), physiological measures of attention and…
- Conditions
- Major Depression, Generalized Anxiety, Emotions
- Trial name
- NCT07891624
- Testing
- Academic Performance Feedback
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Miami
Anxiety Disorders
Expectation of Unpleasant Events in Anxiety Disorders
Fear and anxiety are normal responses to a threat. However, anxiety is considered abnormal when the response to the threat is excessive or inappropriate.
- Trial name
- NCT00055224
- Testing
- Threat of shock
- Where
- United States
- Volunteers
- 921 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)